A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis
In conclusion, our study delivers a generic methodology for developing and assessing AOP networks. The quantitative WoE scoring method facilitates in determining the level of support for KERs within the optimized AOP network, offering valuable insights into its utility in both scientific research and regulatory contexts. KERs supported by robust evidence represent promising candidates for inclusion in an in vitro test battery for reliably predicting chemical-induced liver steatosis within regulatory frameworks.PMID:38677583 | DOI:10.1016/j.tox.2024.153814 (Source: Toxicology)
Source: Toxicology - April 27, 2024 Category: Toxicology Authors: Anouk Verhoeven Jonas van Ertvelde Joost Boeckmans Alexandra Gatzios Ramiro Jover Birgitte Lindeman Graciela Lopez-Soop Robim M Rodrigues Anna Rapisarda Julen Sanz-Serrano Marth Stinckens Sara Sepehri Marc Teunis Mathieu Vinken Jian Jiang Tamara Vanhaecke Source Type: research
Acute Hepatitis of Unknown Origin in Children: Analysis of 17 Cases Admitted to the Bambino Ges ù Children's Hospital in Rome
This study described 17 cases of children admitted to the Bambino Gesù Children's Hospital with acute hepatitis of unknown origin between mid-April and November 2022. Following the World Health Organization's working case definition of probable cases, 17 children, with a median age of 2.1 years (interquartile range: 1.0-7.1), presenting with acute hepatitis non-AE, with serum transaminase >500 IU/L, were included in the study. A pre-specified set of microbiological tests was performed on different biological specimens for all pediatric patients. All patients resulted negative for the common hepatotropic viruses. The mo...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Velia Chiara Di Maio Leonarda Gentile Rossana Scutari Luna Colagrossi Luana Coltella Stefania Ranno Giulia Linardos Daniela Liccardo Maria Sole Basso Andrea Pietrobattista Simona Landi Lorena Forqu é Marta Ciofi Degli Atti Lara Ricotta Andrea Onetti Muda Source Type: research
The Effect of Pringle Maneuver Applied during Living Donor Hepatectomy on the Ischemia-Reperfusion Injury Observed in the Donors and Recipients
Conclusions: Although the histological scoring of hepatocyte damage was found to be higher in the Pringle maneuver group, the Pringle maneuver did not augment ischemia-reperfusion injury in donors and recipients that was evaluated by clinical and laboratory analyses.PMID:38674295 | PMC:PMC11051728 | DOI:10.3390/medicina60040649 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Yasin Dalda Sami Akbulut Tevfik Tolga Sahin Adem Tuncer Zeki Ogut Basri Satilmis Ozlem Dalda Mehmet Gul Sezai Yilmaz Source Type: research
A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis
In conclusion, our study delivers a generic methodology for developing and assessing AOP networks. The quantitative WoE scoring method facilitates in determining the level of support for KERs within the optimized AOP network, offering valuable insights into its utility in both scientific research and regulatory contexts. KERs supported by robust evidence represent promising candidates for inclusion in an in vitro test battery for reliably predicting chemical-induced liver steatosis within regulatory frameworks.PMID:38677583 | DOI:10.1016/j.tox.2024.153814 (Source: Toxicology)
Source: Toxicology - April 27, 2024 Category: Toxicology Authors: Anouk Verhoeven Jonas van Ertvelde Joost Boeckmans Alexandra Gatzios Ramiro Jover Birgitte Lindeman Graciela Lopez-Soop Robim M Rodrigues Anna Rapisarda Julen Sanz-Serrano Marth Stinckens Sara Sepehri Marc Teunis Mathieu Vinken Jian Jiang Tamara Vanhaecke Source Type: research
The Effect of Pringle Maneuver Applied during Living Donor Hepatectomy on the Ischemia-Reperfusion Injury Observed in the Donors and Recipients
Conclusions: Although the histological scoring of hepatocyte damage was found to be higher in the Pringle maneuver group, the Pringle maneuver did not augment ischemia-reperfusion injury in donors and recipients that was evaluated by clinical and laboratory analyses.PMID:38674295 | PMC:PMC11051728 | DOI:10.3390/medicina60040649 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Yasin Dalda Sami Akbulut Tevfik Tolga Sahin Adem Tuncer Zeki Ogut Basri Satilmis Ozlem Dalda Mehmet Gul Sezai Yilmaz Source Type: research
A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis
In conclusion, our study delivers a generic methodology for developing and assessing AOP networks. The quantitative WoE scoring method facilitates in determining the level of support for KERs within the optimized AOP network, offering valuable insights into its utility in both scientific research and regulatory contexts. KERs supported by robust evidence represent promising candidates for inclusion in an in vitro test battery for reliably predicting chemical-induced liver steatosis within regulatory frameworks.PMID:38677583 | DOI:10.1016/j.tox.2024.153814 (Source: Toxicology)
Source: Toxicology - April 27, 2024 Category: Toxicology Authors: Anouk Verhoeven Jonas van Ertvelde Joost Boeckmans Alexandra Gatzios Ramiro Jover Birgitte Lindeman Graciela Lopez-Soop Robim M Rodrigues Anna Rapisarda Julen Sanz-Serrano Marth Stinckens Sara Sepehri Marc Teunis Mathieu Vinken Jian Jiang Tamara Vanhaecke Source Type: research
The Effect of Pringle Maneuver Applied during Living Donor Hepatectomy on the Ischemia-Reperfusion Injury Observed in the Donors and Recipients
Conclusions: Although the histological scoring of hepatocyte damage was found to be higher in the Pringle maneuver group, the Pringle maneuver did not augment ischemia-reperfusion injury in donors and recipients that was evaluated by clinical and laboratory analyses.PMID:38674295 | PMC:PMC11051728 | DOI:10.3390/medicina60040649 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Yasin Dalda Sami Akbulut Tevfik Tolga Sahin Adem Tuncer Zeki Ogut Basri Satilmis Ozlem Dalda Mehmet Gul Sezai Yilmaz Source Type: research
The Effect of Pringle Maneuver Applied during Living Donor Hepatectomy on the Ischemia-Reperfusion Injury Observed in the Donors and Recipients
Conclusions: Although the histological scoring of hepatocyte damage was found to be higher in the Pringle maneuver group, the Pringle maneuver did not augment ischemia-reperfusion injury in donors and recipients that was evaluated by clinical and laboratory analyses.PMID:38674295 | PMC:PMC11051728 | DOI:10.3390/medicina60040649 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Yasin Dalda Sami Akbulut Tevfik Tolga Sahin Adem Tuncer Zeki Ogut Basri Satilmis Ozlem Dalda Mehmet Gul Sezai Yilmaz Source Type: research
Cancers, Vol. 16, Pages 1700: Application of Deep Learning for Real-Time Ablation Zone Measurement in Ultrasound Imaging
Conclusion: The study validates the Mask2Former model as a promising tool for automating AZ measurement in RFA research, offering a significant step towards reducing manual measurement variability. (Source: Cancers)
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Corinna Zimmermann Adrian Michelmann Yannick Daniel Markus D. Enderle Nermin Salkic Walter Linzenbold Tags: Article Source Type: research
Radiological and Surgical Treatments of Portal Hypertension
Interventions for portal hypertension are continuously evolving and expanding beyond the realm of medical management. When complications such as varices and ascites persist despite conservative interventions, procedures including transjugular intrahepatic portosystemic shunt creation, transvenous obliteration, portal vein recanalization, splenic artery embolization, surgical shunt creation, and devascularization are all potential interventions detailed in this article. Selection of the optimal procedure to address the underlying cause, treat symptoms, and, in some cases, bridge to liver transplantation depends on the speci...
Source: Clinics in Liver Disease - April 27, 2024 Category: Gastroenterology Authors: Charlotte Hunt, Mausam Patel, Maria del Pilar Bayona Molano, Madhukar S. Patel, Lisa B. VanWagner Source Type: research
Changing etiological spectrum of acute liver failure
ConclusionsThe most common cause for ALF was hepatitis A virus, followed by hepatitis B virus, while in ALF mimics it was malaria followed by dengue fever, in our study. Patients of ALF mimics can have similar presentation, but a high index of suspicion and awareness is required to identify the common infectious ALF mimics for early diagnosis.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 27, 2024 Category: Gastroenterology Source Type: research
Viruses, Vol. 16, Pages 682: Reduction of the Risk of Hepatocellular Carcinoma over Time Using Direct-Acting Antivirals: A Propensity Score Analysis of a Real-Life Cohort (PITER HCV)
unetto
Anna Linda Zignego
Carmine Coppola
Andrea Iannone
Elisa Biliotti
Elena Rosselli Del Turco
Marco Massari
Anna Licata
Francesco Barbaro
Marcello Persico
Filomena Morisco
Maurizio Pompili
Federica Cerini
Massimo Puoti
Teresa Santantonio
Antonio Craxì
Loreta A. Kondili
Liliana Chemello Investigators
on behalf of PITER Collaborating Investigators on behalf of PITER Collaborating Investigators
The treatment of hepatitis C virus (HCV) with direct-acting antivirals (DAA) leads to high sustained virological response (SVR) rates, but hepatocellular carcinoma (HCC) risk persists in peop...
Source: Viruses - April 26, 2024 Category: Virology Authors: Maria Giovanna Quaranta Luisa Cavalletto Francesco Paolo Russo Vincenza Calvaruso Luigina Ferrigno Alberto Zanetto Benedetta Mattioli Roberta D ’Ambrosio Valentina Panetta Giuseppina Brancaccio Giovanni Raimondo Maurizia Rossana Brunetto Anna Linda Zign Tags: Article Source Type: research
Trends in Current Use of Machine Perfusion for Donation after Cardiac Death Donors in the United States
The recent meta-analysis of machine-perfusion techniques for liver transplant by Parente et al.1 provides a much-awaited comprehensive assessment of the current literature on machine perfusion compared to static cold storage. With the promise of optimizing marginal and extended criteria grafts, and minimizing their risk of ischemic reperfusion injury, the transplant community has seen a progressive adoption of various perfusion strategies in the last several years. However, the landscape remains in flux regarding its optimal role and indications. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Lauren E. Matevish, Parsia A. Vagefi, Madhukar S. Patel Tags: Letter to the Editor Source Type: research
Difficult transplant decisions in acute liver failure —Benefit versus futility, where to draw a line
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 26, 2024 Category: Gastroenterology Source Type: research
