Routine utilization of machine perfusion in liver transplantation: Ready for prime time?
World J Gastroenterol. 2024 Mar 21;30(11):1488-1493. doi: 10.3748/wjg.v30.i11.1488.ABSTRACTThe last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver preservation. Robust evidence from numerous randomized controlled trials has been pooled by meta-analyses, providing the highest available evidence on the protective effect of machine perfusion (MP) over static cold storage in liver transplantation (LT). Based on a protective effect with less complications and improved graft survival, the field has seen a paradigm shift in organ preservation. This editorial fo...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Alessandro Parente Keyue Sun Philipp Dutkowski Am James Shapiro Andrea Schlegel Source Type: research
Gastroenterology/Hepatology: What You May Have Missed in 2023
This article summarizes clinically important gastroenterology developments from 2023 for internal medicine specialists. In colorectal cancer screening, a new RNA fecal screening test is on the horizon, as well as a new analysis on the benefits of using artificial intelligence in screening colonoscopy to detect more polyps. There is new evidence for management of gastrointestinal bleeding, a new drug for treatment of recurrent small-intestinal angiodysplasia, and a new endoscopic treatment method in patients with gastrointestinal tumor bleeding. The authors feature a randomized trial about amitriptyline as treatment for pat...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Sama Anvari Kayla Dadgar Ciar án Galts Michael Bretthauer Source Type: research
Routine utilization of machine perfusion in liver transplantation: Ready for prime time?
World J Gastroenterol. 2024 Mar 21;30(11):1488-1493. doi: 10.3748/wjg.v30.i11.1488.ABSTRACTThe last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver preservation. Robust evidence from numerous randomized controlled trials has been pooled by meta-analyses, providing the highest available evidence on the protective effect of machine perfusion (MP) over static cold storage in liver transplantation (LT). Based on a protective effect with less complications and improved graft survival, the field has seen a paradigm shift in organ preservation. This editorial fo...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Alessandro Parente Keyue Sun Philipp Dutkowski Am James Shapiro Andrea Schlegel Source Type: research
Routine utilization of machine perfusion in liver transplantation: Ready for prime time?
World J Gastroenterol. 2024 Mar 21;30(11):1488-1493. doi: 10.3748/wjg.v30.i11.1488.ABSTRACTThe last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver preservation. Robust evidence from numerous randomized controlled trials has been pooled by meta-analyses, providing the highest available evidence on the protective effect of machine perfusion (MP) over static cold storage in liver transplantation (LT). Based on a protective effect with less complications and improved graft survival, the field has seen a paradigm shift in organ preservation. This editorial fo...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Alessandro Parente Keyue Sun Philipp Dutkowski Am James Shapiro Andrea Schlegel Source Type: research
Gastroenterology/Hepatology: What You May Have Missed in 2023
This article summarizes clinically important gastroenterology developments from 2023 for internal medicine specialists. In colorectal cancer screening, a new RNA fecal screening test is on the horizon, as well as a new analysis on the benefits of using artificial intelligence in screening colonoscopy to detect more polyps. There is new evidence for management of gastrointestinal bleeding, a new drug for treatment of recurrent small-intestinal angiodysplasia, and a new endoscopic treatment method in patients with gastrointestinal tumor bleeding. The authors feature a randomized trial about amitriptyline as treatment for pat...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Sama Anvari Kayla Dadgar Ciar án Galts Michael Bretthauer Source Type: research
Routine utilization of machine perfusion in liver transplantation: Ready for prime time?
World J Gastroenterol. 2024 Mar 21;30(11):1488-1493. doi: 10.3748/wjg.v30.i11.1488.ABSTRACTThe last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver preservation. Robust evidence from numerous randomized controlled trials has been pooled by meta-analyses, providing the highest available evidence on the protective effect of machine perfusion (MP) over static cold storage in liver transplantation (LT). Based on a protective effect with less complications and improved graft survival, the field has seen a paradigm shift in organ preservation. This editorial fo...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Alessandro Parente Keyue Sun Philipp Dutkowski Am James Shapiro Andrea Schlegel Source Type: research
Routine utilization of machine perfusion in liver transplantation: Ready for prime time?
World J Gastroenterol. 2024 Mar 21;30(11):1488-1493. doi: 10.3748/wjg.v30.i11.1488.ABSTRACTThe last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver preservation. Robust evidence from numerous randomized controlled trials has been pooled by meta-analyses, providing the highest available evidence on the protective effect of machine perfusion (MP) over static cold storage in liver transplantation (LT). Based on a protective effect with less complications and improved graft survival, the field has seen a paradigm shift in organ preservation. This editorial fo...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Alessandro Parente Keyue Sun Philipp Dutkowski Am James Shapiro Andrea Schlegel Source Type: research
Gastroenterology/Hepatology: What You May Have Missed in 2023
This article summarizes clinically important gastroenterology developments from 2023 for internal medicine specialists. In colorectal cancer screening, a new RNA fecal screening test is on the horizon, as well as a new analysis on the benefits of using artificial intelligence in screening colonoscopy to detect more polyps. There is new evidence for management of gastrointestinal bleeding, a new drug for treatment of recurrent small-intestinal angiodysplasia, and a new endoscopic treatment method in patients with gastrointestinal tumor bleeding. The authors feature a randomized trial about amitriptyline as treatment for pat...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Sama Anvari Kayla Dadgar Ciar án Galts Michael Bretthauer Source Type: research
Routine utilization of machine perfusion in liver transplantation: Ready for prime time?
World J Gastroenterol. 2024 Mar 21;30(11):1488-1493. doi: 10.3748/wjg.v30.i11.1488.ABSTRACTThe last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver preservation. Robust evidence from numerous randomized controlled trials has been pooled by meta-analyses, providing the highest available evidence on the protective effect of machine perfusion (MP) over static cold storage in liver transplantation (LT). Based on a protective effect with less complications and improved graft survival, the field has seen a paradigm shift in organ preservation. This editorial fo...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Alessandro Parente Keyue Sun Philipp Dutkowski Am James Shapiro Andrea Schlegel Source Type: research
Routine utilization of machine perfusion in liver transplantation: Ready for prime time?
World J Gastroenterol. 2024 Mar 21;30(11):1488-1493. doi: 10.3748/wjg.v30.i11.1488.ABSTRACTThe last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver preservation. Robust evidence from numerous randomized controlled trials has been pooled by meta-analyses, providing the highest available evidence on the protective effect of machine perfusion (MP) over static cold storage in liver transplantation (LT). Based on a protective effect with less complications and improved graft survival, the field has seen a paradigm shift in organ preservation. This editorial fo...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Alessandro Parente Keyue Sun Philipp Dutkowski Am James Shapiro Andrea Schlegel Source Type: research
Diagnosing and Grading of Sinusoidal Obstructive Syndrome after Hematopoietic Stem Cell Transplant of Children, Adolescent and Young Adults treated in a Pediatric Institution with Pediatric Protocols
Sinusoidal obstructive syndrome (SOS), previously known as hepatic veno-occlusive disease (VOD), has been recognized as a complex and life-threatening complication following hematopoietic stem cell transplantation (HSCT). SOS is a complication that develops after injury to the micro-vasculature and endothelial cells of the liver. Damage to endothelial cells promotes increased expression of pro-inflammatory cytokines and adhesion molecules in the vascular endothelium, leading to sinusoidal narrowing and micro-vascular occlusion, altered liver cytoskeletal architecture, weakened intercellular junctions, and further liver dam...
Source: Biology of Blood and Marrow Transplantation - April 15, 2024 Category: Hematology Authors: Gabriel Salinas Cisneros, Christopher C Dvorak, Janel Long-Boyle, Sandhya Kharbanda, Kristin A Shimano, Alexis Melton, Julia Chu, Lena E Winestone, Jasmeen Dara, James N Huang, Michelle L Hermiston, Matt Zinter, Christine S Higham Source Type: research
Safety and efficacy of elexacaftor/tezacaftor/ivacaftor in people with Cystic Fibrosis following liver transplantation: A systematic review
Cystic fibrosis (CF) is a multisystem disease caused by variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and resulting in deficient or dysfunctional CFTR protein [1]. F508del is the most prevalent disease-causing variant in people with CF (pwCF), occurring in 80 –85 % of cases [2,3]. The prognosis has largely been determined by the pulmonary complications of the disease. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 13, 2024 Category: Respiratory Medicine Authors: Ilaria Testa, Giuseppe Indolfi, Rossa Brugha, Henkjan J Verkade, Vito Terlizzi Tags: Review Source Type: research
Spatially resolved immune exhaustion within the alloreactive microenvironment predicts liver transplant rejection
Sci Adv. 2024 Apr 12;10(15):eadm8841. doi: 10.1126/sciadv.adm8841. Epub 2024 Apr 12.ABSTRACTAllograft rejection is common following clinical organ transplantation, but defining specific immune subsets mediating alloimmunity has been elusive. Calcineurin inhibitor dose escalation, corticosteroids, and/or lymphocyte depleting antibodies have remained the primary options for treatment of clinical rejection episodes. Here, we developed a highly multiplexed imaging mass cytometry panel to study the immune response in archival biopsies from 79 liver transplant (LT) recipients with either no rejection (NR), acute T cell-mediated ...
Source: Adv Data - April 12, 2024 Category: Epidemiology Authors: Arianna Barbetta Brittany Rocque Sarah Bangerth Kelly Street Carly Weaver Shefali Chopra Janet Kim Linda Sher Brice Gaudilliere Omid Akbari Rohit Kohli Juliet Emamaullee Source Type: research
New and emerging treatments for metabolic dysfunction-associated steatohepatitis
Cell Metab. 2024 Apr 7:S1550-4131(24)00090-1. doi: 10.1016/j.cmet.2024.03.011. Online ahead of print.ABSTRACTMetabolic dysfunction-associated steatohepatitis (MASH) is a leading etiology of chronic liver disease worldwide, with increasing incidence and prevalence in the setting of the obesity epidemic. MASH is also a leading indication for liver transplantation, given its associated risk of progression to end-stage liver disease. A key challenge in managing MASH is the lack of approved pharmacotherapy. In its absence, lifestyle interventions with a focus on healthy nutrition and regular physical activity have been the corn...
Source: Cell Metabolism - April 12, 2024 Category: Cytology Authors: Monica A Tincopa Quentin M Anstee Rohit Loomba Source Type: research
Gut microbiome-mediated monocytes promote liver metastasis
In this study, we found that fecal microbiome transplantation (FMT) from the stool of patients with liver metastasis (LM) significantly promoted liver metastasis compared with healthy donors (HD). Monocytes were upregulated in liver tissues by the CCL2/CCR2 axis in LM patients' stool transplanted mouse model. CCL2/CCR2 inhibition and monocyte depletion significantly suppress liver metastasis. FMT using LM patients' stool enhanced the plasma lipopolysaccharides (LPS) concentration. The LPS/TLR4 signaling pathway is crucial for gut microbiome-mediated liver metastasis. These results indicated that monocytes contribute to liv...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Wenzhong Zhang Jie Ling Baiying Xu Jie Wang Zexu Chen Gang Li Source Type: research
