Spatially resolved immune exhaustion within the alloreactive microenvironment predicts liver transplant rejection
Sci Adv. 2024 Apr 12;10(15):eadm8841. doi: 10.1126/sciadv.adm8841. Epub 2024 Apr 12.ABSTRACTAllograft rejection is common following clinical organ transplantation, but defining specific immune subsets mediating alloimmunity has been elusive. Calcineurin inhibitor dose escalation, corticosteroids, and/or lymphocyte depleting antibodies have remained the primary options for treatment of clinical rejection episodes. Here, we developed a highly multiplexed imaging mass cytometry panel to study the immune response in archival biopsies from 79 liver transplant (LT) recipients with either no rejection (NR), acute T cell-mediated ...
Source: Adv Data - April 12, 2024 Category: Epidemiology Authors: Arianna Barbetta Brittany Rocque Sarah Bangerth Kelly Street Carly Weaver Shefali Chopra Janet Kim Linda Sher Brice Gaudilliere Omid Akbari Rohit Kohli Juliet Emamaullee Source Type: research
Gut microbiome-mediated monocytes promote liver metastasis
In this study, we found that fecal microbiome transplantation (FMT) from the stool of patients with liver metastasis (LM) significantly promoted liver metastasis compared with healthy donors (HD). Monocytes were upregulated in liver tissues by the CCL2/CCR2 axis in LM patients' stool transplanted mouse model. CCL2/CCR2 inhibition and monocyte depletion significantly suppress liver metastasis. FMT using LM patients' stool enhanced the plasma lipopolysaccharides (LPS) concentration. The LPS/TLR4 signaling pathway is crucial for gut microbiome-mediated liver metastasis. These results indicated that monocytes contribute to liv...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Wenzhong Zhang Jie Ling Baiying Xu Jie Wang Zexu Chen Gang Li Source Type: research
New and emerging treatments for metabolic dysfunction-associated steatohepatitis
Cell Metab. 2024 Apr 7:S1550-4131(24)00090-1. doi: 10.1016/j.cmet.2024.03.011. Online ahead of print.ABSTRACTMetabolic dysfunction-associated steatohepatitis (MASH) is a leading etiology of chronic liver disease worldwide, with increasing incidence and prevalence in the setting of the obesity epidemic. MASH is also a leading indication for liver transplantation, given its associated risk of progression to end-stage liver disease. A key challenge in managing MASH is the lack of approved pharmacotherapy. In its absence, lifestyle interventions with a focus on healthy nutrition and regular physical activity have been the corn...
Source: Cell Metabolism - April 12, 2024 Category: Cytology Authors: Monica A Tincopa Quentin M Anstee Rohit Loomba Source Type: research
Genes, Vol. 15, Pages 487: The Effect of Short-Term Artificial Feed Domestication on the Expression of Oxidative-Stress-Related Genes and Antioxidant Capacity in the Liver and Gill Tissues of Mandarin Fish (Siniperca chuatsi)
ui Xie
Guoqing Zeng
To investigate whether Mandarin fish developed oxidative stress after being domesticated with artificial feed, we conducted a series of experiments. Oxidative stress is an important factor leading to diseases and aging in the body. The liver integrates functions such as digestion, metabolism, detoxification, coagulation, and immune regulation, while the gills are important respiratory organs that are sensitive to changes in the water environment. Therefore, we used the liver and gills of Mandarin fish as research materials. The aim of this study was to investigate the effects of short-term artific...
Source: Genes - April 12, 2024 Category: Genetics & Stem Cells Authors: Zhou Zhang Xiping Yuan Hao Wu Jinwei Gao Jiayu Wu Zhenzhen Xiong Zhifeng Feng Min Xie Shaoming Li Zhonggui Xie Guoqing Zeng Tags: Article Source Type: research
The impact of county-level food access on the mortality and post-transplant survival among patients with steatotic liver disease
The impact of county-level food access on mortality associated with steatotic liver disease, as well as post –liver transplant outcomes among individuals with steatotic liver disease, have not been characterized. (Source: Surgery)
Source: Surgery - April 12, 2024 Category: Surgery Authors: Yutaka Endo, Diamantis I. Tsilimigras, Mujtaba Khalil, Jason Yang, Selamawit Woldesenbet, Kazunari Sasaki, Ashley Limkemann, Austin Schenk, Timothy M. Pawlik Source Type: research
Dynamic Assessment of Modified Quick Sequential Organ Failure Assessment in Acutely Deteriorated Patients with Chronic Liver Disease
CONCLUSION: Baseline and dynamic changes in m-qSOFA were useful to identify patients with a high risk of organ failure development and short-term mortality among CLD patients with acute deterioration.PMID:38600873 | DOI:10.3350/cmh.2023.0563 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 11, 2024 Category: Gastroenterology Authors: Do Seon Song Hee Yeon Kim Young Kul Jung Tae Hyung Kim Hyung Joon Yim Eileen L Yoon Ki Tae Suk Jeong-Ju Yoo Sang Gyune Kim Moon Young Kim Young Chang Soung Won Jeong Jae Young Jang Sung-Eun Kim Jung-Hee Kim Jung Gil Park Won Kim Jin Mo Yang Dong Joon Kim Source Type: research
Ischemia-free liver transplantation improves the prognosis of recipients using Functioned Marginal Liver grafts
CONCLUSION: FMLs function as a more important negative prognostic parameter than other marginal livers do. IFLT might ameliorate liver injury in FMLs by inhibiting the infiltration of NK cells, consequently leading to the abortion of IL-32, which drives pyroptosis in monocytes and macrophages.PMID:38600871 | DOI:10.3350/cmh.2024.0139 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 11, 2024 Category: Gastroenterology Authors: Shuai Wang Xiaohong Lin Yunhua Tang Yichen Liang Min Zhang Zhonghao Xie Yiwen Guo Yuqi Dong Qiang Zhao Zhiyong Guo Dongping Wang Xiaoshun He Weiqiang Ju Maogen Chen Source Type: research
Dynamic Assessment of Modified Quick Sequential Organ Failure Assessment in Acutely Deteriorated Patients with Chronic Liver Disease
CONCLUSION: Baseline and dynamic changes in m-qSOFA were useful to identify patients with a high risk of organ failure development and short-term mortality among CLD patients with acute deterioration.PMID:38600873 | DOI:10.3350/cmh.2023.0563 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 11, 2024 Category: Gastroenterology Authors: Do Seon Song Hee Yeon Kim Young Kul Jung Tae Hyung Kim Hyung Joon Yim Eileen L Yoon Ki Tae Suk Jeong-Ju Yoo Sang Gyune Kim Moon Young Kim Young Chang Soung Won Jeong Jae Young Jang Sung-Eun Kim Jung-Hee Kim Jung Gil Park Won Kim Jin Mo Yang Dong Joon Kim Source Type: research
Ischemia-free liver transplantation improves the prognosis of recipients using Functioned Marginal Liver grafts
CONCLUSION: FMLs function as a more important negative prognostic parameter than other marginal livers do. IFLT might ameliorate liver injury in FMLs by inhibiting the infiltration of NK cells, consequently leading to the abortion of IL-32, which drives pyroptosis in monocytes and macrophages.PMID:38600871 | DOI:10.3350/cmh.2024.0139 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 11, 2024 Category: Gastroenterology Authors: Shuai Wang Xiaohong Lin Yunhua Tang Yichen Liang Min Zhang Zhonghao Xie Yiwen Guo Yuqi Dong Qiang Zhao Zhiyong Guo Dongping Wang Xiaoshun He Weiqiang Ju Maogen Chen Source Type: research
Clinical practice recommendations on lipoprotein apheresis for children with homozygous familial hypercholesterolaemia: An expert consensus statement from ERKNet and ESPN
We present a consensus statement on lipoprotein apheresis in children based on the current available evidence and opinions from experts in lipoprotein apheresis from over the world. It comprises practical statements regarding the indication, methods, treatment goals and follow-up of lipoprotein apheresis in children with homozygous familial hypercholesterolaemia and on the role of lipoprotein(a) and liver transplantation.PMID:38598969 | DOI:10.1016/j.atherosclerosis.2024.117525 (Source: Atherosclerosis)
Source: Atherosclerosis - April 10, 2024 Category: Cardiology Authors: M Doortje Reijman D Meeike Kusters Jaap W Groothoff Klaus Arbeiter Eldad J Dann Lotte M de Boer Sarah D de Ferranti Antonio Gallo Susanne Greber-Platzer Jacob Hartz Lisa C Hudgins Daiana Ibarretxe Meral Kayikcioglu Reinhard Klingel Genovefa D Kolovou Jun Source Type: research
Optimizing nutrition in hepatic cirrhosis: A comprehensive assessment and care approach
World J Gastroenterol. 2024 Mar 14;30(10):1313-1328. doi: 10.3748/wjg.v30.i10.1313.ABSTRACTCirrhosis is considered a growing cause of morbidity and mortality, which represents a significant public health problem. Currently, there is no effective treatment to reverse cirrhosis. Treatment primarily centers on addressing the underlying liver condition, monitoring, and managing portal hypertension-related complications, and evaluating the potential for liver transplantation in cases of decompensated cirrhosis, marked by rapid progression and the emergence of complications like variceal bleeding, hepatic encephalopathy, ascites...
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Osvely Mendez-Guerrero Anaisa Carranza-Carrasco Luis Alberto Chi-Cervera Aldo Torre Nalu Navarro-Alvarez Source Type: research
Optimizing nutrition in hepatic cirrhosis: A comprehensive assessment and care approach
World J Gastroenterol. 2024 Mar 14;30(10):1313-1328. doi: 10.3748/wjg.v30.i10.1313.ABSTRACTCirrhosis is considered a growing cause of morbidity and mortality, which represents a significant public health problem. Currently, there is no effective treatment to reverse cirrhosis. Treatment primarily centers on addressing the underlying liver condition, monitoring, and managing portal hypertension-related complications, and evaluating the potential for liver transplantation in cases of decompensated cirrhosis, marked by rapid progression and the emergence of complications like variceal bleeding, hepatic encephalopathy, ascites...
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Osvely Mendez-Guerrero Anaisa Carranza-Carrasco Luis Alberto Chi-Cervera Aldo Torre Nalu Navarro-Alvarez Source Type: research
Identification and characterization of myeloid cells localized in the tadpole liver cortex in Xenopus laevis
Dev Comp Immunol. 2024 Apr 8:105178. doi: 10.1016/j.dci.2024.105178. Online ahead of print.ABSTRACTIn the present study, using transgenic frogs that express GFP specifically in myeloid cells under the myeloperoxidase enhancer sequence, we found that myeloperoxidase-positive cells are localized in the liver cortex at the late tadpole stages. Immunohistochemical analysis revealed that myelopoiesis in the liver cortex became evident after st. 50 and reached its peak by st. 56. Transplantation experiments indicated that cells with a high density at the liver cortex were derived from the dorso-lateral plate tissue in the neurul...
Source: Developmental and Comparative Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Mitsugu Ma éno Miki Tanabe Ayame Ogawa Haruka Kobayashi Yumi Izutsu Takashi Kato Source Type: research
Clinical practice recommendations on lipoprotein apheresis for children with homozygous familial hypercholesterolaemia: An expert consensus statement from ERKNet and ESPN
We present a consensus statement on lipoprotein apheresis in children based on the current available evidence and opinions from experts in lipoprotein apheresis from over the world. It comprises practical statements regarding the indication, methods, treatment goals and follow-up of lipoprotein apheresis in children with homozygous familial hypercholesterolaemia and on the role of lipoprotein(a) and liver transplantation.PMID:38598969 | DOI:10.1016/j.atherosclerosis.2024.117525 (Source: Atherosclerosis)
Source: Atherosclerosis - April 10, 2024 Category: Cardiology Authors: M Doortje Reijman D Meeike Kusters Jaap W Groothoff Klaus Arbeiter Eldad J Dann Lotte M de Boer Sarah D de Ferranti Antonio Gallo Susanne Greber-Platzer Jacob Hartz Lisa C Hudgins Daiana Ibarretxe Meral Kayikcioglu Reinhard Klingel Genovefa D Kolovou Jun Source Type: research
Optimizing nutrition in hepatic cirrhosis: A comprehensive assessment and care approach
World J Gastroenterol. 2024 Mar 14;30(10):1313-1328. doi: 10.3748/wjg.v30.i10.1313.ABSTRACTCirrhosis is considered a growing cause of morbidity and mortality, which represents a significant public health problem. Currently, there is no effective treatment to reverse cirrhosis. Treatment primarily centers on addressing the underlying liver condition, monitoring, and managing portal hypertension-related complications, and evaluating the potential for liver transplantation in cases of decompensated cirrhosis, marked by rapid progression and the emergence of complications like variceal bleeding, hepatic encephalopathy, ascites...
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Osvely Mendez-Guerrero Anaisa Carranza-Carrasco Luis Alberto Chi-Cervera Aldo Torre Nalu Navarro-Alvarez Source Type: research
