A consortium of < em > Hordeum vulgare < /em > and gut microbiota against non-alcoholic fatty liver disease via data-driven analysis
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):250-260. doi: 10.1080/21691401.2024.2347380. Epub 2024 Apr 30.ABSTRACTDespite many recent studies on non-alcoholic fatty liver disease (NAFLD) therapeutics, the optimal treatment has yet to be determined. In this unfinished project, we combined secondary metabolites (SMs) from the gut microbiota (GM) and Hordeum vulgare (HV) to investigate their combinatorial effects via network pharmacology (NP). Additionally, we analyzed GM or barley - signalling pathways - targets - metabolites (GBSTMs) in combinatorial perspectives (HV, and GM). A total of 31 key targets were analysed via ...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 30, 2024 Category: Biotechnology Authors: Su-Been Lee Haripriya Gupta Byeong-Hyun Min Raja Ganesan Satya Priya Sharma Sung-Min Won Jin-Ju Jeong Min-Gi Cha Goo-Hyun Kwon Min-Kyo Jeong Ji-Ye Hyun Jung-A Eom Hee-Jin Park Sang-Jun Yoon Sang Youn Lee Mi-Ran Choi Dong Joon Kim Ki-Kwang Oh Ki-Tae Suk Source Type: research
Clinical characteristics and outcomes of acute liver failure in neonates: a retrospective cohort in China
Conclusion: Hypoxic/ischemic injury and infection are the predominant etiologies of NALF in China. The overall prognosis of NALF is poor, but its short-term prognosis is determined by the etiology. What is Known: • Neonatal acute liver failure (NALF) is a rare disorder with limited cohort studies, especially in China. • Gestational alloimmune liver disease, viral infections (especially herpes simplex virus), metabolic diseases and ischemic insults are common etiologies of NALF, which are significantly different from other populations. • There are no reliable biochemical markers to predict the outcome of NALF. What is...
Source: Herpes - April 30, 2024 Category: Infectious Diseases Authors: Suhua Xu Peng Zhang Mengmeng Ge Yuanyuan Shan Guoqiang Cheng Source Type: research
A consortium of < em > Hordeum vulgare < /em > and gut microbiota against non-alcoholic fatty liver disease via data-driven analysis
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):250-260. doi: 10.1080/21691401.2024.2347380. Epub 2024 Apr 30.ABSTRACTDespite many recent studies on non-alcoholic fatty liver disease (NAFLD) therapeutics, the optimal treatment has yet to be determined. In this unfinished project, we combined secondary metabolites (SMs) from the gut microbiota (GM) and Hordeum vulgare (HV) to investigate their combinatorial effects via network pharmacology (NP). Additionally, we analyzed GM or barley - signalling pathways - targets - metabolites (GBSTMs) in combinatorial perspectives (HV, and GM). A total of 31 key targets were analysed via ...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 30, 2024 Category: Biotechnology Authors: Su-Been Lee Haripriya Gupta Byeong-Hyun Min Raja Ganesan Satya Priya Sharma Sung-Min Won Jin-Ju Jeong Min-Gi Cha Goo-Hyun Kwon Min-Kyo Jeong Ji-Ye Hyun Jung-A Eom Hee-Jin Park Sang-Jun Yoon Sang Youn Lee Mi-Ran Choi Dong Joon Kim Ki-Kwang Oh Ki-Tae Suk Source Type: research
A consortium of Hordeum vulgare and gut microbiota against non-alcoholic fatty liver disease via data-driven analysis
Volume 52, Issue 1, December 2024, Page 250-260 . (Source: Artificial Cells, Blood Substitutes, and Biotechnology)
Source: Artificial Cells, Blood Substitutes, and Biotechnology - April 30, 2024 Category: Biotechnology Authors: Su-Been LeeHaripriya GuptaByeong-Hyun MinRaja GanesanSatya Priya SharmaSung-Min WonJin-Ju JeongMin-Gi ChaGoo-Hyun KwonMin-Kyo JeongJi-Ye HyunJung-A EomHee-Jin ParkSang-Jun YoonSang Youn LeeMi-Ran ChoiDong Joon KimKi-Kwang OhKi-Tae SukInstitute for Liver a Source Type: research
Dengue-related acute liver failure —A scoping review
AbstractInfection by dengue virus is common in tropical countries. Hepatic involvement in dengue can range from asymptomatic elevation of transaminases to life-threatening acute liver failure (ALF). Dengue-related ALF (DALF) is responsible for significant morbidity and mortality, especially in Southeast Asia. However, there is a scarcity of literature on DALF, necessitating a thorough examination of its clinical determinants and management strategies. All relevant studies related to DALF were reviewed until December 2023. Case reports, case series and studies reporting ALF in dengue infection were included. Demographics, c...
Source: Indian Journal of Gastroenterology - April 30, 2024 Category: Gastroenterology Source Type: research
Pulmonary Complications of Portal Hypertension
Portopulmonary hypertension (POPH), hepatopulmonary syndrome, and hepatic hydrothorax constitute significant complications of portal hypertension, with important implications for management and liver transplantation (LT) candidacy. POPH is characterized by obstruction and remodeling of the pulmonary resistance arterial bed. Hepatopulmonary syndrome is the most common pulmonary vascular disorder, characterized by intrapulmonary vascular dilatations causing impaired gas exchange. LT may improve prognosis in select patients with POPH. LT is the only effective treatment of hepatopulmonary syndrome. Hepatic hydrothorax is defin...
Source: Clinics in Liver Disease - April 30, 2024 Category: Gastroenterology Authors: Shoma Bommena, Michael B. Fallon Source Type: research
Dengue-related acute liver failure —A scoping review
AbstractInfection by dengue virus is common in tropical countries. Hepatic involvement in dengue can range from asymptomatic elevation of transaminases to life-threatening acute liver failure (ALF). Dengue-related ALF (DALF) is responsible for significant morbidity and mortality, especially in Southeast Asia. However, there is a scarcity of literature on DALF, necessitating a thorough examination of its clinical determinants and management strategies. All relevant studies related to DALF were reviewed until December 2023. Case reports, case series and studies reporting ALF in dengue infection were included. Demographics, c...
Source: Indian Journal of Gastroenterology - April 30, 2024 Category: Gastroenterology Source Type: research
Cardiac Amyloidosis: A Contemporary Review of Medical and Surgical Therapy
Curr Cardiol Rev. 2024;20(2):72-81. doi: 10.2174/011573403X240302230925043500.ABSTRACTAmyloidosis is a systemic disease initiated by deposition of misfolded proteins in the extracellular space, due to which multiple organs may be affected concomitantly. Cardiac amyloidosis, however, remains a major cause of morbidity and mortality in this population due to infiltrative /restrictive cardiomyopathy. This review attempts to focus on contemporary medical and surgical therapies for the different types of cardiac amyloidosis. Amyloidosis affecting the heart are predominantly of the transthyretin type (acquired in the older or ge...
Source: Current Cardiology Reviews - April 29, 2024 Category: Cardiology Authors: Drew Brownell Aiswarya J Pillai Nandini Nair Source Type: research
Hepatocellular carcinoma and musculoskeletal system: A narrative literature review
World J Gastroenterol. 2024 Apr 21;30(15):2109-2117. doi: 10.3748/wjg.v30.i15.2109.ABSTRACTMusculoskeletal alterations in hepatocellular carcinoma (HCC) are less common than liver-related complications. However, they can significantly impact the quality of life and overall prognosis of patients with HCC. The main obstacle in the clinical assessment of HCC-induced musculoskeletal alterations is related to effective and timely diagnosis because these complications are often asymptomatic and unapparent during routine clinical evaluations. This narrative literature review aimed to provide a comprehensive overview of the contem...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Jelena Jadzic Danijela Djonic Source Type: research
Current status of liver transplantation for human immunodeficiency virus-infected patients in mainland China
This study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation (LT) in mainland China. To date, our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV, and all but one, who died two months postoperatively due to sepsis and progressive multi-organ failure, have survived. Comparative analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions, cytomegalovirus infection, bacteremia, pulmonary infections, acute kidney injury, new-onset can...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Jian-Xin Tang Dong Zhao Source Type: research
Hepatocellular carcinoma and musculoskeletal system: A narrative literature review
World J Gastroenterol. 2024 Apr 21;30(15):2109-2117. doi: 10.3748/wjg.v30.i15.2109.ABSTRACTMusculoskeletal alterations in hepatocellular carcinoma (HCC) are less common than liver-related complications. However, they can significantly impact the quality of life and overall prognosis of patients with HCC. The main obstacle in the clinical assessment of HCC-induced musculoskeletal alterations is related to effective and timely diagnosis because these complications are often asymptomatic and unapparent during routine clinical evaluations. This narrative literature review aimed to provide a comprehensive overview of the contem...
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Jelena Jadzic Danijela Djonic Source Type: research
Current status of liver transplantation for human immunodeficiency virus-infected patients in mainland China
This study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation (LT) in mainland China. To date, our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV, and all but one, who died two months postoperatively due to sepsis and progressive multi-organ failure, have survived. Comparative analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions, cytomegalovirus infection, bacteremia, pulmonary infections, acute kidney injury, new-onset can...
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Jian-Xin Tang Dong Zhao Source Type: research
Mortality rate after total knee arthroplasty or total hip arthroplasty in patients with a history of liver transplant
World J Orthop. 2024 Apr 18;15(4):310-311. doi: 10.5312/wjo.v15.i4.310. eCollection 2024 Apr 18.ABSTRACTIn this editorial I comment on the article by Ahmed et al published in a recent issue of the World J Orthop 2023; 14: 784-790. It is well known that patients who have undergone a liver transplant (LT) may need to have a total hip arthroplasty (THA) or total knee arthroplasty (TKA) implanted. Ahmed et al stated that the mortality rate in these patients was similar to the one of the general population. However, there are three articles previously published that found higher mortality in LT patients who experienced THA/TKA ...
Source: World Journal of Orthopaedics - April 29, 2024 Category: Orthopaedics Authors: E Carlos Rodriguez-Merchan Source Type: research
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages
In conclusion, this study supports the concept that intake of MCD predisposes to experimental colitis and enhances its pathogenesis via modulating gut microbes and macrophages in mice.PMID:38684800 | DOI:10.1038/s41401-024-01291-y (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 29, 2024 Category: Drugs & Pharmacology Authors: Mo-Ting Liu Yao Zhang Cai-Gui Xiang Tao Yang Xiao-Han Wang Qiu-Kai Lu Hui-Min Lu Chen Fan Chun-Lan Feng Xiao-Qian Yang Duo-Wu Zou Heng Li Wei Tang Source Type: research
Cardiac Amyloidosis: A Contemporary Review of Medical and Surgical Therapy
Curr Cardiol Rev. 2024;20(2):72-81. doi: 10.2174/011573403X240302230925043500.ABSTRACTAmyloidosis is a systemic disease initiated by deposition of misfolded proteins in the extracellular space, due to which multiple organs may be affected concomitantly. Cardiac amyloidosis, however, remains a major cause of morbidity and mortality in this population due to infiltrative /restrictive cardiomyopathy. This review attempts to focus on contemporary medical and surgical therapies for the different types of cardiac amyloidosis. Amyloidosis affecting the heart are predominantly of the transthyretin type (acquired in the older or ge...
Source: Current Cardiology Reviews - April 29, 2024 Category: Cardiology Authors: Drew Brownell Aiswarya J Pillai Nandini Nair Source Type: research
