Diagnosing and Grading of Sinusoidal Obstructive Syndrome after Hematopoietic Stem Cell Transplant of Children, Adolescent and Young Adults treated in a Pediatric Institution with Pediatric Protocols

Sinusoidal obstructive syndrome (SOS), previously known as hepatic veno-occlusive disease (VOD), has been recognized as a complex and life-threatening complication following hematopoietic stem cell transplantation (HSCT). SOS is a complication that develops after injury to the micro-vasculature and endothelial cells of the liver. Damage to endothelial cells promotes increased expression of pro-inflammatory cytokines and adhesion molecules in the vascular endothelium, leading to sinusoidal narrowing and micro-vascular occlusion, altered liver cytoskeletal architecture, weakened intercellular junctions, and further liver damage.

Source: Biology of Blood and Marrow Transplantation - April 15, 2024 Category: Hematology Authors: Gabriel Salinas Cisneros, Christopher C Dvorak, Janel Long-Boyle, Sandhya Kharbanda, Kristin A Shimano, Alexis Melton, Julia Chu, Lena E Winestone, Jasmeen Dara, James N Huang, Michelle L Hermiston, Matt Zinter, Christine S Higham Source Type: research