Neural tube defects: role of lithium carbonate exposure in embryonic neural development in a murine model.
CONCLUSIONS: Lithium-induced NTDs model in C57BL/6 mice was established. Enhanced cell proliferation and decreased apoptosis following lithium exposure were closely associated with the impairment of inositol biosynthesis, which may contribute to lithium-induced NTDs.
IMPACT: Impairment of inositol biosynthesis has an important role in lithium exposure-induced NTDs in mice model. Lithium-induced NTDs model on C57BL/6 mice was established. Based on this NTDs model, lithium-induced impairment of inositol biosynthesis resulted in the imbalance between cell proliferation and apoptosis, which may contribute to lithium-in...
Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Li S, Luo D, Yue H, Lyu J, Yang Y, Gao T, Liu Y, Qin J, Wang X, Guan Z, Wang F, Zhang F, Niu B, Zhang T, Zhong R, Guo J, Wang J Tags: Pediatr Res Source Type: research
The impact of BDNF variant on bipolar susceptibility, suicidal behavior, and response to lithium carbonate in bipolar patients
Publication date: Available online 4 November 2020Source: Meta GeneAuthor(s): Sara Sadat Aghabozorg Afjeh, Jamal Shams, Safar Hamednia, Behzad Bushehri, Amir Olfat, Mir Davood Omrani (Source: Meta Gene)
Source: Meta Gene - November 4, 2020 Category: Genetics & Stem Cells Source Type: research
Characterization of Aspergillus niger MK981235 xylanase with extraction of anti-hepatotoxic, antioxidant, hypocholesterolemic and prebiotic Corchorus olitorius stems xylooligosaccharides.
This study succeeded in utilization of Aspergillus niger MK981235 xylanase under different saccharification conditions designed by central composite design (CCD) for extraction of 15 biologically active XOS (anti-hepatotoxic, antioxidant, hypocholesterolemic and prebiotic) with different monosaccharides constituents composition and percent. A. niger MK981235 xylanase showed the highest activity 6.60 U·ml-1 at 50 °C with 1.5% xylan. The kinetics included Km and Vmax were determined to be 6.67 mg·ml-1 and 20 μmol·ml-1·min-1, respectively. Moreover, A. niger MK981235 xylanase thermodynamics Ea (activation energy...
Source: International Journal of Biological Macromolecules - November 2, 2020 Category: Biochemistry Authors: Saleh SAA, Abdel Wahab WA, El-Dein AN, Abdelwahab WA, Ahmed AAM, Helmy WA, Mostafa FA Tags: Int J Biol Macromol Source Type: research
Potentiation of Rocuronium Bromide by Lithium Carbonate: A Case Report.
Authors: Kishimoto N, Yoshikawa H, Seo K
Abstract
Lithium carbonate is a medication used for the management of various mental disorders. The present report describes a case of prolongation of rocuronium bromide in a patient concurrently taking lithium carbonate. A 64-year-old woman was scheduled to undergo cystectomy under general anesthesia. The patient took lithium carbonate (600 mg/d) for treatment of bipolar affective disorder. General anesthesia was induced with propofol, fentanyl, remifentanil, and sevoflurane. After loss of consciousness, rocuronium bromide (50 mg) was administered, and the trachea ...
Source: Anesthesia Progress - October 1, 2020 Category: Anesthesiology Tags: Anesth Prog Source Type: research
Lithium intoxication –induced dysgeusia accompanied by glossalgia in a patient receiving lithium carbonate: a case report
ConclusionsWe present a rare case of lithium carbonate –induced dysgeusia accompanied by glossalgia. Early detection of these symptoms is important in clinical settings because they can be overlooked until patients lose their appetite, which severely impairs their quality of life. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - September 9, 2020 Category: General Medicine Source Type: research
RPS warns of 'huge extra cost' to NHS after bipolar drug withdrawn
The Royal Pharmaceutical Society has warned of a “huge extra cost” to the NHS, after a manufacturer announced plans to discontinue production of one of its branded lithium carbonate products. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - September 7, 2020 Category: Drugs & Pharmacology Source Type: research
Investigation of the impact of an ADCY2 polymorphism as a predictive biomarker in bipolar disorder, suicide tendency and response to lithium carbonate therapy: the first report from Iran
Pharmacogenomics, Ahead of Print. (Source: Future Medicine: Pharmacogenomics)
Source: Future Medicine: Pharmacogenomics - September 6, 2020 Category: Genetics & Stem Cells Authors: Sara Sadat Aghabozorg Afjeh Jamal Shams Safar Hamednia Behzad Boshehri Amir Olfat Mir Davood Omrani Source Type: research
Does Lithium Deserve a Place in the Treatment Against COVID-19? A Preliminary Observational Study in Six Patients, Case Report
Lithium has shown the capacity to: a) inhibit the replication of several types of viruses, some of which are similar to the SARS-CoV-2 virus, b) increase the immune response by reducing lymphopenia, and c) reduce inflammation by preventing or reducing the cytokine storm. In the present study, we have treated six patients with severe COVID-19 infection with lithium carbonate. We found that lithium carbonate significantly reduced plasma reactive C-Protein levels, increased lymphocyte numbers and decreased the neutrophil-lymphocyte ratio, improving both inflammatory activity and the immune response in these patients. We propo...
Source: Frontiers in Pharmacology - August 26, 2020 Category: Drugs & Pharmacology Source Type: research
Effectiveness of Zinc Supplementation on Lithium-Induced Alterations in Thyroid Functions.
Abstract
Lithium is an integral drug used in the management of acute mania, unipolar and bipolar depression, and prophylaxis of bipolar disorders. Thyroid abnormalities have been associated with treatment with lithium. Zinc is an essential trace element that plays a role in several biological activities. Therefore, the present study was aimed at investigating the potential role of zinc in the thyroid gland following lithium administration to explore the role of zinc under such conditions. To achieve this goal, male Wistar rats (150-195 g) were divided into four groups: Group 1 animals were fed standard pe...
Source: Biological Trace Element Research - August 25, 2020 Category: Biology Authors: Pathak R, Pathak A Tags: Biol Trace Elem Res Source Type: research
In Vitro and In Vivo Evidence on the Role of Mitochondrial Impairment as a Mechanism of Lithium-Induced Nephrotoxicity.
Abstract
Lithium is abundantly administered against bipolar disorder. On the other hand, the lithium-induced renal injury is a clinical complication which commonly reveals as drug-induced diabetes insipidus. However, lithium-induced cytotoxicity might also play a role in the adverse effects of this drug on the kidney. There is no clear cellular and molecular mechanism(s) for lithium-induced nephrotoxicity. The current study was designed to assess the effect of lithium on kidney tissue oxidative stress biomarkers and mitochondrial function and its relevance to drug-induced nephrotoxicity and electrolyte imb...
Source: Biological Trace Element Research - July 24, 2020 Category: Biology Authors: Ommati MM, Niknahad H, Farshad O, Azarpira N, Heidari R Tags: Biol Trace Elem Res Source Type: research
Lithium carbonate recovery from brines using membrane electrolysis
Publication date: Available online 22 July 2020Source: Journal of Membrane ScienceAuthor(s): Walter R. Torres, César H. Diaz Nieto, Antonin Prévoteau, Korneel Rabaey, Victoria Flexer (Source: Journal of Membrane Science)
Source: Journal of Membrane Science - July 24, 2020 Category: Materials Science Source Type: research
Microbubble-assisted pressure carbonation for preparation of high purity lithium carbonate
Publication date: September–October 2020Source: Journal of Materials Research and Technology, Volume 9, Issue 5Author(s): Jinliang Wang, Huazhou Hu (Source: Journal of Materials Research and Technology)
Source: Journal of Materials Research and Technology - July 17, 2020 Category: Materials Science Source Type: research
Effect of lithium carbonate on the function of the thyroid gland: mechanism of action and clinical implications.
Authors: Czarnywojtek A, Zgorzalewicz-Stachowiak M, Czarnocka B, Sawicka-Gutaj N, Gut P, Krela-Kazmierczak I, Ruchala M
Abstract
Lithium carbonate, a drug known for more than 100 years, has been successfully used as a psychiatric medication. Currently, it is a commonly used drug to treat patients with unipolar and bipolar depression, and for the prophylaxis of bipolar disorders and acute mania. Lithium salts may cause the development of goiter, hypothyroidism, or rarely hyperthyroidism. The present review examined the current state of knowledge on the effect of lithium carbonate on the thyroid gland. The P...
Source: Journal of Physiology and Pharmacology - July 9, 2020 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Microdose Lithium Treatment Reduced Inflammatory Factors and Neurodegeneration in Organotypic Hippocampal Culture of Old SAMP-8 Mice.
Abstract
It was already shown that microdoses of lithium carbonate (Li2CO3) promoted memory stabilization in humans and mice. Prolonged treatment also reduced neuronal loss and increased the density of the neurotrophin BDNF in transgenic mice for Alzheimer's disease. The aim of this study was to evaluate whether lithium ions affect inflammatory profiles and neuronal integrity in an animal model of accelerated senescence (SAMP-8). Organotypic hippocampal cultures obtained from 11 to 12-month-old SAMP-8 mice were treated with 2 µM, 20 µM and 200 µM Li2CO3. 2 µM Li2CO3 promoted a significant reductio...
Source: Cellular and Molecular Neurobiology - July 7, 2020 Category: Cytology Authors: Toricelli M, Evangelista SR, Buck HS, Viel TA Tags: Cell Mol Neurobiol Source Type: research
Reactive-crystallization method for purification of LiCl salt waste
AbstractOwing to its capability of high-temperature operation, a salt waste treatment process in a pyrochemical process which uses molten salt as an electrolyte for the recycling of spent nuclear fuel adopted melt-crystallization method to purify a molten salt waste generated during the processes. However, because of its high operating temperature, there is a corrosion problem in the crystallizer made of Inconel 625 alloy, resulting in the contamination of crystallized salt on the crystallization plates. To solve the corrosion problem stemming from the molten salt waste under high operation temperature, a reactive-crystall...
Source: Journal of Radioanalytical and Nuclear Chemistry - June 14, 2020 Category: Nuclear Medicine Source Type: research
