GSK3 β Regulates Brain Energy Metabolism
Publication date: 15 May 2018 Source:Cell Reports, Volume 23, Issue 7 Author(s): Stephen A. Martin, Dylan C. Souder, Karl N. Miller, Josef P. Clark, Abdul Kader Sagar, Kevin W. Eliceiri, Luigi Puglielli, T. Mark Beasley, Rozalyn M. Anderson GSK3β is a serine threonine kinase implicated in the progression of Alzheimer’s disease. Although the role of GSK3β in growth and pathology has been extensively studied, little is known about the metabolic consequences of GSK3β manipulation, particularly in the brain. Here, we show that GSK3β regulates mitochondrial energy metabolism in human H4 neuroglioma cells and ra...
Source: Cell Reports - May 16, 2018 Category: Cytology Source Type: research
Inhibition of the dopamine transporter as an animal model of bipolar disorder mania: Locomotor response, neuroimmunological profile and pharmacological modulation
Publication date: Available online 6 April 2018 Source:Journal of Psychiatric Research Author(s): Juliana R. Bastos, Katherinne M. Perico, Érica L. Marciano Vieira, Antônio L. Teixeira, Fabiana S. Machado, Aline S. de Miranda, Fabrício A. Moreira Inhibition of dopamine transporter (DAT) by GBR12909 has been proposed as a pharmacological model of mania related to bipolar disorder (BD). Here we tested the hypothesis that GBR12909 injection impairs habituation and induces hyperlocomotion in mice, along with changes in cytokines and neurotrophic factors levels, as observed in BD patients. We also tested if lithium ...
Source: Journal of Psychiatric Research - April 7, 2018 Category: Psychiatry Source Type: research
Microstructure of ultra high performance concrete containing lithium slag
Publication date: 5 July 2018 Source:Journal of Hazardous Materials, Volume 353 Author(s): Zhi-hai He, Shi-gui Du, Deng Chen Lithium slag (LS) is discharged as a byproduct in the process of the lithium carbonate, and it is very urgent to explore an efficient way to recycle LS in order to protect the environments and save resources. Many available supplementary cementitious materials for partial replacement of cement and/or silica fume (SF) can be used to prepare ultra high performance concrete (UHPC). The effect of LS to replace SF partially by weight used as a supplementary cementitious material (0%, 5%, 10% and 15% ...
Source: Journal of Hazardous Materials - April 7, 2018 Category: Environmental Health Source Type: research
A lithium –oxygen battery with a long cycle life in an air-like atmosphere
A lithium–oxygen battery with a long cycle life in an air-like atmosphere
Nature 555, 7697 (2018). doi:10.1038/nature25984
Authors: Mohammad Asadi, Baharak Sayahpour, Pedram Abbasi, Anh T. Ngo, Klas Karis, Jacob R. Jokisaari, Cong Liu, Badri Narayanan, Marc Gerard, Poya Yasaei, Xuan Hu, Arijita Mukherjee, Kah Chun Lau, Rajeev S. Assary, Fatemeh Khalili-Araghi, Robert F. Klie, Larry A. Curtiss & Amin Salehi-Khojin
Lithium–air batteries are considered to be a potential alternative to lithium-ion batteries for transportation applications, owing to their high theoretical specific energy. So f...
Source: Nature - March 21, 2018 Category: Research Authors: Mohammad Asadi Baharak Sayahpour Pedram Abbasi Anh T. Ngo Klas Karis Jacob R. Jokisaari Cong Liu Badri Narayanan Marc Gerard Poya Yasaei Xuan Hu Arijita Mukherjee Kah Chun Lau Rajeev S. Assary Fatemeh Khalili-Araghi Robert F. Klie Larry A. Curtiss Amin Sa Tags: Letter Source Type: research
Stabilizing effect of ion complex formation in lithium –oxygen battery electrolytes
Publication date: Available online 8 March 2018 Source:Journal of Electroanalytical Chemistry Author(s): Amir Chamaani, Meer Safa, Neha Chawla, Marcus Herndon, Bilal El-Zahab Glyme-based electrolytes with various lithium bis(trifluoromethane) sulfonamide (LiTFSI) salt concentrations have been investigated for their use in Li‑oxygen battery applications. Charge/discharge cycling with a cycle capacity of 500 mAh·g−1 showed an improvement as high as 300% for electrolytes containing higher LiTFSI concentrations. Electrochemical impedance spectroscopy (EIS) studies of full batteries and Raman spectroscopy studies ...
Source: Journal of Electroanalytical Chemistry - March 8, 2018 Category: Chemistry Source Type: research
Clinical Features of Machado-Joseph Disease.
Authors: Mendonça N, França MC, Gonçalves AF, Januário C
Abstract
Machado-Joseph disease (MJD) also known as Spinocerebellar ataxia type 3, is a hereditary neurodegenerative disease associated with severe clinical manifestations and premature death. Although rare, it is the most common autosomal dominant spinocerebellar ataxia worldwide and has a distinct geographic distribution, reaching peak prevalence in certain regions of Brazil, Portugal and China. Due to its clinical heterogeneity, it was initially described as several different entities and as had many designations over the last decades. An accu...
Source: Advances in Experimental Medicine and Biology - February 11, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research
Pharmacological management of agitation among individuals with moderate to severe acquired brain injury: A systematic review.
CONCLUSIONS: Studies consistently demonstrated that pharmacological treatment was effective in reducing agitation post ABI; however, there was insufficient information to develop a conclusion due to the limited number of studies and overall weakness of evidence for each individual medication.
PMID: 29359952 [PubMed - as supplied by publisher] (Source: Brain Injury)
Source: Brain Injury - January 25, 2018 Category: Neurology Tags: Brain Inj Source Type: research
Lithium-associated nephropathy in the renal allograft
A 58-year-old man, the recipient of a kidney transplant, was admitted to the hospital for evaluation of impairment of renal allograft function. The patient had a medical history of bipolar disorder since 1989, which required long-term treatment with lithium carbonate (Li). Eight years later, he developed end-stage renal disease, and, at that time, a native kidney biopsy showed chronic interstitial nephropathy. The patient started hemodialysis, and 1 year later he received a kidney transplant from a deceased donor. (Source: Kidney International)
Source: Kidney International - December 29, 2017 Category: Urology & Nephrology Authors: Cristian Rodelo-Haad, Maria L. Ag üera, Rosa Ortega, Ana Martinez-Lopez, M. Dolores Navarro, Alberto Rodriguez-Benot, Pedro Aljama Tags: Nephrology Image Source Type: research
Case of myxedema coma induced by lithium carbonate in a patient with schizophrenia
(Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - December 23, 2017 Category: Neuroscience Authors: Ryo Sawagashira, Yoshihisa Sasagawa, Mayumi Matsukura, Yuji Takamaru Tags: Letter to the Editor Source Type: research
Lithium prevents scopolamine-induced memory impairment in zebrafish
We examined whether lithium carbonate (Li2CO3, 100mg/L) is able to prevent memory impairment induced by scopolamine. Moreover, we evaluated the effects of lithium on anxiety-like behavior and acetylcholinesterase activity in adult zebrafish. We demonstrated that lithium prevents the memory impairment induced by scopolamine, decreases exploration and increases the activity of acetylcholinesterase in zebrafish. Collectively, this contributes to a better understanding of the pharmacology of lithium, its interaction with cholinergic neurotransmission, and its possible application to therapeutic treatments aimed at improving co...
Source: Neuroscience Letters - December 16, 2017 Category: Neuroscience Source Type: research
MnCo2O4/MoO2 Nanosheets Grown on Ni foam as Carbon- and Binder-free Cathode for Lithium-Oxygen Batteries with Long Life and High Efficiency.
Abstract
Carbon is usually used as cathode material for Li-O2 batteries. However, the discharge product, such as Li2O2 and LiO2, could react with carbon to form insulating lithium carbonate layer, resulting in cathode passivation and capacity fading. To solve this problem, the development of non-carbon cathode is highly demanded. Herein, we have successfully synthesized MnCo2O4 (MCO) nanoparticles anchored on porous MoO2 nanosheets that are grown on Ni foam (current collector) (MCO/MoO2@Ni), acting as a carbon- and binder-free cathode for Li-O2 batteries, in an attempt to improve the electrical conductivit...
Source: ChemSusChem - December 13, 2017 Category: Chemistry Authors: Cao X, Sun Z, Zheng X, Jin C, Tian J, Li X, Yang R Tags: ChemSusChem Source Type: research
Should the Australian Therapeutic Goods Administration recommend rapid dosing of lithium carbonate in acute mania?
PMID: 29216733 [PubMed - as supplied by publisher] (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - December 1, 2017 Category: Psychiatry Authors: Schubert KO, Wisdom A Tags: Aust N Z J Psychiatry Source Type: research
A case of myxedema coma induced by lithium carbonate in a patient with schizophrenia
We present a rare case of myxedema coma (MC), the most extreme manifestation of hypothyroidism, induced by lithium carbonate (Li) in a patient with schizophrenia. A 68‐year‐old man presented to the emergency department due to unconsciousness. After developing schizophrenia, he had been living in a nursing home for the previous 40 years; he had no any other physical illness. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - December 1, 2017 Category: Neuroscience Authors: Ryo Sawagashira, Yoshihisa Sasagawa, Mayumi Matsukura, Yuji Takamaru Tags: Letter to the Editor Source Type: research
Residual
Lithium Carbonate Predominantly Accounts
for First Cycle CO2 and CO Outgassing of Li-Stoichiometric and Li-Rich Layered Transition-Metal
Oxides
Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b08461 (Source: Journal of the American Chemical Society)
Source: Journal of the American Chemical Society - November 22, 2017 Category: Chemistry Authors: Sara E. Renfrew and Bryan D. McCloskey Source Type: research
Characterization of potassium doped Li2ZrO3 based CO2 sorbents: Stability properties and CO2 desorption kinetics
Publication date: 15 March 2018 Source:Chemical Engineering Journal, Volume 336 Author(s): D. Peltzer, J. Mùnera, L. Cornaglia, M. Strumendo In this work, potassium doped and undoped Li2ZrO3-based sorbents for CO2 capture at high temperatures were synthesized through wet impregnation of Li and K salts over a colloidal suspension of zirconia nanoparticles. The synthesized sorbents were characterized by XRD and Raman spectroscopy, and the CO2 sorption/desorption properties of the sorbents were investigated by in-situ Raman spectroscopy and by thermogravimetric analysis at different temperatures and CO2 partial pressur...
Source: Chemical Engineering Journal - November 15, 2017 Category: Chemistry Source Type: research
