Editorial Board
Publication date: October 2018Source: Journal of Psychiatric Research, Volume 105Author(s): (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 22, 2018 Category: Psychiatry Source Type: research

Gender moderates the relationship between stressful life events and psychopathology: Findings from a national study
Publication date: Available online 20 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Jessica L. Armstrong, Silvia Ronzitti, Rani A. Hoff, Marc N. PotenzaAbstractBackgroundWhile data suggest a strong relationship between trauma exposure and psychopathology, less research has investigated relationships between psychopathology and stressful life events more broadly, and how these relationships may differ by gender.AimTo examine strengths of associations between stressful life events and psychiatric disorders (i.e., past-year Axis I and lifetime Axis II, per DSM-IV) and how they may differ by gender.MethodsDat...
Source: Journal of Psychiatric Research - September 21, 2018 Category: Psychiatry Source Type: research

The neurobiological hypothesis of neurotrophins in the pathophysiology of schizophrenia: A meta-analysis
DiscussionWe confirm that decreased peripheral neurotrophin levels are significantly associated with schizophrenia, thereby confirming the neurobiological hypothesis of neurotrophins in schizophrenia. Low levels of neurotrophins in peripheral blood of patients with schizophrenia may explain, in part, the pathophysiology of schizophrenia. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 20, 2018 Category: Psychiatry Source Type: research

Views of the Importance of Psychiatric Genetic Research by Potential Volunteers from Stakeholder Groups
Publication date: Available online 19 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Laura Weiss Roberts, Tenzin Tsungmey, Jane Paik Kim, Melinda HantkeAbstractFew studies have explored potential volunteers’ attitudes toward genetic research. To address this gap in the literature, we developed an empirical project to document views held by individuals who may wish to enroll in genetic studies involving mental disorders. People living with mental illness, family members of people with mental illness, and community comparison volunteers were queried regarding their views on the importance of genetic re...
Source: Journal of Psychiatric Research - September 20, 2018 Category: Psychiatry Source Type: research

Predictors of cognitive performance in bipolar disorder: The role of educational degree and inflammatory markers
ConclusionThe major determinants of poor cognitive performance in BD were education and IL6 plasma levels. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 18, 2018 Category: Psychiatry Source Type: research

Perspectives of psychiatric investigators and IRB chairs regarding benefits of psychiatric genetics research
Publication date: Available online 15 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Laura Weiss Roberts, Laura B. Dunn, Jane Paik Kim, Maryam RostamiAbstractThere is hope that psychiatric genetics inquiry will provide important insights into the origins and treatment of mental illness given the burden of these conditions. We sought to examine perspectives of psychiatric genetic investigators regarding the potential benefits of genetic research in general and the potential benefits of genetic research for the diagnosis and treatment of mental illnesses specifically. We compared investigator attitudes with ...
Source: Journal of Psychiatric Research - September 15, 2018 Category: Psychiatry Source Type: research

Comorbid social anxiety disorder in patients with alcohol use disorder: A systematic review
ConclusionThe present systematic review shows that it is important to screen for other psychiatric comorbidities (especially MDD), suicidality, and improve treatment adherence in patients with AUD and comorbid SAD. Future prospective studies should clarify the impact of comorbid SAD. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 14, 2018 Category: Psychiatry Source Type: research

Clinical outcome of maintenance electroconvulsive therapy in comorbid Posttraumatic Stress Disorder and major depressive disorder
This study investigated the efficacy of mECT in the treatment of MDD with and without comorbid syndromal PTSD.MethodsThis retrospective study includes 36 patients, 26 with MDD and 10 with comorbid MDD & PTSD receiving monthly mECT for a mean of 1.5 years. The mean age was 52 ± 14 years and 25% were female. The change in PTSD and MDD symptoms in response to mECT was assessed using Clinical Global Impression - Severity Scale (CGI-S). Heart rate variability (HRV), 12-month hospitalization rate, suicide rate and all-cause mortality in response to mECT were assessed and compared between groups using repeated gene...
Source: Journal of Psychiatric Research - September 14, 2018 Category: Psychiatry Source Type: research

Aggression, impulsivity and inflammatory markers as risk factors for suicidal behavior
ConclusionThese results identify recent aggressive behavior, higher levels of impulsivity, and lower levels of IL-1β as risk factors for a history of multiple suicide attempts in a group suffering from major depressive episodes. These measures appear to be additive in their effects. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 12, 2018 Category: Psychiatry Source Type: research

Relationship between schizophrenia and changes in the expression of the long non-coding RNAs Meg3, Miat, Neat1 and Neat2
In conclusion, Neat2 and Miat may function as important regulators of SZ. Our findings provide important clues for new targets of lncRNAs that are involved in SZ. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 12, 2018 Category: Psychiatry Source Type: research

Diet quality in persons with and without depressive and anxiety disorders
ConclusionDiet quality is poorer in persons with depressive and anxiety disorders; in particular in those with comorbidity. The more severe and chronic the symptoms, the poorer the diet quality. Prospective studies are needed to confirm the direction of the relationship of depressive and anxiety disorders with diet quality and to examine whether improving diet quality could improve mental health. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 12, 2018 Category: Psychiatry Source Type: research

“Clinical outcome of maintenance electroconvulsive therapy in comorbid Posttraumatic Stress Disorder and major depressive disorder”
This study investigated the efficacy of mECT in the treatment of MDD with and without comorbid syndromal PTSD.MethodsThis retrospective study includes 36 patients, 26 with MDD and 10 with comorbid MDD & PTSD receiving monthly mECT for a mean of 1.5 years. The mean age was 52 ± 14 years and 25% were female. The change in PTSD and MDD symptoms in response to mECT was assessed using Clinical Global Impression - Severity Scale (CGI-S). Heart rate variability (HRV), 12-month hospitalization rate, suicide rate and all-cause mortality in response to mECT were assessed and compared between groups using repeated gene...
Source: Journal of Psychiatric Research - September 8, 2018 Category: Psychiatry Source Type: research

Implementation of the safewards model to reduce the use of coercive measures in adult psychiatric inpatient units: An interrupted time-series analysis
Publication date: Available online 8 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Lærke Stensgaard, Maria Kreutzmann Andersen, Merete Nordentoft, Carsten HjorthøjAbstractThe aim of this study was to investigate whether the implementation of the Safewards model reduces the frequency of coercive measures in adult psychiatric inpatient units. Data on all coercive measures performed in psychiatric hospitals in the Region of Southern Denmark 1/1/2012–31/3/2017 were collected retrospectively through The Register of Coercive Measures in Psychiatric Treatment. Interrupted time series analysis ...
Source: Journal of Psychiatric Research - September 8, 2018 Category: Psychiatry Source Type: research

The effect of exercise on resting concentrations of peripheral brain-derived neurotrophic factor (BDNF) in major depressive disorder: A meta-analysis
Publication date: Available online 6 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Adam Dinoff, Nathan Herrmann, Walter Swardfager, Damien Gallagher, Krista L. LanctôtAbstractExercise interventions have been shown to successfully improve depression in patients with major depressive disorder (MDD), but like other forms of antidepressant treatment, exercise is not effective in all patients and its mechanisms of action have not been fully elucidated. Brain-derived neurotrophic factor (BDNF), a key mediator of neurogenesis and neuronal survival, has been shown to be decreased in individuals with MDD. On...
Source: Journal of Psychiatric Research - September 7, 2018 Category: Psychiatry Source Type: research

Second generation atypical antipsychotics olanzapine and aripiprazole reduce expression and secretion of inflammatory cytokines in human immune cells
In this study, we used ex vivo stimulation of primary human peripheral blood mononuclear cells (PBMC) from healthy blood donors with atypical antipsychotics olanzapine or aripiprazole to examine effects on cytokine production independent from metabolic side effects and disease status.Both olanzapine and aripiprazole stimulation decreased mRNA levels of IL-1β, IL-6, and TNF-α and resulted in diminished protein concentrations of IL-6 and TNF-α in conditioned medium of stimulated PBMC. A multiplex approach revealed additional downregulation of IL-2; MIP-1β and IP-10 secretion. Similarly, olanzapine and a...
Source: Journal of Psychiatric Research - September 5, 2018 Category: Psychiatry Source Type: research

Cerebrospinal fluid monoamine metabolite concentrations in depressive disorder: A meta-analysis of historic evidence
Publication date: Available online 4 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Shintaro Ogawa, Shoko Tsuchimine, Hiroshi KunugiAbstractAltered monoaminergic functions have been implicated in the pathophysiology of depressive disorder. However, previously reported cerebrospinal fluid (CSF) monoamine metabolite concentrations in major depression have been inconsistent. We performed a meta-analysis of historic evidence to determine whether CSF monoamine metabolite levels were different between patients with depression and normal controls, and could be used as depression biomarkers. Relevant studies that ...
Source: Journal of Psychiatric Research - September 5, 2018 Category: Psychiatry Source Type: research

Impact of perceived rearing and social support on bonding failure and depression among mothers: A longitudinal study of pregnant women
ConclusionsThese results showed that bonding failure in the postpartum period was significantly influenced by mothers' own perceived rearing and social support during pregnancy. In addition, depression in the postpartum period was strongly influenced by social support during pregnancy. These findings suggest that psychosocial interventions that focus on both mothers' recollections of their own upbringing and social support during pregnancy are effective for preventing bonding failure and depression in the postpartum period. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 5, 2018 Category: Psychiatry Source Type: research

Maternal C-reactive protein and cytokine levels during pregnancy and the risk of selected neuropsychiatric disorders in offspring: A systematic review and meta-analysis
Publication date: Available online 4 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Jian Zhang, Wanjun Luo, Pengcheng Huang, Linrui Peng, Qitao HuangAbstractThe pathophysiology of neuropsychiatric disorders is unclear. Increasing evidence has suggested maternal immune system dysregulation may be implicated in offspring's early brain development and related to an increased risk of neuropsychiatric disorders in offspring. The primary objective of this meta-analysis was to investigate the association of maternal CRP and cytokine levels with offspring's neuropsychiatric disorders. We identified relevant studie...
Source: Journal of Psychiatric Research - September 5, 2018 Category: Psychiatry Source Type: research

The effect of being left home alone at age 3 years on schizotypy and antisocial behavior at ages 17 and 23 years
ConclusionsFindings appear to be the first to show the negative effects of dual-parental daytime absence on adult schizotypy and crime, a finding that cannot be accounted for by verbal and spatial cognitive impairments. Results suggest an early common psychosocial denominator to the two comorbid conditions of antisocial behavior and schizotypy. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 4, 2018 Category: Psychiatry Source Type: research

Electrophysiological predictors of cognitive-behavioral therapy outcome in tic disorders
Publication date: Available online 4 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Simon Morand-Beaulieu, Kieron P. O'Connor, Pierre J. Blanchet, Marc E. LavoieAbstractCognitive-behavioral therapy (CBT) constitutes an empirically based treatment for tic disorders (TD), but much remains to be learned about its impact at the neural level. Therefore, we examined the electrophysiological correlates of CBT in TD patients, and we evaluated the utility of event-related potentials (ERP) as predictors of CBT outcome. ERPs were recorded during a stimulus-response compatibility (SRC) task in 26 TD patients and 26 he...
Source: Journal of Psychiatric Research - September 4, 2018 Category: Psychiatry Source Type: research

Association between resting-state brain functional connectivity and cortisol levels in unmedicated major depressive disorder
Publication date: Available online 1 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Ying Wang, Guanmao Chen, Shuming Zhong, Yanbin Jia, Liu Xia, Shunkai Lai, Lianping Zhao, Li Huang, Tiebang LiuAbstractDisturbed hypothalamus–pituitary–adrenal axis function, which leads to excessive and prolonged hypercortisolemia, is a core feature of major depressive disorder (MDD). However, the relationships between depression, brain structure and function, and cortisol levels are unclear. The current study examined the whole-brain functional connectivity pattern of patients with MDD and evaluated the associa...
Source: Journal of Psychiatric Research - September 2, 2018 Category: Psychiatry Source Type: research

Assessment of neuroplasticity in late-life depression with transcranial magnetic stimulation
ConclusionOur results suggest that associative plasticity does not differ substantially between older adults with depression and age-matched HC. Continued research is needed to more comprehensively understand the role of neuroplasticity in the pathophysiology of LLD. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 1, 2018 Category: Psychiatry Source Type: research

Corrigendum to “Short-term efficacy and tolerability of lurasidone in the treatment of acute schizophrenia: A meta-analysis of randomized controlled trials” [J. Psychiatr. Res. 103 (2018) 244-251]
Publication date: Available online 20 August 2018Source: Journal of Psychiatric ResearchAuthor(s): Wei Zheng, Dong-Bin Cai, Xin-Hu Yang, Lu Li, Qing-E. Zhang, Chee H. Ng, Gabor S. Ungvari, Xian-Bin Li, Yu-Ping Ning, Yu-Tao Xiang (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - August 20, 2018 Category: Psychiatry Source Type: research

Editorial Board
Publication date: September 2018Source: Journal of Psychiatric Research, Volume 104Author(s): (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - August 18, 2018 Category: Psychiatry Source Type: research

Differential relations of suicidality in depression to brain activation during emotional and executive processing
In this study, we investigated brain activation in suicidal and non-suicidal patients with MDD during facial emotion processing and executive control. Functional magnetic resonance imaging (fMRI) data from the NESDA-fMRI study (MDD patients N = 103, healthy controls N = 26, HC) were analyzed. Patients were divided in a group of suicide attempters (N = 18, SA), suicide ideators (N = 31, SI) and a patient-control group (N = 73, PC). A gender discrimination task with emotional faces and the Tower of London executive planning task were investigated. An ANOVA was performed to co...
Source: Journal of Psychiatric Research - August 15, 2018 Category: Psychiatry Source Type: research

Differences in excitatory and inhibitory neurotransmitter levels between depressed patients and healthy controls: A systematic review and meta-analysis
Publication date: Available online 11 August 2018Source: Journal of Psychiatric ResearchAuthor(s): Kate E.M. Godfrey, Abby C. Gardner, Sehyun Kwon, Sopanhara Chea, S.D. MuthukumaraswamyAbstractDysfunction of gamma-aminobutyric acid (GABA) and/or glutamate neurotransmitter systems have increasingly been implicated in the aetiology of Major Depressive Disorder (MDD). It has been proposed that alterations in GABA and/or glutamate result in an imbalance of inhibition and excitation. In a review of the current literature, we identified studies using Magnetic Resonance Spectroscopy (MRS) to examine the neurotransmitters GABA, gl...
Source: Journal of Psychiatric Research - August 12, 2018 Category: Psychiatry Source Type: research

Learn to forget: Does post-exposure administration of d-cycloserine enhance fear extinction in agoraphobia?
Publication date: Available online 11 August 2018Source: Journal of Psychiatric ResearchAuthor(s): L. Pyrkosch, J. Mumm, I. Alt, L. Fehm, T. Fydrich, J. Plag, A. StröhleAbstractThe use of d-cycloserine (DCS) to augment exposure based therapy for anxiety disorders has shown mixed, although overall positive effects. Aim of the present study was to examine post-exposure administration of DCS in patients with agoraphobia with or without panic disorder. 73 patients with agoraphobia (with or without panic disorder) were treated with 12 sessions of cognitive behavioral therapy (CBT) including 3 exposures. Following successfu...
Source: Journal of Psychiatric Research - August 12, 2018 Category: Psychiatry Source Type: research

Comorbidity of personality disorder with intermittent explosive disorder
Publication date: Available online 10 August 2018Source: Journal of Psychiatric ResearchAuthor(s): Emil F. Coccaro, Carolyn K. Shima, Royce J. LeeAbstractThere is ambiguity in how recurrent anger and aggression are accounted for by psychiatric nosology. One area of uncertainty is the extent to which Intermittent Explosive Disorder (IED) overlaps with and is distinct from Personality Disorder (PD). Accordingly, we conducted a study of individuals with IED and PD in order to understand the nature of comorbidity relationships seen across these two areas of psychopathology. One-thousand-five-hundred-twenty-one adults were stud...
Source: Journal of Psychiatric Research - August 11, 2018 Category: Psychiatry Source Type: research

A longitudinal study of reciprocal risk between mental and substance use disorders among Mexican youth
DiscussionWe found limited longitudinal evidence of bidirectional influences between substance use disorders and mood, anxiety and disruptive behavior disorders with effect sizes that were modest at most under all circumstances. Mechanisms for these complex relationships need to be addressed in future research. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - August 11, 2018 Category: Psychiatry Source Type: research

Epigenome-wide association study of suicide attempt in schizophrenia
In this study, epigenome-wide patterns of methylation were measured in schizophrenia suicide attempters (n = 54) and schizophrenia non-suicide attempters (n = 69) using DNA extracted from white blood cells (WBC). Analyses focused on identifying differentially methylated CpG sites and gene regions between the attempters and non-attempters. We identified the CpG site cg19647197 within the CCDC53 gene, which is characterized by hypomethylation of WBC in the attempters compared to the non-attempters. Our results suggest that there is variation in DNA methylation associated with suicide attempt that may offer novel high...
Source: Journal of Psychiatric Research - August 10, 2018 Category: Psychiatry Source Type: research

FKBP5 polymorphisms and hypothalamic-pituitary-adrenal axis negative feedback in major depression and obsessive-compulsive disorder
Publication date: Available online 9 August 2018Source: Journal of Psychiatric ResearchAuthor(s): Alex Ferrer, Javier Costas, Javier Labad, Neus Salvat-Pujol, Cinto Segalàs, Mikel Urretavizcaya, Eva Real, Aida de Arriba-Arnau, Pino Alonso, José M. Crespo, Marta Barrachina, Carles Soriano-Mas, Ángel Carracedo, José M. Menchón, Virginia SoriaAbstractMajor depressive disorder (MDD) and obsessive-compulsive disorder (OCD) have both been linked to abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. Polymorphisms in the genes involved in HPA axis activity, such as FKBP5, and their i...
Source: Journal of Psychiatric Research - August 9, 2018 Category: Psychiatry Source Type: research

Neuroimaging hippocampal subfields in schizophrenia and bipolar disorder: A systematic review and meta-analysis
Publication date: Available online 7 August 2018Source: Journal of Psychiatric ResearchAuthor(s): Unn K. Haukvik, Christian K. Tamnes, Erik Söderman, Ingrid AgartzAbstractThe hippocampus is a complex structure consisting of subregions with specialized cytoarchitecture and functions. Magnetic resonance imaging (MRI) studies in psychotic disorders show hippocampal subfield abnormalities, but affected regions differ between studies. We here present an overview of hippocampal anatomy and function relevant to psychosis, and the first systematic review and meta-analysis of MRI studies of hippocampal subfield morphology in s...
Source: Journal of Psychiatric Research - August 8, 2018 Category: Psychiatry Source Type: research

Integrated profiling of phenotype and blood transcriptome for stress vulnerability and depression
This study presents an opportunity to understand how multiple psychological traits and underlying molecular mechanisms interact to render individuals vulnerable to depression. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - August 7, 2018 Category: Psychiatry Source Type: research

Genetic disposition to inflammation and response to antidepressants in major depressive disorder
DiscussionA differential association between CRP-PRS and antidepressant drug that is in a direction opposite to that found with serum CRP measurement suggests that previously observed effect of inflammation on antidepressant efficacy may be driven by state factors distinct from genetic influences on systemic inflammation. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - August 7, 2018 Category: Psychiatry Source Type: research

Reliability of retrospective reports on childhood abuse and its determinants in older adults during a 6-year follow-up
In conclusion, test-retest reliability of retrospective self-reports on childhood abuse seems moderate to good, but slightly dependent on the type of abuse. The test-retest reliability was influenced neither by age nor cognition, only reporting of emotional neglect was associated with depression state. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - August 6, 2018 Category: Psychiatry Source Type: research

Efficacy of the Unified Protocol for transdiagnostic treatment of comorbid psychopathology accompanying emotional disorders compared to treatments targeting single disorders
ConclusionsResults suggest that both the UP and SDPs are efficacious in reducing symptoms of comorbid emotional disorders. The clinical, practical, and cost-effective advantages of transdiagnostic CBT are discussed. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - August 4, 2018 Category: Psychiatry Source Type: research

Prevalence and incidence of postpartum depression among healthy mothers: A systematic review and meta-analysis
Publication date: Available online 3 August 2018Source: Journal of Psychiatric ResearchAuthor(s): Shefaly Shorey, Cornelia Chee Yin Ing, Esperanza Debby Ng, Chan Yiong Huak, Wilson Tam Wai San, Chong Yap SengAbstractThis review aims to examine the prevalence and incidence of postpartum depression among healthy mothers without prior history of depression including postpartum depression and who gave birth to healthy full-term infants. A systematic search of ClinicalTrials.gov, CINAHL, EMBASE, PsycINFO, and PubMed was performed for English articles from the inception of the database to November 2017, as well as a manual searc...
Source: Journal of Psychiatric Research - August 4, 2018 Category: Psychiatry Source Type: research

Negative affect is more strongly associated with suicidal thinking among suicidal patients with borderline personality disorder than those without
Publication date: Available online 3 August 2018Source: Journal of Psychiatric ResearchAuthor(s): David Mou, Evan M. Kleiman, Szymon Fedor, Stuart Beck, Jeff C. Huffman, Matthew K. NockAbstractPatients suffering from borderline personality disorder (BPD) are at elevated risk for suicidal thoughts and behaviors (STBs), but this well-described and clinically important association is not well-understood. Prior research suggests that STBs often function as an attempt to escape aversive affect, and that people with BPD experience stronger emotion reactivity and greater discomfort with emotion than those without BPD. Here, we te...
Source: Journal of Psychiatric Research - August 3, 2018 Category: Psychiatry Source Type: research

Photoperiod during maternal pregnancy and lifetime depression in offspring
We examined photoperiod (i.e., day length) metrics during maternal pregnancy in relation to lifetime depression in the longitudinal Nurses' Health Study (NHS) and NHS II. 160,723 participants reported birth date and birth state (used to derive daily photoperiod based on published mathematical equations), and clinician-diagnosed depression and antidepressant use throughout adulthood. Logistic regression was used to estimate odds ratios (OR) (and 95% confidence intervals [CI]) for depression (defined as clinician diagnosis and antidepressant use) across quintiles of two exposures during maternal pregnancy: 1) total photoperi...
Source: Journal of Psychiatric Research - August 3, 2018 Category: Psychiatry Source Type: research

Taurine modulates acute ethanol-induced social behavioral deficits and fear responses in adult zebrafish
Publication date: Available online 3 August 2018Source: Journal of Psychiatric ResearchAuthor(s): Barbara D. Fontana, Flavia V. Stefanello, Nathana J. Mezzomo, Talise E. Müller, Vanessa A. Quadros, Matthew O. Parker, Eduardo P. Rico, Denis B. RosembergAbstractEthanol (EtOH) is a central nervous system (CNS) depressant drug that modifies various behavioral domains (e.g., sociability, aggressiveness, and memory) by promoting disinhibition of punished operant behavior and neurochemical changes. Taurine (TAU) is a β-amino sulfonic acid with pleiotropic roles in the brain. Although exogenous TAU is found in energy dri...
Source: Journal of Psychiatric Research - August 3, 2018 Category: Psychiatry Source Type: research

Prevalence and correlates of HIV testing and HIV-positive status in the US: Results from the National Epidemiological Survey on Alcohol and Related Conditions III (NESARC-III)
Publication date: Available online 3 August 2018Source: Journal of Psychiatric ResearchAuthor(s): Carlos Blanco, Melanie M. Wall, Wilson M. Compton, Shoshana Kahana, Tianshu Feng, Tulshi Saha, Jennifer C. Elliott, H. Irene Hall, Bridget F. GrantAbstractWe used the 2012–2013 National Epidemiologic Survey on Alcohol and Related Conditions III (NESARC-III), a nationally representative sample of US adults (n = 34,653), to estimate the prevalence and correlates of HIV testing and HIV status. The diagnostic interview used was the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-5 Version. W...
Source: Journal of Psychiatric Research - August 3, 2018 Category: Psychiatry Source Type: research

ECT augmentation of clozapine for clozapine-resistant schizophrenia: A meta-analysis of randomized controlled trials
Publication date: Available online 2 August 2018Source: Journal of Psychiatric ResearchAuthor(s): Gang Wang, Wei Zheng, Xian-Bin Li, Shi-Bin Wang, Dong-Bin Cai, Xin-Hu Yang, Gabor S. Ungvari, Yu-Tao Xiang, Christoph U. CorrellAbstractTreatment-resistant schizophrenia (TRS) is common and debilitating. A subgroup of patients even has clozapine-resistant schizophrenia (CRS). We aimed to evaluate the efficacy and safety of electroconvulsive therapy (ECT) augmentation of clozapine for CRS. Systematic literature search of randomized controlled trials (RCTs) reporting on ECT augmentation of clozapine in CRS. Co-primary outcomes i...
Source: Journal of Psychiatric Research - August 3, 2018 Category: Psychiatry Source Type: research

Disease trajectories in behavioural variant frontotemporal dementia, primary psychiatric and other neurodegenerative disorders presenting with behavioural change
Publication date: Available online 1 August 2018Source: Journal of Psychiatric ResearchAuthor(s): Lianne M. Reus, Everard GB. Vijverberg, Betty M. Tijms, Mara ten Kate, Flora Gossink, Welmoed A. Krudop, Marta del Campo, Charlotte E. Teunissen, Frederik Barkhof, Wiesje M. van der Flier, Pieter Jelle Visser, Annemiek Dols, Yolande AL. PijnenburgAbstractBehavioural variant frontotemporal dementia (bvFTD) is characterized by behavioural and social cognitive disturbances, while various psychiatric and neurodegenerative disorders may have similar clinical symptoms. Since neurodegenerative disorders are eventually progressive, wh...
Source: Journal of Psychiatric Research - August 1, 2018 Category: Psychiatry Source Type: research

Therapeutic effects of mobile-based text message reminders for medication adherence in bipolar I disorder: Are they maintained after intervention cessation?
Publication date: Available online 26 July 2018Source: Journal of Psychiatric ResearchAuthor(s): Vikas Menon, Nivedhitha Selvakumar, Shivanand Kattimani, Chittaranjan AndradeAbstractMobile phone short message service (SMS) reminders may be a low-cost method for promoting medication adherence. Our objective was to determine whether text SMS reminders improve medication adherence in patients with bipolar I disorder even after discontinuation of the intervention. Participants were stable adult bipolar I disorder outpatients on maintenance medication who were randomized to receive treatment as usual (TAU; n = 70) or TAU pl...
Source: Journal of Psychiatric Research - July 27, 2018 Category: Psychiatry Source Type: research

Efficacy and tolerability of adjunctive gabapentin and memantine in obsessive compulsive disorder: Double-blind, randomized, placebo-controlled trial
ConclusionsThe present pattern of results suggests that glutamatergic medications such as gabapentin and memantine adjuvant to a standard treatment with an SSRI have no additional positive impact on patients with OCD, as measured with the Y-BOCS. Additionally, side-effects were reported. Future studies should use more fine-grained tools to assess, for example, patients' sleep and cognitive functioning, and patients' view of symptoms. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - July 22, 2018 Category: Psychiatry Source Type: research

Combinatorial pharmacogenomics and improved patient outcomes in depression: Treatment by primary care physicians or psychiatrists
Publication date: Available online 21 July 2018Source: Journal of Psychiatric ResearchAuthor(s): Julie-Anne Tanner, Paige E. Davies, Nicholas C. Voudouris, Anashe Shahmirian, Deanna Herbert, Nicole Braganza, Ana Gugila, Bryan M. Dechairo, James L. KennedyAbstractFailed medication trials are common in the treatment of major depressive disorder (MDD); however, the use of combinatorial pharmacogenomics to guide medication selection has been previously associated with improved outcomes in the psychiatric care setting. The utility of combinatorial pharmacogenomics in patients with MDD in primary care and psychiatric care settin...
Source: Journal of Psychiatric Research - July 22, 2018 Category: Psychiatry Source Type: research

The past and future of novel, non-dopamine-2 receptor therapeutics for schizophrenia: A critical and comprehensive review
Publication date: Available online 21 July 2018Source: Journal of Psychiatric ResearchAuthor(s): Ragy R. Girgis, Anthony W. Zoghbi, Daniel C. Javitt, Jeffrey A. LiebermanAbstractSince the discovery of chlorpromazine in the 1950's, antipsychotic drugs have been the cornerstone of treatment of schizophrenia, and all attenuate dopamine transmission at the dopamine-2 receptor. Drug development for schizophrenia since that time has led to improvements in side effects and tolerability, and limited improvements in efficacy, with the exception of clozapine. However, the reasons for clozapine's greater efficacy remain unclear, desp...
Source: Journal of Psychiatric Research - July 22, 2018 Category: Psychiatry Source Type: research

Assessment of the psychometric properties of the 17- and 6-item Hamilton Depression Rating Scales in major depressive disorder, bipolar depression and bipolar depression with mixed features
Publication date: Available online 21 July 2018Source: Journal of Psychiatric ResearchAuthor(s): Alexandre Kieslich da Silva, Mateus Reche, Ana Flávia da Silva Lima, Marcelo Pio de Almeida Fleck, Edison Capp, Flávio Milman ShansisAbstractAssessing therapeutic response in depression requires scales that adequately measure the core symptoms of depressive symptomatology. The main goal of this study was to assess the psychometric properties of the 17-item Hamilton Depression Rating Scale (HAM-D17) and the 6-item Hamilton Depression Rating Scale (HAM-D6) in patients with Major Depressive Disorder (MDD), bipolar de...
Source: Journal of Psychiatric Research - July 21, 2018 Category: Psychiatry Source Type: research

Epigenome wide association study of suicide attempt in schizophrenia
In this study, epigenome-wide patterns of methylation were measured in schizophrenia suicide attempters (n = 54) and in schizophrenia non suicide attempters (n = 69) using DNA extracted from white blood cells. Analyses focused on identifying differentially methylated CpG sites and gene regions between attempters and non-attempters. We identified the CpG site cg19647197 within the CCDC53 gene, which is characterized by hypomethylation of WBC in schizophrenia attempters compared to non-attempters. Our results suggest that there is variation in DNA methylation associated with suicide attempt that may offer novel highl...
Source: Journal of Psychiatric Research - July 20, 2018 Category: Psychiatry Source Type: research

Bibliometric analysis of manuscript characteristics that influence citations: A comparison of six major psychiatry journals
In this study we investigated the characteristics of psychiatry manuscript that influence its citation rate. We conducted a cross-sectional study of published articles (n = 545), from January to June 2007, from 6 major psychiatry journals with the highest 5-year impact-factor. Citation count for these articles was retrieved from Web Of Science (by Clarivate Analytics) and 22 article characteristics were tabulated manually. We then predicted the citation rate by performing univariate analysis, spearman rank-order correlation, and multiple regression model on the collected variables. Using spearman rank-order correlation...
Source: Journal of Psychiatric Research - July 20, 2018 Category: Psychiatry Source Type: research