Adequate evidence to support improved outcomes in depression by primary care physicians compared to psychiatrists when using combinatorial pharmacogenomics
Publication date: Available online 15 November 2018Source: Journal of Psychiatric ResearchAuthor(s): James Kennedy, Julie-Anne Tanner, Paige Davies, Nicholas C. Voudouris, Bryan M. Dechairo (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - November 16, 2018 Category: Psychiatry Source Type: research

Influence of age on ECT efficacy in depression and the mediating role of psychomotor retardation and psychotic features
Publication date: Available online 15 November 2018Source: Journal of Psychiatric ResearchAuthor(s): Willemijn T.C.J. Heijnen, Astrid M. Kamperman, Lindsay D. Tjokrodipo, Witte J.G. Hoogendijk, Walter W. van den Broek, Tom K. BirkenhägerAbstractObjectiveTo investigate whether older age predicts a higher efficacy of electroconvulsive therapy (ECT) in severely depressed patients. Also, to analyze whether psychomotor disturbance and/or psychotic features might explain the potential higher efficacy of ECT in older age.MethodA total of 96 patients with major depressive disorder treated with bilateral ECT were evaluated. Th...
Source: Journal of Psychiatric Research - November 16, 2018 Category: Psychiatry Source Type: research

Psychotic symptoms in youth with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) May reflect syndrome severity and heterogeneity
ConclusionsOver 1/3 of children with PANS experienced transient hallucinations. They were more impaired than those without psychotic symptoms, but showed no differences in disease progression. This difference may point toward heterogeneity in PANS. When evaluating children with acute psychotic symptoms, clinicians should screen for abrupt-onset of a symptom cluster including OCD and/or food refusal, with neuropsychiatric symptoms (enuresis, handwriting changes, tics, hyperactivity, sleep disorder) before initiating treatment. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - November 15, 2018 Category: Psychiatry Source Type: research

Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders?
Publication date: Available online 13 November 2018Source: Journal of Psychiatric ResearchAuthor(s): Trude Seselie Jahr Vedal, Nils Eiel Steen, Ingrid Dieset, Elina J. Reponen, Jannicke F. Laskemoen, Linn Rødevand, Ingrid Melle, Ole A. Andreassen, Kåre I. Birkeland, Espen Molden, Erik G. Jönsson (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - November 14, 2018 Category: Psychiatry Source Type: research

Letter to the editor: Are thyroid function abnormalities only related to antipsychotic treatment in patients with severe mental disorders?
Publication date: Available online 13 November 2018Source: Journal of Psychiatric ResearchAuthor(s): Rami Bou Khalil, Sami Richa (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - November 14, 2018 Category: Psychiatry Source Type: research

Immunomodulatory effects of antipsychotic treatment on gene expression in first-episode psychosis
In conclusion, risperidone possessed strong immunomodulatory properties affecting mainly innate immune response in FEP patients, whereas the observed effects of quetiapine and olanzapine were only marginal. Our results further emphasize the importance of understanding the immunomodulatory mechanisms of antipsychotic treatment, especially in terms of specific compounds, doses and duration of medication in patients with severe mental illness. Future studies should evaluate the response pre- and post-treatment, and the possible role of this inflammatory activation for the progression of psychiatric and metabolic symptoms. (So...
Source: Journal of Psychiatric Research - November 11, 2018 Category: Psychiatry Source Type: research

A bi-factor model of the montgomery Åsberg depression rating scale and future cognitive impairments in older adults: A 6-year follow-up study
This study evaluated the association of general depressive symptoms and motivational-related symptoms with cognitive impairment 6 years later and to explore the role of potential underlying mechanisms. In 2690 cognitively healthy persons aged ≥60 from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) depressive symptoms were derived from the Montgomery Åsberg Depression Rating Scale (MADRS). Cognitive performance was assessed at baseline and 6 years later in 1810 persons with the Mini Mental State Examination (global cognition), Digit Span Forward (short-term memory), Digit Span Backward (workin...
Source: Journal of Psychiatric Research - November 11, 2018 Category: Psychiatry Source Type: research

abcb1ab p-glycoprotein is involved in the uptake of the novel antidepressant vortioxetine into the brain of mice
Publication date: Available online 10 November 2018Source: Journal of Psychiatric ResearchAuthor(s): Derek Spieler, Christian Namendorf, Tamara Namendorf, Manfred UhrAbstractA clinically important and well-studied transporter of the blood-brain barrier (BBB) is P-glycoprotein (P-gp), the gene product of ABCB1. Animal studies have shown that brain concentrations of many antidepressants depend on P-gp. However, biochemical properties, which might allow the prediction of pharmacodynamical involvement of P-gp have not yet been identified, hence thorough experimental testing of each novel drug is needed to determine its P-gp su...
Source: Journal of Psychiatric Research - November 11, 2018 Category: Psychiatry Source Type: research

Telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde
Publication date: Available online 8 November 2018Source: Journal of Psychiatric ResearchAuthor(s): Naruhisa Yamaki, Sachio Matsushita, Sachiko Hara, Akira Yokoyama, Akitoyo Hishimoto, Susumu HiguchiAbstractHeavy drinking leads to premature aging and precipitates the onset of age-related diseases. Acetaldehyde (AcH), a toxic metabolite of ethanol, has been implicated in various types of cancer. However, whether alcohol accelerates biological aging at a cellular level is controversial and the mechanism involved is unclear. We addressed these questions by measuring telomere length (TL) in peripheral blood leukocytes of Japan...
Source: Journal of Psychiatric Research - November 9, 2018 Category: Psychiatry Source Type: research

Reduced prefrontal-temporal cortical activation during verbal fluency task in obsessive-compulsive disorder: A multi-channel near-infrared spectroscopy study
This study aimed to evaluate the hemodynamic response related to the verbal fluency task (VFT) and assess the relationship between activation and clinical status in OCD patients using a 52-channel NIRS with a wide coverage over the prefrontal and temporal cortices. Seventy patients with OCD and 70 age-, gender- and education level-matched healthy control subjects were examined by NIRS. The relative concentration changes of oxygenated hemoglobin ([oxy-Hb]) were measured. The Yale-Brown obsessive-compulsive scale (Y-BOCS) was used to evaluate the severity of OCD symptoms. Compared to healthy controls group, OCD patients show...
Source: Journal of Psychiatric Research - November 8, 2018 Category: Psychiatry Source Type: research

The emergence of psychotic experiences in the early adolescence of 22q11.2 Deletion Syndrome
Publication date: Available online 5 November 2018Source: Journal of Psychiatric ResearchAuthor(s): Samuel J.R.A. Chawner, Maria Niarchou, Joanne L. Doherty, Hayley Moss, Michael J. Owen, Marianne B.M. van den BreeAbstractIndividuals with 22q11.2 Deletion Syndrome (22q11.2DS) are at substantial increased risk of psychosis spectrum outcomes including schizophrenia. We conducted a prospective, longitudinal study of the psychopathological and neurocognitive correlates of early psychotic phenomena in young people with 22q11.2DS (n = 75, mean age time 1 (T1) 9.9 years, time 2 (T2) 12.5 years). We also assessed unaffected co...
Source: Journal of Psychiatric Research - November 6, 2018 Category: Psychiatry Source Type: research

Corrigendum to ’Ketamine in electroconvulsive therapy for depressive disorder: A systematic review and meta-analysis’ [Journal of Psychiatric Research 104 (2018) 144–156]
Publication date: January 2019Source: Journal of Psychiatric Research, Volume 108Author(s): Li Ren, Jie Deng, Su Min, Lihua Peng, Qinbin Chen (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - November 6, 2018 Category: Psychiatry Source Type: research

Adjunctive second-generation antipsychotics for specific symptom domains of schizophrenia resistant to clozapine: A meta-analysis
Publication date: Available online 3 November 2018Source: Journal of Psychiatric ResearchAuthor(s): Francesco Bartoli, Cristina Crocamo, Carmen Di Brita, Giovanni Esposito, Tommaso Innocenzo Tabacchi, Enrica Verrengia, Massimo Clerici, Giuseppe CarràAbstractA fair amount of subjects with schizophrenia do not respond to clozapine and are defined ‘ultra-resistant’. In this systematic review and meta-analysis, we tested the efficacy of adjunctive second-generation antipsychotics (SGAs) for main symptom domains (positive, negative, and depressive symptoms) in individuals with clozapine-resistant schizophreni...
Source: Journal of Psychiatric Research - November 4, 2018 Category: Psychiatry Source Type: research

Does exercise improve sleep quality in individuals with mental illness? A systematic review and meta-analysis
Publication date: Available online 3 November 2018Source: Journal of Psychiatric ResearchAuthor(s): Oscar Lederman, Philip B. Ward, Joseph Firth, Christopher Maloney, Rebekah Carney, Davy Vancampfort, Brendon Stubbs, Megan Kalucy, Simon RosenbaumAbstractPeople living with mental illness often experience poor sleep quality compared to the general population. Poor sleep quality exacerbates symptoms of mental illness and contributes to increased physical comorbidities. Exercise has been shown to be an effective non-pharmacological treatment for managing poor sleep in the general population. Little is known regarding the effic...
Source: Journal of Psychiatric Research - November 4, 2018 Category: Psychiatry Source Type: research

Brain arousal regulation in SSRI-medicated patients with major depression
Publication date: Available online 3 November 2018Source: Journal of Psychiatric ResearchAuthor(s): Christine Ulke, Dirk A. Wittekind, Janek Spada, Katharina Franik, Philippe Jawinski, Tilman Hensch, Ulrich HegerlAbstractEEG measures of arousal have been suggested as diagnostic and predictive biomarkers for major depression. The aim of the present study was to examine whether self-rated depression severity in SSRI-medicated patients with major depression (MD) is associated with EEG measures of brain arousal. Based on previous studies, we expected that a higher level of brain arousal and a slower arousal decline during a 15...
Source: Journal of Psychiatric Research - November 3, 2018 Category: Psychiatry Source Type: research

Letter to the editor: Inadequate evidence to support improved patient outcomes with combinatorial pharmacogenomics
Publication date: Available online 29 October 2018Source: Journal of Psychiatric ResearchAuthor(s): Joshua D. Rosenblat, Yena Lee, Rodrigo B. Mansur, Elisa Brietzke, Roger S. McIntyre (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 30, 2018 Category: Psychiatry Source Type: research

Thirteen Reasons Why: The impact of suicide portrayal on adolescents’ mental health
Publication date: Available online 30 October 2018Source: Journal of Psychiatric ResearchAuthor(s): Gabriel Santana da Rosa, Gustavo Santos Andrades, Arthur Caye, Maria Paz Hidalgo, Melissa Alves Braga de Oliveira, Luísa K. PilzAbstractWe aimed to investigate the influence of media portrayals of suicide on adolescents’ mood, focusing on the case of 13 Reasons Why, a webseries that raised concerns for approaching suicide explicitly for an audience mostly composed of adolescents. There is already evidence of an increase in suicide-related Internet searches shortly following its release. Our study included 7004 i...
Source: Journal of Psychiatric Research - October 30, 2018 Category: Psychiatry Source Type: research

Early weight gain predicts later metabolic syndrome in depressed patients treated with antidepressants: Findings from the METADAP cohort
ConclusionCompared to Non-early weight gainers, patients with early weight gain in the first month of antidepressant treatment have a significant higher risk of developing MetS during the 6 months of treatment. Early weight monitoring is recommended in order to set preventive measures to avoid new metabolic syndromes in depressed patients treated with antidepressants. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 29, 2018 Category: Psychiatry Source Type: research

Racial and ethnic differences in mental health service utilization in suicidal adults: A nationally representative study
Publication date: Available online 26 October 2018Source: Journal of Psychiatric ResearchAuthor(s): Ana E. Sheehan, Rachel F.L. Walsh, Richard T. LiuAbstractThe current study examined racial/ethnic differences in utilization of mental health services in a nationally representative sample of suicidal adults. Data were extracted from the National Survey on Drug Use and Health (NSDUH) from 2009 to 2016. Participants consisted of adults with severe suicidal ideation and/or behavior in the past 12 months (unweighted n = 17,338). Multivariate logistic regression analyses were conducted to assess racial/ethnic differences in ment...
Source: Journal of Psychiatric Research - October 27, 2018 Category: Psychiatry Source Type: research

Expression of dopamine signaling genes in the post-mortem brain of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes
In conclusion, differential expression of dopamine-related genes was related to altered expression of insulin signaling genes. BMI had region-specific effects, supporting the hypothesis that metabolic systems are critical mediators of dopaminergic function. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 27, 2018 Category: Psychiatry Source Type: research

Comparison of treatment options for depression in heart failure: A network meta-analysis
ConclusionsThis meta-analysis is suggestive of therapeutic benefit of ET and CBT in comparison to usual standard of care in treating depression in HF patients. However, comparison among the three interventions was not conclusive. Future randomized clinical trials are warranted to compare the therapeutic effects of ET, CBT and AD in such patients. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 26, 2018 Category: Psychiatry Source Type: research

Neuroanatomical abnormalities in fragile X syndrome during the adolescent and young adult years
In conclusion, adolescents and young adults with FXS demonstrate neuroanatomical abnormalities consistent with those previously reported in children and adults with FXS. These brain variations likely result from reduced FMRP during early neurodevelopment and mediate downstream deleterious effects on cognitive function. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 26, 2018 Category: Psychiatry Source Type: research

Polygenic Score for Alzheimer Disease and cognition: The mediating role of personality
Publication date: Available online 23 October 2018Source: Journal of Psychiatric ResearchAuthor(s): Yannick Stephan, Angelina R. Sutin, Martina Luchetti, Pauline Caille, Antonio TerraccianoAbstractAlzheimer's disease (AD) polygenic risk score (PGS) is associated with lower cognitive functioning even among older individuals without dementia. We tested the hypothesis that personality traits mediate the association between AD genetic risk and cognitive functioning. Participants (N > 7,000, aged 50–99 years old) from the Health and Retirement Study were genotyped and completed personality and cognition tests at ba...
Source: Journal of Psychiatric Research - October 23, 2018 Category: Psychiatry Source Type: research

Editorial Board
Publication date: November 2018Source: Journal of Psychiatric Research, Volume 106Author(s): (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 23, 2018 Category: Psychiatry Source Type: research

Effect of male-specific childhood trauma on telomere length
Publication date: Available online 22 October 2018Source: Journal of Psychiatric ResearchAuthor(s): Gabriela Xavier, Letícia M. Spindola, Vanessa K. Ota, Carolina M. Carvalho, Pawan Maurya, Priscila F. Tempaku, Patricia N. Moretti, Diego R. Mazotti, João Ricardo Sato, Elisa Brietzke, Euripedes Constantino Miguel, Rodrigo Grassi, Jair Mari, Rodrigo A. Bressan, Ary Gadelha, Pedro M. Pan, Sintia Iole BelangeroAbstractChild maltreatment (CM) is a global issue with serious lifelong consequences. In fact, maltreatment during childhood might be an important risk factor for the development of psychiatric disorders. F...
Source: Journal of Psychiatric Research - October 22, 2018 Category: Psychiatry Source Type: research

Subtypes of aggression in intermittent explosive disorder
We examined aggression subtypes in individuals with IED, healthy subjects, and psychiatric control subjects. We also considered the relationship between aggression subtypes and measures of trait anger and impulsivity to evaluate whether the hostile/instrumental dichotomy adequately captures the heterogeneity of aggressive behavior in this sample. Finally, we consider the implications of these results for research on aggression, including neurobiological research on aggression. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 20, 2018 Category: Psychiatry Source Type: research

An augmentation study of MSI-195 (S-adenosylmethionine) in Major Depressive Disorder
Publication date: Available online 18 October 2018Source: Journal of Psychiatric ResearchAuthor(s): Steven D. Targum, Beth R. Cameron, Ludvina Ferreira, I. David MacDonaldAbstractWe conducted a 6-week double-blind, placebo-controlled, augmentation study comparing the efficacy and safety of MSI-195 800 mg (a proprietary formulation of S-adenosylmethionine) or placebo added to ongoing antidepressant medication (ADT) in acutely depressed subjects with Major Depressive Disorder (MDD) who had experienced an inadequate response to their ongoing ADT (The Horizon Study, ClinicalTrials.gov NCT01912196).There were 234 eligible s...
Source: Journal of Psychiatric Research - October 19, 2018 Category: Psychiatry Source Type: research

Ghrelin cascade changes in the peripheral blood of Japanese patients with Alzheimer's disease
We examined the levels of plasma acyl/des-acyl ghrelin in 75 AD subjects and age- and sex-matched controls, as well as the DNA methylation and mRNA expression of MBOAT4 and GHS-R in peripheral leukocytes. The acyl ghrelin concentration was significantly higher in AD subjects than in controls (2.18 ± 1.25 vs. 1.49 ± 2.3, p = 0.001). The methylation rate of MBOAT4 CpG 2 was significantly lower in AD subjects than in controls (4.0 ± 0.9 vs. 4.7 ± 1.2, p 
Source: Journal of Psychiatric Research - October 19, 2018 Category: Psychiatry Source Type: research

Hypomethylation of LINE-1 elements in schizophrenia and bipolar disorder
Publication date: Available online 10 October 2018Source: Journal of Psychiatric ResearchAuthor(s): Shufen Li, Qiong Yang, Yu Hou, Tingyun Jiang, Lu Zong, Zhongju Wang, Xia Luo, Wenquan Liang, Hu Zhao, Yuping Ning, Cunyou ZhaoAbstractSchizophrenia (SCZ) and bipolar disorder (BPD) are severe mental illnesses with evidence of significant genetic and environmental etiological elements in their complex etiologies. 5‘-Methylcytosine is the main epigenetic DNA modification that mediates the interplay between genetic and environmental components. In humans, most 5‘-methylcytosine modifications are observed in CpG-rich...
Source: Journal of Psychiatric Research - October 11, 2018 Category: Psychiatry Source Type: research

A systematic review of the effectiveness of mobile apps for monitoring and management of mental health symptoms or disorders
ConclusionsMental health apps have potentials in improving the monitoring and management of mental health symptoms or disorders. However, majority of the apps that are currently available lack clinically validated evidence of their efficacy. Given the number and pace at which mobile Health (mHealth) apps are being released, further robust research is warranted to develop and test evidence-based programs. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 6, 2018 Category: Psychiatry Source Type: research

Empirical evidence of the effect of personality pathology on the outcome of panic disorder
ConclusionThe negative effect of personality pathology was confirmed in well-designed longitudinal studies. This was not related to initial clinical severity. Clinical implications are that patients with personality pathology require the therapist to stick more closely to treatment protocols and to mitigate the tendency of these patients to drop out of treatment. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 6, 2018 Category: Psychiatry Source Type: research

Major depression model induced by repeated and intermittent lipopolysaccharide administration: long-lasting behavioral, neuroimmune and neuroprogressive alterations
In conclusion, our results support the validity of the chronic LPS model of major depression and additionally shows its translational relevance with respect to neuroimmune and neuroprogressive pathways. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 6, 2018 Category: Psychiatry Source Type: research

Augmenting Buried in Treasures with in-home uncluttering practice: Pilot study in hoarding disorder
Publication date: Available online 5 October 2018Source: Journal of Psychiatric ResearchAuthor(s): Omer Linkovski, Jordana Zwerling, Elisabeth Cordell, Danae Sonnenfeld, Henry Willis, Christopher N. La Lima, Colleen Baker, Rassil Ghazzaoui, Robyn Girson, Cat Sanchez, Brianna Wright, Mason Alford, Andrea Varias, Maria Filippou-Frye, Hanyang Shen, Booil Jo, Lee Shuer, Randy Frost, Carolyn I. RodriguezAbstractHoarding disorder is characterized by difficulty parting with possessions and by clutter that impairs the functionality of living spaces. Cognitive behavioral therapy conducted by a therapist (individual or in a group) f...
Source: Journal of Psychiatric Research - October 6, 2018 Category: Psychiatry Source Type: research

Examining characteristics of worry in relation to depression, anxiety, and suicidal ideation and attempts
ConclusionsOverall, these findings suggest that controllability of one's thoughts may be a key transdiagnostic factor that confers risk for a variety of psychopathology-related concerns. Clinical relevance includes identifying potential risk factors for varying psychopathology. Future research should examine relationships between worry controllability and anxiety, depression, suicidal ideation, and attempts, within clinical samples and utilizing a variety of methodologies. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 6, 2018 Category: Psychiatry Source Type: research

Cortical Thickness, Brain Metabolic Activity, and In Vivo Amyloid Deposition in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer´s Disease.
Publication date: Available online 5 October 2018Source: Journal of Psychiatric ResearchAuthor(s): Bárbara Duarte-Abritta, Mirta F. Villarreal, Carolina Abulafia, David Loewenstein, Rosie E. Curiel Cid, Mariana N. Castro, Ezequiel Surace, Stella-Maris Sánchez, Daniel E. Vigo, Silvia Vázquez, Charles B. Nemeroff, Gustavo Sevlever, Salvador M. GuinjoanAbstractThe natural history of preclinical late-onset Alzheimer´s disease (LOAD) remains obscure and has received less attention than that of early-onset AD (EOAD), in spite of accounting for more than 99% of cases of AD. With the purpose of detecting...
Source: Journal of Psychiatric Research - October 6, 2018 Category: Psychiatry Source Type: research

Leveraging genome-wide association and clinical data in revealing schizophrenia subgroups
Publication date: Available online 22 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Liangying Yin, Eric Fuk-Chi Cheung, Ronald Yuk-Lun Chen, Emily Hoi-Man Wong, Pak-Chung Sham, Hon-Cheong SoAbstractSchizophrenia(SCZ) has long been recognized as a highly heterogeneous disorder. Patients differed in their clinical manifestations, prognosis, and underlying pathophysiologies. Here we presented and applied a framework for finding subtypes of SCZ utilizing genome-wide association study(GWAS) and clinical data. We postulated that genetic information may help stratify patient into useful subgroups, and incorporat...
Source: Journal of Psychiatric Research - October 4, 2018 Category: Psychiatry Source Type: research

Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication
Publication date: Available online 25 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Trude Seselie Jahr Vedal, Nils Eiel Steen, Kåre I. Birkeland, Ingrid Dieset, Elina J. Reponen, Jannicke F. Laskemoen, Linn Rødevand, Ingrid Melle, Ole A. Andreassen, Espen Molden, Erik G. JönssonAbstractBackgroundDisturbances in thyroid function have been associated with use of psychotropic drugs, including antipsychotics. Still, the thyroid function in relation to commonly prescribed antipsychotic drugs and polypharmacy is not fully known. We investigated thyroid function associated with use of antipsych...
Source: Journal of Psychiatric Research - October 4, 2018 Category: Psychiatry Source Type: research

Interventions for common mental health problems among university and college students: A systematic review and meta-analysis of randomized controlled trials
The objective of this review is to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) examining interventions for CMHPs among university and college students and to estimate their post-intervention effect size (ES), as well as follow-up ES, for depression, anxiety disorder, OCD and PTSD separately. Meta-analytic procedures were conducted in accordance with PRISMA guidelines. We reviewed 7768 abstracts from which 331 full-text articles were reviewed and 51 RCTs were included in the analysis. We found moderate effect sizes for both depression (Hedges' g = −0.60) and anxiety disorde...
Source: Journal of Psychiatric Research - October 4, 2018 Category: Psychiatry Source Type: research

Prospective prediction of first lifetime onset of suicidal ideation in a national study of substance users
This study seeks to identify risk factors for first-onset SI among a high-risk group: individuals receiving treatment for substance use disorders. Data were drawn from the National Treatment Improvement Evaluation Study, a prospective study examining the impact of addiction treatment programs. Patients with no lifetime history of suicide attempts or ideation (n = 2560) were assessed at baseline and one year later for prospectively-occurring SI. Sociodemographic variables, mental health indices, interpersonal factors, and substance use severity indicators were evaluated as prospective predictors of first-onset SI in lin...
Source: Journal of Psychiatric Research - October 4, 2018 Category: Psychiatry Source Type: research

Co-expression network analysis of peripheral blood transcriptome identifies dysregulated protein processing in endoplasmic reticulum and immune response in recurrent MDD in older adults
Publication date: Available online 1 October 2018Source: Journal of Psychiatric ResearchAuthor(s): Liliana G. Ciobanu, Perminder S. Sachdev, Julian N. Trollor, Simone Reppermund, Anbupalam Thalamuthu, Karen A. Mather, Sarah Cohen-Woods, David Stacey, Catherine Toben, K. Oliver Schubert, Bernhard T. BauneAbstractThe molecular factors involved in the pathophysiology of major depressive disorder (MDD) remain poorly understood. One approach to examine the molecular basis of MDD is co-expression network analysis, which facilitates the examination of complex interactions between expression levels of individual genes and how they...
Source: Journal of Psychiatric Research - October 4, 2018 Category: Psychiatry Source Type: research

Influence of adjuvant omega-3-polyunsaturated fatty acids on depression, sleep, and emotion regulation among outpatients with major depressive disorders - Results from a double-blind, randomized and placebo-controlled clinical trial
ConclusionsAmong outpatients with MDD, and compared to placebo, adjuvant O3PUFAs to a standard medication improved not only symptoms of depression, but also dimensions of anxiety and sleep, and above all patients' competencies to regulate their emotions. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 4, 2018 Category: Psychiatry Source Type: research

Current evolutionary adaptiveness of anxiety: Extreme phenotypes of anxiety predict increased fertility across multiple generations
ConclusionThese findings suggest that extreme values from the mean anxiety are associated with increased evolutionary fitness within the modern environment. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 4, 2018 Category: Psychiatry Source Type: research

Altered spatial and temporal concordance among intrinsic brain activity measures in schizophrenia
Publication date: Available online 3 October 2018Source: Journal of Psychiatric ResearchAuthor(s): Jiajia Zhu, Dao-min Zhu, Yinfeng Qian, Xiaohu Li, Yongqiang YuAbstractVarious data-driven voxel-wise measures derived from resting-state functional magnetic resonance imaging (rs-fMRI) have been developed to characterize spontaneous brain activity. These measures have been widely applied to explore brain functional changes in schizophrenia and have enjoyed significant success in unraveling the neural mechanisms of this disorder. However, their spatial and temporal coupling alterations in schizophrenia remain largely unknown. ...
Source: Journal of Psychiatric Research - October 4, 2018 Category: Psychiatry Source Type: research

Voltage-gated calcium channel activity and complex related genes and schizophrenia: A systematic investigation based on Han Chinese population
Publication date: Available online 3 October 2018Source: Journal of Psychiatric ResearchAuthor(s): Tianxiao Zhang, Li Zhu, Tong Ni, Dan Liu, Gang Chen, Zhilan Yan, Huali Lin, Fanglin Guan, John P. RiceAbstractSchizophrenia (SCZ) is a devastating mental disorder affecting approximately 1% of the worldwide population. Early studies have indicated that genetics plays an important role in the onset and development of SCZ. Accumulating evidence supports that SCZ is linked to abnormalities of synapse transmission and synaptic plasticity. Voltage-gated calcium channel (VGCC) subunits are critical for mediating intracellular Ca2&t...
Source: Journal of Psychiatric Research - October 4, 2018 Category: Psychiatry Source Type: research

Rapid and longer-term antidepressant effects of repeated-dose intravenous ketamine for patients with unipolar and bipolar depression
ConclusionSix ketamine infusions were safe and effective in patients with unipolar and bipolar depression. The rapid and robust antidepressant and antisuicidal effects of ketamine infusion within four hours were sustained following the subsequent infusions. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - October 4, 2018 Category: Psychiatry Source Type: research

Editorial Board
Publication date: October 2018Source: Journal of Psychiatric Research, Volume 105Author(s): (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 22, 2018 Category: Psychiatry Source Type: research

Gender moderates the relationship between stressful life events and psychopathology: Findings from a national study
Publication date: Available online 20 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Jessica L. Armstrong, Silvia Ronzitti, Rani A. Hoff, Marc N. PotenzaAbstractBackgroundWhile data suggest a strong relationship between trauma exposure and psychopathology, less research has investigated relationships between psychopathology and stressful life events more broadly, and how these relationships may differ by gender.AimTo examine strengths of associations between stressful life events and psychiatric disorders (i.e., past-year Axis I and lifetime Axis II, per DSM-IV) and how they may differ by gender.MethodsDat...
Source: Journal of Psychiatric Research - September 21, 2018 Category: Psychiatry Source Type: research

The neurobiological hypothesis of neurotrophins in the pathophysiology of schizophrenia: A meta-analysis
DiscussionWe confirm that decreased peripheral neurotrophin levels are significantly associated with schizophrenia, thereby confirming the neurobiological hypothesis of neurotrophins in schizophrenia. Low levels of neurotrophins in peripheral blood of patients with schizophrenia may explain, in part, the pathophysiology of schizophrenia. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 20, 2018 Category: Psychiatry Source Type: research

Views of the Importance of Psychiatric Genetic Research by Potential Volunteers from Stakeholder Groups
Publication date: Available online 19 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Laura Weiss Roberts, Tenzin Tsungmey, Jane Paik Kim, Melinda HantkeAbstractFew studies have explored potential volunteers’ attitudes toward genetic research. To address this gap in the literature, we developed an empirical project to document views held by individuals who may wish to enroll in genetic studies involving mental disorders. People living with mental illness, family members of people with mental illness, and community comparison volunteers were queried regarding their views on the importance of genetic re...
Source: Journal of Psychiatric Research - September 20, 2018 Category: Psychiatry Source Type: research

Predictors of cognitive performance in bipolar disorder: The role of educational degree and inflammatory markers
ConclusionThe major determinants of poor cognitive performance in BD were education and IL6 plasma levels. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 18, 2018 Category: Psychiatry Source Type: research