Prospective testing of a neurophysiologic biomarker for treatment decisions in major depressive disorder: The PRISE-MD trial
Publication date: Available online 26 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Ian A. Cook, Aimee M. Hunter, Marissa M. Caudill, Michelle J. Abrams, Andrew F. Leuchter (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 27, 2020 Category: Psychiatry Source Type: research

Examining the cardiovascular response to fear extinction in a trauma-exposed sample
Publication date: Available online 26 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Antonia V. Seligowski, Julia B. Merker, Adam P. Swiercz, Jeanie Park, Paul J. Marvar, Kerry J. Ressler, Tanja Jovanovic (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 27, 2020 Category: Psychiatry Source Type: research

History of Childhood Abuse and Alcohol Use Disorder: Relationship with Intermittent Explosive Disorder and Intoxicated Aggression Frequency
Publication date: Available online 27 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Alexander A. Puhalla, Mitchell E. Berman, Emil F. Coccaro, Martha K. Fahlgren, Michael S. McCloskey (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 27, 2020 Category: Psychiatry Source Type: research

Clozapine in bipolar disorder: A systematic review and meta-analysis
Publication date: Available online 27 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Andre Delgado, Jorge Velosa, Junyu Zhang, Serdar Dursun, Flavio Kapczinski, Taiane de Azevedo Cardoso (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 27, 2020 Category: Psychiatry Source Type: research

Increased brain vitamin D receptor expression and decreased expression of cathelicidin antimicrobial peptide in individuals who died by suicide
Publication date: Available online 27 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Teodor T. Postolache, Faisal Akram, Ellen E. Lee, Christopher A. Lowry, John W. Stiller, Lisa A. Brenner, Elizabeth A. Streeten, Gustavo Turecki, Yogesh Dwivedi (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 27, 2020 Category: Psychiatry Source Type: research

Duloxetine and cardiovascular adverse events: A systematic review and meta-analysis
Publication date: Available online 27 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Kyounghoon Park, Seonji Kim, Young-Jin Ko, Byung-Joo Park (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 27, 2020 Category: Psychiatry Source Type: research

Self-injurious behavior and gambling-related attitudes, perceptions and behaviors in adolescents
Publication date: Available online 25 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Luis C. Farhat, Aaron J. Roberto, Jeremy Wampler, Marvin A. Steinberg, Suchitra Krishnan-Sarin, Rani A. Hoff, Marc N. Potenza (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 26, 2020 Category: Psychiatry Source Type: research

Use of antidepressants during pregnancy and neonatal outcomes: An umbrella review of meta-analyses of observational studies
Publication date: Available online 26 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Annalisa Biffi, Anna Cantarutti, Federico Rea, Anna Locatelli, Rinaldo Zanini, Giovanni Corrao (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 26, 2020 Category: Psychiatry Source Type: research

Psychiatric comorbidity in adolescent use and poly-use of combustible, vaporized, and edible cannabis products
Publication date: Available online 25 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Adam M. Leventhal, Dayoung Bae, Afton Kechter, Jessica Barrington Trimis (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 25, 2020 Category: Psychiatry Source Type: research

Functional near-infrared spectroscopy reveals decreased resting oxygenation levels and task-related oxygenation changes in mild cognitive impairment and dementia: A systematic review
This article reviews the application of an alternative method, functional near-infrared spectroscopy (fNIRS), to the study of cerebral oxygenation changes in MCI and dementia. We synthesized 36 fNIRS studies that examined hemodynamic changes during both the resting state and the execution of tasks of word retrieval, memory, motor control, and visuospatial perception in MCI and dementia. This qualitative review reveals that (amnestic) MCI and AD patients have disrupted frontal and long-range connectivity in the resting state compared to individuals with normal cognition (NC). These patients also exhibit reduced frontal oxyg...
Source: Journal of Psychiatric Research - February 23, 2020 Category: Psychiatry Source Type: research

Fearlessness about death does not differ by suicide attempt method
Publication date: Available online 22 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Brian W. Bauer, Anna R. Gai, Mary E. Duffy, Megan L. Rogers, Lauren R. Khazem, Rachel L. Martin, Thomas E. Joiner, Daniel W. CapronAbstractModern theories of suicide, such as the Interpersonal Theory of Suicide, have overcome past conceptual limitations within suicide research by examining factors that help differentiate suicide attempters from those who experience suicidal ideation, but never attempt suicide. One such factor that has been studied extensively is fearlessness about death. Given the varying levels of lethalit...
Source: Journal of Psychiatric Research - February 23, 2020 Category: Psychiatry Source Type: research

Editorial Board
Publication date: April 2020Source: Journal of Psychiatric Research, Volume 123Author(s): (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 23, 2020 Category: Psychiatry Source Type: research

Shorter and longer durations of sleep are associated with an increased twelve-month prevalence of psychiatric and substance use disorders: Findings from a nationally representative survey of US adults (NESARC-III)
This study examines the 12-month prevalence of mental disorders stratified by duration of sleep. Data were drawn from face-to-face interviews conducted in the National Epidemiologic Survey on Alcohol and Related Conditions III, a nationally representative survey of US adults (N = 36,309). There were 1893 (5.26%) participants who reported
Source: Journal of Psychiatric Research - February 22, 2020 Category: Psychiatry Source Type: research

Comparisons of different classification algorithms while using text mining to screen psychiatric inpatients with suicidal behaviors
ConclusionThis study confirmed the feasibility of filtering suicidal inpatients with small amounts of representative terms. SVM, Random Forest and AdaBoost weighted by TF have better performance in this task. Our findings provided a practical way to automatically classify patients with or without suicidal behaviors before admission to hospital, which potentially led to considerable savings in time and human resources for identification of high-risk patients and suicide prevention. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 22, 2020 Category: Psychiatry Source Type: research

Metabolic measures 12 months after a randomised controlled trial of treatment of clozapine associated obesity and diabetes with exenatide (CODEX)
We examined whether this effect was maintained at 12-months post-intervention. We followed up CODEX trial participants at 12-months post trial endpoint, collecting information on weight, BMI, waist circumference, blood pressure, fasting glucose, HbA1c, and use of metformin. The primary outcome of interest was change in weight from trial baseline to 12-months post endpoint and trial endpoint to 12-months post endpoint compared between former exenatide and usual care participants. Only HbA1c differed between baseline and 12-months post endpoint between the exenatide and control groups. From endpoint to 12-month follow up the...
Source: Journal of Psychiatric Research - February 19, 2020 Category: Psychiatry Source Type: research

Effect of body anthropometrics on brain structure of offspring of parents with bipolar disorder
ConclusionThese findings suggest that an interaction exists between BMI and CNS structure. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 18, 2020 Category: Psychiatry Source Type: research

Bidirectional longitudinal associations of omega-3 polyunsaturated fatty acid plasma levels with depressive disorders
Publication date: Available online 16 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Carisha S. Thesing, Mariska Bot, Yuri Milaneschi, Erik J. Giltay, Brenda W.J.H. PenninxAbstractBackgroundTemporality of the association of low omega-3 polyunsaturated fatty acid (n-3 PUFA) plasma levels with depression remains questionable. To determine the underlying nature of these associations, this study examined the bidirectional longitudinal associations of n-3 PUFA plasma levels with (presence, onset and course of) depressive disorders and symptoms.MethodsBaseline (n = 2912, 28.6% with current depressive disorder...
Source: Journal of Psychiatric Research - February 16, 2020 Category: Psychiatry Source Type: research

A genome-wide multiphenotypic association analysis identified common candidate genes for subjective well-being, depressive symptoms and neuroticism
Publication date: Available online 12 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Xiaomeng Chu, Li Liu, Yan Wen, Ping Li, Bolun Cheng, Shiqiang Cheng, Lu Zhang, Mei ma, Xin Qi, Chujun Liang, Jing Ye, Om Prakash Kafle, Cuiyan Wu, Sen Wang, Xi Wang, Yujie Ning, Feng ZhangAbstractSubjective well-being (SWB), depressive symptoms, and neuroticism are common and vital traits of mental disorders. Genetic mechanisms of SWB, depressive symptoms and neuroticism remain elusive now. The large-scale GWAS summary datasets of SWB (n = 229,883), depressive symptoms (n = 180,866), and neuroticism (n = 170,911...
Source: Journal of Psychiatric Research - February 13, 2020 Category: Psychiatry Source Type: research

Peripheral biomarkers of mitochondrial dysfunction in adolescents with bipolar disorder
ConclusionThese preliminary results indicate that elevated lactate is observed even among adolescents early in their course of BD, that the association between lactate and ccf-mtDNA appears to be specific to BD, and that ccf-mtDNA is associated with depression symptoms in adolescent BD. In addition, the effect of psychotropic medications used in the treatment of BD on peripheral lactate and ccf-mtDNA requires further investigation. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 12, 2020 Category: Psychiatry Source Type: research

Motivations for Suicide: Converging Evidence from Clinical and Community Samples
Publication date: Available online 10 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Alexis M. May, Mikayla C. Pachkowski, E. David KlonskyAbstractUnderstanding what motivates suicidal behavior is critical to effective prevention and clinical intervention. The Inventory of Motivations for Suicide Attempts (IMSA) is a self-report measure developed to assess a wide variety of potential motivations for suicide. The purpose of this study is to examine the measure’s psychometric and descriptive properties in two distinct populations: 1) adult psychiatric inpatients (n = 59) with recent suicide attempts (me...
Source: Journal of Psychiatric Research - February 10, 2020 Category: Psychiatry Source Type: research

Intraday weather conditions can influence self-report of depressive symptoms
This study aimed to decompose this association and explore age and gender differences in depressive symptoms’ report under different intraday weather conditions. We analyzed data with a total sample size of 20,987 individuals aged 15–96 years obtained via the China Labor-force Dynamic Survey (CLDS) project in 2016. The surveyors filled in the intraday weather conditions (i.e., sunny, cloudy, overcast, light rain, moderate rain, and heavy rain) in the questionnaire with depression being self-reported using the Center for Epidemiologic Studies Depression (CES-D) Scale. In the survey, 17.3% [95% confidence interva...
Source: Journal of Psychiatric Research - February 10, 2020 Category: Psychiatry Source Type: research

A novel method of evaluating semantic intrusion errors to distinguish between amyloid positive and negative groups on the Alzheimer's disease continuum
ConclusionsPIE, a novel and sensitive index of early memory dysfunction, demonstrated high levels of sensitivity and specificity in differentiating CN from amyloid positive persons with preclinical AD. Mean levels of PIE are higher for amyloid positive aMCI and dementia participants relative to their amyloid negative counterparts. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 10, 2020 Category: Psychiatry Source Type: research

Higher integration scores are associated with facial emotion perception differences in dissociative identity disorder
ConclusionsWhile acknowledging the limitations of a cross-sectional design, our results suggest that the process of integration is associated with fewer psychiatric symptoms, and more accurate facial emotion perception. This supports treatment guidelines regarding integration as a therapeutic goal for DID. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 9, 2020 Category: Psychiatry Source Type: research

Assessing BDNF as a mediator of the effects of exercise on depression
In this study, we examine whether increased exercise was associated with enhanced BDNF response in depressed patients, and whether this change mediated clinical benefits. A total of 29 depressed, sedentary participants were randomized to receive either behavioral activation (BA) plus an exercise or stretching prescription. Blood was collected prior to (resting BDNF levels) and following an exercise test (pre-to post-exercise BDNF change) at four points throughout the study. Participants also completed depression and exercise assessments. BDNF increased significantly across all assessment points (p 
Source: Journal of Psychiatric Research - February 9, 2020 Category: Psychiatry Source Type: research

Excitatory amino acid transporter (EAAT)1 and EAAT2 mRNA levels are altered in the prefrontal cortex of subjects with schizophrenia
Publication date: Available online 8 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Georgia M. Parkin, Andrew Gibbons, Madhara Udawela, Brian DeanAbstractExcitatory amino acid transporter (EAAT)1 and EAAT2 mediate glutamatergic neurotransmission and prevent excitotoxicity through binding and transportation of glutamate into glia. These EAATs may be regulated by metabotropic glutamate receptor 5 (mGluR5), which is also expressed by glia. Whilst we have data from an Affymetrix™ Human Exon 1.0 ST Array showing higher levels of EAAT1 mRNA (+36%) in Brodmann's are (BA)9 of subjects with schizophrenia, ther...
Source: Journal of Psychiatric Research - February 8, 2020 Category: Psychiatry Source Type: research

Alteration of the gut microbiome in first-episode drug-naïve and chronic medicated schizophrenia correlate with regional brain volumes
Publication date: Available online 8 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Xiaoqian Ma, Huma Asif, Lulin Dai, Ying He, Wenxiao Zheng, Dong Wang, Honghong Ren, Jinsong Tang, Chunwang Li, Ke Jin, Zongchang Li, Xiaogang ChenAbstractThe human gut microbiome plays an important role in the basic neurodevelopmental processes of the central nervous system and has been implicated in several neuropsychiatric disorders. However, the connection between the gut microbiome and the underlying pathogenesis of schizophrenia (SCZ) is poorly defined. Here we analyzed the faecal samples from 40 first-episode drug-na&i...
Source: Journal of Psychiatric Research - February 8, 2020 Category: Psychiatry Source Type: research

A comparison between self-report and interviewer-rated retrospective reports of childhood abuse among individuals with first-episode psychosis and population-based controls
Publication date: Available online 6 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Charlotte Gayer-Anderson, Ulrich Reininghaus, Isabell Paetzold, Kathryn Hubbard, Stephanie Beards, Valeria Mondelli, Marta Di Forti, Robin M. Murray, Carmine M. Pariante, Paola Dazzan, Thomas J. Craig, Helen L. Fisher, Craig MorganAbstractThe typical reliance on self-report questionnaires in retrospective case-control studies of childhood abuse and psychotic disorders has been criticised, due to the potential for recall bias associated with, amongst other factors, cognitive impairments and detachment from reality, among indi...
Source: Journal of Psychiatric Research - February 7, 2020 Category: Psychiatry Source Type: research

ALDH4A1 expression levels are elevated in postmortem brains of patients with schizophrenia and are associated with genetic variants in enzymes related to proline metabolism
ConclusionThese findings indicate that altered expression of ALDH4A1 may reflect the potential molecular mechanisms underlying the pathogenesis of schizophrenia and bipolar disorder, and may aid in the development of novel drug therapies. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 7, 2020 Category: Psychiatry Source Type: research

Editorial Board
Publication date: March 2020Source: Journal of Psychiatric Research, Volume 122Author(s): (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 6, 2020 Category: Psychiatry Source Type: research

Abnormal beta and gamma frequency neural oscillations mediate auditory sensory gating deficit in schizophrenia
ConclusionOur findings support a disruption in initial sensory registration in those with SZ, and do not support an active mechanism throughout the delay interval. The degree of response to S1 and early beta and gamma frequency oscillations in the delay interval provides information about the mechanisms supporting auditory sensory gating, and may provide a framework for studying the mechanisms that support sensory inhibition. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 1, 2020 Category: Psychiatry Source Type: research

Using filled prescription sequences to rank antidepressants according to their acceptability in the general population: The constances cohort
This study aimed to rank antidepressants according to the proportion of filled prescription sequences consistent with a continuation of the first treatment versus those consistent with a change. A first step was validating this measure as a proxy of acceptability by examining the association of these two kinds of sequences with levels of depressive symptoms. Among 64,467 individuals included in the French population-based Constances cohort, reimbursements of antidepressants from January 2009 to December 2015 were extracted from the French national health insurance system claims database. Depressive symptoms were measured a...
Source: Journal of Psychiatric Research - January 31, 2020 Category: Psychiatry Source Type: research

Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease
Publication date: Available online 30 January 2020Source: Journal of Psychiatric ResearchAuthor(s): Inés Del Cerro, Mirta F. Villarreal, Carolina Abulafia, Bárbara Duarte-Abritta, Stella M. Sánchez, Mariana N. Castro, Hernán Bocaccio, Isidre Ferrer, José Manuel Menchón, Gustavo Sevlever, Charles B. Nemeroff, Carles Soriano-Mas, Salvador M. GuinjoanAbstractPrevention and early treatment strategies for Alzheimer's disease (AD) are hampered by the lack of research biomarkers. Neuropathological changes in the Locus Coeruleus (LC) are detected early in AD, and noradrenaline plays a neur...
Source: Journal of Psychiatric Research - January 31, 2020 Category: Psychiatry Source Type: research

Effects of interventions to reduce adolescent depression in low- and middle-income countries: A systematic review and meta-analysis
ConclusionsAcross twenty-eight studies, the evidence showed that cognitive behavioral therapy that delivered by nurses, social workers and counselors at community-based settings were more effective treatments in decreasing adolescent depression in LMICs. Future studies should implement these universal treatment approaches to identify accessible, feasible, affordable and sustainable depression treatments in the countries with less available resources. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 31, 2020 Category: Psychiatry Source Type: research

The Overt Aggression Scale Modified (OAS-M) for clinical trials targeting impulsive aggression and intermittent explosive disorder: Validity, reliability, and correlates
Publication date: Available online 29 January 2020Source: Journal of Psychiatric ResearchAuthor(s): Emil F. CoccaroAbstractWhile aggressive behavior is common, and a disorder of impulsive aggression has been defined in the DSM-5 (Intermittent Explosive Disorder: IED), there are no currently FDA approved interventions to reduce these behaviors. One obstacle to the development of interventions to treat aggression is the paucity of psychometrically valid measures to assess aggressive behavior in the context of clinical trials, especially those in the outpatients setting. While there are many assessment of trait aggression, ve...
Source: Journal of Psychiatric Research - January 31, 2020 Category: Psychiatry Source Type: research

The Functional Connectivity Profile of Tics and Obsessive-Compulsive Symptoms in Tourette Syndrome
Publication date: Available online 30 January 2020Source: Journal of Psychiatric ResearchAuthor(s): Tracy Bhikram, Paul Arnold, Adrian Crawley, Elia Abi-Jaoude, Paul SandorAbstractTourette Syndrome (TS) is characterized by the presence of tics and sensory phenomena, such as premonitory urges, and is often accompanied by significant obsessive-compulsive symptoms (OCS). The goal of this exploratory study was to determine the association between functional connectivity and the different symptom domains of TS, as little is currently known about how they differ. Resting-state functional magnetic resonance imaging was performed ...
Source: Journal of Psychiatric Research - January 31, 2020 Category: Psychiatry Source Type: research

The effectiveness of eye movement desensitization and reprocessing toward anxiety disorder: A meta-analysis of randomized controlled trials
ConclusionsOur meta-analysis indicates that EMDR is efficacious for reducing symptoms of anxiety, panic, phobia, and behavioural/somatic symptoms. Further research is needed to explore EMDR's long term efficacy on anxiety disorders. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 29, 2020 Category: Psychiatry Source Type: research

Improve cognition of depressive patients through the regulation of basal ganglia connectivity: Combined medication using Shuganjieyu capsule
Publication date: Available online 28 January 2020Source: Journal of Psychiatric ResearchAuthor(s): Sha Liu, Wentao Zhao, Yaojun Li, Xinrong Li, Jing Li, Hongbao Cao, Zhi Yang, Yong XuAbstractShuganjieyu capsule (Shugan) is a combined extract of Hypericum perforatum (HP) and Eleutherococcus senticosus (ES). Both HP and ES have been proven effective in the treatment of depression and impaired cognition. However, for mild to moderate depression (MMD), the treatment effect and underlying mechanism by combining both HP and ES are largely unknown. Here, we aim to evaluate the therapeutic effects on impaired cognition using Shug...
Source: Journal of Psychiatric Research - January 29, 2020 Category: Psychiatry Source Type: research

Major depressive disorder and insomnia: Exploring a hypothesis of a common neurological basis using waking and sleep-derived heart rate variability
Publication date: Available online 28 January 2020Source: Journal of Psychiatric ResearchAuthor(s): David Eddie, Kate H. Bentley, Richard Bernard, Albert Yeung, Maren Nyer, Paola Pedrelli, David Mischoulon, John WinkelmanAbstractIt remains unclear whether neurobiological dysfunction observed in major depressive disorder (MDD) and insomnia is an expression of common or independent bases. The present investigation sought to explore differences in heart rate variability (HRV)—a widely utilized biomarker of neurobiological functioning—among individuals with MDD, insomnia, and healthy controls, while awake and durin...
Source: Journal of Psychiatric Research - January 29, 2020 Category: Psychiatry Source Type: research

The importance of physical and mental health in explaining health-related academic role impairment among college students
Publication date: Available online 29 January 2020Source: Journal of Psychiatric ResearchAuthor(s): Chelsey R. Wilks, Randy P. Auerbach, Jordi Alonso, Corina Benjet, Ronny Bruffaerts, Pim Cuijpers, David D. Ebert, Jennifer G. Green, Claude A. Mellins, Philippe Mortier, Ekaterina Sadikova, Nancy A. Sampson, Ronald C. KesslerAbstractResearch consistently documents high rates of mental health problems among college students and strong associations of these problems with academic role impairment. Less is known, though, about prevalence and effects of physical health problems in relation to mental health problems. The current r...
Source: Journal of Psychiatric Research - January 29, 2020 Category: Psychiatry Source Type: research

High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior
This study highlights the possible implication of polygenic burden in the alteration of epigenetic changes in suicidal behavior. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 29, 2020 Category: Psychiatry Source Type: research

Sluggish cognitive tempo and ADHD symptoms in relation to task-unrelated thought: Examining unique links with mind-wandering and rumination
Publication date: Available online 29 January 2020Source: Journal of Psychiatric ResearchAuthor(s): Joseph W. Fredrick, Michael J. Kofler, Matthew A. Jarrett, G. Leonard Burns, Aaron M. Luebbe, Annie A. Garner, Sherelle L. Harmon, Stephen P. BeckerAbstractRecent theoretical and empirical evidence highlights associations between attention-deficit/hyperactivity disorder (ADHD) symptoms and task-unrelated thought, including mind-wandering and rumination. However, it has been hypothesized that sluggish cognitive tempo (SCT), characterized by daydreaming and staring behaviors, may uniquely relate to task-unrelated thought. The ...
Source: Journal of Psychiatric Research - January 29, 2020 Category: Psychiatry Source Type: research

A literature review and meta-analysis on the effects of ADHD medications on functional outcomes
ConclusionsThese findings suggest that ADHD medication treatments are associated with decreases in the risks for a wide range of ADHD-associated functional outcomes supporting efforts aimed at early diagnosis and treatment of individuals with ADHD. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 28, 2020 Category: Psychiatry Source Type: research

Donepezil, a cholinesterase inhibitor used in Alzheimer's disease therapy, is actively exported out of the brain by abcb1ab p-glycoproteins in mice
In conclusion, in mice donepezil's brain bioavailability depends on P-gp.Graphical abstract (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 28, 2020 Category: Psychiatry Source Type: research

Validity of the Mood Disorder Questionnaire (MDQ) as a Screening Tool for Bipolar Spectrum Disorders in Anabaptist Populations
This study assessed diagnostic validity of the MDQ among Anabaptists, an underserved population frequently involved in genetic research. 161 participants completed the MDQ and were diagnosed by a best-estimate final diagnosis (BEFD). Diagnostic agreements between alternate MDQ scoring methods and the BEFD were quantified using Cohen’s Kappa (κ), sensitivity (α), and specificity (β). Scoring criteria evaluated included>7 simultaneous symptoms and at least moderate impairment,>7 simultaneous symptoms, with at least mild impairment,>7 symptoms only, with no further requirement, and three novel ...
Source: Journal of Psychiatric Research - January 26, 2020 Category: Psychiatry Source Type: research

Characteristics of youth at high risk for bipolar disorder compared to youth with bipolar I or II disorder
In this study, we examined the clinical and psychosocial characteristics of youth at familial and clinical high risk (HR) for BD, and compared these characteristics to those of youth with BD I and II. Both groups were recruited based on current, active mood symptoms from separate randomized trials of family therapy. A total of 127 HR youth were evaluated: 52 (40.9%) were diagnosed with BD-NOS and 75 (59.1%) were diagnosed with MDD. Compared to adolescents with BD I and II (n=145), HR youth had higher rates of anxiety disorders, and comparable rates of attention-deficit/hyperactivity disorder and oppositional defiant disord...
Source: Journal of Psychiatric Research - January 26, 2020 Category: Psychiatry Source Type: research

Global prevalence of burnout symptoms among nurses: A systematic review and meta-analysis
This study is the first study to synthesize published studies and to estimate pooled-prevalence of burnout symptoms among nurses globally. The findings suggest that nurses have high burnout symptoms prevalence warranting attention and implementation. This study serves as an impetus for intervention studies and policy change to improve nurses’ work conditions and overall healthcare quality.Graphical abstract (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 23, 2020 Category: Psychiatry Source Type: research

Comparison of serum microbiome composition in bipolar and major depressive disorders
In conclusion, the Prevotella 2 and Ruminococcaceae UCG-002 genera were identified as potential candidates for distinguishing bipolar disorder and major depressive disorder. Further studies with larger sample sizes, longitudinal designs, and control for other various confounders are warranted. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 23, 2020 Category: Psychiatry Source Type: research

Working conditions and depression in the French national working population: Results from the SUMER study
ConclusionsSignificant associations were found between psychosocial work exposures and depression, and there were some differences in these associations between genders. This study is one of the first to provide a comprehensive overview of occupational exposures in association with depression. More prevention towards the psychosocial work environment is needed to improve mental health of working populations. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 23, 2020 Category: Psychiatry Source Type: research

Antidepressant and neurocognitive effects of serial ketamine administration versus ECT in depressed patients
ConclusionsDue to its pro-cognitive effects and faster antidepressant effect, serial ketamine administration might be a more favorable short-term treatment option than ECT.LimitationsAs this research employed a naturalistic study design, patients were not systematically randomized, there was no control group and patients received concurrent and partially changing medications during treatment.Clinical trials registrationFunctional and Metabolic Changes in the Course of Antidepressive Treatment, https://clinicaltrials.gov/ct2/show/NCT02099630, NCT02099630. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 17, 2020 Category: Psychiatry Source Type: research

Association between anemia and maternal depression: A systematic review and meta-analysis
Publication date: Available online 8 January 2020Source: Journal of Psychiatric ResearchAuthor(s): Seo Young Kang, Hong-Bae Kim, Sung SunwooAbstractPrevious observational epidemiological studies have reported inconsistent findings regarding the association between anemia and the risk of maternal depression. In the present study, we investigated the relationship between anemia and the risk of maternal depression using a meta-analysis. We searched PubMed, EMBASE, and the bibliographies of relevant articles in May 2019. Three evaluators independently reviewed and selected the eligible studies based on the predetermined select...
Source: Journal of Psychiatric Research - January 8, 2020 Category: Psychiatry Source Type: research