Letter to the Editor: Methodological Comments to “Electroacupuncture for tapering off long-term benzodiazepine use: A randomized controlled trial”
Publication date: Available online 21 February 2019Source: Journal of Psychiatric ResearchAuthor(s): Cong Wang, Yun-fei Chen (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 22, 2019 Category: Psychiatry Source Type: research

Response to letter to the editor: When does selection generate bias in clinical samples?
Publication date: Available online 22 February 2019Source: Journal of Psychiatric ResearchAuthor(s): Nargess Saiepour, Jackob M. Najman, Robert Ware, Peter Baker, Alexandra Clavarino, Gail Williams (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 22, 2019 Category: Psychiatry Source Type: research

Reply to Wang and Chen
Publication date: Available online 22 February 2019Source: Journal of Psychiatric ResearchAuthor(s): Wing-Fai Yeung, Branda Yee-Man Yu (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 22, 2019 Category: Psychiatry Source Type: research

Executive Functioning in Cognitively Normal Middle-Aged Offspring of Late-Onset Alzheimer’s Disease Patients
In conclusion, O-LOAD participants exhibited early subtle cognitive changes in executive processing. Observed memory difficulties may be associated in part to executive deficits suggesting an interplay between memory and executive functions. Process score impairments were observed earlier than clinical decline on neuropsychological scores in this at-risk cohort and might be useful cognitive markers of preclinical LOAD. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 22, 2019 Category: Psychiatry Source Type: research

Brain penetration of ketamine: Intranasal delivery VS parentetal routes of administraion
Publication date: Available online 20 February 2019Source: Journal of Psychiatric ResearchAuthor(s): Vivian Naidoo, Sipho Mdanda, Sphamandla Ntshangase, Tricia Naicker, Hendrik G. Kruger, Thavendran Govender, Panjasaram Naidoo, Sooraj BaijnathAbstractKetamine is approved by the FDA to be used as an anesthetic however, recent reports have exhibited its success in the treatment of major depressive disorder (MDD). Studies have suggested that a sub-anesthetic dose produces rapid antidepressant activity providing significant symptomatic relief particularly in patients with a history of treatment resistant depression (TRD). Many...
Source: Journal of Psychiatric Research - February 21, 2019 Category: Psychiatry Source Type: research

Letter to the editor: When does selection generate bias in clinical samples?
Publication date: Available online 21 February 2019Source: Journal of Psychiatric ResearchAuthor(s): Michael Höfler, Sebastian Trautmann (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 21, 2019 Category: Psychiatry Source Type: research

Differences In Multihormonal Responses To The Dopamine Agonist Apomorphine Between Unipolar And Bipolar Depressed Patients
Publication date: Available online 19 February 2019Source: Journal of Psychiatric ResearchAuthor(s): José Antonio Monreal, Fabrice Duval, Marie-Claude Mokrani, Said Fattah, Diego PalaoSummaryBackgroundA large number of studies suggest that dopaminergic function may be impaired in depressed patients, particularly in bipolar patients. The dopamine D2/D1 agonist apomorphine (APO) can be useful in the evaluation of dopaminergic function. However, most studies show conflicting results in APO test responses when evaluating unipolar and bipolar depressed patients. Thus, the objective of this study was to apply the APO test...
Source: Journal of Psychiatric Research - February 20, 2019 Category: Psychiatry Source Type: research

Hippocampal subfield-specific connectivity findings in major depressive disorder: A 7 Tesla diffusion MRI study
Publication date: Available online 18 February 2019Source: Journal of Psychiatric ResearchAuthor(s): John W. Rutland, Stephanie Brown, Gaurav Verma, Rebecca E. Feldman, Himanshu Sharma, Matthew Markowitz, Molly Schneider, Bradley N. Delman, James Murrough, Priti BalchandaniAbstractObjectiveDiffusion magnetic resonance imaging (dMRI) enables non-invasive characterization of white matter (WM) structures in vivo. Prior studies suggest that certain WM tracts may be affected in major depressive disorder (MDD), however, hippocampal subfield-specific dMRI measures have not yet been explored in MDD. We use 7 Tesla dMRI to investig...
Source: Journal of Psychiatric Research - February 18, 2019 Category: Psychiatry Source Type: research

Effect of lurasidone vs olanzapine on neurotrophic biomarkers in unmedicated schizophrenia: A randomized controlled trial
The objective of the present study was to investigate and compare the effect of olanzapine and lurasidone on the change in serum neurotrophins in patients with schizophrenia. The present study was a randomized, open-label, active-controlled, parallel design clinical trial. After randomization baseline evaluations of serum BDNF, NGF, NT3, Positive and Negative Syndrome Scale (PANSS) scoring, Social and Occupational Functioning Assessment Scale (SOFAS) scoring of 101 unmedicated schizophrenia patients were done. Patients were reassessed after 6 weeks of monotherapy with olanzapine or lurasidone. Serum BDNF increased after tr...
Source: Journal of Psychiatric Research - February 12, 2019 Category: Psychiatry Source Type: research

A Clinical Model for Identifying an Inflammatory Phenotype in Mood Disorders
Publication date: Available online 10 February 2019Source: Journal of Psychiatric ResearchAuthor(s): Nicole Kramer-Lange, Victoria Cosgrove, Kiley Dunlop, Mehala Subramaniapillai, Roger S. McIntyre, Trisha SuppesAbstractIncreasingly, clinical research has found inflammatory correlates of psychiatric disorders, particularly mood symptomatology. Biological measures may provide greater precision in many cases and may capture clinically-relevant inflammatory signposts, such as central obesity risk, inflammation-associated co-morbid medical conditions, or proinflammatory lifestyle choices. In order to expand understanding of th...
Source: Journal of Psychiatric Research - February 10, 2019 Category: Psychiatry Source Type: research

Exploring anxiety sensitivity in the relationship between pain intensity and opioid misuse among opioid-using adults with chronic pain
Publication date: Available online 8 February 2019Source: Journal of Psychiatric ResearchAuthor(s): Andrew H. Rogers, Justin M. Shepherd, Michael F. Orr, Jafar Bakhshaie, R. Kathryn McHugh, Michael J. ZvolenskyAbstractOpioid misuse is a significant public health problem. Chronic pain is one highly prevalent factor that is strongly associated with increased risk for opioid misuse. Anxiety sensitivity (fear of anxiety related physical sensations) is an individual difference factor consistently linked to pain experience, and separately, heroin use. The present study examined if anxiety sensitivity may be one factor related to...
Source: Journal of Psychiatric Research - February 9, 2019 Category: Psychiatry Source Type: research

Sleep complaints and cerebral white matter: A prospective bidirectional study
This study provides evidence against the hypothesis that sleep complaints lead to white matter changes in the aging brain, and shows that white matter properties do not underlie sleep complaints in older persons. As subjective sleep complaints increase in later life, it is important to demonstrate that these are not etiologically related to cerebral white matter pathology. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 9, 2019 Category: Psychiatry Source Type: research

Clinical and genetic analysis of children with a dual diagnosis of Tourette syndrome and autism spectrum disorder
Publication date: Available online 7 February 2019Source: Journal of Psychiatric ResearchAuthor(s): Karin Vanessa Carias, Rachel WevrickAbstractGilles de la Tourette Syndrome (TS) is a neurodevelopmental disorder that causes children to make repeated, brief involuntary movements or sounds. TS can be co-morbid with other neurodevelopmental disorders, including autism spectrum disorder (ASD). Clusters of biologically related genes have been associated with neurodevelopmental disorders, suggesting shared pathologies. However, the genetic contribution to TS remains poorly defined. We asked whether children with both TS and ASD...
Source: Journal of Psychiatric Research - February 8, 2019 Category: Psychiatry Source Type: research

Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls
Publication date: Available online 8 February 2019Source: Journal of Psychiatric ResearchAuthor(s): Burcu Çevik, Öykü Mançe-Çalışır, Eşref Cem Atbaşoğlu, Meram Can Saka, Köksal Alptekin, Alp Üçok, Burcu Sırmatel, Sinan Gülöksüz, Ajlan Tükün, Jim van Os, Güvem Gümüş-AkayAbstractCompared to the general population, individuals diagnosed with Schizophrenia (SCZ) experience a higher frequency and an earlier onset of chronic medical disorders, resulting in a reduction in life expectancy by an average of 15–25 years. Recently, it...
Source: Journal of Psychiatric Research - February 8, 2019 Category: Psychiatry Source Type: research

A pilot investigation of neuroimaging predictors for the benefits from pivotal response treatment for children with Autism
Publication date: Available online 5 February 2019Source: Journal of Psychiatric ResearchAuthor(s): John P. Hegarty, Grace W. Gengoux, Kari L. Berquist, M. Estefanía Millán, Serena M. Tamura, Shweta Karve, Margaret D. Rosenthal, Jennifer M. Phillips, Antonio Y. HardanAbstractChildren with autism spectrum disorder (ASD) frequently exhibit language delays and functional communication deficits. Pivotal response treatment (PRT) is an effective intervention for targeting these skills; however, similar to other behavioral interventions, response to PRT is variable across individuals. Thus, objective markers capable...
Source: Journal of Psychiatric Research - February 6, 2019 Category: Psychiatry Source Type: research

The subjective-objective deficit paradox in schizotypy extends to emotion regulation and awareness
We examined whether this subjective-objective deficit paradox extends to two closely linked affective processes: emotion regulation and awareness. Individuals with elevated social anhedonia (SocAnh; n = 61) and elevated perceptual aberration/magical ideation (PerMag; n = 73) were compared to control participants (n = 81) on subjective and objective measures of emotion regulation and awareness. Subjective measures included self-report questionnaires assessing regulatory ability, attention to emotion, and emotional clarity. Implicit emotion regulation was assessed by the Emotion Regulation-Implicit Association Te...
Source: Journal of Psychiatric Research - February 1, 2019 Category: Psychiatry Source Type: research

Cannabis use behaviors and prevalence of anxiety and depressive symptoms in a cohort of Canadian medicinal cannabis users
Publication date: Available online 31 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Jasmine Turna, William Simpson, Beth Patterson, Philippe Lucas, Michael Van AmeringenAbstractCannabis is commonly used recreationally for its euphoric and relaxing effects, while its medical use is permitted in several jurisdictions. With only low-quality evidence suggesting anxiolytic effects of cannabis and strong public sentiment surrounding such purported effects, the purpose of this study was to examine the prevalence of cannabis for medicinal purposes (CMP) use for anxiety symptoms. An online survey was disseminated to...
Source: Journal of Psychiatric Research - February 1, 2019 Category: Psychiatry Source Type: research

An examination of the relationship between hoarding symptoms and hostility
Publication date: Available online 31 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Brittany M. Mathes, Grace A. Kennedy, Jesse R. Cougle, Norman B. SchmidtAbstractHoarding disorder (HD) is a persistent and severe psychiatric condition in which individuals are unable to discard possessions, which results in considerable clutter. Individuals who hoard often endorse interpersonal difficulties and social isolation. However, little research has examined mechanisms that may help to explain this relationship. One possible mechanism is hostility, which is characterized by increased sensitivity to real or perceived...
Source: Journal of Psychiatric Research - January 31, 2019 Category: Psychiatry Source Type: research

Editorial Board
Publication date: March 2019Source: Journal of Psychiatric Research, Volume 110Author(s): (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 31, 2019 Category: Psychiatry Source Type: research

Microduplications at the 15q11.2 BP1–BP2 locus are enriched in patients with anorexia nervosa
Publication date: Available online 29 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Xiao Chang, Huiqi qu, Yichuan Liu, Joseph Glessner, Cuiping Hou, Fengxiang Wang, Jin Li, Patrick Sleiman, Hakon HakonarsonAbstractMicroduplication at 15q11.2 have been reported in genetic association studies of schizophrenia and autism. Given the potential overlap in psychiatric symptoms of schizophrenia and autism with anorexia nervosa (AN), we were inspired to test the association of this CNV locus with the genetic susceptibility of AN using ParseCNV, a highly quality controlled CNV pipeline developed by our group. The CNV...
Source: Journal of Psychiatric Research - January 30, 2019 Category: Psychiatry Source Type: research

Seasonality of antidepressant prescriptions and sick leaves
Publication date: Available online 26 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Dietmar Winkler, Berthold Reichardt, Georg S. Kranz, Lucie Bartova, Siegfried Kasper, Edda PjrekAbstractThe aim of the present study was to estimate the number of patients with a seasonal prescription pattern of antidepressants, which might be taken as a surrogate marker for medicated patients with seasonal affective disorder (SAD). Furthermore, we examined the time course of sick leaves for patients with seasonal and non-seasonal prescriptions of antidepressants. A retrospective analysis of prescription data of all patients...
Source: Journal of Psychiatric Research - January 26, 2019 Category: Psychiatry Source Type: research

Comparability of blinded remote and site-based assessments of response to adjunctive esketamine or placebo nasal spray in patients with treatment resistant depression
Publication date: April 2019Source: Journal of Psychiatric Research, Volume 111Author(s): S.D. Targum, E. Daly, M. Fedgchin, K. Cooper, J.B. SinghAbstractFunctional unblinding due to treatment emergent adverse events (TEAEs) may occur with any investigational drug and poses a challenge for double-blind, placebo-controlled studies. This pilot study compared site-based Montgomery-Asberg Depression Rating Scale (MADRS) scores to remote, site-independent scores by blinded raters.Audio-digital recordings of site-based MADRS interviews were obtained from a subset of patients during a double-blind, placebo-controlled study of esk...
Source: Journal of Psychiatric Research - January 25, 2019 Category: Psychiatry Source Type: research

Brain-enriched MicroRNA-184 is downregulated in older adults with major depressive disorder: A translational study
Publication date: Available online 23 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Ana Paula Mendes-Silva, Patricia Tiemi Fujimura, Jéssica Regina da Costa Silva, Antonio Lucio Teixeira, Erica Marciano Vieira, Pedro Henrique Gonçalves Guedes, Lucélia Scarabeli Silva Barroso, Mariana de Souza Nicolau, Jéssica Diniz Rodrigues Ferreira, Laiss Bertola, Eduardo de Souza Nicolau, Gesiane Thamire Tolentino-Araújo, Camila Moreira Silva Ferreira Berlezzi, Tamiris Sabrina Rodrigues, Luiza Diniz Ferreira Borges, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Ana Maria Bonetti...
Source: Journal of Psychiatric Research - January 24, 2019 Category: Psychiatry Source Type: research

Telomere shortening in blood leukocytes of patients with Posttraumatic stress disorder
Publication date: Available online 21 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Diana Avetyan, Roksana Zakharyan, Martin Petrek, Arsen ArakelyanAbstractTelomeres are protective fragments on chromosome ends involved in maintaining genome stability, preventing chromosomal fusions, regulation of cell division. It was shown that telomere attrition rate is accelerated in age-related diseases, as well as in response to physiological and psychosocial stress. The aim of this study was to evaluate relative leukocyte telomere length (LTL) in patients with post traumatic stress disorder (PTSD), as well as to inves...
Source: Journal of Psychiatric Research - January 22, 2019 Category: Psychiatry Source Type: research

Mortality in hospital patients with and without mental disorders: A data-linkage cohort study
Publication date: Available online 21 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Rafid S. Karim, Marcella MS. Kwan, Angus JF. Finlay, Srinivas Kondalsamy-Chennakesavan, Maree R. Toombs, Geoffrey C. Nicholson, Matthew McGrail, Neeraj S. GillAbstractObjectiveIn the general population, people with mental disorders have increased mortality. This association, however, has not been explored in a population who at some time were inpatients of a public hospital.MethodsThe sampling frame was patients admitted to an Australian regional public hospital 1996–2010. Those with known mental disorder were compared...
Source: Journal of Psychiatric Research - January 22, 2019 Category: Psychiatry Source Type: research

Exploration of microbiota targets for major depressive disorder and mood related traits
In conclusion, our results revealed microbiota targets for depression that are independent of fat intake. It is worthwhile to conduct further studies to replicate the current findings and to integrate with biochemistry and metabolomics data to better understand the functions of identified targets. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 20, 2019 Category: Psychiatry Source Type: research

Comparability of blinded remote and site-based assessments of response to esketamine or placebo nasal spray in patients with treatment resistant depression
Publication date: Available online 19 January 2019Source: Journal of Psychiatric ResearchAuthor(s): S.D. Targum, E. Daly, M. Fedgchin, K. Cooper, J.B. SinghAbstractFunctional unblinding due to treatment emergent adverse events (TEAEs) may occur with any investigational drug and poses a challenge for double-blind, placebo-controlled studies. This pilot study compared site-based Montgomery-Asberg Depression Rating Scale (MADRS) scores to remote, site-independent scores by blinded raters.Audio-digital recordings of site-based MADRS interviews were obtained from a subset of patients during a double-blind, placebo-controlled st...
Source: Journal of Psychiatric Research - January 20, 2019 Category: Psychiatry Source Type: research

Comparative efficacy and tolerability of antipsychotics as augmentations in adults with treatment-resistant obsessive-compulsive disorder: A network meta-analysis
Publication date: Available online 14 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Dong-Dong Zhou, Xiao-Xin Zhou, Zhen Lv, Xiao-Rong Chen, Wo Wang, Gao-Mao Wang, Chuan Liu, Da-Qi Li, Li KuangAbstractWe performed a network meta-analysis to build clear hierarchies of efficacy and tolerability of antipsychotics to augment serotonin reuptake inhibitors (SRIs) for treatment-resistant obsessive-compulsive disorder (OCD) in adults. PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched on September 8, 2018. Randomized controlled trials investigating antipsychotics as augmentati...
Source: Journal of Psychiatric Research - January 16, 2019 Category: Psychiatry Source Type: research

The role of illness engulfment in the association between insight and depressive symptomatology in schizophrenia
Publication date: Available online 11 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Susanna Konsztowicz, Martin LepageAbstractGood clinical insight in schizophrenia tends to be associated with better outcomes, but also with increased depression. We hypothesized that illness engulfment, a process whereby an individual’s self-concept becomes defined solely by illness and the ‘patient identity’ becomes primary, is a mediating and/or moderating factor in the association between insight and depressive symptomatology in schizophrenia. Mediation and moderation analyses were conducted using the PR...
Source: Journal of Psychiatric Research - January 12, 2019 Category: Psychiatry Source Type: research

Gender inequality and depression among medical students: A global meta-regression analysis
Publication date: Available online 11 January 2019Source: Journal of Psychiatric ResearchAuthor(s): João Pedro Gonçalves Pacheco, Júlia Belizário Silveira, Raphael Paiva Cock Ferreira, Kenneth Lo, Jenyfer Regonini Schineider, Henrique Ton Azevedo Giacomin, Wilson Wai San TamAbstractDepression is a serious mental health problem with a high prevalence among medical students. It is unclear whether a gender disparity of depression exists in this population, and whether gender inequality influences depression estimates by gender. We conducted a systematic search for published systematic reviews or me...
Source: Journal of Psychiatric Research - January 12, 2019 Category: Psychiatry Source Type: research

Late-life Depression and Cognitive Function among Older Adults in the U.S.: The National Health and Nutrition Examination Survey, 2011-2014
Publication date: Available online 11 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Jingkai Wei, Meiling Ying, Liyang Xie, Eeshwar K. Chandrasekar, Haidong Lu, Tiansheng Wang, Changwei LiAbstractDiscrepancies exist on the associations of late-life depression with cognition, and synergistic effect of depression and diabetes on cognition among older adults was suggested in literature. We aimed to examine the associations of late-life depression with cognitive function in a representative sample of older adults in the U.S., and to examine the associations among individuals with diabetes. A total of 3,101 adult...
Source: Journal of Psychiatric Research - January 12, 2019 Category: Psychiatry Source Type: research

Child abuse interacts with hippocampal and corpus callosum volume on psychophysiological response to startling auditory stimuli in a sample of veterans
Publication date: Available online 11 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Dmitri A. Young, Thomas C. Neylan, Linda L. Chao, Aoife O'Donovan, Thomas J. Metzler, Sabra S. InslichtAbstractChild abuse (CA), which is linked to posttraumatic stress disorder (PTSD), has been associated with a reduction in both hippocampal and corpus callosum (CC) volume. However, few studies have explored these relationships on psychophysiological variables related to trauma exposure. Therefore, we assessed whether the interaction between CA and hippocampal and CC volume were associated with enhanced fear potentiated psy...
Source: Journal of Psychiatric Research - January 12, 2019 Category: Psychiatry Source Type: research

A schizophrenia associated CMYA5 allele displays differential binding with desmin
Publication date: Available online 10 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Anting Hsiung, Francisco J. Naya, Xiangning Chen, Rita ShiangAbstractCMYA5 is a candidate gene for schizophrenia because of the genetic association of variant rs10043986 (C > T) to this severe mental disorder. Studies of CMYA5 and its gene product, myospryn, in the brain and neuronal cells have not been previously reported. The SNP rs10043986 changes the 4,063rd amino acid from Pro to Leu, which is likely to alter protein function. To understand its potential role in the brain, we examined the neuronal expression of m...
Source: Journal of Psychiatric Research - January 11, 2019 Category: Psychiatry Source Type: research

Maternal inflammation during pregnancy and offspring psychiatric symptoms in childhood: Timing and sex matter
ConclusionThese findings demonstrate that elevated maternal inflammation during pregnancy is associated with the emergence of separate psychological phenotypes and that timing of exposure and fetal sex matter for offspring outcomes. Given that internalizing and externalizing symptoms in childhood increase risk for a variety of mental disorders later in development, these findings potentially have major implications for early intervention and prevention work. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 11, 2019 Category: Psychiatry Source Type: research

Increased levels of serum leptin in the early stages of psychosis
Publication date: Available online 11 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Lourdes Martorell, Gerard Muntané, Sara Porta-López, Irene Moreno, Laura Ortega, Itziar Montalvo, Vanessa Sanchez-Gistau, Rosa Monseny, Javier Labad, Elisabet VilellaAbstractBackgroundStudies evaluating leptin levels in patients with first-episode psychoses (FEP) have been inconclusive, and apparently, the high levels of leptin reported in patients with schizophrenia may be associated with weight gain. The aim of this study was to evaluate leptin levels at the early stages of the disease and the relationship be...
Source: Journal of Psychiatric Research - January 11, 2019 Category: Psychiatry Source Type: research

More optimal but less regulated dorsal and ventral visual networks in patients with major depressive disorder
In this study, resting-state functional magnetic resonance imaging data were collected from 159 participants, including 86 medication-free MDD patients and 73 matched healthy controls. The dorsal/ventral visual networks were defined based on our previously published brain coordinates from activation likelihood estimation analyses. The static and dynamic network properties were respectively calculated and compared between MDD and control groups. Moreover, the inter-network connectivities quantified using the multivariate distance correlation between the dorsal attention network (DAN) and the two visual networks were also an...
Source: Journal of Psychiatric Research - January 10, 2019 Category: Psychiatry Source Type: research

Debt stress, psychological distress and overall health among adults in Ontario
The objective of this study was to examine debt stress and its association with psychological distress and overall health. Data were derived from the 2014–2016 annual cycles of a cross-sectional telephone survey of the general population of adults 18 years of age and older within the province of Ontario, Canada. The present analyses focused on a pooled sample of 8045 adults. Results indicated that a large proportion of the sample reported experiencing debt-related stress. Those who were female, separated or divorced, and from lower income households were at higher odds of greater debt stress relative to no debt stres...
Source: Journal of Psychiatric Research - January 10, 2019 Category: Psychiatry Source Type: research

Sex Differences in Response to Ketamine as A Rapidly Acting Intervention for Treatment Resistant Depression
ConclusionsResults do not support differential efficacy or tolerability of ketamine for the treatment of TRD between women and men, nor based on menopause status among women. However, larger trials with these a priori aims are needed to confirm these results. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 8, 2019 Category: Psychiatry Source Type: research

The cortisol awakening response at admission to hospital predicts depression severity after discharge in MDD patients
Publication date: Available online 7 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Fillip F. Eikeseth, Sabrina Denninghaus, Mark Cropley, Michael Witthöft, Markus Pawelzik, Stefan SütterlinAbstractMajor Depressive Disorder (MDD) is associated with hypothalamic-pituitary-adrenal axis (HPA) dysregulation and altered cortisol awakening response (CAR), a non-invasive biomarker for HPA axis reactivity. We theorized that the CAR resembles the accumulated effects of depression over time, and may therefore predict depressive symptom severity once patients return home following inpatient treatment. Two stu...
Source: Journal of Psychiatric Research - January 7, 2019 Category: Psychiatry Source Type: research

Brain-derived neurotrophic factor is a biomarker for subjective insomnia but not objectively assessable poor sleep continuity
ConclusionsIndependently of symptoms of depression or anxiety, sBDNF appears to be a biomarker for the clinical diagnosis of insomnia, but not for objectively assessed poor sleep continuity. A possible link between sBDNF and insomnia seems to be via regulation of REM-sleep, but not salivary morning cortisol. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 5, 2019 Category: Psychiatry Source Type: research

Hypertensive disorders of pregnancy and the risk of anxiety disorders in adolescence: Findings from the ALSPAC study
ConclusionsOur study showed that adolescents exposed to HDP had higher risk of anxiety disorders compared with unexposed adolescents and suggests that prevention and treatment of maternal HDP could possibly prevent offspring anxiety in adolescence. Early screening for anxiety disorders in offspring of women with HDP may also be warranted. Further research is needed to explain the pathways by which HDP may increase the risk of offspring psychopathology. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 4, 2019 Category: Psychiatry Source Type: research

Impact of pharmacogenomics on clinical outcomes in major depressive disorder in the GUIDED trial: A large, patient- and rater-blinded, randomized, controlled study
Publication date: Available online 4 January 2019Source: Journal of Psychiatric ResearchAuthor(s): John F. Greden, Sagar V. Parikh, Anthony J. Rothschild, Michael E. Thase, Boadie W. Dunlop, Charles DeBattista, Charles R. Conway, Brent P. Forester, Francis M. Mondimore, Richard C. Shelton, Matthew Macaluso, James Li, Krystal Brown, Alexa Gilbert, Lindsey Burns, Michael R. Jablonski, Bryan DechairoAbstractCurrent prescribing practices for major depressive disorder (MDD) produces limited treatment success. Although pharmacogenomics may improve outcomes by identifying genetically inappropriate medications, studies to date wer...
Source: Journal of Psychiatric Research - January 4, 2019 Category: Psychiatry Source Type: research

Childhood adversities, negative life events and outcomes of non-pharmacological treatments for depression in primary care: A secondary analysis of a randomized controlled trial
Publication date: Available online 4 January 2019Source: Journal of Psychiatric ResearchAuthor(s): Diego Yacaman-Mendez, Mats Hallgren, Yvonne ForsellAbstractNon-pharmacological treatments for depression are effective and available in primary care, but useful prognostic factors are lacking. Childhood adversities (CA) and negative recent life events (RLE) increase the risk and severity of depression, though their effect on treatment outcomes remains understudied. Using a sample of 737 adult participants of a multicenter randomized controlled trial receiving physical exercise, internet based cognitive-behavioral therapy or t...
Source: Journal of Psychiatric Research - January 4, 2019 Category: Psychiatry Source Type: research

Editorial Board
Publication date: February 2019Source: Journal of Psychiatric Research, Volume 109Author(s): (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - December 28, 2018 Category: Psychiatry Source Type: research

Discoidin domain receptor 1 gene variants are associated with decreased white matter fractional anisotropy and decreased processing speed in schizophrenia
Publication date: Available online 24 December 2018Source: Journal of Psychiatric ResearchAuthor(s): Cinta Gas, Erick Jorge Canales-Rodríguez, Joaquim Radua, Nerea Abasolo, Maria José Cortés, Ester Salvadó, Gerard Muntané, Yasser Alemán-Gómez, Toni Julià, Sara Marsal, Julio Sanjuan, Miriam Guitart, Javier Costas, Lourdes Martorell, Edith Pomarol-Clotet, Elisabet VilellaAbstractDDR1 has been linked to schizophrenia (SZ) and myelination. Here, we tested whether DDR1 variants in people at risk for SZ influence white matter (WM) structural variations and cognitive process...
Source: Journal of Psychiatric Research - December 24, 2018 Category: Psychiatry Source Type: research

Does attrition affect estimates of association: A longitudinal study
This study provides a test of the extent to which selective loss to follow-up in a longitudinal study may lead to biased findings.The Mater-University Study of Pregnancy collected baseline information for 7718 pregnant women. Follow-ups occurred five years, 14 years, 21 years and 27 years after the birth, for 6753 eligible women. Participants at baseline were partitioned according to follow-up status for each follow-up. We compare baseline (at recruitment) measures of association, with these same measures of association for those retained in the study (Group A) and those lost to follow-up (Group B) at each phase of data. U...
Source: Journal of Psychiatric Research - December 24, 2018 Category: Psychiatry Source Type: research

L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial
Publication date: March 2019Source: Journal of Psychiatric Research, Volume 110Author(s): Jerome Sarris, Gerard J. Byrne, Lachlan Cribb, Georgina Oliver, Jenifer Murphy, Patricia Macdonald, Sonia Nazareth, Diana Karamacoska, Samantha Galea, Anika Short, Carolyn Ee, Yoann Birling, Ranjit Menon, Chee H. NgAbstractPartial or non-response to antidepressants in Generalized Anxiety Disorder (GAD) is common in clinical settings, and adjunctive biological interventions may be required. Adjunctive herbal and nutraceutical treatments are a novel and promising treatment option. L-theanine is a non-protein amino acid derived most-comm...
Source: Journal of Psychiatric Research - December 21, 2018 Category: Psychiatry Source Type: research

Ambient temperature and solar insolation are associated with decreased prevalence of SSRI-treated psychiatric disorders
Publication date: Available online 19 December 2018Source: Journal of Psychiatric ResearchAuthor(s): J.R. Wortzel, J.G. Norden, B.E. Turner, D.R. Haynor, S.T. Kent, M.Z. Al-Hamdan, D.H. Avery, M.J. NordenAbstractSerotonergic function is known to fluctuate in association with light and temperature. Serotonin-related behaviors and disorders similarly vary with climatic exposure, but the associations are complex. This complexity may reflect the importance of dose and timing of exposure, as well as acclimation. This cross-sectional study tests how average climate exposures (ambient temperature and solar insolation) vary with t...
Source: Journal of Psychiatric Research - December 21, 2018 Category: Psychiatry Source Type: research

Sub-threshold bipolar disorder in medication-free young subjects with major depression: Clinical characteristics and antidepressant treatment response
ConclusionFindings of the study indicate that a substantial proportion of young MDD subjects share BPD illness characteristics. These HRMDD subjects, if treated with antidepressants, need to be monitored for development of BPD.Trial registrationNCT01811147. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - December 21, 2018 Category: Psychiatry Source Type: research

Latent toxoplasmosis and psychiatric symptoms – A role of tryptophan metabolism?
Publication date: Available online 17 December 2018Source: Journal of Psychiatric ResearchAuthor(s): Cecilie Bay-Richter, Henriette Nørmølle Buttenschøn, Ole Mors, Amanda Eskelund, David Budac, Linda Kærlev, Gregers WegenerAbstractToxoplasma gondii (TOX) is a common parasite which infects approximately one third of the human population. In recent years, it has been suggested that latent toxoplasmosis may be a risk factor for the development of mental disorders, particularly schizophrenia and anxiety. With regards to depression the results have been varied.The main objective of this study was to e...
Source: Journal of Psychiatric Research - December 18, 2018 Category: Psychiatry Source Type: research