The Effect of Organic Lithium Salts on Plasma 8-Hydroxy-2'-Deoxyguanosine in Bipolar Patients In Vitro.
Conclusion: Lithium pyruvate reduces oxidative DNA damage in the blood of BD patients in vitro, demonstrating the potential of this compound to function not only as a mood stabilizer, but also as an antioxidant and cytoprotector. PMID: 32214518 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Effect of lithium carbonate on autophagy and proliferative activity of isolated hepatocytes.
Abstract The hepatocytes were cultivated in the presence of lithium carbonate (LC) for drugs testing or possible source for transplantation in the treatment of hereditary or terminal liver diseases. The LC, as an inducer of autophagy, is a promising drug for maintaining cell homeostasis and has a significant effect on the ultrastructural organization of hepatocyte cells. Within current investigation, new mechanisms of the biological effects of lithium and the ultrastructural analysis of the primary culture of hepatocytes were studied via flow cytofluorometry, light, and electron microscopy methods. Obtained result...
Source: Biochemical and Biophysical Research communications - March 21, 2020 Category: Biochemistry Authors: Dossymbekova R, Bgatova N, Tungushbaeva Z, Sharipov K, Tanyeva G, Kydyrbaeva A, Solovieva A Tags: Biochem Biophys Res Commun Source Type: research

Phase I Trial of Lithium and Tretinoin for Treatment of Relapsed and Refractory Non-promyelocytic Acute Myeloid Leukemia
Glycogen synthase kinase-3 (GSK3) inhibitors induce differentiation and growth inhibition of acute myeloid leukemia (AML) cells. Our pre-clinical studies showed GSK3 inhibition leads to sensitization of AML cells to tretinoin-mediated differentiation. We conducted a phase I trial of lithium, a GSK3 inhibitor, plus tretinoin for relapsed, refractory non-promyelocytic AML. Nine patients with median (range) age 65 (42–82) years were enrolled. All subjects had relapsed leukemia after prior therapy, with a median (range) of 3 (1–3) prior therapies. Oral lithium carbonate 300 mg was given 2–3 times daily and ad...
Source: Frontiers in Oncology - March 10, 2020 Category: Cancer & Oncology Source Type: research

Lithium Use in a Patient With Bipolar Disorder and End-Stage Kidney Disease on Hemodialysis: A Case Report
Lithium has been implicated in causing chronic tubulointerstitial nephritis and decline in renal function. However, lithium still plays a role in stabilizing patients with bipolar disorder. We illustrated a case of a bipolar I disorder patient approaching end-stage kidney disease (ESKD) with other medical comorbidities. As her mental state was affecting her compliance with medical treatment, she was mentally and medically unwell. Our patient was hospitalized on two separate occasions, for 5 and 4 months respectively, and failed adequate trials of different psychotropics due to inefficacy or intolerable side effects. A deci...
Source: Frontiers in Psychiatry - February 3, 2020 Category: Psychiatry Source Type: research

Study of the influence of dopant precursor on the growth and properties of Li-doped ZnO
Publication date: Available online 10 January 2020Source: Journal of Physics and Chemistry of SolidsAuthor(s): R. Ariza, F. Pavón, A. Urbieta, P. FernándezAbstractLithium-doped ZnO structures with sizes in the micro- and nano-scale and different morphologies were obtained by vapor–solid growth method. Two different precursors, lithium oxide and lithium carbonate, were used as the lithium source in order to study the influence on the morphology and optical properties of the obtained structures. Scanning electron microscopy, cathodoluminescence, photoluminescence, X-ray diffraction, energy dispersive X-ra...
Source: Journal of Physics and Chemistry of Solids - January 11, 2020 Category: Physics Source Type: research

Synergetic effect of secondary nucleation and growth on the lithium carbonate particle size in the gas–liquid reactive crystallization of LiCl–NH3·H2O–CO2
In this study, the gas‒liquid reactive crystallization of LiCl–NH3·H2O–CO2 was adopted to produce Li2CO3. The weakly alkaline nature of NH3·H2O in the absence of any recarbonation process resulted in a unimodal and easily controllable particle size distribution (PSD) of the obtained Li2CO3. The reaction temperature significantly influenced both the Li2CO3 particle size and PSD. By increasing the temperature from 25 to 60 °C, the volume weighted mean particle size increased from 50.5 to 100.5 μm, respectively. The Li2CO3 secondary nucleation rate and growth rate were obtained by focuse...
Source: Particuology - December 24, 2019 Category: Science Source Type: research

Lithium effects on vesicular trafficking in hepatocellular carcinoma cells.
Abstract Hepatocellular carcinoma (HCC) is one of the most commonly malignant tumors worldwide, characterized by the presence of many heterogeneous molecular cell events that contribute to tumor growth and progression. Endocytic processes are intimately involved in various pathological conditions, including cancer, since they interface with various cellular signaling programs. The ability of lithium to induce cell death and autophagy and affect cell proliferation and intracellular signaling has been shown in various experimental tumor models. The aim of this study was to evaluate the effects of lithium on vesicula...
Source: Ultrastructural Pathology - December 11, 2019 Category: Pathology Authors: Taskaeva I, Bgatova N, Gogaeva I Tags: Ultrastruct Pathol Source Type: research

[ASAP] Yttrium Manganese Oxide Phase Stability and Selectivity Using Lithium Carbonate Assisted Metathesis Reactions
Inorganic ChemistryDOI: 10.1021/acs.inorgchem.9b02075 (Source: Inorganic Chemistry)
Source: Inorganic Chemistry - November 4, 2019 Category: Chemistry Authors: Paul K. Todd, Antoinette M. M. Smith, and James R. Neilson* Source Type: research

[ASAP] Influence of Inorganic Solution Components on Lithium Carbonate Crystal Growth
Crystal Growth& DesignDOI: 10.1021/acs.cgd.9b00782 (Source: Crystal Growth and Design)
Source: Crystal Growth and Design - November 4, 2019 Category: Chemistry Authors: Helen E. King* †, Alistair Salisbury†, Jasper Huijsmans†, Nelson Y. Dzade†‡#, and Oliver Plu¨mper† Source Type: research

Cytological Characteristics of a Heterogeneous Population of Hepatocellular Carcinoma-29 Cells after Injection of Lithium Carbonate in the Experiment
Five cytological types of hepatocellular carcinoma-29 (G-29) grown in the muscle tissue of the thigh of experimental animals were identified by transmission electron microscopy; 89% of these were poorly differentiated type I-III cells. Lithium in a concentration of 20 mM produced a damaging effect on poorly differentiated G-29 cells: the number of cells with zones of intracellular component destruction and volume density of these zones increased, while volume density of cisterns of endoplasmic reticulum decreased. These results suggest that lithium carbonate can cause destructive changes in the heterogeneous population of ...
Source: Bulletin of Experimental Biology and Medicine - October 26, 2019 Category: Biology Source Type: research

Combination of Olanzapine and Samidorphan Has No Clinically Significant Effect on the Pharmacokinetics of Lithium or Valproate
ConclusionsConsistent with previously reported findings on olanzapine, administration of multiple doses of OLZ/SAM did not have a clinically significant effect on the pharmacokinetics of lithium or valproate. Co-administration of OLZ/SAM and lithium or valproate was generally well tolerated; the safety profile of OLZ/SAM was consistent with that observed in previous clinical studies. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 4, 2019 Category: Drugs & Pharmacology Source Type: research

[ASAP] Crystallization of Lithium Carbonate from Aqueous Solution: New Insights into Crystal Agglomeration
Industrial& Engineering Chemistry ResearchDOI: 10.1021/acs.iecr.9b03644 (Source: Industrial and Engineering Chemical Research)
Source: Industrial and Engineering Chemical Research - September 18, 2019 Category: Chemistry Authors: Wenchao Yang †, Ling Zhou*†, Jiayu Dai†, Lina Zhou†‡, Meijing Zhang†‡, Chuang Xie†‡, Hongxun Hao†‡, Baohong Hou†‡, Ying Bao†‡, and Qiuxiang Yin*†‡ Source Type: research

Kinetic analysis of lithium–titanium ferrite formation from mechanically milled reagents
In this study, the AGO-2S planetary ball mill was used for mechanical milling of the initial reagents. The X-ray diffraction patterns for mechanically activated mixtures show increased of the width intensities of reflections due to decreased crystallite size which caused by mechanical grinding. Thermal analysis showed that the reaction of lithium-titanium ferrite synthesis proceeds in two stages. For the initial mixture (non-milled), mass reduces within the temperature range of 430–720 °C. The results obtained for mechanically activated samples show that mass reduction in these samples begins at much lower temp...
Source: Materials Chemistry and Physics - August 27, 2019 Category: Materials Science Source Type: research

Propylthiouracil-induced agranulocytosis as a rare complication of antithyroid drugs in a patient with Graves’ disease
In this study, we report agranulocytosis induced by propylthiouracil (PTU) in a patient with GD and the difficulties of clinical management. CASE: RNBA, male, 30 years old, with GD, treated with propylthiouracil (PTU). He progressed with pharyngotonsillitis. Then, PTU was suspended and antibiotic, filgrastim, propranolol, and prednisone were initiated. Due to the decompensation of hyperthyroidism, lithium carbonate, dexamethasone, and Lugol's solution were introduced. Total thyroidectomy (TT) was performed with satisfactory postoperative progression. DISCUSSION: We describe here the case of a young male patient with GD. Fo...
Source: Revista da Associacao Medica Brasileira - July 23, 2019 Category: General Medicine Source Type: research

Recommendations of the Polish Psychiatric Association regarding the treatment of affective disorders in women of childbearing age. Part II: Bipolar disorder.
Authors: Rybakowski J, Cubała WJ, Gałecki P, Rymaszewska J, Samochowiec J, Szulc A, Dudek D Abstract In the article, the recommendations of the Polish Psychiatric Association regarding pharmacological treatment of women with bipolar disorder during pregnancy and postpartum period were presented. The issue pertains to every twentieth woman wanting to get pregnant. Before planned pregnancy, it is advisable to obtain a several-month stabilization of psychiatric state, to establish treatment with one mood-stabilizing drug (except for valproate and carbamazepine) or gradual discontinuation of drugs in case of mild cou...
Source: Psychiatria Polska - July 19, 2019 Category: Psychiatry Tags: Psychiatr Pol Source Type: research

Revisiting Lithium: Utility for Behavioral Stabilization in Adolescents and Adults with Autism Spectrum Disorder.
Conclusions: Lithium carbonate is a viable, efficacious and well tolerated alternative to various neuroleptics and other psychotropic medications for use as a mood stabilizer for patients with ASD. PMID: 31308580 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Ultrastructural Changes in Hepatocellular Carcinoma-29 Cells after Treatment with Lithium Carbonate
We studied the effect of lithium carbonate on hepatocellular carcinoma-29 cells in CBA male mice after injection in a dose of 20 mM along the tumor periphery. Transmission electron microscopy revealed a decrease in the volume density of the granular endoplasmic reticulum in the cell cytoplasm and an increase in the total numerical and volume density of autophagosomes and autolysosomes and zones of destruction of intracellular organelles. The ability of lithium carbonate to activate intracellular degradation processes in tumor cells and to stimulate cell death can be used to develop new combined strategies in the chemothera...
Source: Bulletin of Experimental Biology and Medicine - June 8, 2019 Category: Biology Source Type: research

Battery grade lithium produced following successful first pilot test
Publication date: May 2019Source: Membrane Technology, Volume 2019, Issue 5Author(s): Canada's Saltworks Technologies is helping Standard Lithium – a speciality chemical company that focuses on unlocking the value of existing large-scale US-based lithium-bearing brine resources – to produce high-purity lithium carbonate. (Source: Membrane Technology)
Source: Membrane Technology - May 23, 2019 Category: Materials Science Source Type: research

Mechanically stimulated thermal synthesis of lithium aluminates
Publication date: 2019Source: Materials Today: Proceedings, Volume 12, Part 1Author(s): V.P. Isupov, I.A. Borodulina, N.V. Eremina, N.V. BulinaAbstractThe influence of the conditions of preliminary mechanical activation of a mixture of gibbsite and lithium carbonate in a planetary-type activator and the conditions of subsequent heat treatment on the phase composition of lithium aluminates is studied. It is shown that for the formation of γ-LiAlO2 it is necessary that at the stage of mechanical activation of the mixture an almost complete amorphization of aluminum hydroxide occurs, and the air heat treatment is carrie...
Source: Materials Today: Proceedings - May 21, 2019 Category: Materials Science Source Type: research

Finding the best effective way of treatment for rapid I-131 turnover Graves’ disease patients: A randomized clinical trial
Conclusions: Treatment of rapid turnover Graves’ disease patients with high dose I-131 (7.4 MBq/g) provides significantly higher cure rates at 12 months, and 3 times odds of cure than 3.7 MBq/g I-131 plus LiCO3 with lesser side effects. We thus recommend 7.4 MBq I-131/g for treatment in these patients. (Source: Medicine)
Source: Medicine - May 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

The Effect of a Tropical Climate on Available Nutrient Resources to Springs in Ophiolite-Hosted, Deep Biosphere Ecosystems in the Philippines
This study focuses specifically on surface expressions (springs and seeps) of the deep biosphere sourced in ultramafic rock units in the Philippines. Springs and seeps emanating from ophiolites represent subsurface fluids produced from the process of “serpentinization” that are mixed with fluids of other sources. Briefly, serpentinization is the aqueous alteration of ultramafic rocks (part of the ophiolite body). In terrestrial ophiolites, the process is often recharged by groundwaters, and provides alteration products including mineralogically altered solids, fluids of distinctive geochemistry, gasses such as ...
Source: Frontiers in Microbiology - May 1, 2019 Category: Microbiology Source Type: research

Systems Biology Understanding of the Effects of Lithium on Cancer
Conclusions sections. Both authors shared in the final refinement of the manuscript. Funding Salary support for WG by National Science Foundation grant 1624615 is gratefully acknowledged. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We gratefully acknowledge very useful comments from Peter Klein on an earlier version of this manuscript, and from the reviewers of this paper, whose comments have resulted in improvements. An earlier version of this...
Source: Frontiers in Oncology - April 30, 2019 Category: Cancer & Oncology Source Type: research

Vitamin B12 Enhances Nerve Repair and Improves Functional Recovery After Traumatic Brain Injury by Inhibiting ER Stress-Induced Neuron Injury
In this study, we explored the effect of vitamin B12 on nerve regeneration after TBI both in vivo and in vitro. Meanwhile, we investigated the role of ER stress during the vitamin B12 treatment for TBI by inspecting changes in neuronal apoptosis, microtubule, myelin regeneration, and axonal growth. Materials and Methods Animals Adult C57BL/6 male mice aged 6–8 weeks and weighing 20–26 g were purchased from the Animal Center of the Chinese Academy of Sciences (Shanghai, China). Animals were housed under a 12-h light/dark cycle at 21–23°C and provided access to food and water ad libitum. The care and...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

Impact of Long-Term Lithium Treatment on Renal Function in Patients With Bipolar Disorder Based on Novel Biomarkers
Conclusions We found significantly decreased kidney concentrating ability in the long-term lithium-treated patients compared with the control group. Other renal function markers did not indicate any significant signs of renal dysfunction. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - April 16, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research

Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis
We report many of them for the first time. For the already described citrullinated proteins MBP, GFAP, and vimentin, we could identify additional citrullinated sites. The number of modified proteins in MS white matter was higher than control tissue. Citrullinated peptides are considered neoepitopes that may trigger autoreactivity. We used newly identified epitopes and previously reported immunodominant myelin peptides in their citrullinated and non-citrullinated form to address the recognition of CSF-infiltrating CD4+ T cells from 22 MS patients by measuring proliferation and IFN-γ secretion. We did not detect marked...
Source: Frontiers in Immunology - April 10, 2019 Category: Allergy & Immunology Source Type: research

Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial.
CONCLUSIONS: Long-term lithium attenuates cognitive and functional decline in amnestic MCI, and modifies Alzheimer's disease-related CSF biomarkers. The present data reinforces the disease-modifying properties of lithium in the MCI-Alzheimer's disease continuum.Declaration of interestNone. PMID: 30947755 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - April 6, 2019 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

Closed-loop hydrometallurgical treatment of end-of-life lithium ion batteries: Towards zero-waste process and metal recycling in advanced batteries
Publication date: Available online 26 March 2019Source: Journal of Energy ChemistryAuthor(s): Thomas Abo Atia, Giuseppe Elia, Robert Hahn, Pietro Altimari, Francesca PagnanelliAbstractThis work presents an enhanced hydrometallurgical process for recycling lithium ion batteries. First, end-of-life batteries were processed in a physical pre-treatment plant to obtain a representative electrode material. The resulting leachate was purified forth by iron-precipitation, liquid-liquid extractions, and an innovative Li-Na separation, in order to obtain valuable products. These products include high-grade graphite, cobalt oxide (Co...
Source: Journal of Energy Chemistry - March 27, 2019 Category: Chemistry Source Type: research

Flux growth and enhanced electrochemical properties of LiNi0.5Co0.2Mn0.3O2 cathode material by excess lithium carbonate for lithium-ion batteries
Publication date: 5 June 2019Source: Journal of Alloys and Compounds, Volume 788Author(s): Yanyu Qu, Yan Mo, Xiaobo Jia, Liao Zhang, Baodong Du, Yang Lu, De Li, Yong ChenAbstractLayered LiNi0.5Co0.2Mn0.3O2 (LNCM) cathode material is synthesized via an assisted molten salt method with different amounts of Li2CO3 in this work. Rietveld refinements of X-ray diffraction reveal that the samples treated using excess lithium have better crystalline structures with lower cation mixing than pristine LNCM. With variations in Li/transition metal (TM) molar ratio, the morphology changes from aggregations consisting of primary particle...
Source: Journal of Alloys and Compounds - March 5, 2019 Category: Chemistry Source Type: research

The effect of the Li:Na molar ratio on the structural and sorption properties of mixed zirconates for CO2 capture at high temperature
Publication date: April 2019Source: Journal of Environmental Chemical Engineering, Volume 7, Issue 2Author(s): Diana Peltzer, John Múnera, Laura CornagliaAbstractDifferent Li2ZrO3–Na2ZrO3 based sorbents were synthesized by the wet impregnation of a zirconia nanoparticle suspension with a lithium carbonate solution. The solids were characterized by X-ray diffraction, Raman spectroscopy, Scanning Electron Microscopy and X-ray photoelectron spectroscopy, while sorption properties were studied by thermogravimetric measurements carried out at different CO2 partial pressures. The stability experiments were carried o...
Source: Journal of Environmental Chemical Engineering - February 27, 2019 Category: Chemistry Source Type: research

Dose optimization of lithium to increase the uptake and retention of I-131 in rat thyroid.
Conclusion, a Lithium dose of 10 mg/kg body weight in rats could increase the uptake of I-131 in the thyroid, without disturbing the control circulating levels of thyroid hormones. PMID: 30810817 [PubMed - as supplied by publisher] (Source: Radiation and Environmental Biophysics)
Source: Radiation and Environmental Biophysics - February 27, 2019 Category: Physics Authors: Kumar SB, Kamal R, Khan A, Chadha VD Tags: Radiat Environ Biophys Source Type: research

[ASAP] Iodine Mediator with Anomalously High Redox Potential and Its Application to a Catalytic Cycle for Lithium Carbonate Decomposition toward Future Lithium Reproduction
The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.8b09967 (Source: The Journal of Physical Chemistry C)
Source: The Journal of Physical Chemistry C - February 11, 2019 Category: Chemistry Authors: Tohru Shiga, Hiroki Kondo, Yuichi Kato, Yoko Hase Source Type: research

Advances in the Treatment of Psychotic Depression
AbstractPurpose of reviewOur aim was to update the current understanding of effective treatment strategies for major depression with psychotic features (MDPSY).Recent findingsMost treatment guidelines recommend either the combination of an antidepressant with an antipsychotic or electroconvulsive therapy (ECT) for the treatment of an acute episode of MDPSY. The optimal maintenance treatment after a person responds to either the antidepressant/antipsychotic combination or ECT is unclear particularly as it pertains to length of time the patient needs to take the antipsychotic medication. Further investigation into possible u...
Source: Current Treatment Options in Psychiatry - January 30, 2019 Category: Psychiatry Source Type: research

[ASAP] Probing Lithium Carbonate Formation in Trace-O < sub > 2 < /sub > -Assisted Aprotic Li-CO < sub > 2 < /sub > Batteries Using in Situ Surface-Enhanced Raman Spectroscopy
The Journal of Physical Chemistry LettersDOI: 10.1021/acs.jpclett.8b03272 (Source: The Journal of Physical Chemistry Letters)
Source: The Journal of Physical Chemistry Letters - January 9, 2019 Category: Chemistry Authors: Zhiwei Zhao, Yuwei Su, Zhangquan Peng Source Type: research

Lithium Carbonate in a Poststroke Population: Exploratory Analyses of Neuroanatomical and Cognitive Outcomes
Conclusions Lithium pharmacotherapy may be associated with gray matter volume change and verbal memory improvement in stroke patients, providing a rationale for future trials assessing therapeutic potential of lithium in a poststroke population. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Brief Reports Source Type: research

Population Pharmacokinetics and Exposure –Response of Lithium Carbonate in Patients Based on Tubular Reabsorption Mechanisms
ConclusionRenal function and urinary pH are important indices in lithium treatment, so the serum concentration of lithium may be predicted based on the renal function and urinary pH. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - December 7, 2018 Category: Drugs & Pharmacology Source Type: research

Lithium disturbs homeostasis of essential microelements in erythrocytes of rats: Selenium as a protective agent?
CONCLUSIONS: The beneficial effect of selenium on disturbances of studied microelements homeostasis as well as on preventing lithium accumulation in erythrocytes in Li receiving animals allows suggesting that further research on selenium application as an adjuvant in lithium therapy is worth carrying on. PMID: 30321806 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2018 Category: Drugs & Pharmacology Authors: Kiełczykowska M, Kopciał E, Kocot J, Kurzepa J, Marzec Z, Musik I Tags: Pharmacol Rep Source Type: research

Coal Gasification in the Presence of Lithium Orthosilicate. Part 1: Reaction Kinetics
Publication date: Available online 16 November 2018Source: Chemical Engineering Research and DesignAuthor(s): Michele D. Domenico, Suélen M. Amorim, Gabriela C. Collazzo, Humberto J. José, Regina F.P.M. MoreiraAbstractThe aim of this work was to investigate the simultaneous steam gasification of a Brazilian subbituminous coal and CO2 capture using lithium orthosilicate (Li4SiO4), as a promising process for enhanced hydrogen production. Tests were carried out in a magnetic suspension thermobalance at several conditions (temperature range of 700 to 1000 °C, steam partial pressure range of 0.1 to 0.4&nb...
Source: Chemical Engineering Research and Design - November 17, 2018 Category: Chemistry Source Type: research

Sensors, Vol. 18, Pages 3618: Use of Transient Time Response as a Measure to Characterize Phononic Crystal Sensors
nayiotis Kyriacou Phononic crystals are periodic composite structures with specific resonant features that are gaining popularity in the field as liquid sensors. The introduction of a structural defect in an otherwise periodic regular arrangement can generate a resonant mode, also called defect mode, inside the characteristic band gaps of phononic crystals. The morphology, as well as the frequency in which these defect modes appear, can give useful information on the composition and properties of an analyte. Currently, only gain and frequency measurements are performed using phononic crystal sensors. Other measurements...
Source: Sensors - October 25, 2018 Category: Biotechnology Authors: Sim ón Villa-Arango David Betancur R óbinson Torres Panayiotis Kyriacou Tags: Article Source Type: research

Neuroprotective Lithium Salts Protect Pancreatic β-Сells from Damage
We studied antidiabetic effects and cytoprotective activity of two lithium salts (lithium chloride and lithium carbonate) on the model of streptozotocin-induced diabetes mellitus type 2 in Wistar rats. Using the method of β-cells detection with antibodies to insulin, we demonstrated that streptozotocin reduced the number of β-cells and impaired their morphological structure. Both lithium preparations administered to diabetic animals for 28 days in doses of 10 and 8.9 mg/kg, respectively, attenuated the damaging eff ect of streptozotocin. This cytoprotective effect of lithium salts manifested in weakening of hyper...
Source: Bulletin of Experimental Biology and Medicine - October 23, 2018 Category: Biology Source Type: research

Na+, K+-ATPase inhibition causes hyperactivity and impulsivity in mice via dopamine D2 receptor-mediated mechanism
Publication date: Available online 6 October 2018Source: Neuroscience ResearchAuthor(s): Yuki Kurauchi, Yuko Yoshimaru, Yuto Kajiwara, Taishi Yamada, Keigo Matsuda, Akinori Hisatsune, Takahiro Seki, Hiroshi KatsukiAbstractHyperactivity and impulsivity are common symptoms in several psychiatric disorders. Although dysfunction of Na+, K+-ATPase has been reported to be associated with the psychiatric disorders, it is not clear whether inhibition of Na+, K+-ATPase causes behavioral effects, including hyperactivity and impulsivity, in mice. Here, we evaluated the effect of intracerebroventricular (icv) injection of ouabain, an ...
Source: Neuroscience Research - October 6, 2018 Category: Neuroscience Source Type: research

Na+, K+-ATPase inhibition induces neuronal cell death in rat hippocampal slice cultures: Association with GLAST and glial cell abnormalities
Publication date: Available online 22 September 2018Source: Journal of Pharmacological SciencesAuthor(s): Yuki Kurauchi, Kazuki Noma, Akinori Hisatsune, Takahiro Seki, Hiroshi KatsukiAbstractNa+, K+-ATPase is a highly expressed membrane protein. Dysfunction of Na+, K+-ATPase has been implicated in the pathophysiology of several neurodegenerative and psychiatric disorders, however, the underlying mechanism of neuronal cell death resulting from Na+, K+-ATPase dysfunction is poorly understood. Here, we investigated the mechanism of neurotoxicity due to Na+, K+-ATPase inhibition using rat organotypic hippocampal slice cultures...
Source: Journal of Pharmacological Sciences - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Can lithium salts prevent depressive episodes in the real world?
To critically examine the effectiveness of lithium in preventing depressive symptoms (mixed and depressive episodes) in real life settings, taking into account adherence to drug treatment and its implications for the clinical costs of the disease. Overall, 72 patients with bipolar disorder initially treated with lithium carbonate were included and followed-up for 10 years. Patients were assessed every 8 weeks for morbidity and alcohol/drug consumption. Patients with good adherence to lithium had fewer episodes with depressive features than poor adherers (B  = 2.405, p = 0.046) and also fewer manic and hypomanic epi...
Source: European Neuropsychopharmacology - September 20, 2018 Category: Psychiatry & Psychology Authors: Ana Gonz ález-Pinto, Purificación López-Peña, Cristina Bermúdez-Ampudia, Eduard Vieta, Mónica Martinez-Cengotitabengoa Source Type: research

The effect of alkaline-earth substitution on the Li K-edge of lithium silicate glasses
We present the first Li K-edge XANES study of a varied suite of lithium silicate (LS) and lithium alkaline-earth silicate (LMS) glasses. The LS series contains three glasses with compositions LS4 (20 Li2O–80 SiO2), LS2 (33 Li2O–67 SiO2) and LS1.5 (40 Li2O–60 SiO2) and the LMS series is comprised of four glasses of compositions 20 Li2O–20 M2O–60 SiO2 where M = Mg, Ca, Sr and Ba. The spectra were compared to those of known salts and minerals, particularly to lithium metasilicate (Li2SiO3) and lithium carbonate (Li2CO3). Crystalline lithium metasilicate has a sharp, strong intensity absorptio...
Source: Journal of Non Crystalline Solids - September 15, 2018 Category: Chemistry Source Type: research

Controllable formation of lithium carbonate surface phase during synthesis of nickel-rich LiNi0.9Mn0.1O2 in air and its protection role in electrochemical reaction
Publication date: 15 January 2019Source: Journal of Alloys and Compounds, Volume 771Author(s): J.T. Zhang, X.H. Tan, L.M. Guo, Y. Jiang, S.N. Liu, H.F. Wang, X.H. Kang, W.G. ChuAbstractIt has been well recognized that Li2CO3 is inevitably formed at the surface of nickel rich layered compounds (NRLC) upon storage in air which is usually considered to be detrimental to the performance. Actually, its formation may have been triggered during synthesis of NRLC. However, little is known of its formation during synthesis of NRLC in air and its interaction behaviors with electrolyte during electrochemical process. Herein, we succe...
Source: Journal of Alloys and Compounds - September 1, 2018 Category: Chemistry Source Type: research

Aripiprazole Versus Lithium in Management of Acute Mania: a Randomized Clinical Trial.
CONCLUSION: Lithium is more effective than aripiprazole in improving manic symptoms. PMID: 30146495 [PubMed - in process] (Source: East Asian Archives of Psychiatry)
Source: East Asian Archives of Psychiatry - August 29, 2018 Category: Psychiatry Tags: East Asian Arch Psychiatry Source Type: research

Effect of Lithium Preparations on Cerebral Electrophysiological Activity in Rats
The study examined the effects of a novel neurotropic medication based on a lithium complex composed of lithium citrate, polymethylsiloxane, and aluminum oxide on electrophysiological parameters of the rat brain. In contrast to lithium carbonate (the reference drug), the novel preparation resulted in a wave-like dynamics of electrical activity in the visual cortex. Rhythmic photic stimulation of the rats treated with lithium carbonate resulted in appearance of the signs attesting to up-regulation of excitability of cerebral cortex in all examined ranges. In contrast, the complex lithium preparation diminished the delta pow...
Source: Bulletin of Experimental Biology and Medicine - August 18, 2018 Category: Biology Source Type: research

Evolution of MRI characteristics of heatstroke in a patient with schizophrenia maintained with antipsychotic drugs
AbstractAlthough heatstroke commonly occurs in summer, herein, we present a case of heatstroke that occurred in March. The patient has been schizophrenic for over 20  years and has been receiving long-term medications, such as lithium carbonate, clozapine, and lorazepam. We analyzed the evolution of her cerebellar magnetic resonance imaging characteristics to determine the association of heatstroke in schizophrenia. Patients with schizophrenia are at high risk for developing heatstroke, possibly due to the use of antipsychotic drugs. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - July 19, 2018 Category: Neurology Source Type: research

Lithium entrapped chitosan nanoparticles to reduce toxicity and increase cellular uptake of lithium
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Geeva, Shoba NarayanAbstractLithium carbonate is an effective drug against bipolar disorders. Direct use of lithium carbonate has been reported to result in lithium toxication and pulmonary complications. With chitosan micro and nanoparticles gaining attention for their protein absorption, drug targeting and improved dissolution rate of sparingly water-soluble drugs, this work has focused on chitosan loaded Li as a possible alternative to Li alone for cellular uptake. Well standardized ionic gelation technique employed in this...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Mania-like elevated mood in rats: Enhanced 50-kHz ultrasonic vocalizations after sleep deprivation
In conclusion, SD increased 50-kHz USV emission, an effect prevented by acute lithium administration. This suggests 50-kHz USV as a new marker for mania-like elevated mood, which shows construct validity (associated with increased dopaminergic tone), face validity (reflecting increased positive affect) and predictive validity (high sensitivity to lithium treatment). (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 10, 2018 Category: Psychiatry Source Type: research

Lithium entrapped chitosan nanoparticles to reduce toxicity and increase cellular uptake of lithium
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Geeva, Shoba NarayanAbstractLithium carbonate is an effective drug against bipolar disorders. Direct use of lithium carbonate has been reported to result in lithium toxication and pulmonary complications. With chitosan micro and nanoparticles gaining attention for their protein absorption, drug targeting and improved dissolution rate of sparingly water-soluble drugs, this work has focused on chitosan loaded Li as a possible alternative to Li alone for cellular uptake. Well standardized ionic gelation technique employed in this...
Source: Environmental Toxicology and Pharmacology - July 6, 2018 Category: Environmental Health Source Type: research