Lithium carbonate as add-on therapy to radioiodine in the treatment on hyperthyroidism: a systematic review and meta-analysis
The main purpose is to investigate the effect of LiCO3 as an add-on therapy with radioactive iodine in increasing the cure and decreasing the T4 level compared to radioactive iodine alone. The primary outcome ... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - April 12, 2021 Category: Endocrinology Authors: Mohamed Abd-ElGawad, Mohamed Abdelmonem, Ahmed Eissa Ahmed, Omar Magdy Mohammed, Mohamed Sayed Zaazouee, Ahmed Assar, Mohamed Gadelkarim and Ahmed M. Afifi Tags: Research article Source Type: research
Lithium toxicity and the kidney with special focus on nephrotic syndrome associated with the acute kidney injury: A case ‐based systematic analysis
We present a 49‐year‐old female treated with lithium carbonate due to a recurrent depressive disorder who developed NS during this therapy. NS spontaneously remitted after the drug withdrawal. Since her lithium serum levels were within the recommended values, we performed a retrospective analysis of lithium‐induced NS cases trying to determine causes predisposing to the NS development, underlying histopathology, and preservation or irreversible loss of kidney function. This analysis revealed that in lithium‐induced NS with AKI, lithium serum level was the key determinant of AKI development (theβ coefficient =...
Source: Journal of Applied Toxicology - April 3, 2021 Category: Toxicology Authors: Emilia Łukawska,
Dorota Frankiewicz,
Monika Izak,
Aldona Woźniak,
Grzegorz Dworacki,
Zofia I. Niemir Tags: RESEARCH ARTICLE Source Type: research
Effect of a New Lithium Preparation on the Behavior of CBA/CaLac Mice in an Experimental Conflict Model
The use of lithium drugs in clinical practice requires constant monitoring of lithium plasma concentration, because toxicity is sometimes observed at therapeutic concentrations of lithium. This is often associated with fluctuations of plasma concentration of lithium ions after intake of individual doses. Therefore, the use of a porous carrier providing a stable blood level of the drug is extremely promising and important for clinical practice. We studied activity of a new lithium drug (lithium complex) consisting of aluminum-silicon base and lithium citrate immobilized on its surface. Lithium carbonate served as the refere...
Source: Bulletin of Experimental Biology and Medicine - March 13, 2021 Category: Biology Source Type: research
Systematic literature review and Bayesian network meta-analysis of episodic cluster headache drugs
CONCLUSIONS: The results suggest that galcanezumab is more effective compared to verapamil as a prophylaxis treatment for reducing eCH attacks in adults. Further, head-to-head RCTs of galcanezumab vs. treatments using in clinical practice are needed to better assess its comparative efficacy and benefit-risk profile.PMID:33629333 | DOI:10.26355/eurrev_202102_24874 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 25, 2021 Category: Drugs & Pharmacology Authors: G Pompilio A Migliore D Integlia Source Type: research
Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.
Abstract
The contribution of glutamatergic transmission to generation of initial convulsive seizures (CS) is debated. We tested whether pretreatment with a glutamine synthetase (GS) inhibitor, methionine sulfoximine (MSO), affects the onset and progression of initial CS by cholinergic stimulus in juvenile rats. Male rats (24 days old, Sprague Dawley) sequentially received i.p. injections of lithium-carbonate, MSO, methyl-scopolamine, and pilocarpine (Pilo). Pilo was given 150 min after MSO. Animals were continuously monitored using the Racine scale, EEG/EMG and intrahippocampal glutamate (Glu) biosensors. ...
Source: Brain Research - January 7, 2021 Category: Neurology Authors: Pawlik MJ, Obara-Michlewska M, Popek MP, Maria Czarnecka A, Czuczwar SJ, Łuszczki J, Kołodziej M, Acewicz A, Wierzba-Bobrowicz T, Albrecht J Tags: Brain Res Source Type: research
Lithium for Carbamazepine-Induced Syndrome of Inappropriate Antidiuretic Hormone
Conclusions
Carbamazepine may sometimes be the best or only viable treatment option for patients with bipolar illness or other conditions. When its use is complicated by syndrome of inappropriate ADH, dose reduction and fluid restriction are the simplest options but, if ineffective, addition of lithium may be a feasible, albeit somewhat complicated, alternative. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2021 Category: Neurology Tags: Case Reports Source Type: research
Molecular layer deposition of Li-ion conducting "Lithicone" solid electrolytes.
Abstract
We demonstrate the fabrication of Li-containing ("lithicone") thin films prepared via molecular layer deposition (MLD) using lithium tert-butoxide and ethylene glycol. X-ray photoelectron spectroscopy reveals that the stoichiometry of the lithicone is Li1.5C2O1.8 (H omitted), with C-O-Li moieties present in the film. The bonding environment of lithicone is distinct from that of lithium carbonate or MLD alucone films. Electrochemical impedance spectroscopy measurements show that annealed lithicone films exhibit room temperature ionic conductivity of 3.6-5 × 10-8 S cm-1 with an activation energy of...
Source: Chemical Communications - December 23, 2020 Category: Chemistry Authors: Kazyak E, Shin M, LePage WS, Cho TH, Dasgupta NP Tags: Chem Commun (Camb) Source Type: research
In Vitro Effects of Lithium Carbonate on Cell Cycle, Apoptosis, and Autophagy in Hepatocellular Carcinoma-29 Cells
We studied the effects of lithium carbonate on the cell cycle, apoptosis, and autophagy in hepatocellular carcinoma-29 cells (HCC-29)in vitro. Flow cytofluorometry analysis revealed accumulation of G2/M-phase HCC-29 cells and increase in the number of apoptotic cells in 48 h after administration of 5 mM lithium carbonate. Induction of autophagy in HCC-29 cells was detected by transmission electron microscopy and immunofluorescence staining. Thus, lithium carbonate produces an antitumor effect by arresting cell cycle in the G2/M-phase and induction of apoptosis and autophagy in HCC-29 cells, which confirms the lithium poten...
Source: Bulletin of Experimental Biology and Medicine - December 2, 2020 Category: Biology Source Type: research
Ultrastructure of the kidney filtration barrier in conditions of distant tumor growth and lithium treatment.
Abstract
Toxic products generated in the process of tumor growth and as a result of treatment may cause damage to organs distant from the tumor growth, including kidneys. The aim of the work was to identify ultrastructural changes in the components of kidney filtration barrier in conditions of distant tumor growth and lithium carbonate treatment. Tumor growth was induced by the inoculation of hepatocellular carcinoma-29 cells into the right thigh muscle of CBA mice. Lithium carbonate was injected along the periphery of the tumor. Ultrastructural analysis of podocytes and endotheliocytes of glomerular capil...
Source: Ultrastructural Pathology - November 30, 2020 Category: Pathology Authors: Bgatova N, Taskaeva I Tags: Ultrastruct Pathol Source Type: research
