Dose-Dependent Enuresis in Methylphenidate Use
Conclusions
Clinicians should be aware that methylphenidate used in ADHD causes dose-dependent enuresis. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2022 Category: Neurology Tags: Case Reports Source Type: research
Clozapine-Induced Fever and Plasma Cytokine Changes in a Patient With Schizophrenia
Conclusions
To our knowledge, this is the first case presentation of clozapine-induced fever discussing the mechanism, differential diagnosis, and decision making of clozapine treatment focusing on plasma cytokines. If once fever occurs, an extensive medical workup for the fever and a careful systemic medical management should be promptly proceeded to avoid clozapine-associated severe complications. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2022 Category: Neurology Tags: Case Reports Source Type: research
A Case of Priapism in a Child With Autism Spectrum Disorder, Possibly Due to Risperidone Treatment With Addition of Atomoxetine
Conclusions
Priapism is a condition viewed as a medical emergency. Although risperidone-induced priapism is a rare phenomenon, it is advised for clinicians to consider the drug interactions in treatment of ASD and ADHD in terms of early diagnosis and intervention. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2022 Category: Neurology Tags: Case Reports Source Type: research
Efficacy of Valproic Acid Against Coronavirus Disease 2019 Infection or Severity: A Pilot Study
Conclusions
In this pilot study, no support was found for the hypothesis of a protective effect of VPA against the infectivity rate of COVID-19. Neither was there any indication of a disease-modulating effect of VPA in people with active COVID-19 infection. Larger, randomized controlled trials would be warranted to substantiate our conclusion. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2022 Category: Neurology Tags: Original Articles Source Type: research
Protective Effects of Ursodeoxycholic Acid Against Oxidative Stress and Neuroinflammation Through Mitogen-Activated Protein Kinases Pathway in MPTP-Induced Parkinson Disease
Conclusions
This study revealed protective effects of UDCA against oxidative stress and neuroinflammation through mitogen-activated protein kinases pathways in MPTP-induced PD, suggesting that UDCA may be a novel therapeutic candidate for PD. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2022 Category: Neurology Tags: Original Articles Source Type: research
The Efficacy and Safety of Adjuvant Lomustine to Chemotherapy for Recurrent Glioblastoma: A Meta-analysis of Randomized Controlled Studies
Conclusions
Adjuvant lomustine to other chemotherapy may provide no obvious benefits for the treatment of recurrent glioblastoma. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2022 Category: Neurology Tags: Original Articles Source Type: research
The Effects of Disease-Modifying Therapies on Oxidative Stress in Patients With Relapsing-Remitting Multiple Sclerosis
Objective
Oxidative stress (OS) has a role in the pathogenesis and progression of multiple sclerosis. The effects of disease-modifying therapies (DMTs) on OS are unclear. We aimed to explore the association between DMTs and OS in patients with relapsing-remitting multiple sclerosis (RRMS).
Methods
The study conducted in 167 patients (102 received and 65 not received the DMTs). The DMTs included interferon beta-1a (n = 15), interferon beta-1b (n = 20), glatiramer acetate (n = 10), and sphingosine-1-phosphate receptor modulators (n = 57). Oxidative stress assessed by total antioxidant status (TAS) and total oxidan...
Source: Clinical Neuropharmacology - November 1, 2022 Category: Neurology Tags: Original Articles Source Type: research
Effects of GRIN2B, GRIA1, and BDNF Polymorphisms on the Therapeutic Action of Ketamine and Esketamine in Treatment-Resistant Depression Patients: Secondary Analysis From a Randomized Clinical Trial
Conclusions
We found no association between the studied single nucleotide polymorphisms (rs6265, rs1805502, and rs1994862) and ketamine's therapeutic action in TRD patients. Further studies with larger samples are needed to clarify the utility of these genes of interest as predictors for antidepressant treatment. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2022 Category: Neurology Tags: Original Articles Source Type: research
Cultural Considerations in Fahr's Syndrome: A Case Report
Conclusions
Cultural considerations in medicine can enhance patient-physician relationships and ultimately strengthen clinical outcomes. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2022 Category: Neurology Tags: Case Reports Source Type: research
Posterior Reversible Encephalopathy Syndrome Occurred During the Use of Pseudoephedrine: A Case Report
Conclusion
We presented a PRES case with seizures after using 2 doses of pseudoephedrine. In addition to hypertension, several factors have been blamed, such as eclampsia-preeclampsia, some immunosuppressive and chemotherapeutic drugs, some kidney diseases. Although the patient had no known risk factors for PRES, he was diagnosed with hypertension and diabetes mellitus during follow-up. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2022 Category: Neurology Tags: Case Reports Source Type: research
Intravenous Fosphenytoin Therapy as an Acute Rescue Treatment for Glossopharyngeal Neuralgia Crisis in Patients Awaiting Neurosurgical Procedures: A Case Series
Conclusions
These results provide new insights into the innovative therapeutic option of intravenous fosphenytoin and contribute to advancements in treating acute GPN crisis. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2022 Category: Neurology Tags: Case Reports Source Type: research
Ocrelizumab for Post-Alemtuzumab Paradoxical Disease Activity in Highly Active Multiple Sclerosis
We present a case of a person with multiple sclerosis with severe disease activation after alemtuzumab administration that may represent paradoxical B cell–mediated disease activity. The patient was successfully treated with ocrelizumab. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2022 Category: Neurology Tags: Case Reports Source Type: research
Persistent Hiccups Induced by Supratentorial Infarcts and Successful Treatment With a Combination of Perampanel and Baclofen: A Case Report
Conclusions
Our patient's case suggested that perampanel with baclofen may be effective for myoclonus due to respiratory reflex disinhibition and can be used to treat hiccups derived from cerebral infarctions. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2022 Category: Neurology Tags: Case Reports Source Type: research
Evidence for Anti-inflammatory Effects of Adalimumab in Treatment of Patients With Major Depressive Disorder: A Pilot, Randomized, Controlled Trial
This study aimed to evaluate the efficacy and safety of adalimumab adjunct to sertraline in adults with MDD and increased levels of systemic inflammation.
Methods
In a 6-week, randomized, double-blind, placebo-controlled trial, 36 patients with MDD and high-sensitivity C-reactive protein ≥3 mg/L were equally assigned to receive sertraline plus either adalimumab or placebo. Participants were assessed using the Hamilton Depression Rating Scale (HAM-D) at baseline, week 3, and week 6. Moreover, serum concentrations of inflammatory biomarkers were measured at baseline and trial end point. Finally, patients were assess...
Source: Clinical Neuropharmacology - September 1, 2022 Category: Neurology Tags: Original Articles Source Type: research
Resveratrol Treatment of Autism Spectrum Disorder—A Pilot Study
Conclusions
RSV is a safe molecule for administrating in the pediatric population, able to modulate behavior alterations and molecules associated with the immune system, becoming a promising therapeutic strategy for large-scale studies in ASD, to investigate both behavioral and molecular approaches. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2022 Category: Neurology Tags: Original Articles Source Type: research
