Beneficial Effect of a Relatively Low Dose of Clozapine in a Bipolar Depression Patient With Comorbid Obsessive-Compulsive Disorder and Severe Suicidality
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Letter to the Editor Source Type: research

One Plus One Sometimes Equals More Than Two: Long-acting Injectable Aripiprazole Adjunction in Clozapine-Resistant Schizophrenia
In this report, we present a patient whose positive symptoms did not improve despite being treated with clozapine monotherapy at a therapeutic dose for 4 months, and whose symptoms began to resolve after aripiprazole long-acting injection adjunction to clozapine. A 22-year-old man was diagnosed as having schizophrenia last year in his first admission, with symptoms of auditory hallucinations, persecutory delusions, and associated social withdrawal. His positive symptoms did not improve despite being treated with risperidone, olanzapine, and paliperidone. Oral clozapine monotherapy was planned, and the daily dose was increa...
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Resolution of Citalopram Sexual Adverse Effects With Low Dose of Cariprazine: A Case Report
We report a case of substantial improvement in sexual function with cariprazine at very low dosage. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Trigeminal Neuralgia With Extraoral Trigger Zone Successfully Treated With Intraoral Injections of Botulinum Toxin: A Case Report
We present the case of a patient with trigeminal neuralgia with multiple misdiagnoses and poorly managed pain. Despite the presence of trigger zones both inside and outside her mouth, complete symptom resolution was ultimately achieved through onabotulinumtoxinA injections, delivered solely intraorally. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Lithium Use During Pregnancy in a Patient With Bipolar Disorder and Multiple Sclerosis
Although lithium is widely used as a first-line treatment for mood disorders, its mood-stabilizing effects remain not fully understood. A growing body of data are stressing that lithium seems to show broader properties, including neuroprotective effects. Lithium's ability to inhibit glycogen synthase kinase 3β, an enzyme that participates in the phosphorylation of τ, a microtubule-associated protein, stimulated interest in its possible therapeutic role in Alzheimer disease and other neurodegenerative disorders. Preliminary data also support exploration of lithium's potential therapeutic role in multiple sclerosis,...
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Vitamin B6 Deficiency in Patients With Parkinson Disease Treated With Levodopa/Carbidopa
Conclusions Vitamin B6 could play an important role in PD and its levels seem to be influenced by L-DOPA/CD. Plasma vitamin B6 levels should be monitored in patients receiving high L-DOPA/CD doses, especially those treated with intraduodenal infusion. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Effect of Lomerizine Hydrochloride on Preventing Strokes in Patients With Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
Conclusions Our results suggest the effect of lomerizine on preventing secondary stroke in CADASIL patients. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Does Pregnenolone Adjunct to Risperidone Ameliorate Irritable Behavior in Adolescents With Autism Spectrum Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial?
Conclusions Pregnenolone adjunct to risperidone could attenuate core features associated with ASD. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Nalbuphine Exhibited a Better Adjuvant Than Dexmedetomidine in Supraclavicular Brachial Plexus Block in Youths
Conclusion In summary, our study suggests that nalbuphine is a better anesthesia adjuvant for supraclavicular brachial plexus block in young patients. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Dextromethorphan Abuse Among Opioid-Dependent Patients
Conclusions Further studies are necessary to examine dextromethorphan and its impact on patients with psychiatric comorbidities and psychiatric medication. According to literature, there is a significant drug interaction risk due to the impact of dextromethorphan misuse on serotonin syndrome and psychiatric symptoms.1–3 We recommend active inquiry into and testing for concomitant drug abuse among substituted opioid-dependent patients to reduce the risk of drug interactions and side effects in this especially vulnerable group of patients. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Treatment of Isolated Cataplexy With Low-dose Aripiprazole in an Adolescent Patient
Conclusions In this case report, we present an adolescent girl with IC that is successfully treated with aripiprazole, an antipsychotic. This case report suggests that aripiprazole may be safely used in some adolescents who diagnosed with IC. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Low-dose Aripiprazole Induced Enuresis Continuum in a Child
In this report, we present the case of a 9-year-old boy who developed enuresis continuum after the initiation of a low dose of aripiprazole and describe his rapid improvement when administration of the drug was ended. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Topiramate-Responsive Tremor in a Novel Pathogenic Variant of SPG15 Patient
We reported a case of a HSP-15 girl with a previously reported novel mutation of SPG15 complained of a life disturbing tremor and topiramate as a drug therapy for tremor in our HSP patient. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Topiramate-Associated Movement Disorder: Case Series and Literature Review
Conclusions To the authors' knowledge, there are 6 cases of myoclonus, 5 RLS, 2 dystonia, 1 dyskinesia, and 1 periodic limb MD. The best management is probably the discontinuation of TPM, but in RLS patients, the addition of a dopaminergic agonist can be beneficial. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Skin Picking Successfully Treated With Atomoxetine in Comorbid Skin Picking and Attention-Deficit/Hyperactivity Disorder: A Case Report
“Skin picking disorder” (SPD: also known as neurotic excoriation, psychogenic excoriation, or dermatillomania) is classified in the “obsessive-compulsive and related disorders” category in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and characterized by unintentional, repetitive skin picking behaviors. Atomoxetine is a selective noradrenaline reuptake inhibitor used in the treatment of attention-deficit/hyperactivity disorder (ADHD). In this case report, we present a 9-year-old girl with the comorbid diagnosis of ADHD and SPD treated successfully with atomoxetine. To ou...
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

The Importance of Thiopurine S-Methyltransferase Gene Analysis Before Azathioprine Therapy
We report a 9-year-old girl with a diagnosis of neuromyelitis optica, who developed azathioprine-induced pancytopenia that was subsequently found to be caused by thiopurine-methyltransferase mutation. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

The Efficacy and Safety of DFN-15 for the Treatment of Migraine: A Meta-Analysis of Randomized Controlled Studies
Objectives The efficacy of DFN-15 for pain control of migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of DFN-15 versus placebo on pain control in migraine patients. Patients and Methods We search PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases through November 2019 for randomized controlled trials assessing the effect of DFN-15 versus placebo on pain control in migraine patients. This meta-analysis is performed using the random-effects model. Results Three randomized controlled trials are included in the meta-analysis. Overall, compared...
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Review Articles Source Type: research

The Efficacy and Safety of Piribedil Relative to Pramipexole for the Treatment of Early Parkinson Disease: A Systematic Literature Review and Network Meta-Analysis
Conclusions No significant differences were found for pramipexole versus piribedil in the UPDRS II/III scores from baseline in early PD, with similar safety profiles. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Review Articles Source Type: research

Meta-analysis of Ginkgo biloba Preparation for the Treatment of Alzheimer's Disease
The objective of this study was to investigate the efficacy and safety of Ginkgo biloba preparation for the treatment of Alzheimer disease (AD). Methods Both English (PubMed, Embase, Cochrane Library databases, and the Cochrane Controlled Trials Register) and Chinese (WanFang, Chinese Biomedical, CNKI, and VIP databases) databases were systematically and independently searched by 2 authors from their inception until July 3, 2019. All relevant studies included AD patients who were treated with Ginkgo biloba. The efficacy and safety of the medicine were used as the main measurement index. Results Seven studies (N = 939...
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Review Articles Source Type: research

Low-Dose Aripiprazole Augmentation in the Treatment of Burning Mouth Syndrome: A Case Report
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2020 Category: Neurology Tags: Letter to the Editor Source Type: research

Dose-Dependent Effects of Lithium Treatment on the Aggravation of Antipsychotic-Induced Pisa Syndrome
Pisa syndrome (PS) is a rare lateral truncal dystonia that is related to dopamine-acetylcholine imbalances, and most cases develop during antipsychotic treatment. Here, we report a case of PS that developed during switching to new antipsychotics and titrating lithium, and PS was aggravated when the lithium dose was increased. Truncal deviation was not relieved with switching back to prior antipsychotics or by discontinuation of all antipsychotics. Pisa syndrome resolved only after discontinuing the lithium treatment. This is the first report of dose-dependent effects of lithium treatment on the aggravation of PS, which may...
Source: Clinical Neuropharmacology - May 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

A Case of Abulia From Left Middle Cerebral Artery Stroke in an Adolescent Treated Successfully With Short Duration Olanzapine
Conclusion Further research is needed to develop a better understanding of the pathophysiology of abulia leading to more effective treatment algorithms including more specific diagnostic tools and effective pharmacological interventions. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Successful Treatment With Lithium in a Refractory Patient With Periodic Catatonic Features: A Case Report
Conclusion We concluded that lithium is an optional treatment in patients in whom standard treatment failed. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Life-Threatening Serotonin Syndrome Precipitated by Discontinuation of Serotonin-Dopamine Antagonist in the Presence of Serotonergic Agents: A Case Report
Conclusions Discontinuation of antipsychotics that are 5-HT2 receptor antagonists may lead to serotonin syndrome in patients who take serotonergic agents. As extrapyramidal symptoms and serotonin toxicity share some clinical features, detailed drug history and physical examination are necessary for successful treatment. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Carbamazepine-, Oxcarbazepine-, Eslicarbazepine-Associated Movement Disorder: A Literature Review
Conclusions The number of cases associated with CBZ is higher than those with OXC + ESL. We believe that the study of CBZ contributes not only to the improvement of this drug but also to the knowledge about the drug-induced MD of OXC and ESL. In the literature, the description of the MD onset and recovery has been poorly reported. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2020 Category: Neurology Tags: Review Articles Source Type: research

Effect of Antidepressants on Psychotic Symptoms in Parkinson Disease: A Review of Case Reports and Case Series
Conclusions Whereas the conclusions that can be drawn on the efficacy of antidepressants at reducing PD psychosis are limited because of the poor quality of the reported studies, it is encouraging to notice that there are positive anecdotal reports. Further studies are needed to confirm the potential of these drugs and also to determine if a subtype of patients or of psychotic features may be more likely to be improved by antidepressants. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2020 Category: Neurology Tags: Review Articles Source Type: research

Real-Word Effectiveness and Safety of Dimethyl Fumarate in a Multiple Sclerosis Portuguese Population
Objectives The aim of this study was to evaluate postmarketing dimethyl fumarate (DMF) safety and effectiveness in a real-world population with relapsing-remitting multiple sclerosis (RRMS). Methods This was a retrospective, single-center study with RRMS patients treated with DMF. Demographic, clinical, and imagiological characteristics were analyzed, including annualized relapse rate (ARR), Expanded Disability Status Scale, “No Evidence of Disease Activity 3,” previous treatment, adverse events, treatment duration, and reason for discontinuation. We investigated which baseline variables were associated wi...
Source: Clinical Neuropharmacology - May 1, 2020 Category: Neurology Tags: Original Article Source Type: research

Case Report of Probable Duloxetine-Induced Hyperosmia
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Letter to the Editor Source Type: research

Positive Magnetic Resonance Imaging Evidence of Transient Global Amnesia Following the Use of Sildenafil
Transient global amnesia (TGA) has been proposed as a possible adverse effect of sildenafil. There are rare cases in the literature, but none had strong evidence to support. Our case is the first to demonstrate a focal punctate diffusion-weighted imaging lesion at the right hippocampus after the use of sildenafil. This finding, which is suggestive of cytotoxic edema and is typical for TGA, may provide us evidence for the implication of sildenafil in TGA. We speculate that sildenafil may precipitate TGA by altering blood flow, inducing venous congestion or cortical spreading depression at the hippocampus. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

A Severe Adverse Effect of Atomoxetine: Hypertensive Crisis
Atomoxetine, a selective norepinephrine (noradrenaline) reuptake inhibitor, is an effective medication in attention-deficit hyperactivity disorder with a generally well-tolerated adverse effect profile. However, unusual side effects may occur during treatment. Here we report a case of hypertensive crisis in an 8-year-old male patient with autism spectrum disorder and attention-deficit hyperactivity disorder receiving atomoxetine treatment. We plan to discuss the clinical picture of the subject and importance of close monitoring during atomoxetine treatment. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Olanzapine-Associated Pisa Syndrome in an Autistic Adolescent
Conclusions In patients with balance problems and abnormal posture as a result of olanzapine use, the clinician should keep in mind Pisa syndrome. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Atomoxetine Induced Skin Picking: A Case Report
“Skin picking disorder,” also known as “dermatillomania” or “psychogenic excoriation,” is classified in the “Obsessive Compulsive and Related Disorders” category in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and characterized by repetitive skin picking behaviors resulting in skin lesions. Atomoxetine (ATX) is a selective norepinephrine (noradrenaline) reuptake inhibitor commonly used in the management of attention-deficit/hyperactivity disorder. Atomoxetine is considered to increase levels of noradrenaline and dopamine by inhibiting norepinephrine tr...
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Prednisolone as Adjunctive Treatment to Risperidone in Children With Regressive Type of Autism Spectrum Disorder: A Randomized, Placebo-Controlled Trial
This study aimed to evaluate efficacy and safety of prednisolone as an adjunctive treatment to risperidone, in children with regressive autism spectrum disorder (ASD). Methods The current 12-week, randomized, single-blinded, placebo-controlled trial recruited 37 patients with regressive ASD. The participants were allocated to receive either 1 mg/kg per day prednisolone or matched placebo in addition to risperidone. The Aberrant Behavior Checklist-Community Edition (ABC-C) scale and Childhood Autism Rating Scale (CARS) were used to measure behavioral outcomes at weeks 0, 4, 8, and 12 of the study course. The primary outc...
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Fingolimod for Relapsing-Remitting Multiple Sclerosis: The Experience From Saudi Arabia
Conclusions Our multicenter study provides further evidence for the efficacy of fingolimod in reducing clinical and radiological disease activity in patients with RRMS. The reduction in relapse rate, stabilization of the EDSS score, and improvement in magnetic resonance imaging images were similar to other observational studies conducted in different countries worldwide. Fingolimod seems to be well tolerated for our multiple sclerosis population. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Coma Reversal After Intravenous Lipid Emulsion Therapy in a Trazodone-Poisoned Patient
A 77-year-old woman developed a deep coma (Glasgow Coma Scale score at 3/15) after a trazodone overdose (maximal ingested dose, 4500 mg), and orotracheal intubation was required for mechanical ventilation. In addition, she presented sinus bradycardia ( (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Adolescent Polypharmacy and Serotonin Syndrome
Conclusions Patients with ADHD often have comorbid psychiatric illness and are treated with multiple psychotropic medications. Given the effects of drug-drug interactions and the serotonergic effects of psychostimulants, clinicians should remain vigilant for the triad of altered mental status, neuromuscular abnormalities, and autonomic hyperactivity seen in serotonin syndrome. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Knee Buckling (Negative Myoclonus) Associated With Clozapine: Reports on 3 Cases
Conclusions Since the number of reported cases on negative myoclonus is limited, there is still a lack of well-established consensus on the management of this disease. It can be concluded that myoclonic jerk may be dose-dependent, sudden dose changes may be effective, anticonvulsants are not effective in all cases, and treatment can be achieved by reducing the dose. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Systematic Evaluation of Levodopa Effect on Visual Improvement in Amblyopia: A Meta-analysis
This study aims to evaluate the effectiveness of levodopa as a therapeutic drug in the treatment of children and adults with amblyopia. Methods We performed a systematic review and meta-analysis with randomized controlled trials of levodopa and placebo in the treatment of amblyopia. All data were identified and extracted from the PubMed, EMBASE, Cochrane libraries, and the Chinese knowledge resource integration database. Results After screening the literature and evaluating the quality, 11 studies met the criteria from 308 studies. The mean difference of LogMAR visual acuity between levodopa and the placebo group was...
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Review Article Source Type: research

Contrast-Induced Encephalopathy Resulting From Use of Ioversol and Iopromide
Conclusions Compared with ioversol, iopromide appeared more likely to lead to CIE. Acute cerebral infarction was an independent risk factor for CIE. The earliest CIE onset was within 5 minutes after injecting contrast. The characteristics of CIE varied significantly for different contrast media. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Experience of Using Adrenocorticotropic Hormone in the Treatment of Patients With Acute Neuromyelitis Optica Who Failed Systemic Steroids: A Case Series
Conclusions Adrenocorticotropic hormone treatment for acute NMO was associated with clinical improvement, suggesting that ACTH could have a role in treating acute NMO patients failing IVMP and declining other treatments. Fewer/less severe AEs were observed with ACTH versus IVMP. Larger, controlled clinical studies are needed. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Psychiatric Patients on Neuroleptics: Evaluation of Parkinsonism and Quantified Assessment of Gait
Objectives We aimed to characterize parkinsonian features and gait performance of psychiatric patients on neuroleptics (PPN) and to compare them to Parkinson's disease (PD) and healthy controls (HC). Methods Hospitalized PPN (n = 27) were recruited, examined, and rated for parkinsonian signs according to the motor part of the Movement Disorders Society Unified Parkinson's Disease Rating Scale and performed a 10-m “timed-up-and-go” (TUG) test with a smartphone-based motion capture system attached to their sternum. Gait parameters and mUPDRS scores were compared to those of consecutive age-matched PD patient...
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

A Preschooler Girl With Hyperekplexia Treated With Escitalopram
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2019 Category: Neurology Tags: Letter to the Editor Source Type: research

Lisdexamfetamine in Pediatric Binge Eating Disorder: A Retrospective Chart Review
Conclusions Lisdexamfetamine dimesylate may have clinical utility for BED in adolescents, but randomized, placebo-controlled studies of its efficacy, tolerability, and safety in this population are needed. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Bupropion Hydrochloride Sustained Release and Diurnal Enuresis: A Previously Unreported Adverse Effect
Bupropion hydrochloride (HCl) is an antidepressant that has many different biological targets, acting as both a norepinephrine-dopamine reuptake inhibitor as well as a nicotinic antagonist. This second-generation antidepressant is available in 3 bioequivalent formulations: immediate release, sustained release, and extended release, allowing providers to customize a patient's regimen for maximum tolerability and compliance. Although bupropion HCl's safety and tolerability have been demonstrated through several clinical trials, there are still a number of adverse effects that have been reported in the literature. These inclu...
Source: Clinical Neuropharmacology - November 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Rocuronium Continuous Infusion for Profound Neuromuscular Blockade: A Systematic Review and Meta-analysis
Conclusions Rocuronium continuous infusion for profound neuromuscular blockade presents inherent advantages in terms of maintenance and stability of the paralysis. Further studies should address the methodological approaches and benefits/drawbacks of this approach. Registration number: CRD42018106626 (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2019 Category: Neurology Tags: Review Article Source Type: research

Efficacy and Placebo Response of Multimodal Treatments for Primary Insomnia: A Network Meta-Analysis
Conclusions The pharmacotherapy seems the most effective in improving sleep efficiency. However, the optimal therapeutic regimen is still uncertain. In addition, the placebo response is significant and robust in treatments of primary insomnia. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Risperidone Combination Therapy With Propentofylline for Treatment of Irritability in Autism Spectrum Disorders: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Conclusions Our findings demonstrated that adjunctive treatment with propentofylline is effective in alleviating disease severity and improving irritability in ASD patients. However, larger studies with longer durations are required to confirm these results. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

The Naranjo Scale and Tardive Syndromes, a Historical Perspective
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2019 Category: Neurology Tags: Letter to the Editor Source Type: research

Treatment of Catatonia in Frontotemporal Dementia: A Lesson From Zolpidem Test
Conclusions In dementia patients, different catatonic symptoms may show differential responses to the therapeutic agents and, if verbal symptoms are dominant, it is worthy to try zolpidem in the early stage. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Priapism With Methylphenidate Use in a Preschool-Aged Boy Resolved With Switching to Atomoxetine
Conclusions This case report suggests that ATX may be safely used in some children who experienced priapism with MPH. Future studies are needed to clarify the risk factors and etiologic mechanisms of this adverse reaction. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2019 Category: Neurology Tags: Case Reports Source Type: research