Coma Reversal After Intravenous Lipid Emulsion Therapy in a Trazodone-Poisoned Patient
A 77-year-old woman developed a deep coma (Glasgow Coma Scale score at 3/15) after a trazodone overdose (maximal ingested dose, 4500 mg), and orotracheal intubation was required for mechanical ventilation. In addition, she presented sinus bradycardia ( (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Adolescent Polypharmacy and Serotonin Syndrome
Conclusions Patients with ADHD often have comorbid psychiatric illness and are treated with multiple psychotropic medications. Given the effects of drug-drug interactions and the serotonergic effects of psychostimulants, clinicians should remain vigilant for the triad of altered mental status, neuromuscular abnormalities, and autonomic hyperactivity seen in serotonin syndrome. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Knee Buckling (Negative Myoclonus) Associated With Clozapine: Reports on 3 Cases
Conclusions Since the number of reported cases on negative myoclonus is limited, there is still a lack of well-established consensus on the management of this disease. It can be concluded that myoclonic jerk may be dose-dependent, sudden dose changes may be effective, anticonvulsants are not effective in all cases, and treatment can be achieved by reducing the dose. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Systematic Evaluation of Levodopa Effect on Visual Improvement in Amblyopia: A Meta-analysis
This study aims to evaluate the effectiveness of levodopa as a therapeutic drug in the treatment of children and adults with amblyopia. Methods We performed a systematic review and meta-analysis with randomized controlled trials of levodopa and placebo in the treatment of amblyopia. All data were identified and extracted from the PubMed, EMBASE, Cochrane libraries, and the Chinese knowledge resource integration database. Results After screening the literature and evaluating the quality, 11 studies met the criteria from 308 studies. The mean difference of LogMAR visual acuity between levodopa and the placebo group was...
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Review Article Source Type: research

Contrast-Induced Encephalopathy Resulting From Use of Ioversol and Iopromide
Conclusions Compared with ioversol, iopromide appeared more likely to lead to CIE. Acute cerebral infarction was an independent risk factor for CIE. The earliest CIE onset was within 5 minutes after injecting contrast. The characteristics of CIE varied significantly for different contrast media. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Experience of Using Adrenocorticotropic Hormone in the Treatment of Patients With Acute Neuromyelitis Optica Who Failed Systemic Steroids: A Case Series
Conclusions Adrenocorticotropic hormone treatment for acute NMO was associated with clinical improvement, suggesting that ACTH could have a role in treating acute NMO patients failing IVMP and declining other treatments. Fewer/less severe AEs were observed with ACTH versus IVMP. Larger, controlled clinical studies are needed. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Psychiatric Patients on Neuroleptics: Evaluation of Parkinsonism and Quantified Assessment of Gait
Objectives We aimed to characterize parkinsonian features and gait performance of psychiatric patients on neuroleptics (PPN) and to compare them to Parkinson's disease (PD) and healthy controls (HC). Methods Hospitalized PPN (n = 27) were recruited, examined, and rated for parkinsonian signs according to the motor part of the Movement Disorders Society Unified Parkinson's Disease Rating Scale and performed a 10-m “timed-up-and-go” (TUG) test with a smartphone-based motion capture system attached to their sternum. Gait parameters and mUPDRS scores were compared to those of consecutive age-matched PD patient...
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

A Preschooler Girl With Hyperekplexia Treated With Escitalopram
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2019 Category: Neurology Tags: Letter to the Editor Source Type: research

Lisdexamfetamine in Pediatric Binge Eating Disorder: A Retrospective Chart Review
Conclusions Lisdexamfetamine dimesylate may have clinical utility for BED in adolescents, but randomized, placebo-controlled studies of its efficacy, tolerability, and safety in this population are needed. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Bupropion Hydrochloride Sustained Release and Diurnal Enuresis: A Previously Unreported Adverse Effect
Bupropion hydrochloride (HCl) is an antidepressant that has many different biological targets, acting as both a norepinephrine-dopamine reuptake inhibitor as well as a nicotinic antagonist. This second-generation antidepressant is available in 3 bioequivalent formulations: immediate release, sustained release, and extended release, allowing providers to customize a patient's regimen for maximum tolerability and compliance. Although bupropion HCl's safety and tolerability have been demonstrated through several clinical trials, there are still a number of adverse effects that have been reported in the literature. These inclu...
Source: Clinical Neuropharmacology - November 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Rocuronium Continuous Infusion for Profound Neuromuscular Blockade: A Systematic Review and Meta-analysis
Conclusions Rocuronium continuous infusion for profound neuromuscular blockade presents inherent advantages in terms of maintenance and stability of the paralysis. Further studies should address the methodological approaches and benefits/drawbacks of this approach. Registration number: CRD42018106626 (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2019 Category: Neurology Tags: Review Article Source Type: research

Efficacy and Placebo Response of Multimodal Treatments for Primary Insomnia: A Network Meta-Analysis
Conclusions The pharmacotherapy seems the most effective in improving sleep efficiency. However, the optimal therapeutic regimen is still uncertain. In addition, the placebo response is significant and robust in treatments of primary insomnia. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Risperidone Combination Therapy With Propentofylline for Treatment of Irritability in Autism Spectrum Disorders: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Conclusions Our findings demonstrated that adjunctive treatment with propentofylline is effective in alleviating disease severity and improving irritability in ASD patients. However, larger studies with longer durations are required to confirm these results. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

The Naranjo Scale and Tardive Syndromes, a Historical Perspective
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2019 Category: Neurology Tags: Letter to the Editor Source Type: research

Treatment of Catatonia in Frontotemporal Dementia: A Lesson From Zolpidem Test
Conclusions In dementia patients, different catatonic symptoms may show differential responses to the therapeutic agents and, if verbal symptoms are dominant, it is worthy to try zolpidem in the early stage. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Priapism With Methylphenidate Use in a Preschool-Aged Boy Resolved With Switching to Atomoxetine
Conclusions This case report suggests that ATX may be safely used in some children who experienced priapism with MPH. Future studies are needed to clarify the risk factors and etiologic mechanisms of this adverse reaction. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Bupropion Causes Misdiagnosis in Brain Dopamine Transporter Imaging for Parkinsonism
Conclusions Bupropion has previously generally been discontinued 1 week prior DAT imaging, which meets the recommended, albeit arbitrary, time interval of 5 plasma clearance half-lives before the scan. One-week discontinuation of bupropion before DAT imaging may be insufficiently short. Our case shows that longer medication washout and rescan may be needed when there is contradiction between the imaging result and clinical outcome in patients with medications affecting DAT binding. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Hypothermia Associated With Melatonin Ingestion in a Child With Autism
We present a case of hypothermia in an autistic child with a sleep disorder whose body temperature decreased to 34°C after a single dose of melatonin. Hypothermia continued for 2 more days, but her nighttime sleeping problems decreased. This case is important because it demonstrates the possible risk of hypothermia with melatonin use in children with autism with a sleep disorder. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Long-term Apomorphine Infusion Users Versus Short-term Users: An International Dual-center Analysis of the Reasons for Discontinuing Therapy
Conclusions Apomorphine infusion is a minimally invasive therapy and therefore very easy to discontinue if difficulties arise. This fact might explain the high dropout rate of this technique. Successful long-term adherence to APO therapy requires a multidisciplinary health care team approach including regular patient follow-up and assessment and prompt resolution of queries and concerns. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Role of Pregabalin in Treatment of Polyneuropathy in Multiple Myeloma Patients: A Retrospective Study
Conclusions In this retrospective study, improvement in neurological symptoms during PGB therapy was observed in the total population, despite the presence of a distal, sensory axonal neuropathy, as evidenced by neurophysiological examination. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Real-World Effectiveness and Safety of Fingolimod in Patients With Relapsing Remitting Multiple Sclerosis: A Prospective Analysis in Buenos Aires, Argentina
Conclusions The effectiveness of fingolimod in a newly real-world setting was consistent with information provided from phase III clinical trials. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Cerebrospinal Fluid Concentrations of Nimodipine Correlate With Long-term Outcome in Aneurysmal Subarachnoid Hemorrhage: Pilot Study
Conclusions Cerebrospinal fluid nimodipine concentrations measured during hospital drug infusion showed a correlation with long-term clinical outcome in patients with aneurysmal subarachnoid hemorrhage. These very preliminary data suggest that CSF concentrations monitoring may have some value in managing these patients. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Pharmacodynamics, Efficacy, and Safety of IPX203 in Parkinson Disease Patients With Motor Fluctuations
Objectives IPX203 is an investigational oral extended-release capsule formulation of carbidopa and levodopa. The pharmacodynamics and efficacy of IPX203 were compared with immediate-release carbidopa-levodopa (IR CD-LD) in this open-label, rater-blinded, multicenter, crossover study in patients with advanced Parkinson disease (PD). Methods Twenty-eight patients were randomized to 2 weeks of treatment with IR CD-LD followed by IPX203 or IPX203 followed by IR CD-LD. Pharmacokinetic and motor assessments were conducted on days 1 and 15 of each treatment period. Efficacy was assessed using a 3-day PD diary. Pharmacodynami...
Source: Clinical Neuropharmacology - September 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Coprolalia Successfully Treated With Aripiprazole in a Child With Tourette Syndrome
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2019 Category: Neurology Tags: Letters to the Editor Source Type: research

Levetiracetam-Induced Seizure Aggravation in Patients With Focal Cortical Dysplasia
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2019 Category: Neurology Tags: Letters to the Editor Source Type: research

Beneficial Effect of Betahistine, a Structural Analog of Histamine, in Clozapine-Related Sedation
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2019 Category: Neurology Tags: Letters to the Editor Source Type: research

Visual Hallucinations Induced by Clarithromycin in a Child: A Case Report and Literature Review
Conclusion This report highlights neuropsychological adverse effects due to therapeutic doses of clarithromycin therapy as a possible adverse effect in children. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Repetitive Behaviors Treated With N-Acetylcysteine: Case Series
Conclusions Outcome of our cases demonstrates the efficacy of NAC, which is effective and well tolerated on the treatment of obsessive-compulsive disorder–related disorders. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Catatonia in Adolescence: First Onset Psychosis or Anti-NMDAr Encephalitis?
Catatonia is a rare condition that can occur in developmental disorders, but it is more frequently seen in schizophrenia. Recently, a high prevalence of cerebrospinal fluid abnormalities including the detection of antineuronal autoantibodies has been observed in psychotic patients. Among these autoimmune encephalopathies associated with a psychiatric condition, a great deal of attention has been paid to anti–N-methyl-D-aspartate receptor (NMDAr) encephalitis, which may present, among other things, symptoms such as catatonia, which therefore imposes a differential diagnosis with respect to the early psychosis. The aim...
Source: Clinical Neuropharmacology - July 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Memantine Rescues Neurosyphilis-Related Schizophrenic-like Features and Cognitive Deficit
Conclusions Memantine has an adjunctive effect on neurosyphilis-related neuropsychiatric disorder via modulation of the glutamatergic neurotransmission and microglia-induced neuroinflammation. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Treatment of Sleep Bruxism With a Single Daily Dose of Buspirone in a 7-Year-Old Boy
We present a 7-year-old boy whose sleep bruxism symptoms disappeared with a single daily dose of buspirone treatment in this report. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Long-Term Selegiline Monotherapy for the Treatment of Early Parkinson Disease
Objectives The aim of this open-label study was to investigate the long-term safety and efficacy of selegiline as monotherapy in Japanese patients with early Parkinson disease (PD). Methods We conducted a 56-week prospective study in patients with early PD (N = 134) who had previously completed the randomized, double-blind, placebo-controlled phase III trial of selegiline monotherapy for 12 weeks. In the present study, dosing was titrated from 2.5 to 10 mg/d in increments of 2.5 mg/d for 2 weeks. From the seventh week, the dosage was maintained at 10 mg/d until week 56. The primary outcome was any change in the total ...
Source: Clinical Neuropharmacology - July 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Curcumin as Add-On to Antipsychotic Treatment in Patients With Chronic Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study
Conclusions The promising results of curcumin as an add-on to antipsychotics in the treatment of negative symptoms may open a new and safe therapeutic option for the management of schizophrenia. However, these results should be replicated in further studies. ClinicalTrials.gov Identifier: NCT 02298985 (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Subcutaneous Administration of Carbidopa Enhances Oral Levodopa Pharmacokinetics: A Series of Studies Conducted in Pigs, Mice, and Healthy Volunteers
Objectives Although commercially available levodopa (LD) formulations include carbidopa (CD) or benserazide for gastrointestinal L-aromatic amino acid decarboxylase inhibition, little is known how manipulating CD delivery affects the pharmacokinetics of LD. Our research systematically evaluated the peripheral and central pharmacokinetics of LD during continuous subcutaneous CD delivery. Methods We conducted pharmacokinetic experiments in pigs, mice, and humans to characterize effects of continuous subcutaneous CD delivery co-administered with LD as compared with oral LD/CD administration on LD pharmacokinetics. The po...
Source: Clinical Neuropharmacology - July 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Nortriptyline Abuse: A Case Report and Review of the Literature
This article reviews the prior literature in regard to tricyclic antidepressants and anticholinergics as substances of abuse, the proposed mechanisms of this, and susceptible populations, as well as a case review of a patient who admitted to using nortriptyline for its “buzz.” (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Cessation of Skin Picking Symptoms With Methylphenidate Treatment in a Child With Comorbid Skin Picking and Attention-Deficit/Hyperactivity Disorder
Skin picking disorder includes behaviors such as picking, scratching, and squeezing of the normal skin in an impulsive, repetitive manner despite the fact that no dermatological condition is detected. Skin picking disorder may also be comorbid in children with attention-deficit/hyperactivity disorder (ADHD) and vice versa. There is a great deal of data regarding the efficacy and safety of methylphenidate (MPH) treatment of ADHD. In this article, we report the cessation of skin picking behaviors in a 10-year-old girl diagnosed as having skin picking disorder and ADHD after modified-release MPH treatment. To our knowledge, t...
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Serotonin Syndrome After an Alcohol Intake in a Patient Treated With Escitalopram and Clomipramine
Conclusions The present case report suggests that there may be an interaction between alcohol and antidepressants resulting in the serotonin syndrome, and clinicians should be aware of this possibility. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Two Cases of De Novo Pathological Gambling Associated With Aripiprazole
Conclusions In addition to previously recognized risk factors, pathological gambling might occur in young patients whose history did not reveal an addictive tendency while they were sensitive to the pharmacological effect, as well as adverse effects, of psychotropic agents. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Sertraline-Related Amenorrhea in an Adolescent
Amenorrhea is one of the clinical consequences of hyperprolactinemia. Although symptomatic hyperprolactinemia is among the well-described adverse reactions of antipsychotic agents, it may also be reported with the use of selective serotonin reuptake inhibitors. Hereby, we present a case of sertraline-related hyperprolactinemic amenorrhea in an adolescent. Amenorrhea occurred 2 months after starting sertraline, and menstrual cycle restored after stopping the treatment. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Levetiracetam-Related Mania-Like Symptoms: An Adolescent Case
Levetiracetam is an antiepileptic agent that is used for partial and generalized epilepsy. Although it is well tolerated in most cases, behavioral and nonbehavioral adverse effects may be observed. Among behavioral symptoms, depression, hostility, and agitation have been frequently reported. However, mania or mania-like symptoms are relatively rare, especially in children and adolescents. Hereby, we report mania-like symptoms with levetiracetam use in a 15-year-old boy. Mania-like symptoms emerged 3 weeks after starting levetiracetam and disappeared after adding risperidone to ongoing levetiracetam treatment. (Source: Clin...
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Drug-Induced Parkinsonism Manifesting as Gait Freezing in a Patient With Traumatic Brain Injury: A Case Report
Conclusions This is a rare report of drug-induced parkinsonism manifested as freezing of gait, which showed improvement after discontinuation of the causative drugs and subsequent rehabilitation. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Gabapentin-Associated Urinary Incontinence: A Case Verified by Rechallenge
Conclusions Only a few cases with GBP-associated urinary incontinence have been reported in the literature. To the authors' knowledge, these cases described individuals with only 1 attempt of the use of GBP. In this way, the present case was the first to describe a subject with the recurrence of urinary incontinence with the GBP rechallenge. This adverse effect, although not potentially fatal, can be very embarrassing to patients and lead to poor compliance with therapy. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

An Option to Consider for Alternating Hemiplegia of Childhood: Aripiprazole
We report the medical treatment in a case of AHC in a-12-year-old male patient with convulsions. The patient did not respond to available therapies for AHC, except for aripiprazole. After the initiation of aripiprazole therapy, duration and frequency of hemiplegia episodes were decreased. Also, he is currently seizure-free with topiramate treatment for 3 months. On follow-up, a compound heterozygous ATP1A3 mutation c.868C> T (p.R290C)/c.684 + 1G> A was determined. Aripiprazole may reduce the attacks of AHC, which are resistant to other available therapies. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Chronotherapeutics: Recognizing the Importance of Timing Factors in the Treatment of Disease and Sleep Disorders
This article also reviews innovative ways in which physicians are applying time-specified drug treatment (chronopharmacology) for sleep disorders. Here, we present a systematic description of chronopharmacology as well as definitions of key terms that, we believe, will be helpful for newcomers to the field. It is hoped that greater awareness of this new perspective on pharmacology will promote its adoption by researchers and clinicians. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Review Article Source Type: research

The Dopamine Receptor Antagonism of Opipramol: Relevance to Parkinsonism?
Drug-induced Parkinsonism (DIP) represents the second most-frequent etiology of Parkinson syndromes after neurodegenerative disorders. It has been described mainly for antipsychotics, Ca++-channel blockers, antiemetics, and gastrointestinal prokinetics. In this article, we present a clinical case series of 10 patients, retrieved within our movement disorders hospital, with DIP under intake of opipramol. Symptoms completely resolved after drug withdrawal, and associated risk factors were old age, high doses, and presence of cortical atrophy. This frequently prescribed anxiolytic drug has so far not been associated with DIP....
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Effect of Duloxetine for the Treatment of Chronic Central Poststroke Pain
Conclusions Our findings suggest that duloxetine can be effective for managing CPSP. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Factors Associated With Delirium in Surgical Intensive Care Unit Patients Treated With Supplemental Melatonin: A Case-Cohort Study
Conclusions This study describes the use of melatonin in the SICU and characterizes the patients who receive it. Further research is needed to determine the role of melatonin in deliriogenesis and to clarify its utility as a delirioprotectant for postsurgical, critical care patients. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Postinjection Delirium/Sedation Syndrome After 31st Long-Acting Olanzapine Depot Injection
Conclusions More research is necessary to understand the syndrome and the association between PDSS and long-acting olanzapine injection. Clinicians should keep in mind that PDSS may worsen compliance in an index patient and affect the course of the illness. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

Treatment of Poststroke Pathologic Laughing With Duloxetine: A Case Series
Conclusions This case series demonstrates that duloxetine could attenuate pathologic laughing exhibited by stroke patients; however, further randomized controlled studies are necessary to validate our findings. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2019 Category: Neurology Tags: Case Reports Source Type: research

A Case of Schizophrenia With Catatonia Resistant to Lorazepam and Olanzapine Monotherapy But Responsive to Combination Treatment: Is It Time to Consider Using Select Second-Generation Antipsychotics Earlier in the Treatment Algorithm for This Patient Type?
Conclusion We propose a modification to the standard treatment protocol for catatonia, especially in those patients with schizophrenia with catatonic features. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2019 Category: Neurology Tags: Case Reports Source Type: research