Atomoxetine (Strattera)-Induced Pathologic Laughing in a Patient With Pontine Hemorrhage: A Case Report
Conclusions Previously, no single medication has been reported to cause pathologic laughing. Atomoxetine is a stimulant that increases norepinephrine and dopamine levels in the prefrontal cortex. This report suggests that, unlike what is known thus far, norepinephrine and dopamine might play a crucial role in the development of pathologic laughing. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Gabapentin-Induced Myokymia: A Case Report
Conclusions Myokymia is a newly described motor symptom associated with gabapentin toxicity. The mechanism of gabapentin-associated myokymia is currently unknown. A brief medication holiday resulted in the resolution of motor symptoms without significant withdrawal symptoms. Knowledge of this newly reported adverse manifestation can aid physicians in the diagnosis of gabapentin toxicity and prompt treatment, as gabapentin levels are not widely or immediately available. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Late Presentation of Linezolid-Induced Serotonin Syndrome After Maprotiline and Mirtazapine Therapy: A Case Report
Conclusions This case report highlights that linezolid-induced serotonin syndrome can occur late in the course of therapy and the importance of the serotonergic agent washout period before the introduction of linezolid. A multidisciplinary team is important for optimal diagnosis and management of such cases. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Atomoxetine Reduced Binge/Purge Symptoms in a Case of Anorexia Nervosa Binge/Purge Type
Psychopharmacologic treatments for eating disorders (EDs) remain unclear, particularly for anorexia nervosa. As in attention-deficit hyperactivity disorder, a dopaminergic mechanism has been implicated in EDs, prompting our use of atomoxetine in an 18-year-old woman with anorexia nervosa, binge/purge type. Atomoxetine is a highly selective norepinephrine reuptake inhibitor with nonaddictive properties and limited effects of appetite suppression. Doses followed those used in a previous trial of atomoxetine in the treatment of binge ED, and response was assessed over 4 months, with significant improvement in ED behaviors and...
Source: Clinical Neuropharmacology - March 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Subcortical Structure Disruption in Diffusion Tensor Tractography of the Patient With the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity Combined With Neuroleptic Malignant Syndrome: A Case Report
Conclusion This case suggests that the clinical use of diffusion tensor tractography could be helpful to explain the clinical features in the case of SILENT combined with NMS. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Muscle-Specific Tyrosine Kinase Antibody Positive Myasthenia Gravis With Peripheral Nerve Hyperexcitability: Case Report and Literature Review
Conclusions Afterdischarges can be an important indicator of muscle-specific tyrosine kinase antibody positive myasthenia gravis with peripheral nerve hyperexcitability correlated with acetylcholinesterase inhibitors. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

No Association Between SLC6A4 Gene Polymorphisms With Treatment Remission to Venlafaxine in Han Chinese Depressive Patients
Conclusions It suggested that rs6354 or rs1487971 within SLC6A4 appears not to be involved in the venlafaxine treatment outcome in Han Chinese patients with MDD. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2021 Category: Neurology Tags: Original Articles Source Type: research

Oral Levodopa Formulation Does Not Affect Progression of Parkinson Disease
Conclusions We found no difference in symptom progression rate in patients taking IR, CR, or CLE. This clinical observation supports pharmacokinetic studies demonstrating that none of these oral levodopa formulations achieve continuous dopamine stimulation. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2021 Category: Neurology Tags: Original Articles Source Type: research

A Systematic Review of Seizure-Freedom Rates in Patients With Benign Epilepsy of Childhood With Centrotemporal Spikes Receiving Antiepileptic Drugs
Conclusions The available literature suggests the use of sulthiame, levetiracetam, or clobazam as first-line agents for the treatment of BECTS. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2021 Category: Neurology Tags: Original Articles Source Type: research

Methylphenidate-Induced Enuresis: 3 Case Reports
This report presents the cases of 3 children with ADHD who displayed enuresis during MPH treatment. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Fluoxetine-induced Systemic Hypertension in a 12-Year-Old Girl: A Case Report
Fluoxetine, a selective serotonin reuptake inhibitor, is an efficacious medication in social anxiety disorder with a generally well-tolerated adverse effect profile. However, infrequent side effects may occur during treatment. Here, we report a case of systemic hypertension in a 12-year-old female patient with social anxiety disorder receiving fluoxetine treatment. To the best of our knowledge, this is the first report of fluoxetine-induced systemic hypertension in children and adolescences. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Lithium for Carbamazepine-Induced Syndrome of Inappropriate Antidiuretic Hormone
Conclusions Carbamazepine may sometimes be the best or only viable treatment option for patients with bipolar illness or other conditions. When its use is complicated by syndrome of inappropriate ADH, dose reduction and fluid restriction are the simplest options but, if ineffective, addition of lithium may be a feasible, albeit somewhat complicated, alternative. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Flumazenil for Successful Seizure Induction With Electroconvulsive Therapy: Case Report and Literature Review
Conclusions Flumazenil, an antidote of benzodiazepines, may be effective regardless of whether benzodiazepines are in use. Because inefficient ECT is clinically problematic, more studies are necessary to investigate the effectiveness of flumazenil for successful seizure induction with ECT. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Modafinil Induced Spontaneous Ejaculation Without Orgasm: A Case Report
Modafinil is used for the treatment of narcolepsy and obstructive sleep apnea syndrome, and as add-on therapy for psychiatric diseases such as attention-deficit/hyperactivity disorder, schizophrenia, depression, cocaine addiction. The exact mechanism of action is unknown. Modafinil may be helpful for the treatment of erectile dysfunction and premature ejaculation. The addition of modafinil to antidepressant treatment may provide positive effects on sexual dysfunction. However, side effects such as hypersexuality and unwanted orgasm have been reported with modafinil treatment. In this article, a patient who had developed sp...
Source: Clinical Neuropharmacology - January 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Intravenous Immunoglobulin in the Treatment of Alternating Hemiplegia of Childhood
We described 2 patients with AHC who were exposed to intravenous immunoglobulin (IVIG) treatment because of an alternative diagnosis. An 8-year-old girl received 4 years of periodic IVIG infusion and was free of paroxysmal events during the first 16 months of therapy. A 2-year-old boy received IVIG infusion for 10 months and remained seizure-free for 2 years since the beginning of the treatment, but without a definite change in hemiplegic episodes. Our report is the first description of IVIG use in patients with AHC. Although these patients did not achieve complete remission, partial responsiveness was noted. Although the ...
Source: Clinical Neuropharmacology - January 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Severe Relapses of Neuromyelitis Optica Spectrum Disorder During Treatment With Dimethyl Fumarate
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disease of the central nervous system, characterized by a specific antibody that selectively binds aquaporin-4 channel. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2021 Category: Neurology Tags: Case Reports Source Type: research

Supplementation With Dexmedetomidine for Transsphenoidal Resection of Pituitary Adenoma: A Meta-Analysis of Randomized Controlled Trials
Introduction The effect of dexmedetomidine supplementation on hemodynamic stability for transsphenoidal resection of pituitary adenoma remains controversial. We conduct a systematic review and meta-analysis to explore the influence of dexmedetomidine supplementation on hemodynamic stability for transsphenoidal resection of pituitary adenoma. Methods We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through August 2020 for randomized controlled trials assessing the effect of dexmedetomidine supplementation on transsphenoidal resection of pituitary adenoma. Results Four ...
Source: Clinical Neuropharmacology - January 1, 2021 Category: Neurology Tags: Original Articles Source Type: research

Effects of Rivastigmine on Brain Functional Networks in Patients With Alzheimer Disease Based on the Graph Theory
Conclusions There are similar systemic network properties between patients with AD and HC. Rivastigmine cannot alter systemic network attributes in patients with AD. However, it improves the topological properties of regional networks and between-node information transmission in patients with AD. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2021 Category: Neurology Tags: Original Articles Source Type: research

The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies
Introduction The efficacy of vitamin D for migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of vitamin D versus placebo on treatment in migraine patients. Methods We search PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases through April 2020 for randomized controlled trials assessing the effect of vitamin D versus placebo on treatment efficacy in migraine patients. This meta-analysis is performed using the random-effect model. Results Five randomized controlled trials are included in the meta-analysis. Overall, compared with cont...
Source: Clinical Neuropharmacology - January 1, 2021 Category: Neurology Tags: Original Articles Source Type: research

Botulinum Toxin Monotherapy for the Treatment of Essential Tremor: Life Quality Effect
Conclusion We believe that our study is valuable because there is no research on the effect of BoNT-A administration on ET treatment in the our country population and because the effect of BoNT-A treatment on quality of life in patients with ET was evaluated using the ET-specific QUEST scale. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2021 Category: Neurology Tags: Original Articles Source Type: research

Capgras Syndrome Associated With Bromazepam in a Patient With Vascular Dementia
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2020 Category: Neurology Tags: Letters to the Editor Source Type: research

Lipid Emulsion Treatment for Trazodone Toxicity–Induced Coma
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2020 Category: Neurology Tags: Letters to the Editor Source Type: research

Patient Case Report: Memantine for the Treatment of Occipital Neuralgia
Occipital neuralgia (ON) is described as a shooting, stabbing pain in the posterior part of the scalp that involves the occipital nerve. The epidemiology and pathophysiology are uncertain, but ON is considered distinct from other headache types. At the time of this writing, memantine for the treatment of ON has not been described in the literature. The following details a case report of successful treatment of ON with memantine. A 64-year-old, 91-kg, White man presented with severe headache associated with ON. Previous trials of oral medications, acupuncture, or physical therapy did not provide relief. The patient reported...
Source: Clinical Neuropharmacology - November 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Sertraline for Trypophobia: Report of an Adolescent Case
Trypophobia is a clinical entity that is characterized by unpleasant feelings related to or an aversion to irregular patterns of small holes or bumps. There are insufficient data about the etiological factors underlying trypophobia. It has been associated with anxiety disorders because it shows comorbidity and symptom similarity with anxiety disorders. Literature on the treatment strategies of trypophobia is somewhat limited. In this case report, we present an adolescent girl with trypophobia that is successfully treated with sertraline. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

The Efficacy of Lasmiditan for the Treatment of Migraine: A Meta-Analysis of Randomized Controlled Studies
Introduction The efficacy of lasmiditan is used to alleviate migraine. We conduct a systematic review and meta-analysis to explore the influence of lasmiditan versus placebo on pain control in patients with migraine. Methods We search the PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through June 2020 for randomized controlled trials (RCTs) assessing the effect of lasmiditan versus placebo on pain control in patients with migraine. This meta-analysis was performed using the random effects model. Results Four randomized controlled trials are included in the meta-analysis. Overall, c...
Source: Clinical Neuropharmacology - November 1, 2020 Category: Neurology Tags: Review Article Source Type: research

The Optimal Dose of Amobarbital in the Wada Test for the Presurgical Evaluation of Patients With Temporal Lobe Epilepsy
Objective The use of amobarbital in the Wada test varied between epilepsy centers, with no unified dosing or protocols available in the literature to standardize its use. We aimed to determine the dose of amobarbital in the presurgical evaluations of patients with temporal lobe epilepsy. Methods A retrospective study of patients with temporal lobe epilepsy seen between January 2004 and December 2018 in King Faisal Specialist Hospital and Research Centre in Jeddah, Saudi Arabia, was conducted, and those who successfully underwent a Wada test were studied. A neuropsychologist or a neurologist will assess the memor...
Source: Clinical Neuropharmacology - November 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

The Effect of Epilepsy and Antiepileptic Drugs on Cortical Motor Excitability in Patients With Temporal Lobe Epilepsy
This study included 40 adults (males, 22; females, 18) with TLE with impaired awareness or to bilateral tonic clonic seizures (mean age, 32.50 ± 3.38 years; duration of illness, 6.15 ± 2.02 years) and on treatment with AEDs (valproate, 15; carbamazepine, 15; levetiracetam, 10]. The majority (62.5%) were seizure-free for ≥1 year on AEDs before TMS testing. All had normal brain magnetic resonance imaging except two, who had mesial temporal sclerosis. Comparing the entire patients with controls, patients had significantly bihemispheric higher RMT and AMT particularly over the epileptic hemisphere and shorter ...
Source: Clinical Neuropharmacology - November 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Quetiapine Relieved Pisa Syndrome in Patient With Parkinson Disease
Conclusions Drug-related Pisa syndrome may be associated with the imbalance in dopamine-choline. Pisa syndrome may have similar mechanisms and treatment options to dystonia. This is the first report of quetiapine relieving Pisa syndrome in a patient with Parkinson disease. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Beneficial Effect of a Relatively Low Dose of Clozapine in a Bipolar Depression Patient With Comorbid Obsessive-Compulsive Disorder and Severe Suicidality
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Letter to the Editor Source Type: research

One Plus One Sometimes Equals More Than Two: Long-acting Injectable Aripiprazole Adjunction in Clozapine-Resistant Schizophrenia
In this report, we present a patient whose positive symptoms did not improve despite being treated with clozapine monotherapy at a therapeutic dose for 4 months, and whose symptoms began to resolve after aripiprazole long-acting injection adjunction to clozapine. A 22-year-old man was diagnosed as having schizophrenia last year in his first admission, with symptoms of auditory hallucinations, persecutory delusions, and associated social withdrawal. His positive symptoms did not improve despite being treated with risperidone, olanzapine, and paliperidone. Oral clozapine monotherapy was planned, and the daily dose was increa...
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Resolution of Citalopram Sexual Adverse Effects With Low Dose of Cariprazine: A Case Report
We report a case of substantial improvement in sexual function with cariprazine at very low dosage. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Trigeminal Neuralgia With Extraoral Trigger Zone Successfully Treated With Intraoral Injections of Botulinum Toxin: A Case Report
We present the case of a patient with trigeminal neuralgia with multiple misdiagnoses and poorly managed pain. Despite the presence of trigger zones both inside and outside her mouth, complete symptom resolution was ultimately achieved through onabotulinumtoxinA injections, delivered solely intraorally. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Lithium Use During Pregnancy in a Patient With Bipolar Disorder and Multiple Sclerosis
Although lithium is widely used as a first-line treatment for mood disorders, its mood-stabilizing effects remain not fully understood. A growing body of data are stressing that lithium seems to show broader properties, including neuroprotective effects. Lithium's ability to inhibit glycogen synthase kinase 3β, an enzyme that participates in the phosphorylation of τ, a microtubule-associated protein, stimulated interest in its possible therapeutic role in Alzheimer disease and other neurodegenerative disorders. Preliminary data also support exploration of lithium's potential therapeutic role in multiple sclerosis,...
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Vitamin B6 Deficiency in Patients With Parkinson Disease Treated With Levodopa/Carbidopa
Conclusions Vitamin B6 could play an important role in PD and its levels seem to be influenced by L-DOPA/CD. Plasma vitamin B6 levels should be monitored in patients receiving high L-DOPA/CD doses, especially those treated with intraduodenal infusion. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Effect of Lomerizine Hydrochloride on Preventing Strokes in Patients With Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
Conclusions Our results suggest the effect of lomerizine on preventing secondary stroke in CADASIL patients. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Does Pregnenolone Adjunct to Risperidone Ameliorate Irritable Behavior in Adolescents With Autism Spectrum Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial?
Conclusions Pregnenolone adjunct to risperidone could attenuate core features associated with ASD. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Nalbuphine Exhibited a Better Adjuvant Than Dexmedetomidine in Supraclavicular Brachial Plexus Block in Youths
Conclusion In summary, our study suggests that nalbuphine is a better anesthesia adjuvant for supraclavicular brachial plexus block in young patients. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Dextromethorphan Abuse Among Opioid-Dependent Patients
Conclusions Further studies are necessary to examine dextromethorphan and its impact on patients with psychiatric comorbidities and psychiatric medication. According to literature, there is a significant drug interaction risk due to the impact of dextromethorphan misuse on serotonin syndrome and psychiatric symptoms.1–3 We recommend active inquiry into and testing for concomitant drug abuse among substituted opioid-dependent patients to reduce the risk of drug interactions and side effects in this especially vulnerable group of patients. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - September 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Treatment of Isolated Cataplexy With Low-dose Aripiprazole in an Adolescent Patient
Conclusions In this case report, we present an adolescent girl with IC that is successfully treated with aripiprazole, an antipsychotic. This case report suggests that aripiprazole may be safely used in some adolescents who diagnosed with IC. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Low-dose Aripiprazole Induced Enuresis Continuum in a Child
In this report, we present the case of a 9-year-old boy who developed enuresis continuum after the initiation of a low dose of aripiprazole and describe his rapid improvement when administration of the drug was ended. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Topiramate-Responsive Tremor in a Novel Pathogenic Variant of SPG15 Patient
We reported a case of a HSP-15 girl with a previously reported novel mutation of SPG15 complained of a life disturbing tremor and topiramate as a drug therapy for tremor in our HSP patient. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Topiramate-Associated Movement Disorder: Case Series and Literature Review
Conclusions To the authors' knowledge, there are 6 cases of myoclonus, 5 RLS, 2 dystonia, 1 dyskinesia, and 1 periodic limb MD. The best management is probably the discontinuation of TPM, but in RLS patients, the addition of a dopaminergic agonist can be beneficial. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Skin Picking Successfully Treated With Atomoxetine in Comorbid Skin Picking and Attention-Deficit/Hyperactivity Disorder: A Case Report
“Skin picking disorder” (SPD: also known as neurotic excoriation, psychogenic excoriation, or dermatillomania) is classified in the “obsessive-compulsive and related disorders” category in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and characterized by unintentional, repetitive skin picking behaviors. Atomoxetine is a selective noradrenaline reuptake inhibitor used in the treatment of attention-deficit/hyperactivity disorder (ADHD). In this case report, we present a 9-year-old girl with the comorbid diagnosis of ADHD and SPD treated successfully with atomoxetine. To ou...
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

The Importance of Thiopurine S-Methyltransferase Gene Analysis Before Azathioprine Therapy
We report a 9-year-old girl with a diagnosis of neuromyelitis optica, who developed azathioprine-induced pancytopenia that was subsequently found to be caused by thiopurine-methyltransferase mutation. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

The Efficacy and Safety of DFN-15 for the Treatment of Migraine: A Meta-Analysis of Randomized Controlled Studies
Objectives The efficacy of DFN-15 for pain control of migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of DFN-15 versus placebo on pain control in migraine patients. Patients and Methods We search PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases through November 2019 for randomized controlled trials assessing the effect of DFN-15 versus placebo on pain control in migraine patients. This meta-analysis is performed using the random-effects model. Results Three randomized controlled trials are included in the meta-analysis. Overall, compared...
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Review Articles Source Type: research

The Efficacy and Safety of Piribedil Relative to Pramipexole for the Treatment of Early Parkinson Disease: A Systematic Literature Review and Network Meta-Analysis
Conclusions No significant differences were found for pramipexole versus piribedil in the UPDRS II/III scores from baseline in early PD, with similar safety profiles. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Review Articles Source Type: research

Meta-analysis of Ginkgo biloba Preparation for the Treatment of Alzheimer's Disease
The objective of this study was to investigate the efficacy and safety of Ginkgo biloba preparation for the treatment of Alzheimer disease (AD). Methods Both English (PubMed, Embase, Cochrane Library databases, and the Cochrane Controlled Trials Register) and Chinese (WanFang, Chinese Biomedical, CNKI, and VIP databases) databases were systematically and independently searched by 2 authors from their inception until July 3, 2019. All relevant studies included AD patients who were treated with Ginkgo biloba. The efficacy and safety of the medicine were used as the main measurement index. Results Seven studies (N = 939...
Source: Clinical Neuropharmacology - July 1, 2020 Category: Neurology Tags: Review Articles Source Type: research

Low-Dose Aripiprazole Augmentation in the Treatment of Burning Mouth Syndrome: A Case Report
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2020 Category: Neurology Tags: Letter to the Editor Source Type: research

Dose-Dependent Effects of Lithium Treatment on the Aggravation of Antipsychotic-Induced Pisa Syndrome
Pisa syndrome (PS) is a rare lateral truncal dystonia that is related to dopamine-acetylcholine imbalances, and most cases develop during antipsychotic treatment. Here, we report a case of PS that developed during switching to new antipsychotics and titrating lithium, and PS was aggravated when the lithium dose was increased. Truncal deviation was not relieved with switching back to prior antipsychotics or by discontinuation of all antipsychotics. Pisa syndrome resolved only after discontinuing the lithium treatment. This is the first report of dose-dependent effects of lithium treatment on the aggravation of PS, which may...
Source: Clinical Neuropharmacology - May 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

A Case of Abulia From Left Middle Cerebral Artery Stroke in an Adolescent Treated Successfully With Short Duration Olanzapine
Conclusion Further research is needed to develop a better understanding of the pathophysiology of abulia leading to more effective treatment algorithms including more specific diagnostic tools and effective pharmacological interventions. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2020 Category: Neurology Tags: Case Reports Source Type: research