Ultrastructure of the kidney filtration barrier in conditions of distant tumor growth and lithium treatment.

Ultrastructure of the kidney filtration barrier in conditions of distant tumor growth and lithium treatment. Ultrastruct Pathol. 2020 Nov 30;:1-10 Authors: Bgatova N, Taskaeva I Abstract Toxic products generated in the process of tumor growth and as a result of treatment may cause damage to organs distant from the tumor growth, including kidneys. The aim of the work was to identify ultrastructural changes in the components of kidney filtration barrier in conditions of distant tumor growth and lithium carbonate treatment. Tumor growth was induced by the inoculation of hepatocellular carcinoma-29 cells into the right thigh muscle of CBA mice. Lithium carbonate was injected along the periphery of the tumor. Ultrastructural analysis of podocytes and endotheliocytes of glomerular capillaries in the dynamics of tumor growth and lithium carbonate treatment was carried out. Under conditions of distant tumor growth, ultrastructural changes of the kidney filtration barrier were noted. Podocyte hypertrophy was detected, the width of foot process and glomerular membrane were increased. The number of fenestrae was decreased and cell hypertrophy was developed in the structure endothelium of glomerular capillary. Lithium carbonate had some protective effect on podocytes, but caused a significant hypertrophy of endotheliocytes leading to glomerular capillary occlusion. PMID: 33251931 [PubMed - as supplied by publisher]
Source: Ultrastructural Pathology - Category: Pathology Authors: Tags: Ultrastruct Pathol Source Type: research