Lithium May Mildly Slow Aging via Reducing the Age-Related Loss of Kidney Function
The relationship between low dose lithium intake and slowed aging is an interesting one, through not of any practical value given that the effect size is small, where rigorously tested in animal studies. It is visible in human epidemiology thanks to differing levels of lithium in the water supply. Researchers here suggest that this relationship is mediated by a slowing of the age-related decline in kidney function. Loss of kidney function is harmful to organs throughout the body, and it is worthy of note that one of the better studied longevity genes, klotho, appears to function via protection of kidney function in aging.
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Source: Fight Aging! - April 19, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty.
Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying r...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
GSK3 β Overexpression and Cellular Senescence in the Aging Kidney
Senescent cells accumulate with age, a growing imbalance between pace of creation and pace of clearance. The majority of senescent cells come into being as cells reach the Hayflick limit on replication, and survive for only a short time before succumbing to programmed cell death or immune system activity. But senescent cells can be created by injury, inflammation, and other forms of damage as well. Senescent cells secrete pro-growth, inflammatory signals. This is useful in the short term as a way to help the body clear up damage or potentially cancerous cells, but when sustained over the long term it is highly disruptive t...
Source: Fight Aging! - February 25, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
February 2021: Clinical Presentation Provides Clue to Toxicity
A 43-year-old man with a history of bipolar disorder, hypertension, and asthma presented with altered mental status and a tremor. He reported increasing fatigue and hand tremors for one day. He said he and his family recently had food poisoning with vomiting and diarrhea for several days. Those symptoms had resolved. He continued to take all of his prescribed medications, which included lithium carbonate (Lithobid) 800 mg BID and amlodipine 10 mg daily.His initial vital signs were a heart rate of 104 bpm, a blood pressure of 136/82 mm Hg, a respiratory rate of 16 bpm, an oxygen saturation of 99% on room air, and a temperat...
Source: The Tox Cave - January 29, 2021 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Paper Device Rapidly Measures Lithium Levels in Blood
Researchers
at Hokkaido University in Japan have developed a paper-based point-of-care
device which can measure lithium levels in a drop of blood. The device could
help patients with bipolar disorder to keep track of their blood lithium levels.
Lithium carbonate is used to treat bipolar disorder, but must be administered carefully as the concentration range in which the drug is therapeutically active is close to its toxic range. This means that patients require regular blood tests to make sure that they are not receiving too high a dose of the drug.
At present, these blood tests need large blood samples and expensiv...
Source: Medgadget - May 22, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Psychiatry Source Type: blogs
The Side Effects of Lithium: My Love Affair with Water
I never go anywhere without a drink in my hand. My nosey neighbor had the nerve to ask me if I was an alcoholic.
I’m not an alcoholic. I just love ice water, huge, plastic glasses of ice water.
The lithium did that to me. Lithium carbonate, which used to be a medication of choice for bipolar individuals, is a salt. It makes you ridiculously thirsty. For over 15 years, I ingested a lot of it daily. The result was a constant, unquenchable thirst.
I don’t physically need water anymore, but I’m kind of addicted to it psychologically.
Funny, I don’t want juice or coffee or pop. I want water.
This drinking activity will ...
Source: World of Psychology - March 16, 2018 Category: Psychiatry & Psychology Authors: Laura Yeager Tags: Antidepressant Bipolar Creativity Depression Habits Medications Personal Adverse Side Effects Bipolar Disorder Lithium Medication Side Effects Mood Stabilizer Sex Drive Sexual Dysfunction Weight Gain Source Type: blogs
Top 25 Psychiatric Medications for 2016
Most people understand that the role of psychiatric medications is to help alleviate the symptoms associated with different types of mental disorders, such as depression, bipolar disorder, ADHD, schizophrenia, anxiety, and more. Psychiatric medications are an important part of a comprehensive treatment plan for effectively treating people who have a mental health concern or mental illness.
It’s good to know what drugs are being most-often prescribed for mental disorders in the U.S. These are the top 25 psychiatric medications by number of U.S. prescriptions dispensed in 2016, according to QuintilesIMS, a global infor...
Source: World of Psychology - October 12, 2017 Category: Psychiatry & Psychology Authors: John M. Grohol, Psy.D. Tags: General Medications Psychiatry Treatment medications for mental illness Psychiatric Drugs Psychiatric Medications psychiatric meds top psychiatric medications Source Type: blogs
Collective knowledge is the answer … what ’ s the question?
Three’s Company, Ten’s a Crowd
Under the right circumstances, groups are remarkably intelligent, and are often smarter than the smartest people in them. —James Surowiecki, The Wisdom of Crowds
More Undoctored Wisdom:
Let’s take that further: “Groups are remarkably intelligent, and are often smarter than the smartest people in them” . . . including doctors.
Mass panic, stampedes, shoppers trampled on Black Friday—crowds in a panic or seized by anger or greed can be frightening. But what about crowds quietly contemplating a question, each individual applying his or her unique insight and experience? Can we ...
Source: Wheat Belly Blog - October 5, 2017 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Undoctored U Wheat Belly/Undoctored Cruise diy health Dr. Davis healthcare Source Type: blogs
Nightwing #26: Kanium
Nightwing #26 Some Strings Attached
Kyle Higgins, writer
Will Conrad, penciler
I’m always fascinated when a new drug is mentioned in a comic book, especially when the writer puts some thought into it. Example: Kanium, introduced in Nightwing #26:
A decade ago, scientists discovered a new element called Kanium.
Drexler Chemicals was the first to develop its medical potential, converting the alkali metal with carbon and oxygen to create Kanium Carbonate.
They’ve been touting the compound as a breakthrough anti-psychotic…
So how realistic is Kanium? Unlikely, but not entirely impossible.
1. According to Nightwing, ...
Source: Polite Dissent - February 11, 2014 Category: Family Physicians Authors: Scott Tags: newtag Source Type: blogs
