Mapping the selection, availability, price and affordability of essential medicines for mental health conditions at a global level
CONCLUSION: Access to medicines for mental health conditions is an ongoing challenge for health systems worldwide, and no countries can claim to be fully aligned with the general principle of providing full access to essential psychotropic medicines. Low availability and high costs are major barriers to the use of and adherence to essential psychotropic medicines, particularly in low-and middle-income countries.PMID:35438063 | DOI:10.1017/S2045796022000087 (Source: Epidemiology and Psychiatric Sciences)
Source: Epidemiology and Psychiatric Sciences - April 19, 2022 Category: Psychiatry Authors: B Todesco G Ostuzzi C Barbui Source Type: research
Efficacy and Safety of Lithium Treatment in SARS-CoV-2 Infected Patients
At the beginning of the pandemic, we observed that lithium carbonate had a positive effect on the recovery of severely ill patients with COVID-19. Lithium is able to inhibit the replication of several types of viruses, some of which are similar to the SARS-CoV-2 virus, increase the immune response and reduce inflammation by preventing or reducing the cytokine storm. Previously, we published an article with data from six patients with severe COVID-19 infection, where we proposed that lithium carbonate could be used as a potential treatment for COVID-19. Now, we set out to conduct a randomized clinical trial number EudraCT 2...
Source: Frontiers in Pharmacology - April 14, 2022 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 27, Pages 2253: Lithium Ascorbate as a Promising Neuroprotector: Fundamental and Experimental Studies of an Organic Lithium Salt
G. Kalacheva
Given the observable toxicity of lithium carbonate, neuropharmacology requires effective and non-toxic lithium salts. In particular, these salts can be employed as neuroprotective agents since lithium ions demonstrate neuroprotective properties through inhibition of glycogen synthetase kinase-3β and other target proteins, increasing concentrations of endogenous neurotrofic factors. The results of theoretical and experimental studies of organic lithium salts presented here indicate their potential as neuroprotectors. Chemoreactomic modeling of lithium salts made it possible to select lithium a...
Source: Molecules - March 30, 2022 Category: Chemistry Authors: Ivan Yu. Torshin Olga A. Gromova Konstantin S. Ostrenko Marina V. Filimonova Irina V. Gogoleva Vladimir I. Demidov Alla G. Kalacheva Tags: Article Source Type: research
Convulsive Status Epilepticus Induced by Electroconvulsive Therapy in a Patient with Major Depression
We present here an unusual case of a 34-year-old patient with major depression, who developed convulsive status epilepticus persistent for eight days in connection to her first ECT-a very uncommon but serious complication. The patient was, prior to ECT treatment, treated with lithium carbonate and clomipramine for her depression. Six years prior to the ECT, the patient had experienced a convulsive syncope resulting in traumatic subarachnoid haemorrhage. This case emphasizes the importance of medical recording to detect possible risk factors when considering ECT treatment.PMID:35342656 | PMC:PMC8947920 | DOI:10.1155/2022/85...
Source: Case Reports in Psychiatry - March 28, 2022 Category: Psychiatry Authors: Emilie Wieben Marianne Juel Kjeldsen Claus H S ørensen Source Type: research
Neuroprotective substances: are they able to protect the pancreatic beta-cells too?
CONCLUSION: The presented data indicate that the neuroprotective substances attenuating the damaging effect of oxidative stress and neurotrophins deficit cannot only protect neurons but also exert their cytoprotective effect towards pancreatic β-cells. These data may provide a theoretical basis for the further study of neuroprotective drugs as potential therapeutic options for T2D prevention and treatment.PMID:35240968 | DOI:10.2174/1871530322666220303162844 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 4, 2022 Category: Drugs & Pharmacology Authors: Sergei V Ivanov Rita U Ostrovskaya Source Type: research
Neuroprotective substances: are they able to protect the pancreatic beta-cells too?
CONCLUSION: The presented data indicate that the neuroprotective substances attenuating the damaging effect of oxidative stress and neurotrophins deficit cannot only protect neurons but also exert their cytoprotective effect towards pancreatic β-cells. These data may provide a theoretical basis for the further study of neuroprotective drugs as potential therapeutic options for T2D prevention and treatment.PMID:35240968 | DOI:10.2174/1871530322666220303162844 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 4, 2022 Category: Endocrinology Authors: Sergei V Ivanov Rita U Ostrovskaya Source Type: research
Neuroprotective substances: are they able to protect the pancreatic beta-cells too?
CONCLUSION: The presented data indicate that the neuroprotective substances attenuating the damaging effect of oxidative stress and neurotrophins deficit cannot only protect neurons but also exert their cytoprotective effect towards pancreatic β-cells. These data may provide a theoretical basis for the further study of neuroprotective drugs as potential therapeutic options for T2D prevention and treatment.PMID:35240968 | DOI:10.2174/1871530322666220303162844 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 4, 2022 Category: Drugs & Pharmacology Authors: Sergei V Ivanov Rita U Ostrovskaya Source Type: research
Neuroprotective substances: are they able to protect the pancreatic beta-cells too?
CONCLUSION: The presented data indicate that the neuroprotective substances attenuating the damaging effect of oxidative stress and neurotrophins deficit cannot only protect neurons but also exert their cytoprotective effect towards pancreatic β-cells. These data may provide a theoretical basis for the further study of neuroprotective drugs as potential therapeutic options for T2D prevention and treatment.PMID:35240968 | DOI:10.2174/1871530322666220303162844 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 4, 2022 Category: Endocrinology Authors: Sergei V Ivanov Rita U Ostrovskaya Source Type: research
Neuroprotective substances: are they able to protect the pancreatic beta-cells too?
CONCLUSION: The presented data indicate that the neuroprotective substances attenuating the damaging effect of oxidative stress and neurotrophins deficit cannot only protect neurons but also exert their cytoprotective effect towards pancreatic β-cells. These data may provide a theoretical basis for the further study of neuroprotective drugs as potential therapeutic options for T2D prevention and treatment.PMID:35240968 | DOI:10.2174/1871530322666220303162844 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 4, 2022 Category: Drugs & Pharmacology Authors: Sergei V Ivanov Rita U Ostrovskaya Source Type: research
