Vitamin B12 Enhances Nerve Repair and Improves Functional Recovery After Traumatic Brain Injury by Inhibiting ER Stress-Induced Neuron Injury
This study also demonstrated that the vitamin B12 could maintain the stability of the microtubule after TBI. As shown in Figure 4, vitamin B12 exerted microtubule-stabilizing effect in vitro and in vivo. Meanwhile, the high dose (1.5 mg/kg) of vitamin B12 treatment showed better effectiveness than the 0.5 mg/kg dose in TBI mice. In addition, the combination therapy with the ER stress inhibitor 4-PBA partially strengthened the neuro-protective effect of vitamin B12. However, whether vitamin B12 directly inhibits the ER stress signaling pathway requires further investigation.
CNS injury-induced growth cone collapse and retr...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research
Impact of Long-Term Lithium Treatment on Renal Function in Patients With Bipolar Disorder Based on Novel Biomarkers
Conclusions
We found significantly decreased kidney concentrating ability in the long-term lithium-treated patients compared with the control group. Other renal function markers did not indicate any significant signs of renal dysfunction. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - April 16, 2019 Category: Psychiatry Tags: Original Contributions Source Type: research
Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis
We report many of them for the first time. For the already described citrullinated proteins MBP, GFAP, and vimentin, we could identify additional citrullinated sites. The number of modified proteins in MS white matter was higher than control tissue. Citrullinated peptides are considered neoepitopes that may trigger autoreactivity. We used newly identified epitopes and previously reported immunodominant myelin peptides in their citrullinated and non-citrullinated form to address the recognition of CSF-infiltrating CD4+ T cells from 22 MS patients by measuring proliferation and IFN-γ secretion. We did not detect ...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research
Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial.
CONCLUSIONS: Long-term lithium attenuates cognitive and functional decline in amnestic MCI, and modifies Alzheimer's disease-related CSF biomarkers. The present data reinforces the disease-modifying properties of lithium in the MCI-Alzheimer's disease continuum.Declaration of interestNone.
PMID: 30947755 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - April 6, 2019 Category: Psychiatry Tags: Br J Psychiatry Source Type: research
Closed-loop hydrometallurgical treatment of end-of-life lithium ion batteries: Towards zero-waste process and metal recycling in advanced batteries
Publication date: Available online 26 March 2019Source: Journal of Energy ChemistryAuthor(s): Thomas Abo Atia, Giuseppe Elia, Robert Hahn, Pietro Altimari, Francesca PagnanelliAbstractThis work presents an enhanced hydrometallurgical process for recycling lithium ion batteries. First, end-of-life batteries were processed in a physical pre-treatment plant to obtain a representative electrode material. The resulting leachate was purified forth by iron-precipitation, liquid-liquid extractions, and an innovative Li-Na separation, in order to obtain valuable products. These products include high-grade graphite, cobalt oxide (Co...
Source: Journal of Energy Chemistry - March 27, 2019 Category: Chemistry Source Type: research
Flux growth and enhanced electrochemical properties of LiNi0.5Co0.2Mn0.3O2 cathode material by excess lithium carbonate for lithium-ion batteries
Publication date: 5 June 2019Source: Journal of Alloys and Compounds, Volume 788Author(s): Yanyu Qu, Yan Mo, Xiaobo Jia, Liao Zhang, Baodong Du, Yang Lu, De Li, Yong ChenAbstractLayered LiNi0.5Co0.2Mn0.3O2 (LNCM) cathode material is synthesized via an assisted molten salt method with different amounts of Li2CO3 in this work. Rietveld refinements of X-ray diffraction reveal that the samples treated using excess lithium have better crystalline structures with lower cation mixing than pristine LNCM. With variations in Li/transition metal (TM) molar ratio, the morphology changes from aggregations consisting of primary particle...
Source: Journal of Alloys and Compounds - March 5, 2019 Category: Chemistry Source Type: research
The effect of the Li:Na molar ratio on the structural and sorption properties of mixed zirconates for CO2 capture at high temperature
Publication date: April 2019Source: Journal of Environmental Chemical Engineering, Volume 7, Issue 2Author(s): Diana Peltzer, John Múnera, Laura CornagliaAbstractDifferent Li2ZrO3–Na2ZrO3 based sorbents were synthesized by the wet impregnation of a zirconia nanoparticle suspension with a lithium carbonate solution. The solids were characterized by X-ray diffraction, Raman spectroscopy, Scanning Electron Microscopy and X-ray photoelectron spectroscopy, while sorption properties were studied by thermogravimetric measurements carried out at different CO2 partial pressures. The stability experiments were carried out in a th...
Source: Journal of Environmental Chemical Engineering - February 27, 2019 Category: Chemistry Source Type: research
Dose optimization of lithium to increase the uptake and retention of I-131 in rat thyroid.
Conclusion, a Lithium dose of 10 mg/kg body weight in rats could increase the uptake of I-131 in the thyroid, without disturbing the control circulating levels of thyroid hormones.
PMID: 30810817 [PubMed - as supplied by publisher] (Source: Radiation and Environmental Biophysics)
Source: Radiation and Environmental Biophysics - February 27, 2019 Category: Physics Authors: Kumar SB, Kamal R, Khan A, Chadha VD Tags: Radiat Environ Biophys Source Type: research
[ASAP] Iodine Mediator with Anomalously High Redox Potential and Its Application to a Catalytic Cycle for Lithium Carbonate Decomposition toward Future Lithium Reproduction
The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.8b09967 (Source: The Journal of Physical Chemistry C)
Source: The Journal of Physical Chemistry C - February 11, 2019 Category: Chemistry Authors: Tohru Shiga, Hiroki Kondo, Yuichi Kato, Yoko Hase Source Type: research
Advances in the Treatment of Psychotic Depression
AbstractPurpose of reviewOur aim was to update the current understanding of effective treatment strategies for major depression with psychotic features (MDPSY).Recent findingsMost treatment guidelines recommend either the combination of an antidepressant with an antipsychotic or electroconvulsive therapy (ECT) for the treatment of an acute episode of MDPSY. The optimal maintenance treatment after a person responds to either the antidepressant/antipsychotic combination or ECT is unclear particularly as it pertains to length of time the patient needs to take the antipsychotic medication. Further investigation into possible u...
Source: Current Treatment Options in Psychiatry - January 30, 2019 Category: Psychiatry Source Type: research
[ASAP] Probing Lithium Carbonate Formation in Trace-O < sub > 2 < /sub > -Assisted Aprotic Li-CO < sub > 2 < /sub > Batteries Using in Situ Surface-Enhanced Raman Spectroscopy
The Journal of Physical Chemistry LettersDOI: 10.1021/acs.jpclett.8b03272 (Source: The Journal of Physical Chemistry Letters)
Source: The Journal of Physical Chemistry Letters - January 9, 2019 Category: Chemistry Authors: Zhiwei Zhao, Yuwei Su, Zhangquan Peng Source Type: research
Lithium Carbonate in a Poststroke Population: Exploratory Analyses of Neuroanatomical and Cognitive Outcomes
Conclusions
Lithium pharmacotherapy may be associated with gray matter volume change and verbal memory improvement in stroke patients, providing a rationale for future trials assessing therapeutic potential of lithium in a poststroke population. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Brief Reports Source Type: research
Population Pharmacokinetics and Exposure –Response of Lithium Carbonate in Patients Based on Tubular Reabsorption Mechanisms
ConclusionRenal function and urinary pH are important indices in lithium treatment, so the serum concentration of lithium may be predicted based on the renal function and urinary pH. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - December 7, 2018 Category: Drugs & Pharmacology Source Type: research
Lithium disturbs homeostasis of essential microelements in erythrocytes of rats: Selenium as a protective agent?
CONCLUSIONS: The beneficial effect of selenium on disturbances of studied microelements homeostasis as well as on preventing lithium accumulation in erythrocytes in Li receiving animals allows suggesting that further research on selenium application as an adjuvant in lithium therapy is worth carrying on.
PMID: 30321806 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 1, 2018 Category: Drugs & Pharmacology Authors: Kiełczykowska M, Kopciał E, Kocot J, Kurzepa J, Marzec Z, Musik I Tags: Pharmacol Rep Source Type: research
Coal Gasification in the Presence of Lithium Orthosilicate. Part 1: Reaction Kinetics
Publication date: Available online 16 November 2018Source: Chemical Engineering Research and DesignAuthor(s): Michele D. Domenico, Suélen M. Amorim, Gabriela C. Collazzo, Humberto J. José, Regina F.P.M. MoreiraAbstractThe aim of this work was to investigate the simultaneous steam gasification of a Brazilian subbituminous coal and CO2 capture using lithium orthosilicate (Li4SiO4), as a promising process for enhanced hydrogen production. Tests were carried out in a magnetic suspension thermobalance at several conditions (temperature range of 700 to 1000 °C, steam partial pressure range of 0.1 to 0.4 bar and Li4S...
Source: Chemical Engineering Research and Design - November 17, 2018 Category: Chemistry Source Type: research
