Bacterial persister cells tackled
nde Chronic infections can be hard to treat because slow-growing bacteria known as persister cells are usually unharmed by antibiotics. The identification of molecules that target such cells might provide a solution. (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Julian G. Hurdle Aditi Deshpande Tags: News & Views Source Type: research

50 & 100 years ago
50 & 100 years ago Nature 556, 7699 (2018). doi:10.1038/d41586-018-03910-1 Author: (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Tags: News & Views Source Type: research

Two-pore channels open up
Nature 556, 7699 (2018). doi:10.1038/d41586-018-02783-8 Author: Sandip Patel Two-pore channels span the membranes of acidic organelles inside cells. A structural and functional analysis reveals secrets about how these channels open to allow ions to pass across the membrane. (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Sandip Patel Tags: News & Views Source Type: research

Novel electronic states seen in graphene
Nature 556, 7699 (2018). doi:10.1038/d41586-018-02660-4 Author: Eugene J. Mele A simple system made from two sheets of graphene has been converted from an insulator to a superconductor. The finding holds promise for opening up studies of an unconventional form of superconductivity. (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Eugene J. Mele Tags: News & Views Source Type: research

Forests in flux as climate varies
sen How do changes in climate affect forest ecosystems? A study of temperate forests in the United States has assessed alterations in biomass and tree-species composition across a 20-year period of climate variability. (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Sebastiaan Luyssaert J. Hans C. Cornelissen Tags: News & Views Source Type: research

G ünter Blobel (1936–2018)
Günter Blobel (1936–2018) Nature 556, 7699 (2018). doi:10.1038/d41586-018-03849-3 Author: Sanford Simon Biologist who decoded how proteins are sorted in cells. (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Sanford Simon Tags: Obituary Source Type: research

Swansong of Hans Rosling, data visionary
Nature 556, 7699 (2018). doi:10.1038/d41586-018-03921-y Author: Jim O’Neill Jim O’Neill hails the last book by a statistician who recast progress in health and development. (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Jim O ’Neill Tags: Books and Arts Source Type: research

Reward food companies for improving nutrition
Nature 556, 7699 (2018). doi:10.1038/d41586-018-03918-7 Author: Lawrence Haddad Governments must provide incentives for businesses to fix the global food system, not just punish them for acting irresponsibly, argues Lawrence Haddad. (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Lawrence Haddad Tags: Comment Source Type: research

Beguiling dark-matter signal persists 20 years on
Nature 556, 7699 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03991-y Author: Davide Castelvecchi Physicists at experiment in Italy continue to see a data fluctuation that they say represents dark matter — but the mystery deepens. (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Davide Castelvecchi Tags: News Source Type: research

Cancer researchers push to relax rules for clinical trials
Nature 556, 7699 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03355-6 Author: Heidi Ledford US government examines whether criteria for participating in drug studies unnecessarily exclude some people. (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Heidi Ledford Tags: News Source Type: research

NASA reveals major delay for $8-billion Hubble successor
Nature 556, 7699 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03863-5 Author: Alexandra Witze Setback for James Webb Space Telescope could have broader effects on agency’s astrophysics programme. (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Alexandra Witze Tags: News Source Type: research

Use our personal data for the common good
Nature 556, 7699 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03912-z Author: Hetan Shah Technology giants should take lessons from the Human Genome Project and be data stewards, not data owners, says Hetan Shah. (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Hetan Shah Tags: Column Source Type: research

Time to talk about why so many postgrads have poor mental health
Nature 556, 7699 (2018). doi:10.1038/d41586-018-04023-5 Author: An outpouring on Twitter highlights the acute pressures on young scientists. (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Tags: Editorial Source Type: research

Erratum: Evolutionary history resolves global organization of root functional traits
Nature 556, 7699 (2018). doi:10.1038/nature26163 Author: Zeqing Ma, Dali Guo, Xingliang Xu, Mingzhen Lu, Richard D. Bardgett, David M. Eissenstat, M. Luke McCormack & Lars O. Hedin Nature555, 94–97 (2018); doi:10.1038/nature25783In this Letter, owing to an error during the production process, only author L.O.H. was listed as a corresponding author, instead of both D.G. (guodl@igsnrr.ac.cn) and L.O.H. (lhedin@princeton.edu). This has been corrected online. (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Zeqing Ma Dali Guo Xingliang Xu Mingzhen Lu Richard D. Bardgett David M. Eissenstat M. Luke McCormack Lars O. Hedin Tags: Erratum Source Type: research

Erratum: Asparagine bioavailability governs metastasis in a model of breast cancer
Nature 556, 7699 (2018). doi:10.1038/nature26162 Author: Simon R. V. Knott, Elvin Wagenblast, Showkhin Khan, Sun Y. Kim, Mar Soto, Michel Wagner, Marc-Olivier Turgeon, Lisa Fish, Nicolas Erard, Annika L. Gable, Ashley R. Maceli, Steffen Dickopf, Evangelia K. Papachristou, Clive S. D’Santos, Lisa A. Carey, John E. Wilkinson, J. Chuck Harrell, Charles M. Perou, Hani Goodarzi, George Poulogiannis & Gregory J. Hannon Nature554, 378–381 (2018); doi:10.1038/nature25465In this Letter, several errors were inadvertently introduced during the production process. In Fig. 3d, the blue bars should be l...
Source: Nature - April 4, 2018 Category: Research Authors: Simon R. V. Knott Elvin Wagenblast Showkhin Khan Sun Y. Kim Mar Soto Michel Wagner Marc-Olivier Turgeon Lisa Fish Nicolas Erard Annika L. Gable Ashley R. Maceli Steffen Dickopf Evangelia K. Papachristou Clive S. D ’Santos Lisa A. Carey John E. Wilkinson Tags: Erratum Source Type: research

Corrigendum: Commensal bacteria make GPCR ligands that mimic human signalling molecules
Nature 556, 7699 (2018). doi:10.1038/nature25997 Author: Louis J. Cohen, Daria Esterhazy, Seong-Hwan Kim, Christophe Lemetre, Rhiannon R. Aguilar, Emma A. Gordon, Amanda J. Pickard, Justin R. Cross, Ana B. Emiliano, Sun M. Han, John Chu, Xavier Vila-Farres, Jeremy Kaplitt, Aneta Rogoz, Paula Y. Calle, Craig Hunter, J. Kipchirchir Bitok & Sean F. Brady Nature549, 48–53 (2017); doi:10.1038/nature23874In this Article, the description in the Methods of the human stool samples used for the analysis presented in Extended Data Fig. 9 was incomplete. All samples were collected with informed consent under (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Louis J. Cohen Daria Esterhazy Seong-Hwan Kim Christophe Lemetre Rhiannon R. Aguilar Emma A. Gordon Amanda J. Pickard Justin R. Cross Ana B. Emiliano Sun M. Han John Chu Xavier Vila-Farres Jeremy Kaplitt Aneta Rogoz Paula Y. Calle Craig Hunter J. Kipchirc Tags: Corrigendum Source Type: research

Climatic control of Mississippi River flood hazard amplified by river engineering
rey P. Donnelly Over the past century, many of the world’s major rivers have been modified for the purposes of flood mitigation, power generation and commercial navigation. Engineering modifications to the Mississippi River system have altered the river’s sediment levels and channel morphology, but the influence of these modifications on flood hazard is debated. Detecting and attributing changes in river discharge is challenging because instrumental streamflow records are often too short to evaluate the range of natural hydrological variability before the establishment of flood mitigation infrastructure. Her...
Source: Nature - April 4, 2018 Category: Research Authors: Samuel E. Munoz Liviu Giosan Matthew D. Therrell Jonathan W. F. Remo Zhixiong Shen Richard M. Sullivan Charlotte Wiman Michelle O ’Donnell Jeffrey P. Donnelly Tags: Letter Source Type: research

Molecular nucleation mechanisms and control strategies for crystal polymorph selection
ike Sleutel The formation of condensed (compacted) protein phases is associated with a wide range of human disorders, such as eye cataracts, amyotrophic lateral sclerosis, sickle cell anaemia and Alzheimer’s disease. However, condensed protein phases have their uses: as crystals, they are harnessed by structural biologists to elucidate protein structures, or are used as delivery vehicles for pharmaceutical applications. The physiochemical properties of crystals can vary substantially between different forms or structures (‘polymorphs’) of the same macromolecule, and dictate their usability in a scienti...
Source: Nature - April 4, 2018 Category: Research Authors: Alexander E. S. Van Driessche Nani Van Gerven Paul H. H. Bomans Rick R. M. Joosten Heiner Friedrich David Gil-Carton Nico A. J. M. Sommerdijk Mike Sleutel Tags: Letter Source Type: research

A density cusp of quiescent X-ray binaries in the central parsec of the Galaxy
n J. Hord The existence of a ‘density cusp’—a localized increase in number—of stellar-mass black holes near a supermassive black hole is a fundamental prediction of galactic stellar dynamics. The best place to detect such a cusp is in the Galactic Centre, where the nearest supermassive black hole, Sagittarius A*, resides. As many as 20,000 black holes are predicted to settle into the central parsec of the Galaxy as a result of dynamical friction; however, so far no density cusp of black holes has been detected. Low-mass X-ray binary systems that contain a stellar-mass black hole are natural trace...
Source: Nature - April 4, 2018 Category: Research Authors: Charles J. Hailey Kaya Mori Franz E. Bauer Michael E. Berkowitz Jaesub Hong Benjamin J. Hord Tags: Letter Source Type: research

Investigating non-Joulian magnetostriction
Huibin Xu ARISING FROM H. D.Chopra & M.WuttigNature521, 340–343 (2015); doi:10.1038/nature14459Ferromagnetic materials change their shape under an applied magnetic field—a phenomenon known as magnetostriction. This phenomenon was first described for iron by Joule in (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Yangkun He Yongjun Han P. Stamenov B. Kundys J. M. D. Coey Chengbao Jiang Huibin Xu Tags: Brief Communication Arising Source Type: research

Liu et al. reply
aas & Kang Zhang REPLYING TO D. G.Vavvaset al. Nature556, 10.1038/nature26149 (2018); A. L.Solebo, C. J. Hammond & J. S.RahiNature556, 10.1038/nature26148 (2018)In the accompanying Comments, Vavvas et (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Yizhi Liu David Granet Haotian Lin Sally Baxter Hong Ouyang Jie Zhu Shan Huang Zhenzhen Liu Xiaokang Wu Fangbing Yan Xialin Liu Lixia Luo Christopher Heichel Meixia Zhang Wenjia Cai Richard L. Maas Kang Zhang Tags: Brief Communication Arising Source Type: research

Lens regeneration in children
, Miltiadis Tsilimbaris, Douglas Rhee, Kathryn Colby, David G. Hunter, Solon Thanos, Taiji Sakamoto, Louis R. Pasquale, Joan W. Miller, Deborah VanderVeen & Scott R. Lambert ARISING FROM H.Linet al. Nature531, 323–328 (2016); doi:10.1038/nature17181Congenital cataracts are the primary cause of treatable childhood blindness worldwide, affecting about four infants per 10,000 live births. Current surgical techniques have helped thousands (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Demetrios G. Vavvas Thaddeus P. Dryja M. Edward Wilson Timothy W. Olsen Ankoor Shah Ula Jurkunas Roberto Pineda Vasiliki Poulaki Sotiria Palioura Peter Veldman Javier Moreno-Monta ñés Maria D. Pinazo-Duran Jos é Carlos Pastor Miltiadis Tsilimbaris Doug Tags: Brief Communication Arising Source Type: research

Improving outcomes in congenital cataract
. Rahi ARISING FROM H.Linet al. Nature531, 323–328 (2016); doi:10.1038/nature17181Lens regeneration after cataract surgery in infants is a clinical phenomenon with which paediatric ophthalmologists battle. Lin et al. reported a novel surgical technique (Source: Nature)
Source: Nature - April 4, 2018 Category: Research Authors: Ameenat Lola Solebo Christopher J. Hammond Jugnoo S. Rahi Tags: Brief Communication Arising Source Type: research

The tornadoes of sudden cardiac arrest
Nature 555, 7698 (2018). doi:10.1038/d41586-018-01950-1 Author: José Jalife A clever combination of techniques has enabled, for the first time, simultaneous visualization of the 3D waves of electrical and mechanical activity that are responsible for many cases of sudden cardiac death. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Jos é Jalife Tags: News & Views Source Type: research

50 & 100 years ago
50 & 100 years ago Nature 555, 7698 (2018). doi:10.1038/d41586-018-03728-x Author: (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Tags: News & Views Source Type: research

The healthy diabetic cavefish conundrum
Nature 555, 7698 (2018). doi:10.1038/d41586-018-03242-0 Author: Sylvie Rétaux Some Mexican cavefish have a mutation in an insulin receptor protein that affects blood-glucose regulation. The same mutation causes diabetes and health problems in humans, but the diabetic cavefish thrive. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Sylvie R étaux Tags: News & Views Source Type: research

Killer T cells show their kinder side
Ogg The immune system protects the body by responding to invading organisms. But how is an attack on useful resident microbes prevented? A pathway has now been identified that allows immune cells to sense and respond to beneficial bacteria. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Paul Klenerman Graham Ogg Tags: News & Views Source Type: research

Wing origami
Nature 555, 7698 (2018). doi:10.1038/d41586-018-03775-4 Author: Ryan Wilkinson Conventional origami-based techniques for structural design have a limited range of folding patterns. An approach inspired by the wings of earwigs produces structures that were not possible using previous methods. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Ryan Wilkinson Tags: News & Views Source Type: research

A trio of ion channels takes the heat
sta Of the various temperature-sensitive ion channels identified previously, three have now been found to act in concert to detect painful heat and initiate protective reflexes. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Rose Z. Hill Diana M. Bautista Tags: News & Views Source Type: research

Starless night
Nature 555, 7698 (2018). doi:10.1038/d41586-018-03810-4 Author: Andrew Johnston Cold comfort. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Andrew Johnston Tags: Futures Source Type: research

John Sulston (1942 –2018)
John Sulston (1942–2018) Nature 555, 7698 (2018). doi:10.1038/d41586-018-03443-7 Author: Georgina Ferry Nobel-prizewinning champion of the Human Genome Project and open data. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Georgina Ferry Tags: Obituary Source Type: research

Conclusion of conflict and climate analysis questioned
Burke (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Solomon Hsiang Marshall Burke Tags: Correspondence Source Type: research

Boost children ’s digital intelligence to protect against online threats
Boost children’s digital intelligence to protect against online threats Nature 555, 7698 (2018). doi:10.1038/d41586-018-03797-y Author: Yuhyun Park (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Yuhyun Park Tags: Correspondence Source Type: research

Details matter for contaminants in genetic-engineering kits
h Busch (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Nina Koehler Armin Baiker Ulrich Busch Tags: Correspondence Source Type: research

Climate change as a contributor to human conflict
fford (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Colin D. Butler Ben J. Kefford Tags: Correspondence Source Type: research

Critique of conflict and climate analysis is oversimplified
Kelley (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Peter H. Gleick Stephan Lewandowsky Colin Kelley Tags: Correspondence Source Type: research

The ageless appeal of 2001: A Space Odyssey
Nature 555, 7698 (2018). doi:10.1038/d41586-018-03790-5 Author: Piers Bizony Fifty years on, Arthur C. Clarke and Stanley Kubrick’s masterpiece looks more prophetic than ever, reflects Piers Bizony. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Piers Bizony Tags: Books and Arts Source Type: research

How the world goes to work, revelations about microbes and the many faces of motherhood: Books in brief
Nature 555, 7698 (2018). doi:10.1038/d41586-018-03792-3 Author: Barbara Kiser Barbara Kiser reviews five of the week’s best science picks. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Barbara Kiser Tags: Books and Arts Source Type: research

Einstein, Bohr and the war over quantum theory
Nature 555, 7698 (2018). doi:10.1038/d41586-018-03793-2 Author: Ramin Skibba Ramin Skibba explores a history of unresolved questions beyond the Copenhagen interpretation. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Ramin Skibba Tags: Books and Arts Source Type: research

Freeman Dyson ’s life of scientific delight
Freeman Dyson’s life of scientific delight Nature 555, 7698 (2018). doi:10.1038/d41586-018-03791-4 Author: Ann Finkbeiner Ann Finkbeiner is charmed by the originality and acuity in the physicist’s letters. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Ann Finkbeiner Tags: Books and Arts Source Type: research

Cybersecurity needs women
Nature 555, 7698 (2018). doi:10.1038/d41586-018-03327-w Author: Winifred R. Poster Safeguarding our lives online requires skills and experiences that lie beyond masculine stereotypes of the hacker and soldier, says Winifred R. Poster. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Winifred R. Poster Tags: Comment Source Type: research

Divided by DNA: The uneasy relationship between archaeology and ancient genomics
Nature 555, 7698 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03773-6 Author: Ewen Callaway Two fields in the midst of a technological revolution are struggling to reconcile their views of the past. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Ewen Callaway Tags: Feature Source Type: research

US science agencies set to win big in budget deal
ielmi Lawmakers are set to vote this week on legislation that includes significant funding increases for many science agencies. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Lauren Morello Giorgia Guglielmi Tags: News Source Type: research

First space mission dedicated to exoplanet atmospheres gets green light
Nature 555, 7698 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03445-5 Author: Elizabeth Gibney Scientists hope to learn what makes a ‘typical’ solar system from the European Space Agency’s €450-million probe. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Elizabeth Gibney Tags: News Source Type: research

Reduced- calorie diet shows signs of slowing ageing in people
Reduced-calorie diet shows signs of slowing ageing in people Nature 555, 7698 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03431-x Author: Alison Abbott Most comprehensive study yet demonstrates that cutting people’s energy intake turns down their metabolism. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Alison Abbott Tags: News Source Type: research

Ocean scientists work to forecast huge plankton blooms in Arabian Sea
Nature 555, 7698 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03698-0 Author: Jeff Tollefson An operational forecast could help countries prepare for booms in these tiny marine creatures. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Jeff Tollefson Tags: News Source Type: research

Four-in-one 3D printer paves way for custom-made robots and phones
Nature 555, 7698 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03446-4 Author: Mark Zastrow Experimental device is a route to printing smartphones and other electronics. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Mark Zastrow Tags: News Source Type: research

Pioneering Alzheimer ’s study in Colombia zeroes in on enigmatic protein
Pioneering Alzheimer’s study in Colombia zeroes in on enigmatic protein Nature 555, 7698 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03848-4 Author: Sara Reardon Researchers tracking a genetic mutation that causes an early-onset form of the disease hope to uncover new drug targets. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Sara Reardon Tags: News Source Type: research

Athlete brain bank, costly weather and science on social media
Nature 555, 7698 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03772-7 Author: The week in science: 23–29 March 2018. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Tags: Seven Days Source Type: research

Drug executives should take a Hippocratic oath
Nature 555, 7698 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03230-4 Author: Bob More The industry must earn patients’ trust that new medicines really are worth the price, says Bob More. (Source: Nature)
Source: Nature - March 28, 2018 Category: Research Authors: Bob More Tags: Column Source Type: research