Neural tube defects: role of lithium carbonate exposure in embryonic neural development in a murine model.

CONCLUSIONS: Lithium-induced NTDs model in C57BL/6 mice was established. Enhanced cell proliferation and decreased apoptosis following lithium exposure were closely associated with the impairment of inositol biosynthesis, which may contribute to lithium-induced NTDs. IMPACT: Impairment of inositol biosynthesis has an important role in lithium exposure-induced NTDs in mice model. Lithium-induced NTDs model on C57BL/6 mice was established. Based on this NTDs model, lithium-induced impairment of inositol biosynthesis resulted in the imbalance between cell proliferation and apoptosis, which may contribute to lithium-induced NTDs. Providing evidence to further understand the molecular mechanisms of lithium-induced NTDs and enhancing its primary prevention. PMID: 33173184 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33173184?dopt=Abstract

Source: Pediatric Research - November 10, 2020 Category: Pediatrics Authors: Li S, Luo D, Yue H, Lyu J, Yang Y, Gao T, Liu Y, Qin J, Wang X, Guan Z, Wang F, Zhang F, Niu B, Zhang T, Zhong R, Guo J, Wang J Tags: Pediatr Res Source Type: research