Association of common polymorphisms in IL-6 and IL6ST genes with levels of inflammatory markers and coronary stenosis
Publication date: Available online 5 June 2019Source: Meta GeneAuthor(s): Marina V. Klimushina, Nadezhda G. Gumanova, Vladimir A. Kutsenko, Mikhail G. Divashuk, Stepan A. Smetnev, Anna V. Kiseleva, Victoria A. Metelskaya, Alexey N. MeshkovAbstractInflammation is an important factor in the onset and development of pathological lesions of coronary arteries. Various cytokines, including interleukin-6 (IL-6), and pattern recognition receptors, such as C-reactive protein (CRP), are the key inflammatory mediators. We aimed to identify associations of single nucleotide polymorphisms (SNPs) rs1800795 of the IL-6 gene and rs3729960...
Source: Meta Gene - June 6, 2019 Category: Genetics & Stem Cells Source Type: research

First application of next-generation sequencing in patients with hypertrophic cardiomyopathy in Morocco and report of a novel frameshift mutation of MYBPC3 gene: Case report
ConclusionMolecular diagnosis by NGS customized multigenes panel allowed us to set up a fast and firstline upon request cost-efficient strategy in order to screen various genes and diseases including HCM. This approach is well suited to general medical genetics laboratories dealing with almost all types of rare genetic diseases with limited funds for a molecular testing more cost-effective. (Source: Meta Gene)
Source: Meta Gene - June 1, 2019 Category: Genetics & Stem Cells Source Type: research

Corrigendum to DNA methylation and Expression status of Glutamate Receptor Genes in Patients with Oral Squamous Cell Carcinoma
Publication date: Available online 30 May 2019Source: Meta GeneAuthor(s): (Source: Meta Gene)
Source: Meta Gene - May 31, 2019 Category: Genetics & Stem Cells Source Type: research

Mutational, functional and evolutionary analysis of interleukin-11 in Homo sapiens: A detailed in silico exploration for platelet recovery due to chemotherapy induced thrombocytopenia
This study focused on the evolutionary relatedness and residual conservation between the closely related species of IL11. Mutational impact in human due to I171V, which was observed in four species (Urocitellus parryii, Otolemur garnettii, Lagenorhynchus obliquidens and Delphinapterus leucas) in the multiple sequence alignment, was examined. The mutations other than isoleucine were observed to be highly conserved. All the mutations preserved protein functionality. An overall decreasing thermodynamic stability was inferred for the protein with mutations: I171D, R190E and L194D along-with a deleterious effect. Non-deleteriou...
Source: Meta Gene - May 30, 2019 Category: Genetics & Stem Cells Source Type: research

Single nucleotide polymorphisms of lncRNA H19 are not associated with risk of multiple sclerosis in Iranian population
Publication date: Available online 30 May 2019Source: Meta GeneAuthor(s): Mehrdokht Mazdeh, Rezvan Noroozi, Alireza Komaki, Mohammad Taheri, Soudeh Ghafouri-FardAbstractMultiple Sclerosis (MS) as a chronic demyelinating disorder of the central nervous system (CNS) has been associated with dysregulation of several genetic and epigenetic factors. Long non-coding RNAs (lncRNAs) as important epigenetic regulators of gene expression might also contribute in the pathogenesis of MS. In the current study, we genotyped two single nucleotide polymorphisms (SNPs) within the lncRNA H19 (rs2839698 and rs217727) in a population of 402 M...
Source: Meta Gene - May 30, 2019 Category: Genetics & Stem Cells Source Type: research

Genetic variation in the ABCB1 gene associated with post treatment lyme disease syndrome status
Publication date: Available online 30 May 2019Source: Meta GeneAuthor(s): Joanna Lyon, Hyunuk SeungAbstractPost Treatment Lyme Disease Syndrome (PTLDS) poses a difficult to understand health issue. This multi-centered, randomized control trial studied the possible correlation between ABCB1 (MDR1) gene variants and the incidence of PTLDS in affected patients. Genomic DNA was isolated and analyzed for four ABCB1 gene SNPs (rs1128503, rs1045642, rs2235067, and rs4148740). Significant findings include the association of rs1128503 TC variant with PTLDS status. Additionally, the rs1128503+ rs1045642+ rs2235067 SNP combination in...
Source: Meta Gene - May 30, 2019 Category: Genetics & Stem Cells Source Type: research

Association of genetic variants in IGF-1 gene with susceptibility to gestational and type 2 diabetes mellitus
ConclusionsHuman IGF-1 gene may be a candidate gene for GDM and T2DM risk, as our study suggests a significant association between the IGF-I rs35767 and rs5742612 polymorphisms and the risk of T2DM and GDM in pregnant women, whereas there was no association for rs2288377. (Source: Meta Gene)
Source: Meta Gene - May 25, 2019 Category: Genetics & Stem Cells Source Type: research

Protective effect of high levels of TGF-β1 cytokine and its corresponding allele at C-509T locus in Punjabi ESRD population
Publication date: Available online 22 May 2019Source: Meta GeneAuthor(s): Vikas Gupta, Ajay Kumar, Manoj Chaudhary, Prabodh K. SehajpalAbstractEnd Stage Renal Disease (ESRD) is a chronic inflammatory condition when the kidney function has diminished to
Source: Meta Gene - May 22, 2019 Category: Genetics & Stem Cells Source Type: research

A brief overview of the concepts, methods and computational tools used in phylogenetic tree construction and gene prediction
Publication date: Available online 15 May 2019Source: Meta GeneAuthor(s): Rasoul Godini, Hossein FallahiAbstractThe phylogenetic analysis encompasses several stages where the type of input data affects its specificity and usability. Because of the complexity and diversity of the analysis methods and tools, many users might be confused or misled. There are no easy guidelines to describe many of the molecular evolution approaches in simple and straightforward terms. Here, we have gathered information, algorithms, and methods to facilitate the selection of proper approaches based on the type of inputs and research questions. ...
Source: Meta Gene - May 15, 2019 Category: Genetics & Stem Cells Source Type: research

DNA repair gene (XRCC3) polymorphisms and its association with ovarian carcinoma in Egyptian patients
ConclusionDNA repair gene XRCC3 polymorphism rs 861539 T allele and the rs 861539 T/rs 1799794 A haplotype may boost the susceptibility to ovarian carcinoma with no correlation with the tumor histological subtypes and stages. They may be salutary as a DNA-based diagnostic biomarker for identifying the high-risk Egyptian females susceptible to ovarian cancer. More studies are needed to clarify the underlying mechanisms that can contribute to ovarian cancer, assess the cancer prognosis, and help to determine adequate therapy regimen. (Source: Meta Gene)
Source: Meta Gene - May 10, 2019 Category: Genetics & Stem Cells Source Type: research

Drug-response related genetic architecture of Bangladeshi population
Publication date: Available online 9 May 2019Source: Meta GeneAuthor(s): Tamim Ahsan, Abu Ashfaqur SajibAbstractMany Single Nucleotide Polymorphisms (SNPs) have been discovered to be responsible for inter-individual variability in drug response. Since allelic distribution and extent of linkage disequilibrium (LD) blocks of SNPs vary among populations, frequencies of different SNP alleles associated with drug response and patterns of LD should be analyzed separately for different populations. In the present study, we listed the SNPs associated with drug response along with the responsive drugs and calculated the frequencies...
Source: Meta Gene - May 10, 2019 Category: Genetics & Stem Cells Source Type: research

Association of HLA-G + 3142G > C gene polymorphism and toll-like receptor-9 serum level in systemic lupus erythematosus patients
ConclusionThe HLA-G + 3142G > C homozygous genotype GG and G allele were more associated with SLE patients. The HBs antigen showed no significant association with SLE patients. While, TLR-9 serum level showed a significant association with SLE development. (Source: Meta Gene)
Source: Meta Gene - May 8, 2019 Category: Genetics & Stem Cells Source Type: research

Alteration of the risk of oral pre-cancer and cancer in North Indian population by XPC polymorphism genotypes and haplotypes
In conclusion, results from the present study demonstrate association of XPC polymorphisms with oral pre cancer and cancer. (Source: Meta Gene)
Source: Meta Gene - May 7, 2019 Category: Genetics & Stem Cells Source Type: research

Identification of three novel homozygous NAGLU mutations in Egyptian patients with Sanfilippo syndrome B
ConclusionsThis is the first study of NAGLU gene analysis in Egyptian patients with Sanfilippo type B that involved 3 novel homozygote mutations. This study could have valuable implications in genetic counseling and further clinical genetic studies of MPS IIIB syndrome. (Source: Meta Gene)
Source: Meta Gene - May 4, 2019 Category: Genetics & Stem Cells Source Type: research

Study of vascular endothelial growth factor A gene polymorphisms in association with Iranian rheumatoid arthritis patients
ConclusionsThe alleles and genotypes of VEGFA gene polymorphisms were not associated with the disease susceptibility in Iranian RA population. (Source: Meta Gene)
Source: Meta Gene - May 4, 2019 Category: Genetics & Stem Cells Source Type: research

Publisher's Note
Publication date: June 2019Source: Meta Gene, Volume 20Author(s): (Source: Meta Gene)
Source: Meta Gene - May 1, 2019 Category: Genetics & Stem Cells Source Type: research

Gene coexpression network analysis of multiple cancers discovers the varying stem cell features between gastric and breast cancer
This study hypothesize that varying stem cell properties during cancer progression might be a better concordance among the shared tumour cell properties defined as hallmark of cancer. (Source: Meta Gene)
Source: Meta Gene - April 28, 2019 Category: Genetics & Stem Cells Source Type: research

CYP2C9, CYP2D6, G6PD, GCLC, GSTM1 and NAT2 gene polymorphisms and risk of adverse reactions to sulfamethoxazole and ciprofloxacin in San Luis Potosí, Mexico
Publication date: Available online 26 April 2019Source: Meta GeneAuthor(s): Eduardo Hernández-Verdin, Andrea Ganelón-Ríos, Guillermo Pettet-Ruiz, Mireya Sánchez-Garza, Joaquín Reinoso-Reyes, Rubén López-RevillaAbstractSulfamethoxazole (SMX) and ciprofloxacin (CPFX), two of the most prescribed antimicrobials worldwide, induce adverse reactions (ADRs) determined by clinically relevant variants of the CYP2C9, CYP2D6, G6PD, GCLC, GSTM1, and NAT2 genes. We designed methods to generate and sequence amplification products to identify the relevant single nucleotide polymorphisms (SN...
Source: Meta Gene - April 28, 2019 Category: Genetics & Stem Cells Source Type: research

Evaluation of genetic association of 40 SNPs in candidate genes with cholesterol gallstone disease in north Indian population
ConclusionsOur study suggests that FGFR4, CYP7A1, APOE, TM4SF4, NR1H2, IL10, PLCE1, CYP1A1, SLC10A2, MMP2, CYP8B1 genetic variants confer significant risk for gallstone disease in North Indian population. The association of many genes with disease risk was found to be sex-specific. (Source: Meta Gene)
Source: Meta Gene - April 25, 2019 Category: Genetics & Stem Cells Source Type: research

In silico analysis of non-synonymous single nucleotide polymorphism in a human KLK-2 gene associated with prostate cancer
ConclusionFunction, stability and biochemical properties of hk2 might be affected by different nsSNPs. (Source: Meta Gene)
Source: Meta Gene - April 23, 2019 Category: Genetics & Stem Cells Source Type: research

Expression analysis of miR-100 and selected genes from mTOR pathway in breast cancer patients
ConclusionsWe provided further evidences for implication of miR-100 and mTOR pathway in breast cancer pathogenesis. (Source: Meta Gene)
Source: Meta Gene - April 22, 2019 Category: Genetics & Stem Cells Source Type: research

Endothelial nitric oxide synthase gene polymorphisms modulate the risk of squamous cell carcinoma of head and neck in north Indian population
Conclusions: Our results suggest that eNOS 894G > T and intron 4a/b polymorphisms influence the risk of SCCHN and, eNOS 894G > T polymorphism modulate the risk of disease by modulating plasma nitrite level. (Source: Meta Gene)
Source: Meta Gene - April 22, 2019 Category: Genetics & Stem Cells Source Type: research

Association between genetic variants of NOS3, TGF-β and susceptibility of diabetic nephropathy: A meta-analysis
Publication date: Available online 18 April 2019Source: Meta GeneAuthor(s): Sindhu Varghese, S. Gowtham KumarAbstractBackgroundThis meta-analysis was performed to assess the association between genetic polymorphisms of NOS3 894G>T (rs1799983) and TGF- β 915G>C (rs1800471) with the risk of diabetic nephropathy (DN).MethodsA systematic literature search was performed to collect and select eligible and relevant studies by electronic databases such as Embase, PubMed, and Cochrane Library. Based on the genetic models/contrast such as allelic model, dominant model, recessive model and over-dominant the odds ratio and ...
Source: Meta Gene - April 20, 2019 Category: Genetics & Stem Cells Source Type: research

Karyo-morphological consistency and heterochromatin distribution pattern in diploid and colchitetraploids of Vigna radiata and V. mungo
Publication date: Available online 9 April 2019Source: Meta GeneAuthor(s): Daniel Regie Wahlang, Judith Mary Lamo, Shailendra Goel, Satyawada Rama RaoAbstractA systematic genetic analysis of colchitetraploids of Vigna radiata and V. mungo in three different generations (C1, C2 and C3) was made using karyomorphology of chromosomes and heterochromatin distribution pattern among them. Autotetraploid of both species were produced using aqueous colchicine (0.15 and 0.20%) and maintained through three successive generations (C1, C2 and C3). The karyomorphological studies showed that the chromosome karyotype remain constant with ...
Source: Meta Gene - April 9, 2019 Category: Genetics & Stem Cells Source Type: research

Development and annotation of species-specific microsatellite markers from transcriptome sequencing for a higher group termite, Globitermes sulphureus Haviland (Blattodea: Termitidae)
In this study, samples of G. sulphureus were collected from 10 grounded populations and another 10 native populations throughout the Northern part of Malaysia. 30 novel polymorphic microsatellite markers were developed and characterized from transcriptome dataset of urban-originating G. sulphureus enriched for di-, tri- and tetranucleotide repeat motifs. Thirty primer pairs were successfully amplified DNA fragments from 600 isolates of G. sulphureus, revealing an overall of 180 alleles. The number of alleles per locus identified ranged from 3 to 9. Among sequences containing microsatellites, dinucleotides repeats were the ...
Source: Meta Gene - March 28, 2019 Category: Genetics & Stem Cells Source Type: research

A Comprehensive review of genetic skeletal disorders reported from Pakistan: A brief commentary
Publication date: June 2019Source: Meta Gene, Volume 20Author(s): Muhammad Umair, Farooq Ahamd, Muhammad Bilal, Abdulaziz Asiri, Muhammad Younus, Amjad KhanAbstractGenetic skeletal disorders (GSDs) constitute a heterogeneous, rare and a distinctive group of rare bone growth disorders, leading to abnormal size and shape of the skeleton. Prevalence, mutation spectrum and geographic distribution of genetic skeletal disorders (GSDs) in Pakistan are not known. The present study reviewed different GSDs, listed in the “Nosology and Classification of Genetic Skeletal Disorders: (2015 Revision)” using to-date literature...
Source: Meta Gene - March 27, 2019 Category: Genetics & Stem Cells Source Type: research

TNNT2 5 bp deletion, sedentary lifestyle & abdominal adiposity accentuate the phenotypic severity in hypertrophic cardiomyopathy patients
Publication date: Available online 22 March 2019Source: Meta GeneAuthor(s): Amitabh Biswas, Mitali Kapoor, Soumi Das, Sandeep Seth, Balram Bhargava, Vadlamudi Raghavendra RaoAbstractHypertrophic cardiomyopathy (HCM) is a common cardiac genetic disorder having phenotypic heterogeneity, which can be attributed to interaction of certain environmental risk factors and lifestyle modifications. HCM cases and clinically evaluated controls were evaluated for lifestyle, anthropometric, physiological and biochemical variables, followed by screening of HCM associated genetic variations (5bpDel in TNNT2, 25bpDel in MYBPC3, 287bpDel in...
Source: Meta Gene - March 22, 2019 Category: Genetics & Stem Cells Source Type: research

Association of variants rs7903146 and rs290487 of TCF7L2 gene with diabetic nephropathy and co-morbidities (hypertension and dyslipidemia) in type 2 diabetes mellitus
Publication date: Available online 18 March 2019Source: Meta GeneAuthor(s): Shania Abidi Nee Abbas, Syed Tasleem Raza, Snober S. Mir, Zeba Siddiqi, Alina Zaidi, ZeashanHaider Zaidi, Farzana MahdiAbstractBackgroundDiabetes mellitus is a metabolic disorder which can affects the body's ability to produce or use of the hormone insulin leads to high blood sugar levels and it may serves as a host of complications. Emerging evidence suggests that common and rare genetic polymorphisms can influence the risk of developing diabetic complications. We attempt to evaluate the association of (rs7903146 and rs290487) variants of TCF7L2 g...
Source: Meta Gene - March 18, 2019 Category: Genetics & Stem Cells Source Type: research

DISC1 4 bp deletion in association with schizophrenic patients
In this study, there was no significant relationship between disease genotype for DISC1 gene and schizophrenia. By increasing the heterozygote genotype in the population, the probability of the disease will increase and mutant homozygote genotypes will also be visible. (Source: Meta Gene)
Source: Meta Gene - March 16, 2019 Category: Genetics & Stem Cells Source Type: research

Molecular markers based genetic fidelity assessment of micropropagated Dendrobium chrysotoxum Lindl
Publication date: Available online 14 March 2019Source: Meta GeneAuthor(s): Leimapokpam Tikendra, Arunkumar Singh Koijam, Potshangbam NongdamAbstractPlant tissue culture is one of the most important methods used for effective conservation of many rare and endangered orchids. Genetic variation may appear in regenerants due to numerous factors associated with in vitro culture conditions. Assessment of genetic stability of in vitro regenerants is highly essential if true to type plants are the desired end product. In the present investigation, genetic homogeneity testing of micropropagated Dendrobium chrysotoxum was performed...
Source: Meta Gene - March 15, 2019 Category: Genetics & Stem Cells Source Type: research

Distribution of potential risk alleles and haplotypes of the CYP2C9 and CYP2C19 genes in Mexican native populations: A comparative study among Amerindian populations
Publication date: Available online 15 March 2019Source: Meta GeneAuthor(s): Lilia Carolina León-Moreno, Ana Miriam Saldaña-Cruz, José Sánchez-Corona, Francisco Mendoza-Carrera, Alejandra Guadalupe García-Zapién, Cristina Revilla-Monsalve, Sergio Islas-Andrade, Olga Brito-Zurita, Adrián Pérez-Vargas, Silvia Esperanza Flores-MartínezAbstractObjectivesMexico harbours a very complex genetically diverse population composed of two main groups: Mexican Mestizos and at least 68 heterogeneous native Mexican populations. CYP2C9 and CYP2C19 polymorphisms may confer risk f...
Source: Meta Gene - March 15, 2019 Category: Genetics & Stem Cells Source Type: research

Screening for ARHGAP29 gene variants in Turkish paediatric patients with non-syndromic cleft lip with or without cleft palate
ConclusionThis is the first report investigating ARHGAP29 variants in Turkish patients with nsCL/P. (Source: Meta Gene)
Source: Meta Gene - March 14, 2019 Category: Genetics & Stem Cells Source Type: research

Significance of CYP4F2 polymorphism on oral anticoagulation therapy with acenocoumarol in South Indian patients with mechanical heart valves
ConclusionThe homozygous genotype (AA) of CYP4F2 gene was more prevalent in our study cohort. No significant association was found between CYP4F2 gene polymorphism and acenocoumarol mean dose requirement, both when analyzed individually and in combination with VKORC1 and CYP2C9 polymorphisms. (Source: Meta Gene)
Source: Meta Gene - March 13, 2019 Category: Genetics & Stem Cells Source Type: research

The A1298C methylenetetrahydrofolate reductase polymorphism augments the risk of developing of diabetic retinopathy: A meta-analysis
ConclusionThis meta-analysis demonstrates that the A1298C polymorphism was associated with an increased risk of developing diabetic retinopathy for the Arab population. (Source: Meta Gene)
Source: Meta Gene - March 9, 2019 Category: Genetics & Stem Cells Source Type: research

DNA methylation and expression status of glutamate receptor genes in patients with oral squamous cell carcinoma
Publication date: Available online 7 March 2019Source: Meta GeneAuthor(s): Mohammad Ayoub Rigi-Ladiz, Tayebeh Baranzehi, Behnaz Hassanpour, Mohammad Javad Ashraf, Leila Farhad-Mollashahi, Dor Mohammad Kordi-TamandaniAbstractBackgroundOral cancer represents the third most prevalent form of malignancy in the developing countries and the eight most common form of cancer in developed countries. Alcohol and tobacco users are most affected by oral cancers and 90% of them are OSCC in adult males. In some provinces in Iran such as, Sistan and Baluchestan its prevalence is higher compared to other provinces. One of the primary neur...
Source: Meta Gene - March 7, 2019 Category: Genetics & Stem Cells Source Type: research

The SNPs in bovine MMP14 promoter influence on fat-related traits
In this study, to discover additional genetic markers associated with beef quality, we tried to identify DNA polymorphisms in bovine MMP14 gene. Consequently, two SNPs (single nucleotide polymorphisms) in the CDS (coding sequence) regions and three SNPs in the promoter region of the MMP14 gene were identified. The SNPs in the promoter region were suggested to influence on MMP14 expression, although neither quality or quantity of the MMP14 protein might undergo a change by the SNPs in the CDS regions. Statistical analysis revealed that two SNPs in the promoter region had significant effects on fat-related traits: the effect...
Source: Meta Gene - March 6, 2019 Category: Genetics & Stem Cells Source Type: research

Genetic skeletal disorders in Pakistan: A brief commentary
Publication date: Available online 5 March 2019Source: Meta GeneAuthor(s): Farooq Ahmad, Muhammad Bilal, Amjad Khan, Muhammad UmairAbstractGenetic skeletal disorders (GSDs) constitute a heterogeneous, rare and a distinctive group of rare bone growth disorders, leading to abnormal size and shape of the skeleton. Prevalence, mutation spectrum and geographic distribution of genetic skeletal disorders (GSDs) in Pakistan are not known. The present study reviewed different GSDs, listed in the “Nosology and Classification of Genetic Skeletal Disorders: (2015 Revision)” using to-date literature published in different d...
Source: Meta Gene - March 6, 2019 Category: Genetics & Stem Cells Source Type: research

A novel missense mutation of Isovaleryl-CoA dehydrogenase gene associated with chronic intermittent Isovaleric Acidemia in a Bangladeshi patient
We present here the case of a 9 year old patient diagnosed with IVA at 2 years of age using tandem mass spectrometry (MS/MS) and gas chromatography/mass spectrometry (GC/MS) analysis, as observed by elevated levels of signature disease markers- isovaleryl (C5)-carnitine and isovalerylglycine (IVG) in blood and urine samples, respectively. Over the ensuing seven year follow-up, his most prominent symptoms were hyperammonemia which peaked at>109 μmol/L complimented by developmental and motor dysfunctions. Delayed intervention using sodium benzoate, levocarnitine, multivitamins and a leucine free-diet appeared to ...
Source: Meta Gene - March 6, 2019 Category: Genetics & Stem Cells Source Type: research

Characterization of growth hormone gene (GH) in three Egyptian goat breeds
This study was undertaken to characterize and investigate polymorphic sites in the GH gene in Egyptian goat breeds. Additionally, the effects of the detected mutations on the GH protein's structure and function were predicted using different bioinformatics tools. To achieve these goals, the complete GH gene (promoter, UTR, exons, and introns) was sequenced from 15 blood samples collected from three Egyptian goat breeds (Zaraibi, Barki, and Baladi). The sequencing resulted in a 2500 bp fragment (KU935713, KU976149, KX032517). A protein sequence of 217 amino acids was predicted to include six main domains. Comparisons of t...
Source: Meta Gene - March 1, 2019 Category: Genetics & Stem Cells Source Type: research

Liraglutide alters hepatic metabolism in high-fat fed obese mice: A bioinformatic prediction and functional analysis
ConclusionThe present study reveals relevant information regarding the liraglutide effects in hepatic steatosis. The liraglutide improved hyperglycemia and attenuated hepatic steatosis in mice fed a high-fat diet. (Source: Meta Gene)
Source: Meta Gene - February 23, 2019 Category: Genetics & Stem Cells Source Type: research

Effect of Paraoxonase1 (PON1) gene polymorphisms on PON1 activity, HDL, LDL and MDA levels in women with polycystic ovary syndrome (PCOS): A case-control study
In this study we investigated the association between -108C/T and 55L/M polymorphisms of Paraoxonase1 (PON1) gene with PCOS. PON1 gene codes for the antioxidant enzyme PON1 which is an HDL associated enzyme that prevents oxidative modification of low-density lipoprotein. A total of 192 women with PCOS and 212 control women from an ethnic population (Kashmir) were included in the study. The PON1 polymorphism was genotyped using PCR-RFLP technique. Clinical, Biochemical parameters were analyzed, and HOMA-IR was used to estimate insulin resistance. Serum PON1 activity and MDA levels were also measured. The frequencies of vari...
Source: Meta Gene - February 20, 2019 Category: Genetics & Stem Cells Source Type: research

A new mutation in NTRK1 gene is associated with congenital insensitivity to pain without anhidrosis
Publication date: Available online 14 February 2019Source: Meta GeneAuthor(s): Mogge Hajiesmaei, Fatemeh Yazarlou, Maryam Sobhani, Soudeh Ghafouri-FardAbstractCongenital insensitivity to pain with anhidrosis (CIPA) is a very rare autosomal recessive disease characterized by pain insensitivity, frequent intermittent fevers, anhidrosis, self-mutilating actions and mental retardation. Germline mutations in NTRK1 gene have been associated with CIPA. In the current study, we describe the first reported case from Iran. The patient was a 10 month old girl born to a healthy consanguineous Iranian parent with family history of CI...
Source: Meta Gene - February 16, 2019 Category: Genetics & Stem Cells Source Type: research

PubMedInfo Crawler: An innovative extraction process that leads towards biological information mining
ConclusionThis tools with help the public users to extract the data from Pubmed through an automatic way with less consumption of time. Furthermore it will help the researchers to accomplish their research in a better way with less effort. (Source: Meta Gene)
Source: Meta Gene - February 13, 2019 Category: Genetics & Stem Cells Source Type: research

TAS2R38 gene polymorphism and its association with taste perception, alcoholism and tobacco chewing among the Koraga -a primitive tribal population of Southwest coast of India
In conclusion, increased frequency of non-tasters might have influenced the higher risk of alcohol dependence and tobacco chewing in the Koraga population. (Source: Meta Gene)
Source: Meta Gene - February 5, 2019 Category: Genetics & Stem Cells Source Type: research

Association analysis of interleukin-1 single nucleotide polymorphisms in viral hepatitis of Iraqi patients
In conclusion, T allele (and its homozygous genotype) of IL-1Rpst-I 1970 SNP and haplotypes containing such allele (IL1B+3962-IL1Rpsti 1970) are suggested to be risk factors for HBV infection, while no such conclusion could be reached in HCV infection. (Source: Meta Gene)
Source: Meta Gene - January 30, 2019 Category: Genetics & Stem Cells Source Type: research

Regulation of heat shock protein-70 gene transcripts in breast cancer cells during hypo and hyperthermia exposure
ConclusionThe present study indicates significance of HSPA8 and HSPA14 in regulating sustained behavior of cancer cells in cell dependent manner during hypo and hyperthermic exposure. (Source: Meta Gene)
Source: Meta Gene - January 25, 2019 Category: Genetics & Stem Cells Source Type: research

An insight into bacterial phospholipase C classification and their translocation through Tat and Sec pathways: A data mining study
This study documents a sequence-based method for the classification of putative PLCs from different bacterial sources as well as prediction of their translocation pathways. The analysis indicates that PLCs belonging to a particular group show a distinct conservation of signature residues based on which classification could be done. Tat- and Sec-directed PLCs show differences in the characteristics of their signal peptide which include presence or absence of twin-arginine motif, signal peptide length and hydrophobicity. These features were used as markers for the assignment of translocation pathways. Majority of the PLCs we...
Source: Meta Gene - January 24, 2019 Category: Genetics & Stem Cells Source Type: research

DNA methylation and expression status of glutamate receptor genes in patients with oral squamous cell carcinoma
Publication date: Available online 16 January 2019Source: Meta GeneAuthor(s): Mohammad AyoubRigi-Ladiz, Tayebeh Baranzehi, Behnaz Hassanpour, Mohammad Javad Ashraf, Dor Mohammad Kordi-TamandaniAbstractBackgroundOral cancer represents the third most prevalent form of malignancy in developing countries and the eight most common form of cancer in developed countries. Alcohol and tobacco users are most affected by oral cancers and 90% of them are OSCC in adult males. In some provinces in Iran such as Sistan and Baluchestan, its prevalence is higher compared to other provinces. One of the primary neurotransmitter in the central...
Source: Meta Gene - January 16, 2019 Category: Genetics & Stem Cells Source Type: research

A novel insight of Asp193His mutation on epigenetic methyltransferase activity of human EZH2 protein: An in-silico approach
Publication date: Available online 7 January 2019Source: Meta GeneAuthor(s): Nisha Gautam, Satbir Kaur, Kamaljeet Kaur, Neeraj KumarAbstractEnhancer of Zeste Homolog 2 (EZH2) is a component of Polycomb Repressive Complex (PRC) which plays an important role in epigenetic regulation. Ove rexpression of EZH2 gene has been reported to be associated with aggressiveness of various cancers. In spite of being a profoundly studied molecule, no attempt has been made till present date to comprehensively and methodically analyze the EZH2 gene sequence (Regulatory and Structural). The present study was carried out to annotate the promo...
Source: Meta Gene - January 8, 2019 Category: Genetics & Stem Cells Source Type: research

Genome reconstruction of a novel carbohydrate digesting bacterium from the chicken caecal microflora
Publication date: Available online 4 January 2019Source: Meta GeneAuthor(s): Ankit T. Hinsu, Ramesh J. Pandit, Shriram H. Patel, Androniki Psifidi, Fiona M. Tomley, Subrata K. Das, Damer P. Blake, Chaitanya G. JoshiAbstractThe advent of metagenomics using Next-Generation Sequencing (NGS) has led to the acquisition of unprecedented quantities of bacterial sequence data. One use for these data is the recovery of complete genomes of uncultivable, and thus uncharacterised, organisms. The separation of genome from metagenomics data remains challenging, however genomes of several novel lineages and organisms have been reconstruc...
Source: Meta Gene - January 4, 2019 Category: Genetics & Stem Cells Source Type: research