A high-throughput analytical method for complex contaminant mixtures in biosolids
In this study, a simplified, rapid, and robust method of analysis was developed and validated for a high-priority organic contaminant mixture of 44 endocrine disrupting compounds known to occur in biosolids. Analytes consisted of chemicals from many classes with a wide range of physiochemical properties (e.g., log Kow values from -1.4 to 8.9). The biosolids extraction and cleanup protocol was validated for 42 of the targeted compounds. The UPLC-MS2 parameters were validated for all 44 organic contaminants targeted for study. From the two batches of biosolids tested using this analytical method, most of the targeted contami...
Source: Environmental Pollution - February 12, 2024 Category: Environmental Health Authors: Nicole M Dennis Audrey J Braun Jay Gan Source Type: research
Efficacy of intraoperative systemic lidocaine on quality of recovery after laparoscopic colorectal surgery: a randomized controlled trial
CONCLUSIONS: In patients undergoing laparoscopic colorectal surgery, intraoperative systemic lidocaine resulted in statistically but not clinically significant improvements in quality of recovery (see Graphical Abstract).Trial registration: Chinese Clinical Trial Registry; ChiCTR1900027635.PMID:38346397 | PMC:PMC10863528 | DOI:10.1080/07853890.2024.2315229 (Source: Annals of Medicine)
Source: Annals of Medicine - February 12, 2024 Category: Internal Medicine Authors: Wenjun Lin Ying Yang Yifen Zhuo Chunlin Qiu Yanhua Guo Yusheng Yao Source Type: research
Contribution of chemical and electrical transmission to the low delta-like intrinsic retinal oscillation in mice: A role for daylight-activated neuromodulators
Eur J Pharmacol. 2024 Feb 9:176384. doi: 10.1016/j.ejphar.2024.176384. Online ahead of print.ABSTRACTBasal electroretinogram (ERG) oscillations have shown predictive value for modifiable risk factors for type 2 diabetes. However, their origin remains unknown. Here, we seek to establish the pharmacological profile of the low delta-like (δ1) wave in the mouse because it shows light sensitivity in the form of a decreased peak frequency upon photopic exposure. Applying neuropharmacological drugs by intravitreal injection, we eliminated the δ1 wave using lidocaine or by blocking all chemical and electrical synapses. The δ1 w...
Source: European Journal of Pharmacology - February 11, 2024 Category: Drugs & Pharmacology Authors: Pamela Reyes-Ortega Alejandra Rodr íguez-Arzate Rams és Noguez-Imm Edith Arnold St éphanie C Thébault Source Type: research
A Randomized Comparison of Multimodal Analgesia and Fentanyl-Based Patient-Controlled Analgesia in Women Undergoing Robot-Assisted Bilateral Axillary Breast Approach Thyroidectomy
J Clin Med. 2024 Jan 25;13(3):702. doi: 10.3390/jcm13030702.ABSTRACTOpioid-free multimodal analgesia (MMA) emerges as a preferable approach for postoperative pain management compared to opioid-based patient-controlled analgesia (PCA) in robot-assisted bilateral axillary breast approach thyroidectomy, a procedure commonly undergone by young female patients. We compared the analgesic efficacy and other recovery profiles between MMA and PCA. In total, 88 female patients were administered fentanyl-based PCA or the combination of lidocaine continuous infusion and nefopam injection before recovery from general anesthesia. The vi...
Source: Clinical Breast Cancer - February 10, 2024 Category: Cancer & Oncology Authors: Na-Young Tae Jin Wook Yi Jong-Kwon Jung Junhyung Lee Sooman Jo Hyunzu Kim Source Type: research
A Randomized Comparison of Multimodal Analgesia and Fentanyl-Based Patient-Controlled Analgesia in Women Undergoing Robot-Assisted Bilateral Axillary Breast Approach Thyroidectomy
J Clin Med. 2024 Jan 25;13(3):702. doi: 10.3390/jcm13030702.ABSTRACTOpioid-free multimodal analgesia (MMA) emerges as a preferable approach for postoperative pain management compared to opioid-based patient-controlled analgesia (PCA) in robot-assisted bilateral axillary breast approach thyroidectomy, a procedure commonly undergone by young female patients. We compared the analgesic efficacy and other recovery profiles between MMA and PCA. In total, 88 female patients were administered fentanyl-based PCA or the combination of lidocaine continuous infusion and nefopam injection before recovery from general anesthesia. The vi...
Source: Clinical Genitourinary Cancer - February 10, 2024 Category: Cancer & Oncology Authors: Na-Young Tae Jin Wook Yi Jong-Kwon Jung Junhyung Lee Sooman Jo Hyunzu Kim Source Type: research
Beyond Traditional Pain Relief: A Review of Alternative Analgesics in Myocardial Infarction Patient Management
J Pain Palliat Care Pharmacother. 2024 Feb 8:1-13. doi: 10.1080/15360288.2024.2304008. Online ahead of print.ABSTRACTWhile morphine is the recommended first-line treatment for pain management in patients with acute coronary syndrome, recent studies have raised concerns about its association with adverse outcomes. Morphine has been found to cause delayed antiplatelet effects, decreased ticagrelor absorption, increased platelet reactivity, and compromised efficacy of dual antiplatelet therapy (DAPT). Alternative analgesics, such as lidocaine, fentanyl, and acetaminophen, have begun to emerge as viable alternatives, each with...
Source: Journal of Pain and Palliative Care Pharmacotherapy - February 8, 2024 Category: Palliative Care Authors: Swarali Yatin Chodnekar Nityanand Jain Edouard Lansiaux Deepkanwar Singh Panag Valdis Gibietis Source Type: research
Additional Effect of Extracorporeal Shockwave Therapy with Lidocaine Injection on Clinical and MRI Findings in Frozen Shoulder: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial
ConclusionsThe study concluded that the addition of extracorporeal shockwave therapy after intra-articular lidocaine injection improves pain, functional disability, range of motion, kinesiophobia, depression status, and quality of life in people with frozen shoulder.Trial Registrationhttps://ctri.nic.in, identifier; CTRI/2020/04/024834 prospectively registered on 24/04/2020. (Source: Pain and Therapy)
Source: Pain and Therapy - February 5, 2024 Category: Anesthesiology Source Type: research
Targeted local anesthesia: a novel slow-release Fe3O4 –lidocaine–PLGA microsphere endowed with a magnetic targeting function
ConclusionMagnetically responsive lidocaine microspheres can prolong analgesia by slowly releasing lidocaine, which can be immobilized around the nerve by a magnetic field on the body surface, avoiding premature diffusion of the microspheres to surrounding tissues and improving drug targeting. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - February 4, 2024 Category: Anesthesiology Source Type: research
Pharmacokinetics of intravenous and topical lidocaine in patients undergoing thoracoscopic pulmonary resection: a comparative study
CONCLUSIONS: Topical administration of 3 mg/kg lidocaine via the "spray-as-you-go" method is an effective and safe technology for patients undergoing thoracoscopic pulmonary resection.PMID:38305616 | DOI:10.26355/eurrev_202401_35074 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - February 2, 2024 Category: Drugs & Pharmacology Authors: Z-Y Liu M Zhang Y Jin Z-L Wang F-P Tu Source Type: research
Pharmacokinetics of intravenous and topical lidocaine in patients undergoing thoracoscopic pulmonary resection: a comparative study
CONCLUSIONS: Topical administration of 3 mg/kg lidocaine via the "spray-as-you-go" method is an effective and safe technology for patients undergoing thoracoscopic pulmonary resection.PMID:38305616 | DOI:10.26355/eurrev_202401_35074 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 2, 2024 Category: Drugs & Pharmacology Authors: Z-Y Liu M Zhang Y Jin Z-L Wang F-P Tu Source Type: research
A Cross-Sectional Survey on Pain Management in Dermal Filler Injections from Physicians ’ and Patients’ Perspectives
ConclusionsPain management during hyaluronic acid dermal fillers injection is important from both perspectives of physicians and patients. This survey showed that compared with other analgesic methods, lidocaine-containing hyaluronic acid has offered a more satisfying experience. It also provides insights to physicians and patients in pain management.Level of Evidence VThis journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to Table of Contents or the online Instructions to Authorswww.springer.com/00266. (Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - February 2, 2024 Category: Cosmetic Surgery Source Type: research
Lidocaine
(Source: Reactions Weekly)
Source: Reactions Weekly - February 1, 2024 Category: Drugs & Pharmacology Source Type: research
