Effectiveness and Safety of Sculptra Poly-L-Lactic Acid Injectable Implant in the Correction of Cheek Wrinkles
CONCLUSION: Injectable PLLA-SCA treatments were well tolerated and significantly reduced the severity of moderate/severe cheek lines and wrinkles, while improving skin quality. Effectiveness was durable over the 12-month study period with high subject-reported satisfaction, natural-looking appearance, and enthusiasm for repeat treatments.CLINICALTRIALS: gov registry number: NCT04124692J Drugs Dermatol. 2024;23(1):1297-1305. doi:10.36849/JDD.7729.PMID:38206151 | DOI:10.36849/JDD.7729 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 11, 2024 Category: Dermatology Authors: Sabrina Fabi Tiffani Hamilton Brenda LaTowsky Rebecca Kazin Keith Marcus Flor Mayoral John Joseph Deirdre Hooper Sachin Shridharani Jessica Hicks Daniel Brasater Felipe Weinberg Inna Prygova Source Type: research
Comparative evaluation of efficacy of 2% lidocaine containing adrenaline with and without hyaluronidase in inferior alveolar nerve blocks for patients requiring bilateral mandibular extractions
ConclusionWe conclude that if hyaluronidase is used, better blocks with smaller volumes are produced. LAs with hyaluronidase have been shown to improve the quality and effectiveness of anaesthetic blocks and shorten the time it takes for anaesthesia to begin, accelerate the onset of akinesia and lessen the need for additional anaesthesia. It also increases the duration of anaesthesia. (Source: Oral Surgery)
Source: Oral Surgery - January 10, 2024 Category: ENT & OMF Authors: Piyush Lunkad,
Sonal Shah,
Bhimappa Rudagi,
Mili Mehta,
Bhushan Bhagat,
Smriti Ticku Tags: ORIGINAL ARTICLE Source Type: research
Phenotypic Screening of Prospective Analgesics Among FDA-Approved Compounds using an iPSC-Based Model of Acute and Chronic Inflammatory Nociception
Adv Sci (Weinh). 2024 Jan 8:e2303724. doi: 10.1002/advs.202303724. Online ahead of print.ABSTRACTClassical target-based drug screening is low-throughput, largely subjective, and costly. Phenotypic screening based on in vitro models is increasingly being used to identify candidate compounds that modulate complex cell/tissue functions. Chronic inflammatory nociception, and subsequent chronic pain conditions, affect peripheral sensory neuron activity (e.g., firing of action potentials) through myriad pathways, and remain unaddressed in regard to effective, non-addictive management/treatment options. Here, a chronic inflammato...
Source: Adv Data - January 8, 2024 Category: Epidemiology Authors: Bryan James Black Rasha El Ghazal Neal Lojek Victoria Williams Jai Singh Rajput Jennifer M Lawson Source Type: research
Fabrication of lidocaine-loaded polymer dissolving microneedles for rapid and prolonged local anesthesia
In this study, a dissolving microneedles (MNs) system made of composite matrix materials of polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), and sodium hyaluronate (HA) was successfully developed for the loading of lidocaine hydrochloride (LidH). The morphology, size and mechanical properties of the MNs were also investigated. After the insertion of MNs into the skin, the matrix at the tip of the MNs was swelled and dissolved by absorption of interstitial fluid, leading to a rapid release of loaded LidH from MNs' tips. And the LidH in the back patching was diffused into deeper skin tissue through microchannels created ...
Source: Biomedical Microdevices - January 8, 2024 Category: Biomedical Engineering Authors: Yanan Mao Xiufeng Zhang Yanfang Sun Zhong Shen Chao Zhong Lei Nie Amin Shavandi Khaydar E Yunusov Guohua Jiang Source Type: research
Phenotypic Screening of Prospective Analgesics Among FDA-Approved Compounds using an iPSC-Based Model of Acute and Chronic Inflammatory Nociception
Adv Sci (Weinh). 2024 Jan 8:e2303724. doi: 10.1002/advs.202303724. Online ahead of print.ABSTRACTClassical target-based drug screening is low-throughput, largely subjective, and costly. Phenotypic screening based on in vitro models is increasingly being used to identify candidate compounds that modulate complex cell/tissue functions. Chronic inflammatory nociception, and subsequent chronic pain conditions, affect peripheral sensory neuron activity (e.g., firing of action potentials) through myriad pathways, and remain unaddressed in regard to effective, non-addictive management/treatment options. Here, a chronic inflammato...
Source: Adv Data - January 8, 2024 Category: Epidemiology Authors: Bryan James Black Rasha El Ghazal Neal Lojek Victoria Williams Jai Singh Rajput Jennifer M Lawson Source Type: research
Fabrication of lidocaine-loaded polymer dissolving microneedles for rapid and prolonged local anesthesia
In this study, a dissolving microneedles (MNs) system made of composite matrix materials of polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), and sodium hyaluronate (HA) was successfully developed for the loading of lidocaine hydrochloride (LidH). The morphology, size and mechanical properties of the MNs were also investigated. After the insertion of MNs into the skin, the matrix at the tip of the MNs was swelled and dissolved by absorption of interstitial fluid, leading to a rapid release of loaded LidH from MNs' tips. And the LidH in the back patching was diffused into deeper skin tissue through microchannels created ...
Source: Biomedical Microdevices - January 8, 2024 Category: Biomedical Engineering Authors: Yanan Mao Xiufeng Zhang Yanfang Sun Zhong Shen Chao Zhong Lei Nie Amin Shavandi Khaydar E Yunusov Guohua Jiang Source Type: research
Regional versus systemic dexmedetomidine as an adjuvant to lidocaine for intravenous regional anaesthesia in healthy volunteers: a randomized crossover study
CONCLUSION: The addition of regional dexmedetomidine to lidocaine prolonged tourniquet tolerance time in forearm IVRA to a greater extent compared to systemic dexmedetomidine in healthy volunteers.TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR2300067978.PMID:38175807 | DOI:10.1080/07853890.2023.2300663 (Source: Annals of Medicine)
Source: Annals of Medicine - January 4, 2024 Category: Internal Medicine Authors: Xincheng Liao Jie Lin Xinru Shu Shisen Hong Yusheng Yao Hao Li Source Type: research
Regional versus systemic dexmedetomidine as an adjuvant to lidocaine for intravenous regional anaesthesia in healthy volunteers: a randomized crossover study
CONCLUSION: The addition of regional dexmedetomidine to lidocaine prolonged tourniquet tolerance time in forearm IVRA to a greater extent compared to systemic dexmedetomidine in healthy volunteers.TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR2300067978.PMID:38175807 | PMC:PMC10769556 | DOI:10.1080/07853890.2023.2300663 (Source: Annals of Medicine)
Source: Annals of Medicine - January 4, 2024 Category: Internal Medicine Authors: Xincheng Liao Jie Lin Xinru Shu Shisen Hong Yusheng Yao Hao Li Source Type: research
Comparison of the effects of esketamine, sufentanil, or lidocaine combined with propofol on tussis reflection during upper gastrointestinal endoscopy: study protocol for a randomised, two centre, three-blind, controlled trial
Tussis, which increases the incidence of airway spasm, aspiration, nausea, and vomiting, is a common complication faced during upper gastrointestinal (GI) endoscopy. However, sedatives and analgesics exhibit i... (Source: Trials)
Source: Trials - January 4, 2024 Category: General Medicine Authors: Hai-jun Hou, Lu Liu, Ming Tian and Fu-shan Xue Tags: Study protocol Source Type: research
Lidocaine Inhibits Rat Prostate Cancer Cell Invasiveness and Voltage-Gated Sodium Channel Expression in Plasma Membrane
J Membr Biol. 2024 Jan 2. doi: 10.1007/s00232-023-00302-z. Online ahead of print.ABSTRACTThere is increasing evidence, mostly from breast cancer, that use of local anaesthetics during surgery can inhibit disease recurrence by suppressing the motility of the cancer cells dependent on inherent voltage-gated sodium channels (VGSCs). Here, the possibility that lidocaine could affect cellular behaviours associated with metastasis was tested using the Dunning cell model of rat prostate cancer. Mostly, the strongly metastatic (VGSC-expressing) Mat-LyLu cells were used under both normoxic and hypoxic conditions. The weakly metasta...
Source: Cancer Control - January 2, 2024 Category: Cancer & Oncology Authors: Nahit Rizaner Scott P Fraser Ilknur Bugan Gul Esma Purut Mustafa B A Djamgoz Seyhan Altun Source Type: research
Experience from a single-center study on multimodal medication therapy for patients with complex regional pain syndrome
CONCLUSIONS: Our multimodal medication therapy algorithm effectively controlled pain in patients with CRPS. However, further prospective studies with large sample sizes and randomized controlled trials are needed for more accurate generalization.PMID:38160336 | DOI:10.3233/BMR-230179 (Source: Journal of Back and Musculoskeletal Rehabilitation)
Source: Journal of Back and Musculoskeletal Rehabilitation - December 31, 2023 Category: Orthopaedics Authors: Donghwi Park Jin-Woo Choi Min Cheol Chang Source Type: research
The anterior cingulate cortex and its interface with the dorsal periaqueductal grey regulating nitric oxide-mediated panic-like behaviour and defensive antinociception
Neuropharmacology. 2023 Dec 29:109831. doi: 10.1016/j.neuropharm.2023.109831. Online ahead of print.ABSTRACTThe anterior cingulate cortex (ACC) Cg1 (24b) area modulates glutamate-mediated unconditioned fear and antinociception organised by hypothalamus. However, it remains unknown whether 24b area also modulates these latter defensive responses through connections with dorsal periaqueductal grey matter (dPAG), a midbrain structure implicated in the genesis of innate fear-induced defence. The aim of this work is to examine the correlation between the behavioural effects of intra-ACC microinjections of vehicle, NMDA (1 nmol)...
Source: Neuropharmacology - December 31, 2023 Category: Drugs & Pharmacology Authors: Luiz Luciano Falconi-Sobrinho Tayllon Dos Anjos-Garcia Mac ário Arosti Rebelo Paloma Molina Hernandes Rafael Carvalho Almada Jose Eduardo Tanus-Santos Norberto Cysne Coimbra Source Type: research
Experience from a single-center study on multimodal medication therapy for patients with complex regional pain syndrome
CONCLUSIONS: Our multimodal medication therapy algorithm effectively controlled pain in patients with CRPS. However, further prospective studies with large sample sizes and randomized controlled trials are needed for more accurate generalization.PMID:38160336 | DOI:10.3233/BMR-230179 (Source: Journal of Back and Musculoskeletal Rehabilitation)
Source: Journal of Back and Musculoskeletal Rehabilitation - December 31, 2023 Category: Orthopaedics Authors: Donghwi Park Jin-Woo Choi Min Cheol Chang Source Type: research
