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Vestibulodynia: Clinical characteristics, first-line treatments, and factors associated with escalation of treatment with EMG-guided injections of botulinum toxin in a retrospective french cohort study
CONCLUSION: Our study highlights the current lack of efficacy of first-line treatments in vestibulodynia. Considering the high prevalence of muscular dysfunction, botulinum toxin injections are of particular interest despite a lack of randomized controlled trials in this indication.PMID:38678773 | DOI:10.1016/j.annder.2024.103277 (Source: Annales de Dermatologie et de Venereologie)
Source: Annales de Dermatologie et de Venereologie - April 28, 2024 Category: Dermatology Authors: C Neuville B Parratte S Lombion F Aubin I Gallais S érézal F Pelletier Source Type: research

Lidocaine effects on neutrophil extracellular trapping and angiogenesis biomarkers in postoperative breast cancer patients with different anesthesia methods: a prospective, randomized trial
Anesthesia techniques and drug selection may influence tumor recurrence and metastasis. Neutrophil extracellular trapping (NETosis), an immunological process, has been linked to an increased susceptibility to ... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - April 27, 2024 Category: Anesthesiology Authors: Wenjuan Zhang, Jiao Liu, Xiaohui Li, Zhixia Bai, Yan Sun and Xuexin Chen Tags: Research Source Type: research

Treating Erythromelalgia with Interosseous Membrane Stimulation: An Autonomic Basis for the Condition and Its Treatment
CONCLUSIONS: Interosseous membrane stimulation is a safe, simple, and effective treatment for erythromelalgia, which is notoriously refractory to treatment. This patient's response to treatment might have been a result of localized derangement of her autonomic nervous system. It is possible that manipulation of the autonomic milieu of an extremity is a significant factor in the mechanism of action of interosseous membrane stimulation.PMID:38659724 | PMC:PMC11036148 | DOI:10.1089/acu.2023.0098 (Source: Acupuncture in Medicine)
Source: Acupuncture in Medicine - April 25, 2024 Category: Complementary Medicine Authors: Michael Freedman Benjamin Asa Freedman Jon S Miller Patricia Bierwirth Walter Roger Nelson Source Type: research

Influence of Pre- and Intraoperative Local Anaesthetic in Strabismus Surgery under General Anaesthesia in Adults
CONCLUSION: As this increases patient safety and comfort and is cost-effective (less time in the recovery room), we recommend adding perioperative local anaesthesia to strabismus surgery performed under general anaesthesia.PMID:38653301 | DOI:10.1055/a-2268-9411 (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - April 23, 2024 Category: Opthalmology Authors: Daniel Felber Francoise Roulez Anja Palmowski-Wolfe Source Type: research

mRNA Expression Levels of Cytochrome P450 CYP1A2, CYP3A4, and CYP3A5 in the Epidermis: A Focus on Individual Differences Among Japanese Individuals
Xenobiotica. 2024 Apr 22:1-28. doi: 10.1080/00498254.2024.2344664. Online ahead of print.ABSTRACTVarious cytochrome P450 enzymes (CYPs) that contribute to drug metabolism are expressed in the skin. However, variation among individuals in CYP expression profiles is not well-understood.To investigate CYPs related to the metabolism of transdermal preparations in Japan, multiple skin tissue specimens of individuals of Japanese descent were prepared, and the mRNA expression levels of CYP1A2, CYP3A4, and CYP3A5 were measured. Associations between the expression patterns of these CYPs and body mass index (BMI) were also investiga...
Source: Xenobiotica - April 22, 2024 Category: Research Authors: Hiroko Makihara Mika Maezawa Kazusa Kaiga Toshihiko Satake Mayu Muto Yui Tsunoda Tsutomu Shimada Tomoko Akase Source Type: research

mRNA expression levels of cytochrome P450 CYP1A2 , CYP3A4 , and CYP3A5 in the epidermis: a focus on individual differences among Japanese individuals
Xenobiotica. 2024 Apr 24:1-7. doi: 10.1080/00498254.2024.2344664. Online ahead of print.ABSTRACTVarious cytochrome P450 enzymes (CYPs) that contribute to drug metabolism are expressed in the skin. However, variation among individuals in CYP expression profiles is not well-understood.To investigate CYPs related to the metabolism of transdermal preparations in Japan, multiple skin tissue specimens of individuals of Japanese descent were prepared, and the mRNA expression levels of CYP1A2, CYP3A4, and CYP3A5 were measured. Associations between the expression patterns of these CYPs and body mass index (BMI) were also investigat...
Source: Xenobiotica - April 22, 2024 Category: Research Authors: Hiroko Makihara Mika Maezawa Kazusa Kaiga Toshihiko Satake Mayu Muto Yui Tsunoda Tsutomu Shimada Tomoko Akase Source Type: research

Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite
In this study, we identified an unknown metabolite of the anaesthetic drug lidocaine, which is metabolised by HLM. By screening for lidocaine metabolic activity in five types of foods (blue cheese, shiitake mushroom, natto, yoghurt, and dry yeast), we found that bacteria isolated from natto reproduced the lidocaine metabolic reaction that occurs in HLM. A fraction containing the unknown lidocaine metabolite was prepared through mass cultivation of a Bacillus subtilis standard strain, ethyl acetate extraction, open column chromatography, and HPLC purification. We identified the unknown metabolite as 3-(2,6-dimethylphenyl)-1...
Source: Chemical and Pharmaceutical Bulletin - April 21, 2024 Category: Drugs & Pharmacology Authors: Sho Hori Hikari Taniguchi Sota Yoshimura Kanako Takeda Ryusei Yamashita Atsushi Kimishima Kazuo Harada Source Type: research