Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells
Oncol Rep. 2024 May;51(5):72. doi: 10.3892/or.2024.8731. Epub 2024 Apr 12.ABSTRACTGlioblastoma multiforme (GBM) is the most aggressive type of malignant brain tumor. Currently, the predominant clinical treatment is the combination of surgical resection with concurrent radiotherapy and chemotherapy, using temozolomide (TMZ) as the primary chemotherapy drug. Lidocaine, a widely used amide‑based local anesthetic, has been found to have a significant anticancer effect. It has been reported that aberrant hepatocyte growth factor (HGF)/mesenchymal‑epithelial transition factor (MET) signaling plays a role in the progression o...
Source: Oncology Reports - April 12, 2024 Category: Cancer & Oncology Authors: Ming-Shan Chen Zhi-Yong Chong Cheng Huang Hsiu-Chen Huang Pin-Hsuan Su Jui-Chieh Chen Source Type: research
Parietal abdominal pain with lower leg discrepancy: a case report
ConclusionsStructural misbalances, as may be caused by lower leg discrepancy, may trigger muscular compensations and pain. Complete anamnesis and clinical examination must not be trivialized and may reveal previously ignored information leading to a proper diagnosis. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 12, 2024 Category: General Medicine Source Type: research
Self-induced Hot Water Finger Burn Trying to Get Feeling Back after Ropivacaine Block
Plast Reconstr Surg Glob Open. 2024 Apr 5;12(4):e5704. doi: 10.1097/GOX.0000000000005704. eCollection 2024 Apr.ABSTRACTThis case report is about a patient with self-induced hot water burns several hours after an infraclavicular block with ropivacaine for a scaphoid fracture operation. This patient was honest about what happened. However, some patients are too embarrassed to admit what they did to themselves. The injury may be misdiagnosed by the emergency department physician or by the surgeon because the history is incomplete. The resulting burn, which can lead to fingertip loss when severe, can be erroneously misdiagnose...
Source: Hand Surgery - April 10, 2024 Category: Surgery Authors: Rachel S Rohde Alison Wong Donald H Lalonde Source Type: research
Synergistic interaction of guanfacine or dexmedetomidine coadministered with lidocaine for cutaneous analgesia in rats
CONCLUSIONS: We showed that guanfacine elicits dose-dependent cutaneous analgesia when administered subcutaneously. Lidocaine is less potent than guanfacine or dexmedetomidine. Both guanfacine and dexmedetomidine enhance the potency and duration of lidocaine. Better synergistic responses we are getting with guanfacine plus lidocaine.PMID:38591725 | DOI:10.1080/01616412.2024.2340881 (Source: Neurological Research)
Source: Neurological Research - April 9, 2024 Category: Neurology Authors: An-Kuo Chou Chong-Chi Chiu Jhi-Joung Wang Yu-Wen Chen Ching-Hsia Hung Source Type: research
EMLA cream in burns: A systematic review of safety, analgesic efficacy and effects on burn pathophysiology
Management of procedural pain in burn care is challenging. Lidocaine-prilocaine cream 5% (EMLA ®) is a widely used, effective local anesthetic cream approved for normal intact skin; genital mucosa for superficial surgical procedures; and debridement of chronic leg ulcers. This comprehensive review aimed to determine safety, analgesic efficacy and effects on burn pathophysiology to provide ev idence-based clinical recommendations of introducing the topical anesthetic into burn care. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - April 9, 2024 Category: Cosmetic Surgery Authors: Filip Rangatchew, Lars Schoelzer, Krzysztof T. Drzewiecki, Rikke Holmgaard Source Type: research
Effect of ultrasound-guided stellate ganglion block on lung protection for patients undergoing one-lung ventilation
CONCLUSION: Ultrasound-guided SGB has lung-protective effects on patients undergoing OLV, which significantly improves patients' OI, reduces intrapulmonary shunts, declines ventilator-induced lung damage, and inhibits inflammatory response as well as oxidative stress (China Clinical Trial Registry, registration number ChiCTR2000033385, https://www.chictr.org.cn).PMID:38586109 | PMC:PMC10994812 | DOI:10.62347/UFZF5671 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Yang Xie Li Han Yue Zhao Lihong Zhao Fen Yang Jianfang Cao Qifeng Tang Source Type: research
