Treating Erythromelalgia with Interosseous Membrane Stimulation: An Autonomic Basis for the Condition and Its Treatment
CONCLUSIONS: Interosseous membrane stimulation is a safe, simple, and effective treatment for erythromelalgia, which is notoriously refractory to treatment. This patient's response to treatment might have been a result of localized derangement of her autonomic nervous system. It is possible that manipulation of the autonomic milieu of an extremity is a significant factor in the mechanism of action of interosseous membrane stimulation.PMID:38659724 | PMC:PMC11036148 | DOI:10.1089/acu.2023.0098 (Source: Acupuncture in Medicine)
Source: Acupuncture in Medicine - April 25, 2024 Category: Complementary Medicine Authors: Michael Freedman Benjamin Asa Freedman Jon S Miller Patricia Bierwirth Walter Roger Nelson Source Type: research
Influence of Pre- and Intraoperative Local Anaesthetic in Strabismus Surgery under General Anaesthesia in Adults
CONCLUSION: As this increases patient safety and comfort and is cost-effective (less time in the recovery room), we recommend adding perioperative local anaesthesia to strabismus surgery performed under general anaesthesia.PMID:38653301 | DOI:10.1055/a-2268-9411 (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - April 23, 2024 Category: Opthalmology Authors: Daniel Felber Francoise Roulez Anja Palmowski-Wolfe Source Type: research
mRNA Expression Levels of Cytochrome P450 CYP1A2, CYP3A4, and CYP3A5 in the Epidermis: A Focus on Individual Differences Among Japanese Individuals
Xenobiotica. 2024 Apr 22:1-28. doi: 10.1080/00498254.2024.2344664. Online ahead of print.ABSTRACTVarious cytochrome P450 enzymes (CYPs) that contribute to drug metabolism are expressed in the skin. However, variation among individuals in CYP expression profiles is not well-understood.To investigate CYPs related to the metabolism of transdermal preparations in Japan, multiple skin tissue specimens of individuals of Japanese descent were prepared, and the mRNA expression levels of CYP1A2, CYP3A4, and CYP3A5 were measured. Associations between the expression patterns of these CYPs and body mass index (BMI) were also investiga...
Source: Xenobiotica - April 22, 2024 Category: Research Authors: Hiroko Makihara Mika Maezawa Kazusa Kaiga Toshihiko Satake Mayu Muto Yui Tsunoda Tsutomu Shimada Tomoko Akase Source Type: research
Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite
In this study, we identified an unknown metabolite of the anaesthetic drug lidocaine, which is metabolised by HLM. By screening for lidocaine metabolic activity in five types of foods (blue cheese, shiitake mushroom, natto, yoghurt, and dry yeast), we found that bacteria isolated from natto reproduced the lidocaine metabolic reaction that occurs in HLM. A fraction containing the unknown lidocaine metabolite was prepared through mass cultivation of a Bacillus subtilis standard strain, ethyl acetate extraction, open column chromatography, and HPLC purification. We identified the unknown metabolite as 3-(2,6-dimethylphenyl)-1...
Source: Chemical and Pharmaceutical Bulletin - April 21, 2024 Category: Drugs & Pharmacology Authors: Sho Hori Hikari Taniguchi Sota Yoshimura Kanako Takeda Ryusei Yamashita Atsushi Kimishima Kazuo Harada Source Type: research
Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite
In this study, we identified an unknown metabolite of the anaesthetic drug lidocaine, which is metabolised by HLM. By screening for lidocaine metabolic activity in five types of foods (blue cheese, shiitake mushroom, natto, yoghurt, and dry yeast), we found that bacteria isolated from natto reproduced the lidocaine metabolic reaction that occurs in HLM. A fraction containing the unknown lidocaine metabolite was prepared through mass cultivation of a Bacillus subtilis standard strain, ethyl acetate extraction, open column chromatography, and HPLC purification. We identified the unknown metabolite as 3-(2,6-dimethylphenyl)-1...
Source: Chemical and Pharmaceutical Bulletin - April 21, 2024 Category: Drugs & Pharmacology Authors: Sho Hori Hikari Taniguchi Sota Yoshimura Kanako Takeda Ryusei Yamashita Atsushi Kimishima Kazuo Harada Source Type: research
Does lidocaine reduce pain intensity during corticosteroid injection? A double-blind randomized controlled equivalence trial
J Hand Surg Eur Vol. 2024 Apr 20:17531934241245036. doi: 10.1177/17531934241245036. Online ahead of print.ABSTRACTOf the strategies considered to limit the discomfort of corticosteroid injection, one is to inject without lidocaine to reduce the total volume and avoid acidity. In a Bayesian trial, adults receiving corticosteroid injections were randomized to receive 0.5 mL of triamcinolone with or without 0.5 mL of lidocaine. Serial analysis was performed until a 95% probability of presence or absence of a 1.0-point difference in pain intensity on the 0-10 Numerical Rating Scale was reached. Injections with lidocaine were a...
Source: Hand Surgery - April 20, 2024 Category: Surgery Authors: Teun Teunis George E Sayegh Amir Fatehi David Ring Gregg Vagner Lee Reichel Source Type: research
Neuropathic pain: Evidence based recommendations
Presse Med. 2024 Apr 17:104232. doi: 10.1016/j.lpm.2024.104232. Online ahead of print.ABSTRACTNeuropathic pain continues to be a significant problem that lacks effective solutions for every single patient. In 2015, international guidelines (NeuPSIG) were published, while the French recommendations were updated in 2020. The purpose of this minireview is to provide an update on the process of developing evidence-based recommendations and explore potential changes to the current recommendations. Primary treatments for neuropathic pain include selective serotonin-norepinephrine reuptake inhibitors (SNRIs) such as duloxetine an...
Source: Presse Medicale - April 19, 2024 Category: General Medicine Authors: Xavier Moisset Source Type: research
Neuropathic pain: Evidence based recommendations
Presse Med. 2024 Apr 17:104232. doi: 10.1016/j.lpm.2024.104232. Online ahead of print.ABSTRACTNeuropathic pain continues to be a significant problem that lacks effective solutions for every single patient. In 2015, international guidelines (NeuPSIG) were published, while the French recommendations were updated in 2020. The purpose of this minireview is to provide an update on the process of developing evidence-based recommendations and explore potential changes to the current recommendations. Primary treatments for neuropathic pain include selective serotonin-norepinephrine reuptake inhibitors (SNRIs) such as duloxetine an...
Source: Presse Medicale - April 19, 2024 Category: General Medicine Authors: Xavier Moisset Source Type: research
Hiccups Should Not Be a Hiccup in Patient Care: Utilizing Inhaled Lidocaine for Intractable Hiccups
1. The learner should obtain a basic understanding regarding the hiccup reflex arc.2. The learner should obtain an understanding of the first line medications used to treat intractable hiccups, but learn that inhaled lidocaine can also be utilized if symptoms are refractory to first line treatments. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Shanup Dalal, Zieanna Chang, Carol Chamberlain Source Type: research
50% efficacy dose of intravenous lidocaine in supressing sufentanil-induced cough in children: a randomised controlled trial
Opioids such as sufentanil are used as anaesthetics due to their rapid action and superior analgesic effect. However, sufentanil induces a huge cough in paediatric patients. In contrast, intravenous (IV) lidoc... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - April 19, 2024 Category: Anesthesiology Authors: Yang Hu, Ming-cheng Du, Guo-hong Zhu, Xiang Long, Jing-jing Jiang and Yuan Gong Tags: Research Source Type: research
The Pharmacologic Management of Cardiac Arrest
This article covers the current state of evidence for the effectiveness of the vasopressor epinephrine and the combination of vasopressin-steroids-epinephrine and antiarrhythmic medications amiodarone and lidocaine and reviews the role of other med ications such as calcium, sodium bicarbonate, magnesium, and atropine in cardiac arrest care. We additionally review the role of β-blockers for refractory pulseless ventricular tachycardia/ventricular fibrillation and thrombolytics in undifferentiated cardiac arrest and suspected fatal pulmonary em bolism. (Source: Cardiology Clinics)
Source: Cardiology Clinics - April 16, 2024 Category: Cardiology Authors: Amandeep Singh, Megan Heeney, Martha E. Montgomery Source Type: research
Perioperative intravenous lidocaine in thoracoscopic surgery for improved postoperative pain control: a randomized, placebo-controlled, double-blind, superiority trial
CONCLUSIONS: Our results suggest that perioperative intravenous lidocaine administration reduces pain scores after VATS. The beneficial clinical effects are limited. Nevertheless, intravenous lidocaine may be helpful as part of a multimodal analgesia protocol or with patients in whom the use of other analgesics is contraindicated.TRIAL REGISTRATION: ClinicalTrials.gov NCT03677817.PMID:38617784 | PMC:PMC11009578 | DOI:10.21037/jtd-23-1438 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Aljaz Hojski Daniel Bolliger Makhmudbek Mallaev Sandrine Dackam Nikolay Tsvetkov Mark Wiese Tobias Schneider Andreas Lampart Didier Lardinois Source Type: research
Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells
Oncol Rep. 2024 May;51(5):72. doi: 10.3892/or.2024.8731. Epub 2024 Apr 12.ABSTRACTGlioblastoma multiforme (GBM) is the most aggressive type of malignant brain tumor. Currently, the predominant clinical treatment is the combination of surgical resection with concurrent radiotherapy and chemotherapy, using temozolomide (TMZ) as the primary chemotherapy drug. Lidocaine, a widely used amide‑based local anesthetic, has been found to have a significant anticancer effect. It has been reported that aberrant hepatocyte growth factor (HGF)/mesenchymal‑epithelial transition factor (MET) signaling plays a role in the progression o...
Source: Oncology Reports - April 12, 2024 Category: Cancer & Oncology Authors: Ming-Shan Chen Zhi-Yong Chong Cheng Huang Hsiu-Chen Huang Pin-Hsuan Su Jui-Chieh Chen Source Type: research
