Updates for the treatment of EGPA.
Abstract Eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss syndrome) is the least frequent antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). Major advances of our knowledge on its pathophysiology have revealed features of both AAV and eosinophilic disorders. The development of targeted biotherapies for both diseases opened new possibilities for EGPA management. In this review, we highlight the rationale underlying the routine treatment strategy, which relies mainly on corticosteroids, with immunosuppressant adjunction for severe disease. However, novel therapies are st...
Source: Presse Medicale - July 8, 2020 Category: General Medicine Authors: Raffray L, Guillevin L Tags: Presse Med Source Type: research

Lung involvement in ANCA-associated vasculitis.
nec D Abstract Lung involvement is one of the most common clinical features in ANCA-associated vasculitides (AAV), including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). In this review, we detail the five main presentations of pulmonary involvement in AAV: necrotizing granulomatous inflammation, tracheobronchial inflammation, pulmonary capillaritis, interstitial lung disease (ILD) and asthma with their clinical, radiological and therapeutic characteristics. The prevalence of these manifestations is variable according to the subtyp...
Source: Presse Medicale - July 7, 2020 Category: General Medicine Authors: Sacoto G, Boukhlal S, Specks U, Flores-Suárez LF, Cornec D Tags: Presse Med Source Type: research

Treatment of systemic necrotizing vasculitides: the 40-year experience of the French Vasculitis Study Group.
Abstract Treatment of vasculitides has benefited from the results of several prospective clinical trials focusing on the evaluation of new drugs, therapeutic strategies and adjuvant treatments. In the field of autoimmunity, vasculitides are the group of diseases for which the most important medical progress has been made, combining advances in understanding the pathogenetic mechanisms, classification of the various entities and willingness to evaluate treatments. Several international groups have been actively involved in these tasks. The French Vasculitis Study Group was the first to design and organize prospecti...
Source: Presse Medicale - July 7, 2020 Category: General Medicine Authors: Guillevin L Tags: Presse Med Source Type: research

Cutaneous IgA vasculitis flare-ups associated with intake of red wine.
PMID: 32645415 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - July 6, 2020 Category: General Medicine Authors: Kluger N Tags: Presse Med Source Type: research

Management of Cutaneous Vasculitis.
Abstract Cutaneous vasculitis encompasses cutaneous components of systemic vasculitides, skin-limited variants of systemic vasculitides, such as IgA vasculitis or cutaneous polyarteritis nodosa, and single-organ cutaneous vasculitis, as individualized in 2012 in the Chapel Hill Consensus Conference Nomenclature. In this article, we focus on the management of skin-limited and single-organ vasculitides, often referred to, in clinical practice, as isolated "cutaneous leukocyctoclastic vasculitis", terms which may correspond to histological findings or descriptions, but are imprecise and not specific. Since ...
Source: Presse Medicale - July 6, 2020 Category: General Medicine Authors: Micheletti RG, Pagnoux C Tags: Presse Med Source Type: research

Adult-onset IgA vasculitis (Henoch-Sch önlein): update on therapy.
Adult-onset IgA vasculitis (Henoch-Schönlein): update on therapy. Presse Med. 2020 Jul 06;:104035 Authors: Maritati F, Canzian A, Fenaroli P, Vaglio A Abstract Immunoglobulin A vasculitis (IgAV, formerly Henoch-Schönlein purpura) is a systemic inflammatory disease affecting small vessels. While it is common and usually benign in childhood, in adults it is rarer has a more severe course. Its main manifestations are cutaneous purpura, arthralgias or arthritis, acute enteritis and glomerulonephritis. Renal involvement is associated with a poor prognosis in adults. The treatment of adult-onset I...
Source: Presse Medicale - July 6, 2020 Category: General Medicine Authors: Maritati F, Canzian A, Fenaroli P, Vaglio A Tags: Presse Med Source Type: research

Anca-associated vasculitides: recommendations of the french vasculitis study group on the use of immunosuppressants and biotherapies for remission induction and maintenance.
ANCA-ASSOCIATED VASCULITIDES: RECOMMENDATIONS OF THE FRENCH VASCULITIS STUDY GROUP ON THE USE OF IMMUNOSUPPRESSANTS AND BIOTHERAPIES FOR REMISSION INDUCTION AND MAINTENANCE. Presse Med. 2020 Jul 06;:104031 Authors: Terrier B, Charles P, Aumaître O, Belot A, Bonnotte B, Crabol Y, Durel CA, Ebbo M, Jourde-Chiche N, Lega JC, Puéchal X, Pugnet G, Quemeneur T, Ribi C, Samson M, Vandergheynst F, Guillevin L, French Vasculitis Study Group/pour le Groupe Français d’Etude des Vascularites (GFEV) Abstract Treatment of vasculitides associated with anti-neutrophil cytoplasm antibodies (A...
Source: Presse Medicale - July 6, 2020 Category: General Medicine Authors: Terrier B, Charles P, Aumaître O, Belot A, Bonnotte B, Crabol Y, Durel CA, Ebbo M, Jourde-Chiche N, Lega JC, Puéchal X, Pugnet G, Quemeneur T, Ribi C, Samson M, Vandergheynst F, Guillevin L, French Vasculitis Study Group/pour le Groupe Français d’Etu Tags: Presse Med Source Type: research

Updates in the treatment of Granulomatosis with Polyangiitis and Microscopic Polyangiitis.
Abstract There have been great advances in the management of ANCA associated vasculitis over the past decades. We have gone from an era where the disease was almost universally fatal to trying to prevent long term side effects of treatment regimens. With the ability to use pulse cyclophosphamide or rituximab as alternates to oral cyclophosphamide for induction of remission, side effects of therapy have been greatly reduced. New approaches have drastically changed our approach to maintenance and we now favor much longer durations of maintenance therapy as they are more successful in preventing relapse. Steroids hav...
Source: Presse Medicale - July 4, 2020 Category: General Medicine Authors: Garner S, Khalidi N Tags: Presse Med Source Type: research

A New Challenge For La Presse M édicale.
A New Challenge For La Presse Médicale. Presse Med. 2020 Jul 02;:104030 Authors: Guillevin L PMID: 32622800 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - July 2, 2020 Category: General Medicine Authors: Guillevin L Tags: Presse Med Source Type: research

Interstitial lung diseases in children.
Abstract Interstitial lung disease (ILD) in children (chILD) is a heterogeneous group of rare respiratory disorders that are mostly chronic and associated with high morbidity and mortality. The pathogenesis of the various chILD is complex and the diseases share common features of inflammatory and fibrotic changes of the lung parenchyma that impair gas exchanges. The etiologies of chILD are numerous. In this review, we chose to classify them as ILD related to exposure/environment insults, ILD related to systemic and immunological diseases, ILD related to primary lung parenchyma dysfunctions and ILD specific to infa...
Source: Presse Medicale - June 18, 2020 Category: General Medicine Authors: Nathan N, Berdah L, Delestrain C, Sileo C, Clement A Tags: Presse Med Source Type: research

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Presse Med. 2020 May 21;:104027 Authors: Alamri A, Oriez C, Bouilloud F, Dupuy O, Hamou AB PMID: 32447056 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - May 21, 2020 Category: General Medicine Authors: Alamri A, Oriez C, Bouilloud F, Dupuy O, Hamou AB Tags: Presse Med Source Type: research

Impact of genetic factors on fibrosing interstitial lung diseases Incidence and clinical presentation in adults.
PMID: 32437840 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - May 10, 2020 Category: General Medicine Authors: Borie R, Kannengiesser C, Dupin C, Debray MP, Cazes A, Crestani B Tags: Presse Med Source Type: research

Evolution and treatment of idiopathic pulmonary fibrosis.
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic and devastating disease of unknown etiology, characterized by irreversible morphological changes, ultimately leading to lung fibrosis and death. In recent years, significant progress has been achieved in understanding the pathogenesis of IPF. Moreover, we assisted to the conceptual change of the pathogenic hypothesis that currently considers IPF as a primarily fibrotic driven disease. However, despite the undeniable progress, the diagnosis of IPF remains still very complex requiring the presence of a team of experts to achieve the highest level of diagnosti...
Source: Presse Medicale - May 10, 2020 Category: General Medicine Authors: Torrisi SE, Kahn N, Vancheri C, Kreuter M Tags: Presse Med Source Type: research

Adult interstitial lung diseases and their epidemiology.
nes H PMID: 32437842 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - May 10, 2020 Category: General Medicine Authors: Sesé L, Khamis W, Jeny F, Uzunhan Y, Duchemann B, Valeyre D, Annesi-Maesano I, Nunes H Tags: Presse Med Source Type: research

Diagnostic approach of fibrosing interstitial lung diseases of unknown origin.
PMID: 32437843 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - May 10, 2020 Category: General Medicine Authors: Cottin V, Valenzuela C Tags: Presse Med Source Type: research

[Lung Transplantation for Idiopathic Pulmonary Fibrosis].
PMID: 32437844 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - May 10, 2020 Category: General Medicine Authors: Pavec JL, Dauriat G, Gazengel P, Dolidon S, Hanna A, Feuillet S, Pradere P, Crutu A, Florea V, Boulate D, Mitilian D, Fabre D, Mussot S, Mercier O, Fadel E Tags: Presse Med Source Type: research

Interstitial lung diseases.
PMID: 32387530 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - May 6, 2020 Category: General Medicine Authors: Valeyre D, Humbert M Tags: Presse Med Source Type: research

Pancreatic and biliary tract involvement in IgG4-related disease.
;vy P PMID: 32234378 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 28, 2020 Category: General Medicine Authors: Rebours V, Lévy P Tags: Presse Med Source Type: research

Aortitis And Periaortitis: The Puzzling Spectrum Of Inflammatory Aortic Diseases.
PMID: 32234379 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 28, 2020 Category: General Medicine Authors: Marvisi C, Buttini EA, Vaglio A Tags: Presse Med Source Type: research

Renal involvement in IgG4-related disease.
PMID: 32234380 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 28, 2020 Category: General Medicine Authors: Boffa JJ, Esteve E, Buob D Tags: Presse Med Source Type: research

Pathological characteristics and diagnosis of IgG4-related disease.
PMID: 32234381 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 28, 2020 Category: General Medicine Authors: Zen Y Tags: Presse Med Source Type: research

Pseudoaneurysmal angiolymphoid hyperplasia with eosinophilia and IgG4 –related disease : a possible overlap?
Pseudoaneurysmal angiolymphoid hyperplasia with eosinophilia and IgG4–related disease : a possible overlap? Presse Med. 2020 Mar 28;:104019 Authors: Lacasse M, Merlini T, Miquelestorena-Standley E, Maillot F, Lioger B PMID: 32234382 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 28, 2020 Category: General Medicine Authors: Lacasse M, Merlini T, Miquelestorena-Standley E, Maillot F, Lioger B Tags: Presse Med Source Type: research

Pathophysiology of IgG4-related disease: a T follicular helper cells disease?
itz N PMID: 32234383 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 28, 2020 Category: General Medicine Authors: De Sainte Marie B, Urban ML, Vély F, Seguier J, Grados A, Daniel L, Ebbo M, Schleinitz N Tags: Presse Med Source Type: research

IgG4 hypophysitis: diagnosis and management.
PMID: 32234384 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 28, 2020 Category: General Medicine Authors: Lojou M, Bonneville JF, Ebbo M, Schleinitz N, Castinetti F Tags: Presse Med Source Type: research

What Do The IgG4-Related Disease (IgG4-RD) Classification Criteria.
PMID: 32229230 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 27, 2020 Category: General Medicine Authors: Stone JH Tags: Presse Med Source Type: research

[La Presse M édicale evolves: Not one, but three journals!]
[La Presse Médicale evolves: Not one, but three journals!] Presse Med. 2019 Dec;48(12):1363-1364 Authors: Bodossian P, Comité de Rédaction deLa Presse Médicale PMID: 31822335 [PubMed - in process] (Source: Presse Medicale)
Source: Presse Medicale - December 1, 2019 Category: General Medicine Authors: Bodossian P, Comité de Rédaction deLa Presse Médicale Tags: Presse Med Source Type: research

[Cardiovascular risk in inflammatory bowel disease].
PMID: 31822336 [PubMed - in process] (Source: Presse Medicale)
Source: Presse Medicale - December 1, 2019 Category: General Medicine Authors: Kirchgesner J Tags: Presse Med Source Type: research

[Smoking cessation: Overcoming "nicotinophobia" in patients … and prescribers?]
[Smoking cessation: Overcoming "nicotinophobia" in patients … and prescribers?] Presse Med. 2019 Dec;48(12):1368-1369 Authors: Galera O, Antoine D, Soukarie L, Huet I, Bajon D PMID: 31822337 [PubMed - in process] (Source: Presse Medicale)
Source: Presse Medicale - December 1, 2019 Category: General Medicine Authors: Galera O, Antoine D, Soukarie L, Huet I, Bajon D Tags: Presse Med Source Type: research

[Editorial].
PMID: 31822338 [PubMed - in process] (Source: Presse Medicale)
Source: Presse Medicale - December 1, 2019 Category: General Medicine Authors: Pol S Tags: Presse Med Source Type: research

[Emerging viral outbreaks].
PMID: 31822339 [PubMed - in process] (Source: Presse Medicale)
Source: Presse Medicale - December 1, 2019 Category: General Medicine Authors: Bricaire F Tags: Presse Med Source Type: research

[Human papillomaviruses vaccination: Vaccine intentions of parents of children aged 10  to 11s in Normandy schools after an information campaign during the 2015-2016 school year].
This study assessed the knowledge of parents from Normandy about this vaccine and measured the impact of an information campaign on their intent to have their children vaccinated. METHODS: Parents from Normandy with children in sixth-grade class, aged 10 to 11, during the 2015-2016 school year were included. The secondary schools were selected in collaboration with academic institutions. The intent to have their child vaccinated was measured with a questionnaire distributed to children in April 2016 and collected from May to June 2016 by school nurses. RESULTS: Among the 16 selected secon...
Source: Presse Medicale - November 27, 2019 Category: General Medicine Authors: Jeanne M, Eve S, Pasquier J, Blaizot X, Turck M, Raginel T Tags: Presse Med Source Type: research

[Epidemic and emerging prone-infectious diseases: Lessons learned and ways forward].
te; M Abstract Africa along side with south-east Asia are the epicentres of emerging and epidemic prone-infectious diseases and megacity biosecurity threat scenarios. Massive mobility and reluctance in the populations exposed to epidemic and emerging prone-infectious diseases coupled by a weak health system made disease alert and control measures difficult to implement. The investigation of virus detection and persistence in semen across a range of emerging viruses is useful for clinical and public health reasons, in particular for viruses that lead to high mortality or morbidity rates or to epidemics. Innovating ...
Source: Presse Medicale - November 26, 2019 Category: General Medicine Authors: Denis M, Bernard-Alex G, René M Tags: Presse Med Source Type: research

[Gambling and Gaming disorders and physical health of players: A critical review of the literature].
CONCLUSION: Data reported in this review documented that individuals with gaming or gambling disorders have an impaired physical health. Knowledge of the symptoms reported could help primary care physicians to better screen for gambling and gaming disorders among their patients. PMID: 31767247 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 22, 2019 Category: General Medicine Authors: Benchebra L, Alexandre JM, Dubernet J, Fatséas M, Auriacombe M Tags: Presse Med Source Type: research

[Vagus nerve stimulation and depression].
Abstract Vagus nerve stimulation (VNS) is an old, yet new, option for treatment-resistant depression. Despite several clinical trials over the last 15 years showing a consistent benefit-risk balance of the technic, VNS still struggles to find its place in our therapeutic algorithms. This is especially true in France, where only a few surgeries have been performed nationwide, all in the last year. The reasons behind this lag are manifolds; (1) psychiatrists usually do not consider surgical treatments, even when they are minimally invasive and reversible, (2) early VNS trials stumbled on methodological difficulties ...
Source: Presse Medicale - November 22, 2019 Category: General Medicine Authors: Senova S, Rabu C, Beaumont S, Michel V, Palfi S, Mallet L, Domenech P Tags: Presse Med Source Type: research

[What are the determinants of viral outbreaks and is it possible to predict their emergence?]
Abstract The emergence of a viral disease most often results from an imbalance in the interaction between the infectious agent, the host and the environment. After the introduction phase of a viral disease in a territory or a given population and once the first chains of transmission occur, the spread of the disease or its sustainability are possible if the control measures are not implemented or are not sufficiently effective. If it is difficult to anticipate the occurrence and introduction of an emerging viral disease, the following three key elements must be strengthened to limit its impact: (1) anticipation an...
Source: Presse Medicale - November 22, 2019 Category: General Medicine Authors: Che D Tags: Presse Med Source Type: research

Factors involved in seeking care at a specialty service among alcoholic rural French women: A cross-sectional study of rural women.
CONCLUSION: Increased knowledge of the specific characteristics of rural alcoholic women is needed to develop programs that will increase awareness of and access to specialty treatment services among these women. PMID: 31767250 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 22, 2019 Category: General Medicine Authors: Bourion-Bédès S, Clerc-Urmès I, Bédès A, Baumann C Tags: Presse Med Source Type: research

[FIB-4  index to rule-out advanced liver fibrosis in NAFLD patients].
[FIB-4 index to rule-out advanced liver fibrosis in NAFLD patients]. Presse Med. 2019 Nov 22;: Authors: Mallet V, Parlati L, Vallet-Pichard A, Terris B, Tsochatzis E, Sogni P, Pol S Abstract The FIB-4 index is a biomarker of advanced hepatic fibrosis in a context of fatty liver disease. The calculation of the FIB-4 index requires of age, serum ALT and AST transaminase levels and platelet count. A FIB-4 index1.45 in a context of fatty liver disease. A complete hepatological workup is mafatory for a FIB-4 index>3.25 in a context of fatty liver disease. PMID: 31...
Source: Presse Medicale - November 22, 2019 Category: General Medicine Authors: Mallet V, Parlati L, Vallet-Pichard A, Terris B, Tsochatzis E, Sogni P, Pol S Tags: Presse Med Source Type: research

[Pathogenesis of non-alcoholic fatty liver disease].
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) is a complex chronic disease resulting from an interaction between genetic and environmental factors. The phenotype and pathophysiology of NAFLD is heterogeneous. NAFLD is a continuum of histological lesions of the liver from steatosis, Non-Alcoholic SteatoHepatitis (NASH), NASH with fibrosis, cirrhosis to hepatocellular carcinoma. The pathophysiology encompasses a dysfunction in fatty tissue (sub-cutaneous and visceral) associated with insulin-resistance and metabolic inflammation. NAFLD is a "multi-systemic" disease. Reciprocal and aggravating interact...
Source: Presse Medicale - November 22, 2019 Category: General Medicine Authors: Anty R, Gual P Tags: Presse Med Source Type: research

[Who is at risk for drug-drug interactions in type 2 diabetic patients?]
let B PMID: 31761604 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 21, 2019 Category: General Medicine Authors: Laurent C, Aho Glele LS, Lazzarotti A, Petit JM, Vergès B, Bouillet B Tags: Presse Med Source Type: research

[Radiological and etiological features of acute disseminated encephalomyelitis in adults].
PMID: 31761605 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 21, 2019 Category: General Medicine Authors: Oumerzouk J, Abida N, Bourazza A, Chraa M, Louhab N, Kissani N Tags: Presse Med Source Type: research

[Cardiovascular imaging in heart failure].
hen A Abstract Transthoracic echocardiography remains the first-line cardiac imaging for diagnosis, management and screening of heart failure, whatever its phenotype (heart failure with reduced, mid-range and preserved ejection fraction). It allows anatomic characterization, systolic and diastolic functions of left and right ventricles assessment, intracardiac hemodynamic evaluation and for the assessment of valve disease. Myocardial deformation imaging (strain) is indicated in patients with heart failure for the assessment of systolic ventricles function and the diagnosis of specific heart diseases. Strain is ind...
Source: Presse Medicale - November 21, 2019 Category: General Medicine Authors: Nhan P, Ederhy S, Soulat-Dufour L, Ancedy Y, Chauvet-Droit M, Adavane-Scheublé S, Ben Said R, Lajus M, Boccara F, Cohen A Tags: Presse Med Source Type: research

[Hormonal Assessment of Secondary Hypertension - How to do it and what to expect?]
e B Abstract The Hormonal assessment of Arterial Hypertension (HTA) is an important part of the balance of resistant hypertension. This assessment - going well beyond the search for primary hyperaldosteronism (PHA) - requires a rigorous methodology and a robust experience of the nursing team within a dedicated unit: the HTA Day Hospital. If all the conditions are met and the assessment carried out well, it will allow a significant profitability since in this resistant hypertensive population it will detect a particular mechanism or secondary hypertension in 70% of patients. Since the diagnosis of PHA is ...
Source: Presse Medicale - November 21, 2019 Category: General Medicine Authors: Silhol F, Sarlon-Bartoli G, Vaïsse B Tags: Presse Med Source Type: research

[Assessment for antihypertensive drug intake in France in 2019 and adherence].
a P Abstract Non-adherence to antihypertensive treatment is one of the critical contributors to sub-optimal blood pressure control. The French Society of Hypertension remembered that urine and serum biochemical detection of antihypertensive drugs could be useful in a patient with resistant hypertension. Talking to a patient with biochemically confirmed non-adherence to blood pressure-lowering therapy and repeating them improved adherence to drugs. Despite its usefulness, biochemical detection of antihypertensive drugs is not routinely effective in France as they are not reimbursed by French Medical Care, except in...
Source: Presse Medicale - November 21, 2019 Category: General Medicine Authors: Bouhanick B, Vaïsse B, Schavgoulidze A, Gandia P Tags: Presse Med Source Type: research

[Therapeutic patient education in oncology].
e;e A PMID: 31761609 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 21, 2019 Category: General Medicine Authors: Vallée A Tags: Presse Med Source Type: research

Oesophageal gastric heterotopia.
PMID: 31759789 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 20, 2019 Category: General Medicine Authors: Meriem S, Dorra T, Raja J, Nawel B, Asma O Tags: Presse Med Source Type: research

Therapeutic plasma exchange in thrombotic thrombocytopenic purpura.
po P Abstract Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease related to the formation of microvascular thrombosis and subsequent organ failure. The disease is accompanied with microangiopathic haemolytic anaemia, consumptive thrombocytopenia and lies on a severe deficiency in ADAMTS13, the von Willebrand factor-cleaving protease. In the acquired, immune-mediated form, this deficiency is due to the production of autoantibodies directed against the enzyme. Therapeutic plasma exchange has been used empirically for decades and still represents the cornerstone of TTP treatment. However, a bette...
Source: Presse Medicale - November 20, 2019 Category: General Medicine Authors: Picod A, Provôt F, Coppo P Tags: Presse Med Source Type: research

Leiomyoma in breast ectopic tissue.
PMID: 31759791 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 20, 2019 Category: General Medicine Authors: Arrob A, Sabah TN, Abouchadi A Tags: Presse Med Source Type: research

[Transhumanism: The cutting edge biology of the … 17th century].
[Transhumanism: The cutting edge biology of the… 17th century]. Presse Med. 2019 Nov 20;: Authors: Le Bourg E PMID: 31759792 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 20, 2019 Category: General Medicine Authors: Le Bourg E Tags: Presse Med Source Type: research

[Nutritional Management of Nonalcoholic fatty liver disease (NAFLD)].
Abstract Nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity and insulin resistance. There is currently no pharmacological treatment validated in steatosis. The combination of weight loss and adequate physical activity can improve liver steatosis. In randomized trials and cohort studies, a weight loss of at least 7% and a diet approaching the Mediterranean diet have been associated with an improvement in hepatic fat content, an improvement in hepatic biomarkers, and regression of histological signs of steatosis. Bariatric surgery by losing weight can lead to an improvement in hepatic fat c...
Source: Presse Medicale - November 19, 2019 Category: General Medicine Authors: Ait Boudaoud A, Rives-Lange C, Perregaux JF, Radu A, Messager-Josipowicz D, Barsamian C, Carette C, Czernichow S Tags: Presse Med Source Type: research

[Epidemiology of non-alcoholic steatohepatitis. Extent/burden of the problem and its impact on public health].
Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease, the most common cause of chronic liver function augmentation and it will be the most common indication for liver transplantation in 2020. The prevalence of NAFLD has increased over time in line with the increase of obesity and type 2 diabetes. There is a discrepancy between the studies concerning the prevalence of NAFLD because of the different diagnostic methods used (ultrasound or magnetic resonance, fibroscan, controlled attenuation parameter (CAP), histology). Because of its high prevalence the impact of NAFLD in publ...
Source: Presse Medicale - November 19, 2019 Category: General Medicine Authors: Vallet-Pichard A, Parlati L, Pol S Tags: Presse Med Source Type: research