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[Plague: A regular reemergence but not a past scourge].
PMID: 29224703 [PubMed - in process] (Source: Presse Medicale)
Source: Presse Medicale - December 1, 2017 Category: General Medicine Authors: Bricaire F Tags: Presse Med Source Type: research

[How to improve endometriosis management].
t N PMID: 29224704 [PubMed - in process] (Source: Presse Medicale)
Source: Presse Medicale - December 1, 2017 Category: General Medicine Authors: Daraï E, Chabbert-Buffet N Tags: Presse Med Source Type: research

Erratum à l’article : « Lévothyrox® : les enseignements d’une polémique insensée » [Press. Med. 46(10) (2017) 887–9].
Erratum à l’article : « Lévothyrox® : les enseignements d’une polémique insensée » [Press. Med. 46(10) (2017) 887–9]. Presse Med. 2017 Dec;46(12 Pt 1):1240 Authors: Wémeau JL, Ladsous M PMID: 29224705 [PubMed - in process] (Source: Presse Medicale)
Source: Presse Medicale - December 1, 2017 Category: General Medicine Authors: Wémeau JL, Ladsous M Tags: Presse Med Source Type: research

Iron overload in hematological disorders.
Abstract While most common symptom of impairment of iron homeostasis is iron deficiency anemia, some hematological disorders are associated with iron overload (IO). These disorders are related mainly to chronic severe hemolytic anemia, where red blood cells (RBC) or their precursors are destroyed prematurely (hemolyzed), leading to anemia that cannot be compensated by increased production of new RBC. In such cases, IO is mainly due to repeated RBC transfusions and/or increased uptake of iron in the gastrointestinal tract. Normally, iron is present in the plasma and in the cells bound to compounds that render it re...
Source: Presse Medicale - November 22, 2017 Category: General Medicine Authors: Fibach E, Rachmilewitz EA Tags: Presse Med Source Type: research

Temporal trends in the premorbid use of preventive treatments in patients with acute ischemic cerebrovascular events and a history of vascular disease: The Dijon Stroke Registry (1985-2010).
acute;jot Y Abstract INTRODUCTION: Although secondary prevention in patients with arterial vascular diseases has improved, a gap between recommendations and clinical practice may exist. OBJECTIVES: We aimed to evaluate temporal trends in the premorbid use of preventive treatments in patients with ischemic cerebrovascular events (ICVE) and prior vascular disease. METHODS: Patients with acute ICVE (ischemic stroke/TIA) were identified through the population-based stroke registry of Dijon, France (1985-2010). Only those with history of arterial vascular disease were included and were classified into four gr...
Source: Presse Medicale - November 22, 2017 Category: General Medicine Authors: Khoumri C, Bailly H, Delpont B, Daubail B, Blanc C, Chazalon C, Durier J, Hervieu-Bègue M, Osseby GV, Rouaud O, Giroud M, Vergely C, Béjot Y Tags: Presse Med Source Type: research

[Management of endometrioma].
Abstract Preoperative evaluation: clinical examination, and research for associated lesions. Laparoscopic approach. Cystectomy: gold standard, conformed to the endometrioma pathophysiology (3 zones). Laser CO2 Plasmajet® vaporisation: important data lead to legitimate utilisation. Haemostasis: be patient! Use of bipolar energy sparingly. Look for other endometriotic lesions, and systematic treatment. Preoperative medical treatment not always useful. Postoperative treatment: decrease recurrence. Especially for patients with no immediate pregnancy desire. PMID: 29174658 [PubMed - as supplied by publisher] (...
Source: Presse Medicale - November 21, 2017 Category: General Medicine Authors: Chauvet P, Roman H, Gremeau AS, Canis M, Bourdel N Tags: Presse Med Source Type: research

[Creation of expert centers on endometriosis].
r F Abstract Endometriosis is a frequent pathology with a high incidence of deep infiltrating endometriosis and complex forms that can affect 20% of patients with endometriosis. The incidence of infertility associated with endometriosis can reach 50%. The complexity of care requires the creation of expert centers working in networks with general practitioners. Criteria for defining these expert centers are being drawn up, based on structural criteria (multidisciplinary consultation meeting), links with medical assistance structures for procreation and activity criteria for severe and complex forms (number of inter...
Source: Presse Medicale - November 20, 2017 Category: General Medicine Authors: Daraï E, Bendifallah S, Chabbert-Buffet N, Golfier F Tags: Presse Med Source Type: research

Dysmetabolic iron overload syndrome (DIOS).
né F Abstract Dysmetabolic iron overload syndrome (DIOS) corresponds to mild increase in both liver and body iron stores associated with various components of metabolic syndrome in the absence of any identifiable cause of iron excess. It is characterized by hyperferritinemia with normal or moderately increased transferrin saturation, one or several metabolic abnormalities (increased body mass index with android distribution of fat, elevated blood pressure, dyslipidaemia, abnormal glucose metabolism, steatohepatitis), and mild hepatic iron excess at magnetic resonance imaging or liver biopsy. Alteration of i...
Source: Presse Medicale - November 20, 2017 Category: General Medicine Authors: Deugnier Y, Bardou-Jacquet É, Lainé F Tags: Presse Med Source Type: research

The changing landscape of iron overload disorders at the beginning of the 21st century.
PMID: 29169711 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 20, 2017 Category: General Medicine Authors: Rostoker G Tags: Presse Med Source Type: research

Genetic hemochromatosis: Pathophysiology, diagnostic and therapeutic management.
;al O Abstract The term hemochromatosis (HC) corresponds to several diseases characterized by systemic iron overload of genetic origin and affecting both the quality of life and life expectancy. Major improvement in the knowledge of iron metabolism permits to divide these diseases into two main pathophysiological categories. For most HC forms (types 1, 2, 3 and 4B HC) iron overload is related to cellular hepcidin deprivation which causes an increase of plasma iron concentration and the appearance of plasma non-transferrin bound iron. In contrast, iron excess in type 4A ferroportin disease is related to decreased c...
Source: Presse Medicale - November 17, 2017 Category: General Medicine Authors: Brissot P, Cavey T, Ropert M, Guggenbuhl P, Loréal O Tags: Presse Med Source Type: research

[Imaging in the initial and preoperative assessment of endometriosis].
Abstract The diagnosis of pelvic endometriosis is based on the combination of clinical examination, endovaginal ultrasonography and pelvic MRI. Ultrasonography displays a moderate sensitivity and a high specificity. Pelvien MRI displays a better sensitivity and lower specificity. PMID: 29153376 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 16, 2017 Category: General Medicine Authors: Thomassin-Naggara I, Kermarrec E, Beldjord S, Bazot M, Tavolaro S, Darai E Tags: Presse Med Source Type: research

Iatrogenic iron overload and its potential consequences in patients on hemodialysis.
Abstract Iron overload was considered rare in hemodialysis patients until recently, but its clinical frequency is now increasingly recognized. The liver is the main site of iron storage and the liver iron concentration (LIC) is closely correlated with total iron stores in patients with secondary hemosiderosis and genetic hemochromatosis. Magnetic resonance imaging (MRI) is now the gold standard method for estimating and monitoring LIC. Studies of LIC in hemodialysis patients by magnetic susceptometry thirteen years ago and recently by quantitative MRI have demonstrated a relation between the risk of iron overload ...
Source: Presse Medicale - November 16, 2017 Category: General Medicine Authors: Rostoker G, Vaziri ND Tags: Presse Med Source Type: research

Diagnosis of hyperferritinemia in routine clinical practice.
tte B Abstract The discovery of hyperferritinemia is often fortuitous, revealed in results from a laboratory screening or follow-up test. The aim of the diagnostic procedure is therefore to identify its cause and to identify or rule out hepatic iron overload, in a three-stage process. In the first step, clinical findings and several simple laboratory tests are sufficient to detect four of the most frequent causes of high ferritin concentrations: alcoholism, inflammatory syndrome, cytolysis, and metabolic syndrome. None of these causes is associated with substantial hepatic iron overload. If transferrin saturation ...
Source: Presse Medicale - November 14, 2017 Category: General Medicine Authors: Lorcerie B, Audia S, Samson M, Millière A, Falvo N, Leguy-Seguin V, Berthier S, Bonnotte B Tags: Presse Med Source Type: research

[Pathogenesis, genetics and diagnosis of endometriosis].
h S Abstract Endometriosis is a multifactorial pathology. Trans-tubal reflux theory remains valid. Genetic and epigenetic factors associated with immunological perturbations are involved. The role of endocrine disruptors is discussed although epidemiological studies are contradictory. Therapeutics are primarily based on hormonal treatments but better understanding of pathophysiology should allow targeted non-hormonal therapy. The clinical examination is sometimes negative, which should not eliminate the diagnosis and imposes complementary examinations as best as possible by referents. PMID: 29150232 [PubMed -...
Source: Presse Medicale - November 14, 2017 Category: General Medicine Authors: Daraï E, Ploteau S, Ballester M, Bendifallah S Tags: Presse Med Source Type: research

Management of first depression or generalized anxiety disorder episode in adults in primary care: A systematic metareview.
CONCLUSIONS: From the best evidence-based data, we created two algorithms to guide GPs for the management of MDD and or the management of GAD. These algorithms will be implemented through a website available for GPs consultation. PMID: 29150233 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 14, 2017 Category: General Medicine Authors: Driot D, Bismuth M, Maurel A, Soulie-Albouy J, Birebent J, Oustric S, Dupouy J Tags: Presse Med Source Type: research

[Medical studies in France: How to cope with such a disaster?]
PMID: 29150234 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 14, 2017 Category: General Medicine Authors: Diot P Tags: Presse Med Source Type: research

[Medical treatment of endometriosis: Hormonal treatment of pain, impact on evolution and future perspectives].
CONCLUSION: Hormonal treatment of endometriosis relies on combined hormonal contraceptives (using different routes of administration), progestins and particularly the levonorgestrel-releasing IUS, and GnRH analogs as a last option, in combination with an add-back therapy. Promising alternatives are currently under preclinical and clinical evaluation. PMID: 29133081 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 10, 2017 Category: General Medicine Authors: Geoffron S, Legendre G, Daraï E, Chabbert-Buffet N Tags: Presse Med Source Type: research

[Impact of residents arrival on requests for secondary medicalized inter-hospital transfers].
PMID: 29133082 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 10, 2017 Category: General Medicine Authors: Ameur L, Reuter PG, Akodad H, Adnet F, Lapostolle F Tags: Presse Med Source Type: research

Jejunal diverticulitis. Review and treatment algorithm.
Abstract Diverticulitis is much less common in the jejunum than in colonic diverticula probably because of diverticulum larger size, better intra-luminal flow and relatively sterile jejunal content. Complications of jejunal diverticulitis are acute intestinal obstruction, diverticular bleeding and mainly perforation with mesenteric abscess, localized or generalized peritonitis. The Multi-detector row computed tomography is now the best diagnostic imaging for small bowel diverticulitis as well as its complications. Magnetic resonance enterography is also quite useful but it is still impractical to resort to such an...
Source: Presse Medicale - November 10, 2017 Category: General Medicine Authors: Harbi H, Kardoun N, Fendri S, Dammak N, Toumi N, Guirat A, Mzali R Tags: Presse Med Source Type: research

MRI for the measurement of liver iron content, and for the diagnosis and follow-up of iron overload disorders.
Abstract MRI is now the reference method for detecting and quantifying hepatic and extrahepatic iron overload, regardless of its cause. The decrease of the hepatic signal is proportional to the amount of iron in the tissues. It is more pronounced with T2*-weighted gradient echo sequences. It increases proportionally with the strength of the magnetic field. Thus a 3-T MRI is be more sensitive and probably more accurate to detect a slight iron overload, as seen in dysmetabolic hepatosiderosis. Conversely, a 1.5-T MRI better estimates a high overload. Quantification can be done with the calculation of T2* (or R2*) or...
Source: Presse Medicale - November 10, 2017 Category: General Medicine Authors: Paisant A, d'Assignies G, Bannier E, Bardou-Jacquet E, Gandon Y Tags: Presse Med Source Type: research

[Fertility and deep infiltrating endometriosis].
Abstract Deep infiltrating endometriosis is the most severe form of the disease, defined by infiltration beneath the peritoneum greater than 5mm. It affects several anatomical locations including the bladder, the vesico-uterine cul-de-sac, the torus uterinum, the uterosacral ligament, rectovaginal septum and the colon-rectum. Deep infiltrating endometriosis is associated with infertility. Surgery performed for deep infiltrating endometriosis in the context of pain offers good pregnancy rates either spontaneously or after assisted reproductive technologies. The results are less favorable when digestive tract is inv...
Source: Presse Medicale - November 9, 2017 Category: General Medicine Authors: Cohen J, Mathieu d'Argent E, Selleret L, Antoine JM, Chabbert-Buffet N, Bendifallah S, Ballester M, Darai E Tags: Presse Med Source Type: research

Iron metabolism and the role of the iron-regulating hormone hepcidin in health and disease.
Abstract Although iron is vital, its free form is likely to be involved in oxidation-reduction reactions, leading to the formation of free radicals and oxidative stress. Living organisms have developed protein systems to transport free iron through the cell membranes and biological fluids and store it in a non-toxic and readily mobilizable form to avoid iron toxicity. Hepcidin plays a crucial role in maintaining iron homeostasis. Hepcidin expression is directly regulated by variations in iron intake and its repression leads to an increase in bioavailable serum iron level. However, in pathological situations, prolo...
Source: Presse Medicale - November 9, 2017 Category: General Medicine Authors: Daher R, Manceau H, Karim Z Tags: Presse Med Source Type: research

[Oxacillin-induced DRESS syndrome].
PMID: 29129411 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2017 Category: General Medicine Authors: Rekik S, Abdelkefi I, Boussaid S, Srairi S, Sahli H, Cheour I, Elleuch M Tags: Presse Med Source Type: research

Fatal acute liver failure induced by cyproterone acetate: A new case.
PMID: 29129412 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2017 Category: General Medicine Authors: Nour E, Mehdi K, Hanene J, Hammami A, Ben Slama A, Ali J Tags: Presse Med Source Type: research

[Rickets from vitamin D deficiency and family deficiency].
acute;ron G PMID: 29129413 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2017 Category: General Medicine Authors: Tarbé de Saint Hardouin AL, Angoulvant F, Chéron G Tags: Presse Med Source Type: research

[Surgical management of deep infiltrating endometriosis with bowel involvement and urinary tract involvement].
Abstract Endometriosis is a benign pathology that affects 3% of the general population and about 10% of women of reproductive age. Three anatomoclinical entities are described: peritoneal, ovarian (endometrioma) and deep endometriosis characterized by the infiltration of anatomical structures or organs beyond the peritoneum. Laparoscopic surgery should be performed, as this is associated with a reduction in postoperative complications, length of hospitalization and convalescence. Several surgical techniques allow the removal of deep endometriosis with colorectal involvement: rectal shaving, anterior discoid resect...
Source: Presse Medicale - November 9, 2017 Category: General Medicine Authors: Bendifallah S, Ballester M, Darai E Tags: Presse Med Source Type: research

[IVF and endometriosis, oocyte donation and fertility preservation].
Abstract Endometriosis is a common condition, causing pain and infertility. In infertile woman with superficial peritoneal endometriosis and patent tubes, laparoscopy is recommended, followed by ovarian stimulation alone or in combination with intrauterine inseminations. In case of ovarian or deep endometriosis, the indications of surgery and assisted reproductive technologies remain to be defined precisely. In vitro fertilization is generally proposed after the failure of up to three inseminations, directly for ovarian or deep endometriosis, or in case of an associated factor of infertility, mainly male. Before o...
Source: Presse Medicale - November 9, 2017 Category: General Medicine Authors: d'Argent EM, Antoine JM Tags: Presse Med Source Type: research

Lung transplantation for mitomycin-induced pulmonary veno-occlusive disease.
PMID: 29129416 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2017 Category: General Medicine Authors: Savale L, Chaumais MC, Dorfmuller P, Humbert M, Montani D Tags: Presse Med Source Type: research

[Metronidazole-induced encephalopathy (MIE)].
PMID: 29129417 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2017 Category: General Medicine Authors: Giraud N, Ripault-Cesbron H, Cottier JP, Dardaine-Giraud V Tags: Presse Med Source Type: research

[Should we consume less salt?]
PMID: 29128274 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 8, 2017 Category: General Medicine Authors: Delahaye F Tags: Presse Med Source Type: research

[The infections of the ear].
Abstract In front of external otitis in spite of a well-conducted treatment, especially in immunodeficient patient, it is always necessary to look for an osteomyelitis of the skull base that requires an urgent parenteral antibiotic treatment of several weeks. Acute otitis media (AOM) is the most common bacterial infection of the child. In children under 2 years with purulent AOM, antibiotic therapy with amoxicilline is systematic for a period of 8-10 days. After 2 years of age and with mild symptoms of AOM, symptomatic treatment may be justified as first-line treatment. Chronic otitis media is frequ...
Source: Presse Medicale - October 30, 2017 Category: General Medicine Authors: Nowak C, Tanaka L, Bobin S, Nevoux J Tags: Presse Med Source Type: research

[The tumors of the ear].
Abstract Any cutaneous lesion of the outer ear must be managed jointly by a dermatologist and an ENT, regardless of the age of the patient. The presence of a malignant cutaneous carcinoma (Squamous cell carcinoma or melanoma) of the pavilion requires a minimum extension assessment by a cervical ultrasound, CT-scan and MRI will be prescribed according to the degree of infiltration and the presence of clinics signs (lymphadenopathy, facial paralysis, cognitive impairment). A polyp of the external auditory meatus must be systematically biopsied in consultation and, if necessary, in the operating room with fresh anato...
Source: Presse Medicale - October 30, 2017 Category: General Medicine Authors: Dubernard X, Kleiber JC, Brenet E, Louges MA, Veleine Y, Labrousse M, Makeieff M, Bazin A, Chays A Tags: Presse Med Source Type: research

[Medical devices correcting the deafness: Hearing aids and auditory implants].
cute; Abstract The management of deafness has become a major public health issue as their lack of detection has a deleterious effect in children and increases the risk factors for aggravation of other pathologies in adults. The detection of deafness remains a real challenge: in the newborn, systematic screening at birth is a good strategy, in adults, much remains to be done. The functional rehabilitation of deafness is based on the use of hearing aids by aerial or bone conduction or of auditory implants. There are three types of auditory implants available: bone anchored hearing implants, middle ear implants and c...
Source: Presse Medicale - October 30, 2017 Category: General Medicine Authors: Nevoux J, Coez A, Truy É Tags: Presse Med Source Type: research

[Good practices with tinnitus in adult].
Abstract The interrogation is essential to trace the genesis of the tinnitus and to appreciate its repercussion. Clinical examination should look for a local, vascular or cervical cause. The ENT consultation with audiogram and tinnitus evaluation is essential to know the characteristics of the tinnitus and to consider the treatment. If tinnitus is accompanied by a decrease in hearing, then wearing hearing aids can correct deafness and decrease the tinnitus. The psychological impact of tinnitus must always be taken into account and the use of a multidisciplinary team is an interesting solution. Medical treatments a...
Source: Presse Medicale - October 30, 2017 Category: General Medicine Authors: Le Pajolec C, Ohresser M, Nevoux J Tags: Presse Med Source Type: research

[Techniques and progress in the imaging of the ear].
Abstract Ear and temporal bone imaging is essential for the diagnostic and preoperative management of middle ear lesions. The scanner is the exam of choice to analyze the walls and the contents of the middle ear. MRI is used to characterize the opacities of the middle ear and to evaluate possible neurological complications. Modern imaging techniques allow intraoperative guidance in otological surgery. Hearing implants are not always a contraindication to MRI but require precautions according to the type of implant. PMID: 29097036 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - October 30, 2017 Category: General Medicine Authors: Garin A, Benoudiba F, Ducreux D Tags: Presse Med Source Type: research

[Causes, consequences and treatment of hypophosphatemia: A systematic review].
CONCLUSION: During at-risk situations, the systematic search for hypophosphatemia and its treatment may limit the occurrence of serious consequences. PMID: 29089216 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - October 28, 2017 Category: General Medicine Authors: Padelli M, Leven C, Sakka M, Plée-Gautier E, Carré JL Tags: Presse Med Source Type: research

[Role of ultrasonography in rheumatoid arthritis].
Abstract Ultrasound imaging may have an impact in management patients with rheumatoid arthritis. Through technological improvements, ultrasonography, has become an established imaging technique for the diagnosis and the follow up of this inflammatory chronic disease. In fact, ultrasounds, allow follow up during treatment by evaluating synovitis count and assessment of synovial vascularization by Power Doppler. Besides, erosions are found sooner and more frequently by ultrasonography than with conventional radiography. Rheumatologist training in sonography is essential, this technique has become indispensable in th...
Source: Presse Medicale - October 28, 2017 Category: General Medicine Authors: Miladi S, Ben Abdelghani K, Fazaa A, Laatar A, Zakraoui L Tags: Presse Med Source Type: research

[How to manage vertigo in adult?]
Abstract The interrogation and the clinical examination are critical in the research of vertigo etiology. In the context of vertigo, the vital emergencies are of neurological and vascular origins. It is therefore necessary to be able to identify them quickly and simply. Vertigo is a symptom to relieve and the cause is to be diagnosed. Careful questioning combined with neurological examination, nystagmus study, Halmagyi test and skew deviation search are more reliable than imaging in the first 48hours to detect a stroke. There are 12% false negatives in cerebral MRI and 74% false negative in cerebral CT-scan in the...
Source: Presse Medicale - October 28, 2017 Category: General Medicine Authors: Vuong Chaney H, Rohmer D, Charpiot A Tags: Presse Med Source Type: research

Known, new and emerging risk factors of hepatocellular carcinoma (review).
This article summarizes the known, new and emerging risk factors of HCC. PMID: 29089219 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - October 28, 2017 Category: General Medicine Authors: Trad D, Bibani N, Sabbah M, Elloumi H, Gargouri D, Ouakaa A, Kharrat J Tags: Presse Med Source Type: research

[Genetic hearing loss].
Abstract Deafness is the most common sensory disability in developed countries affecting more than 2 births in 1000. Eighty percent of congenital deafness is genetic. Universal newborn hearing screening has been in place since 2012 in France. All genetic hearing losses are not congenital and all congenital hearing losses are not genetic. Genetic hearing loss may be syndromic (associated with other symptoms) (10 %) or non-syndromic (isolated) (90 %). Hearing loss may initially be the only symptom of syndromic deafness. A genetic origin can be diagnosed and must therefore be evoked systematically...
Source: Presse Medicale - October 28, 2017 Category: General Medicine Authors: Tanaka-Ouyang L, Marlin S, Nevoux J Tags: Presse Med Source Type: research

[Spouses' health-related quality of life evaluation of elderly patients with depression].
CONCLUSION: The sexual quality of life of spouses of elderly patients suffering from a major depressive disorder was significantly impaired. The patients' and spouses' depression and the caregivers' burden also had a negative impact on several aspects of the HRQoL of the spouses. It seems to be important, therefore, to assess the mental state, care burden and HRQoL of spouses caring for elderly patients suffering from depression so as to offer help when required to partners in difficulty. PMID: 29089221 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - October 28, 2017 Category: General Medicine Authors: Jalenques I, Cleret M, Richard B, Rondepierre F, Auclair C Tags: Presse Med Source Type: research

[Management of prostate cancer in patients older than 75  years].
[Management of prostate cancer in patients older than 75 years]. Presse Med. 2017 Oct 17;: Authors: Mongiat-Artus P, Avenin D Abstract Prostate cancer is a disease of the elderly men. Prostate cancer in the elderly men is often poorly managed and under-treated. The digital rectal examination is an effective screening test for elderly prostate cancer patients. In order to choose the appropriated therapeutic option, evaluation of life-expectancy is essential to offer an optimal individualized treatment. It is essential to take into account the patients' aspirations before starting any diagnostic an...
Source: Presse Medicale - October 17, 2017 Category: General Medicine Authors: Mongiat-Artus P, Avenin D Tags: Presse Med Source Type: research

[Rates of total and free PSA prescriptions in France (2012-2014)].
CONCLUSION: Total PSA and free PSA assays are performed in a large number of men, although the value of these tests as first-line test before biopsy remains controversial. These PSA assays are associated with many other laboratory tests looking for possible abnormalities, especially in younger men, and their relevance may therefore not be specifically discussed with the patient. PMID: 29031682 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - October 11, 2017 Category: General Medicine Authors: Tuppin P, Leboucher C, Peyre-Lanquar G, Lamy PJ, Gabach P, Rébillard X Tags: Presse Med Source Type: research

[Focal therapies: An alternative option for low-risk prostate cancer management?]
Abstract Recommended options for low-risk prostate cancer treatment are active surveillance, radical treatments or watchful waiting. Focal therapies are currently assessed for low risk prostate cancer treatment. Focal therapies can be performed in research protocols. Oncologic results of these focal treatments are encouraging and show excellent tolerance with few complications. Radical treatments are still possible after focal therapies failure. Focal therapies are a possible solution to over-treatment issue of low risk prostate cancers. PMID: 29031683 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - October 11, 2017 Category: General Medicine Authors: Lebdai S, Lunelli L, Bigot P, Cussenot O, Azzouzi AR Tags: Presse Med Source Type: research

[Management of prostate cancer: The new challenges].
PMID: 29031684 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - October 11, 2017 Category: General Medicine Authors: Cussenot O Tags: Presse Med Source Type: research

[Progress in prostate cancer study: 3D cell culture enables the ex vivo reproduction of tumor characteristics].
te; X, Beauval JB Abstract Despite new therapeutics options, Prostate Cancer (PCa) remains a public health challenge because of its high incidence and mortality. Limits in PCa research come from the lack of in vitro and in vivo models that mimic the human disease. Currently, 2D in vitro tissue culture models of PCa are widely used but they present numerous limits. They do not reproduce cellular morphology, tissue architecture, inter-patients and intratumor heterogeneity. Furthermore, they lack two key components of PCa tumors, the tumoral microenvironment and the cancer stem cells. In vivo murine models of PCa can...
Source: Presse Medicale - September 26, 2017 Category: General Medicine Authors: Tostivint V, Racaud-Sultan C, Roumiguié M, Soulié M, Gamé X, Beauval JB Tags: Presse Med Source Type: research

[The mouth talks about endocrinopathies].
tte G PMID: 28943222 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - September 21, 2017 Category: General Medicine Authors: Wémeau JL, Lorette G Tags: Presse Med Source Type: research

[The mouth of patients with acromegaly].
Abstract Orofacial changes are frequent in acromegaly. Their evolution is slowly progressive. The lips (everted and thickened), the mandibular morphology (prognathism), the tongue (macroglossia), the soft palate and the uvula (increased and thickened), the parodontis (gingival hyperplasia, paradontitis), the teeth (increased interdental spaces, hypercementosis, increased dental mobility, multiple tooth loss) are concerned. Functional consequences are significant (obstructive sleep apnea syndrome, malocclusion, pain of the oral maxillofacial area, decrease of the quality of life). They are rarely noticed as the fir...
Source: Presse Medicale - September 21, 2017 Category: General Medicine Authors: Cortet-Rudelli C Tags: Presse Med Source Type: research

[Care pathways and outcome of chronic HBV infection: Big data see the forest for the trees].
PMID: 28935444 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - September 18, 2017 Category: General Medicine Authors: Parlati L, Sogni P, Mallet V Tags: Presse Med Source Type: research

[Usefulness of small-bowel capsule endoscopy in gastrointestinal bleeding].
Abstract In France, upper gastrointestinal haemorrhages have an estimated annual incidence of 143 cases per 100,000 inhabitants. Classically, two types of digestive hemorrhage are described: acute and chronic digestive hemorrhages. Upper endoscopy is carried out in case of hematemesis or melena. It requires that the patient has been fasting for at least 6hours for solids and 3hours for liquids. The main etiologies of hemorrhagic hemorrhage of the origin are the vascular abnormalities, inflammatory or drug-induced ulcerations, intestinal tumors, Meckel's diverticulum, and Dieulafoy ulcer. The modalities o...
Source: Presse Medicale - September 18, 2017 Category: General Medicine Authors: Leandri C, Bordacahar B, Ribiere S, Oudjit A, Guillaumot MA, Brieau B, Prat F, Abitbol V, Chaussade S, Coriat R Tags: Presse Med Source Type: research