Recent insights in pituitary diseases
Presse Med. 2021 Nov 6;50(4):104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6;50(4):104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6;50(4):104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6;50(4):104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6;50(4):104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6;50(4):104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6;50(4):104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6:104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6:104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6:104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6:104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6:104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6:104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6:104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6:104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6:104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6:104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6:104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6:104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Recent insights in pituitary diseases
Presse Med. 2021 Nov 6:104094. doi: 10.1016/j.lpm.2021.104094. Online ahead of print.NO ABSTRACTPMID:34752905 | DOI:10.1016/j.lpm.2021.104094 (Source: Presse Medicale)
Source: Presse Medicale - November 9, 2021 Category: General Medicine Authors: Philippe Chanson Source Type: research

Complications of Lipodystrophy Syndromes
Presse Med. 2021 Oct 30:104085. doi: 10.1016/j.lpm.2021.104085. Online ahead of print.ABSTRACTLipodystrophy syndromes are rare complex multisystem disorders caused by generalized or partial lack of adipose tissue. Adipose tissue dysfunction in lipodystrophy is associated with leptin deficiency. Lipodystrophy leads to severe metabolic problems. These abnormalities include, but are not limited to, insulin-resistant diabetes, severe hypertriglyceridemia, and lipid accumulation in ectopic organs such as the liver, and are associated with end-organ complications. Metabolic abnormalities can be present at the time of diagnosis o...
Source: Presse Medicale - November 3, 2021 Category: General Medicine Authors: Gulcin Akinci Merve Celik Baris Akinci Source Type: research

Complications of Lipodystrophy Syndromes
Presse Med. 2021 Oct 30:104085. doi: 10.1016/j.lpm.2021.104085. Online ahead of print.ABSTRACTLipodystrophy syndromes are rare complex multisystem disorders caused by generalized or partial lack of adipose tissue. Adipose tissue dysfunction in lipodystrophy is associated with leptin deficiency. Lipodystrophy leads to severe metabolic problems. These abnormalities include, but are not limited to, insulin-resistant diabetes, severe hypertriglyceridemia, and lipid accumulation in ectopic organs such as the liver, and are associated with end-organ complications. Metabolic abnormalities can be present at the time of diagnosis o...
Source: Presse Medicale - November 3, 2021 Category: General Medicine Authors: Gulcin Akinci Merve Celik Baris Akinci Source Type: research

Complications of Lipodystrophy Syndromes
Presse Med. 2021 Oct 30:104085. doi: 10.1016/j.lpm.2021.104085. Online ahead of print.ABSTRACTLipodystrophy syndromes are rare complex multisystem disorders caused by generalized or partial lack of adipose tissue. Adipose tissue dysfunction in lipodystrophy is associated with leptin deficiency. Lipodystrophy leads to severe metabolic problems. These abnormalities include, but are not limited to, insulin-resistant diabetes, severe hypertriglyceridemia, and lipid accumulation in ectopic organs such as the liver, and are associated with end-organ complications. Metabolic abnormalities can be present at the time of diagnosis o...
Source: Presse Medicale - November 3, 2021 Category: General Medicine Authors: Gulcin Akinci Merve Celik Baris Akinci Source Type: research

Complications of Lipodystrophy Syndromes
Presse Med. 2021 Oct 30:104085. doi: 10.1016/j.lpm.2021.104085. Online ahead of print.ABSTRACTLipodystrophy syndromes are rare complex multisystem disorders caused by generalized or partial lack of adipose tissue. Adipose tissue dysfunction in lipodystrophy is associated with leptin deficiency. Lipodystrophy leads to severe metabolic problems. These abnormalities include, but are not limited to, insulin-resistant diabetes, severe hypertriglyceridemia, and lipid accumulation in ectopic organs such as the liver, and are associated with end-organ complications. Metabolic abnormalities can be present at the time of diagnosis o...
Source: Presse Medicale - November 3, 2021 Category: General Medicine Authors: Gulcin Akinci Merve Celik Baris Akinci Source Type: research

Complications of Lipodystrophy Syndromes
Presse Med. 2021 Oct 30:104085. doi: 10.1016/j.lpm.2021.104085. Online ahead of print.ABSTRACTLipodystrophy syndromes are rare complex multisystem disorders caused by generalized or partial lack of adipose tissue. Adipose tissue dysfunction in lipodystrophy is associated with leptin deficiency. Lipodystrophy leads to severe metabolic problems. These abnormalities include, but are not limited to, insulin-resistant diabetes, severe hypertriglyceridemia, and lipid accumulation in ectopic organs such as the liver, and are associated with end-organ complications. Metabolic abnormalities can be present at the time of diagnosis o...
Source: Presse Medicale - November 3, 2021 Category: General Medicine Authors: Gulcin Akinci Merve Celik Baris Akinci Source Type: research

Complications of Lipodystrophy Syndromes
Presse Med. 2021 Oct 30:104085. doi: 10.1016/j.lpm.2021.104085. Online ahead of print.ABSTRACTLipodystrophy syndromes are rare complex multisystem disorders caused by generalized or partial lack of adipose tissue. Adipose tissue dysfunction in lipodystrophy is associated with leptin deficiency. Lipodystrophy leads to severe metabolic problems. These abnormalities include, but are not limited to, insulin-resistant diabetes, severe hypertriglyceridemia, and lipid accumulation in ectopic organs such as the liver, and are associated with end-organ complications. Metabolic abnormalities can be present at the time of diagnosis o...
Source: Presse Medicale - November 3, 2021 Category: General Medicine Authors: Gulcin Akinci Merve Celik Baris Akinci Source Type: research

Treatment of systemic sclerosis
Presse Med. 2021 Oct 27:104088. doi: 10.1016/j.lpm.2021.104088. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a rare connective tissue disease characterized by skin and visceral fibrosis, vascular hyperreactivity and obliterative vasculopathy. Some of its complications such as interstitial lung disease (ILD), pulmonary arterial hypertension (PAH) and heart involvement can be life-threatening and are associated with a high mortality and a poor prognosis. Many clinical trials were carried out in order to improve the survival and prognosis of SSc patients. The management of SSc is based on the frequent and regular...
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Benjamin Thoreau Benjamin Chaigne Arthur Renaud Luc Mouthon Source Type: research

Diabetes insipidus
Presse Med. 2021 Oct 27:104093. doi: 10.1016/j.lpm.2021.104093. Online ahead of print.NO ABSTRACTPMID:34718110 | DOI:10.1016/j.lpm.2021.104093 (Source: Presse Medicale)
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Mirjam Christ-Crain Odile Gaisl Source Type: research

Clinically non-functioning pituitary adenomas
Presse Med. 2021 Oct 27:104086. doi: 10.1016/j.lpm.2021.104086. Online ahead of print.ABSTRACTClinically non functioning pituitary adenomas (NFPAs) include all pituitary adenomas that are not hormonally active. They are not associated with clinical syndromes such as amenorrhea-galactorrhea (prolactinomas), acromegaly, Cushing's disease or hyperthyroidism (TSH-secreting adenomas) and are therefore usually diagnosed by signs and symptoms related to a mass effect (headache, visual impairment, sometimes pituitary apoplexy), but also incidentally. Biochemical work up often documents several pituitary insufficiencies. In histopa...
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Philippe Chanson Peter Wolf Source Type: research

Cushing's disease
Presse Med. 2021 Oct 27:104091. doi: 10.1016/j.lpm.2021.104091. Online ahead of print.ABSTRACTCushing's disease (CD) is the most prevalent cause of endogenous hypercortisolism. CD is responsible for multiple co-morbidities and increased mortality. Accurate and prompt diagnosis and optimal treatment are essential to improve the prognosis of CD. However, the diagnosis of CD is probably one of the most difficult in endocrinology and, therefore, diagnostic workup should be performed in an experienced center. Transsphenoidal surgery performed by an expert surgeon is the only therapeutic option that can offer definitive cure and...
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Amandine Ferriere Antoine Tabarin Source Type: research

Long-covid: cognitive deficits (brain fog) and brain lesions in non-hospitalized patients
Presse Med. 2021 Oct 27:104090. doi: 10.1016/j.lpm.2021.104090. Online ahead of print.NO ABSTRACTPMID:34718113 | PMC:PMC8552626 | DOI:10.1016/j.lpm.2021.104090 (Source: Presse Medicale)
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Jacques Hugon Source Type: research

Multiple sclerosis diagnostic criteria: from Poser to the 2017 revised McDonald criteria
Presse Med. 2021 Oct 27:104089. doi: 10.1016/j.lpm.2021.104089. Online ahead of print.NO ABSTRACTPMID:34718114 | DOI:10.1016/j.lpm.2021.104089 (Source: Presse Medicale)
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: J érôme de Seze K évin Bigaut Source Type: research

Pathophysiology of systemic sclerosis
Presse Med. 2021 Oct 27:104087. doi: 10.1016/j.lpm.2021.104087. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a rare connective tissue disease characterized by vascular remodeling, fibroblast activation and extra-cellular matrix production in excess and autoimmunity. Environmental factors including mainly silica and solvents have been assumed to contribute to the development of SSc, together with genetic factors including gene variants implicated in innate immunity such as IRF5 and STAT4, and epigenetic factors including histone post-translational modifications, DNA hypomethylation, and microRNAs or long- non c...
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Benjamin Thoreau Benjamin Chaigne Arthur Renaud Luc Mouthon Source Type: research

Treatment of systemic sclerosis
Presse Med. 2021 Oct 27:104088. doi: 10.1016/j.lpm.2021.104088. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a rare connective tissue disease characterized by skin and visceral fibrosis, vascular hyperreactivity and obliterative vasculopathy. Some of its complications such as interstitial lung disease (ILD), pulmonary arterial hypertension (PAH) and heart involvement can be life-threatening and are associated with a high mortality and a poor prognosis. Many clinical trials were carried out in order to improve the survival and prognosis of SSc patients. The management of SSc is based on the frequent and regular...
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Benjamin Thoreau Benjamin Chaigne Arthur Renaud Luc Mouthon Source Type: research

Diabetes insipidus
Presse Med. 2021 Oct 27:104093. doi: 10.1016/j.lpm.2021.104093. Online ahead of print.NO ABSTRACTPMID:34718110 | DOI:10.1016/j.lpm.2021.104093 (Source: Presse Medicale)
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Mirjam Christ-Crain Odile Gaisl Source Type: research

Clinically non-functioning pituitary adenomas
Presse Med. 2021 Oct 27:104086. doi: 10.1016/j.lpm.2021.104086. Online ahead of print.ABSTRACTClinically non functioning pituitary adenomas (NFPAs) include all pituitary adenomas that are not hormonally active. They are not associated with clinical syndromes such as amenorrhea-galactorrhea (prolactinomas), acromegaly, Cushing's disease or hyperthyroidism (TSH-secreting adenomas) and are therefore usually diagnosed by signs and symptoms related to a mass effect (headache, visual impairment, sometimes pituitary apoplexy), but also incidentally. Biochemical work up often documents several pituitary insufficiencies. In histopa...
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Philippe Chanson Peter Wolf Source Type: research

Cushing's disease
Presse Med. 2021 Oct 27:104091. doi: 10.1016/j.lpm.2021.104091. Online ahead of print.ABSTRACTCushing's disease (CD) is the most prevalent cause of endogenous hypercortisolism. CD is responsible for multiple co-morbidities and increased mortality. Accurate and prompt diagnosis and optimal treatment are essential to improve the prognosis of CD. However, the diagnosis of CD is probably one of the most difficult in endocrinology and, therefore, diagnostic workup should be performed in an experienced center. Transsphenoidal surgery performed by an expert surgeon is the only therapeutic option that can offer definitive cure and...
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Amandine Ferriere Antoine Tabarin Source Type: research

Long-covid: cognitive deficits (brain fog) and brain lesions in non-hospitalized patients
Presse Med. 2021 Oct 27:104090. doi: 10.1016/j.lpm.2021.104090. Online ahead of print.NO ABSTRACTPMID:34718113 | PMC:PMC8552626 | DOI:10.1016/j.lpm.2021.104090 (Source: Presse Medicale)
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Jacques Hugon Source Type: research

Multiple sclerosis diagnostic criteria: from Poser to the 2017 revised McDonald criteria
Presse Med. 2021 Oct 27:104089. doi: 10.1016/j.lpm.2021.104089. Online ahead of print.NO ABSTRACTPMID:34718114 | DOI:10.1016/j.lpm.2021.104089 (Source: Presse Medicale)
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: J érôme de Seze K évin Bigaut Source Type: research

Pathophysiology of systemic sclerosis
Presse Med. 2021 Oct 27:104087. doi: 10.1016/j.lpm.2021.104087. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a rare connective tissue disease characterized by vascular remodeling, fibroblast activation and extra-cellular matrix production in excess and autoimmunity. Environmental factors including mainly silica and solvents have been assumed to contribute to the development of SSc, together with genetic factors including gene variants implicated in innate immunity such as IRF5 and STAT4, and epigenetic factors including histone post-translational modifications, DNA hypomethylation, and microRNAs or long- non c...
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Benjamin Thoreau Benjamin Chaigne Arthur Renaud Luc Mouthon Source Type: research

Treatment of systemic sclerosis
Presse Med. 2021 Oct 27:104088. doi: 10.1016/j.lpm.2021.104088. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a rare connective tissue disease characterized by skin and visceral fibrosis, vascular hyperreactivity and obliterative vasculopathy. Some of its complications such as interstitial lung disease (ILD), pulmonary arterial hypertension (PAH) and heart involvement can be life-threatening and are associated with a high mortality and a poor prognosis. Many clinical trials were carried out in order to improve the survival and prognosis of SSc patients. The management of SSc is based on the frequent and regular...
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Benjamin Thoreau Benjamin Chaigne Arthur Renaud Luc Mouthon Source Type: research

Diabetes insipidus
Presse Med. 2021 Oct 27:104093. doi: 10.1016/j.lpm.2021.104093. Online ahead of print.NO ABSTRACTPMID:34718110 | DOI:10.1016/j.lpm.2021.104093 (Source: Presse Medicale)
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Mirjam Christ-Crain Odile Gaisl Source Type: research

Clinically non-functioning pituitary adenomas
Presse Med. 2021 Oct 27:104086. doi: 10.1016/j.lpm.2021.104086. Online ahead of print.ABSTRACTClinically non functioning pituitary adenomas (NFPAs) include all pituitary adenomas that are not hormonally active. They are not associated with clinical syndromes such as amenorrhea-galactorrhea (prolactinomas), acromegaly, Cushing's disease or hyperthyroidism (TSH-secreting adenomas) and are therefore usually diagnosed by signs and symptoms related to a mass effect (headache, visual impairment, sometimes pituitary apoplexy), but also incidentally. Biochemical work up often documents several pituitary insufficiencies. In histopa...
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Philippe Chanson Peter Wolf Source Type: research

Cushing's disease
Presse Med. 2021 Oct 27:104091. doi: 10.1016/j.lpm.2021.104091. Online ahead of print.ABSTRACTCushing's disease (CD) is the most prevalent cause of endogenous hypercortisolism. CD is responsible for multiple co-morbidities and increased mortality. Accurate and prompt diagnosis and optimal treatment are essential to improve the prognosis of CD. However, the diagnosis of CD is probably one of the most difficult in endocrinology and, therefore, diagnostic workup should be performed in an experienced center. Transsphenoidal surgery performed by an expert surgeon is the only therapeutic option that can offer definitive cure and...
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Amandine Ferriere Antoine Tabarin Source Type: research

Long-covid: cognitive deficits (brain fog) and brain lesions in non-hospitalized patients
Presse Med. 2021 Oct 27:104090. doi: 10.1016/j.lpm.2021.104090. Online ahead of print.NO ABSTRACTPMID:34718113 | DOI:10.1016/j.lpm.2021.104090 (Source: Presse Medicale)
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Jacques Hugon Source Type: research

Multiple sclerosis diagnostic criteria: from Poser to the 2017 revised McDonald criteria
Presse Med. 2021 Oct 27:104089. doi: 10.1016/j.lpm.2021.104089. Online ahead of print.NO ABSTRACTPMID:34718114 | DOI:10.1016/j.lpm.2021.104089 (Source: Presse Medicale)
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: J érôme de Seze K évin Bigaut Source Type: research

Pathophysiology of systemic sclerosis
Presse Med. 2021 Oct 27:104087. doi: 10.1016/j.lpm.2021.104087. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a rare connective tissue disease characterized by vascular remodeling, fibroblast activation and extra-cellular matrix production in excess and autoimmunity. Environmental factors including mainly silica and solvents have been assumed to contribute to the development of SSc, together with genetic factors including gene variants implicated in innate immunity such as IRF5 and STAT4, and epigenetic factors including histone post-translational modifications, DNA hypomethylation, and microRNAs or long- non c...
Source: Presse Medicale - October 31, 2021 Category: General Medicine Authors: Benjamin Thoreau Benjamin Chaigne Arthur Renaud Luc Mouthon Source Type: research

Differential diagnosis of Multiple sclerosis
CONCLUSION: Progress of imaging and biological sciences have drastically changed the approach and management of multiple sclerosis. But these developments have also shined a light on a variety of diseases previously unknown or poorly known, therefore greatly expanding the differential diagnosis of multiple sclerosis. While autoimmune, many of these diseases have underlying biological mechanisms that are very different from those of multiple sclerosis, rendering MS therapies usually inefficient. It is crucial to approach these diseases with utmost thoroughness, integrating history, clinical exam, and evolving ancillary test...
Source: Presse Medicale - October 29, 2021 Category: General Medicine Authors: Julien J Cavanagh Michael Levy Source Type: research

Differential diagnosis of Multiple sclerosis
CONCLUSION: Progress of imaging and biological sciences have drastically changed the approach and management of multiple sclerosis. But these developments have also shined a light on a variety of diseases previously unknown or poorly known, therefore greatly expanding the differential diagnosis of multiple sclerosis. While autoimmune, many of these diseases have underlying biological mechanisms that are very different from those of multiple sclerosis, rendering MS therapies usually inefficient. It is crucial to approach these diseases with utmost thoroughness, integrating history, clinical exam, and evolving ancillary test...
Source: Presse Medicale - October 29, 2021 Category: General Medicine Authors: Julien J Cavanagh Michael Levy Source Type: research

Craniopharyngiomas
Presse Med. 2021 Oct 21:104078. doi: 10.1016/j.lpm.2021.104078. Online ahead of print.ABSTRACTCraniopharyngiomas are rare epithelial tumours situated primarily in the sellar/parasellar region, occurring along the path of the craniopharyngeal duct. Whilst classed as histologically benign tumours, their unpredictable growth pattern and proximity to vital structures including the optic chiasm, hypothalamus, and pituitary gland renders them a considerable threat, with significant associated morbidity and increase in mortality. Occurring both in child and adulthood, their clinical manifestations are broad, commonly with symptom...
Source: Presse Medicale - October 24, 2021 Category: General Medicine Authors: Ross Hamblin Georgios Tsermoulas Niki Karavitaki Source Type: research