Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 29;52(3):104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 29;52(3):104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 29;52(3):104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 29;52(3):104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 29;52(3):104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 29;52(3):104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 29;52(3):104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 29;52(3):104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 28:104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer. Diag...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 28:104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer. Diag...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 28:104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer. Diag...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 28:104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer. Diag...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 28:104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer. Diag...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 28:104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer. Diag...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
Alpha1-antitrypsin deficiency: An updated review
Presse Med. 2023 Jul 28:104170. doi: 10.1016/j.lpm.2023.104170. Online ahead of print.ABSTRACTAlpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of AATD, reported 60 years ago associate a severe deficiency, pulmonary emphysema and/or liver fibrosis. Pulmonary emphysema is due to the severe alpha1-antitrypsin deficiency of the ZZ homozygous status and is favored by smoking. Liver fibrosis is due to the ZZ homozygous status and is favored by obesity and excessive chronic alcohol intake, with a risk of liver cancer. Diag...
Source: Presse Medicale - July 30, 2023 Category: General Medicine Authors: Jean-Fran çois Mornex Julie Traclet Olivier Guillaud Magali Dechomet Christine Lombard Mathias Ruiz Didier Revel Philippe Reix Vincent Cottin Source Type: research
