[From acute cough to chronic cough in adults: Overview on a common reason for consultation].
ier A Abstract Cough is divided into two categories: acute cough lasting less than 3 weeks, and chronic cough lasting more than 8 weeks. Acute cough is usually triggered by a viral infection of the upper airways. Evidence of treatment effectiveness is low and management of acute cough is complex in clinical practice. Chronic cough is a common reason for consultation in medicine. The most frequent causes are upper airway diseases, gastroesophageal reflux disease, asthma, eosinophilic bronchitis, and drugs. Before investigation, smoking cessation and drug withdrawal must be achieved for 4 to 6 weeks. Once this step ...
Source: Presse Medicale - March 26, 2019 Category: General Medicine Authors: Guilleminault L, Brouquières D, Didier A Tags: Presse Med Source Type: research

[What is the REAL long-term risk of proton pump inhibitors?]
iat R Abstract Proton pump inhibitors (PPIs) are among the most prescribed drugs in the world. While their efficacy in acute management is indisputable, it has long been suggested that PPI therapy is safe in the long term. In recent years, there has been growing and justified concern about the long-term risks of PPIs. The majority of reported side effects are based on observational studies with a low level of evidence. Concerning digestive risks, PPIs seem to increase the risk of Salmonella and Campylobacter infections. However, the link between PPIs and Clostridium difficile infection is not established. Long-ter...
Source: Presse Medicale - March 26, 2019 Category: General Medicine Authors: Ribiere S, Guillaumot MA, Barré A, Abou Ali E, Barret M, Chaussade S, Coriat R Tags: Presse Med Source Type: research

[Massive rectal bleeding after enemas for constipation].
PMID: 30926205 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 26, 2019 Category: General Medicine Authors: Puia I, Pommaret E, Spindler L, Fathallah N, de Parades V Tags: Presse Med Source Type: research

[Pregnancy after breast cancer: A literature review].
Abstract Pregnancies after breast cancer are still relatively rare observations. It was considered for a long time that a woman previously treated for a breast cancer could favour recurrence by becoming pregnant because of the hormonal impregnation. However, the improvement of the breast cancer treatments thanks to the improvement of the knowledge on this disease, allowed these women to envisage pregnancies after this disease. The current recommendations do not dissuade the pregnancy in case of complete cure. However, a pregnancy in this particular context arouses a number of questions such as the delay between th...
Source: Presse Medicale - March 26, 2019 Category: General Medicine Authors: Trefoux-Bourdet A, Reynaud-Bougnoux A, Body G, Ouldamer L Tags: Presse Med Source Type: research

[IGA Pemphigus].
PMID: 30926207 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 26, 2019 Category: General Medicine Authors: Anouar I, Oukabli M, Hjira N, Boui M Tags: Presse Med Source Type: research

Bilio-digestive secondary to duodenal ulcer.
PMID: 30926208 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 26, 2019 Category: General Medicine Authors: Meriam S, Dorra T, Asma O, Hela E, Dalila G Tags: Presse Med Source Type: research

Endovascular treatment for multiple aortic narrowings in a patient with Takayasu arteritis.
t I PMID: 30926210 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 26, 2019 Category: General Medicine Authors: Djukic M, Djordjevic SA, Bijelic M, Stefanovic I, Dähnert I Tags: Presse Med Source Type: research

A 26-year-old man with a leg ulceration.
PMID: 30926211 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 26, 2019 Category: General Medicine Authors: Diallo K, Nicolas M Tags: Presse Med Source Type: research

[Anoperineal lesions in Crohn's disease: Still frequent despite anti-TNF agents].
PMID: 30926212 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 26, 2019 Category: General Medicine Authors: Severyns T, Fathallah N, Beaussier H, Marteau P, de Parades V Tags: Presse Med Source Type: research

Erythema palmare hereditarum.
PMID: 30926213 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 26, 2019 Category: General Medicine Authors: de Lorenzi C, Quenan S Tags: Presse Med Source Type: research

[Severe asthma revisited by biologic therapies emergences].
This article discuss the different biological available or in development in the field of severe asthma based on their mechanism of action and target. One of the aims is to help clarify the clinical decision-making process taking in account both the phenotype/endotype of the patient and the characteristics of these new drugs. PMID: 30922670 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 25, 2019 Category: General Medicine Authors: Guilleminault L, Didier A Tags: Presse Med Source Type: research

Perianal giant condyloma Acuminatum-Buschke-L öwenstein tumor.
Perianal giant condyloma Acuminatum-Buschke-Löwenstein tumor. Presse Med. 2019 Mar 22;: Authors: Bazouti S, Zizi N, Dikhaye S PMID: 30910273 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 22, 2019 Category: General Medicine Authors: Bazouti S, Zizi N, Dikhaye S Tags: Presse Med Source Type: research

[Environmental risk factors for asthma developement].
Abstract The prevalence of asthma has increased rapidly since the early 1970s, and only changes in exposure to environmental factors; which go together with changes in lifestyle, are likely to explain such a rapid increase. Exposure to allergens is a risk factor for allergic sensitization, and allergic sensitization is a risk factor for allergic asthma. However, apart from indoor mold exposure as a risk factor for childhood asthma, there is insufficient evidence to conclude that the associations between allergen exposure and asthma development are causal. A new challenge for research is to analyze the huge amount ...
Source: Presse Medicale - March 22, 2019 Category: General Medicine Authors: Leynaert B, Le Moual N, Neukirch C, Siroux V, Varraso R Tags: Presse Med Source Type: research

Pancreatic cancer surgical management.
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a dismal prognosis and surgery is the only chance for cure. However, only few of the patients have localized tumor eligible for curative complete resection. Preoperative management and well-staging of the disease are the cornerstone for appropriate surgery and major issues to define the best therapeutic strategy. This review focuses on the surgical and optimal perioperative management of PDAC and summarizes updates data on the subject. PMID: 30905395 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 21, 2019 Category: General Medicine Authors: Jeune F, Coriat R, Prat F, Dousset B, Vaillant JC, Gaujoux S Tags: Presse Med Source Type: research

Chemotherapy for pancreatic cancer.
emos JP Abstract Chemotherapy is an important part of multimodality pancreatic cancer treatment. After curative resection, adjuvant chemotherapy can significantly improve disease free survival and overall survival. The current standard of care is six months adjuvant chemotherapy with modified folinic acid, 5-fluorouracil, irinotecan and oxaliplatin (mFOLFIRINOX) in patients fit enough for this protocol, otherwise six months of gemcitabine and capecitabine based on the European Study Group for Pancreatic Cancer (ESPAC)-4 study. In patients with metastatic disease, combination chemotherapy according to the FOLFIRINO...
Source: Presse Medicale - March 14, 2019 Category: General Medicine Authors: Springfeld C, Jäger D, Büchler MW, Strobel O, Hackert T, Palmer DH, Neoptolemos JP Tags: Presse Med Source Type: research

Diagnostic strategy with a solid pancreatic mass.
Abstract The correct diagnosis of a patient presenting with a solid pancreatic mass requires a careful diagnostic work-up, since many differential diagnoses are possible that completely alter the following treatments. In our chapter, we have discussed the clinical approach to the problem in a sort of diagnostic flow-chart. Firstly, we analysed the different potential presentations of a solid pancreatic mass, which can be both asymptomatic or symptomatic, and the differential diagnosis based on the symptoms of presentation. Then we focused on the various imaging techniques commonly used in the diagnostic work-up, s...
Source: Presse Medicale - March 13, 2019 Category: General Medicine Authors: Guarneri G, Gasparini G, Crippa S, Andreasi V, Falconi M Tags: Presse Med Source Type: research

Pancreatic cancer: Best supportive care.
let C Abstract Palliative and supportive care holds a major place in pancreatic ductal adenocarcinoma (PDAC) management. It aims to prevent and reduce symptoms and hospital admissions, while ensuring optimal health-related quality of life (HRQoL), which has been reported to be correlated with overall survival in PDAC. Best supportive care includes non-specific treatment of pain, anxiety and depression, chemotherapy-related toxicities, as well as thromboembolic disease treatment and prevention in high-risk patients. Moreover, nutrition and physical activity interventions are receiving increasing attention as they a...
Source: Presse Medicale - March 13, 2019 Category: General Medicine Authors: Védie AL, Neuzillet C Tags: Presse Med Source Type: research

Epidemiology and burden of pancreatic cancer.
Abstract Pancreatic cancer, although infrequent, has a very poor prognosis, making it currently the fourth common causes of cancer mortality in most developed countries including the European Union (EU). Its incidence varies across regions, which suggests that lifestyle factors play an important role in its etiology, although part of the variation could be ascribed to difference in diagnostic and coding practices. Because pancreatic cancer is strongly age-dependent, increasing population longevity and ageing will lead to an increase of the global burden of pancreatic cancer. It was estimated that, by 2040, the tot...
Source: Presse Medicale - March 13, 2019 Category: General Medicine Authors: Maisonneuve P Tags: Presse Med Source Type: research

Fatigue after a corticosteroid joint injection.
PMID: 30878336 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 13, 2019 Category: General Medicine Authors: Kedra J, Godot S, Chazerain P, Clavel G, Giovansili L, Ziza JM Tags: Presse Med Source Type: research

Pancreatic cancer is still waiting for the big leap forward.
PMID: 30878337 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 13, 2019 Category: General Medicine Authors: Gaujoux S, Belghiti J Tags: Presse Med Source Type: research

Pancreatic cancer  – What's next?
Pancreatic cancer – What's next? Presse Med. 2019 Mar 13;: Authors: Salvia R, Casciani F, Sereni E, Bassi C Abstract This chapter focuses on the most recent advantages in the medical treatment of localized pancreatic cancer. PMID: 30878338 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 13, 2019 Category: General Medicine Authors: Salvia R, Casciani F, Sereni E, Bassi C Tags: Presse Med Source Type: research

[Role of non pharmacological Interventions for asthma].
Abstract Smoking cessation remains a major issue for asthmatic smokers. Respiratory rehabilitation and respiratory physiotherapy have shown a benefit in controlling symptoms, preventing exacerbations and improving the quality of life. The control of the environment is crucial and must be approached in a global way. Management of obesity and psychological disorders should be systematically proposed. Allergen immunotherapy may be discussed in allergic persistent asthma to house dust mites. Certain dietary interventions or alternative medicines have not proved their worth. PMID: 30871852 [PubMed - as supplied by...
Source: Presse Medicale - March 11, 2019 Category: General Medicine Authors: Bousso A, Chenivesse C, Barnig C Tags: Presse Med Source Type: research

[New protagonists in asthma pathophysiology].
Abstract Asthma is often associated with a Th2-type immune response with well-known cellular and molecular actors such as eosinophils, Th2 lymphocytes and associated cytokines such as interleukin-5 or IL-4. Nevertheless, some of the asthmatic patients show clinical manifestations and characteristics that do not correspond to the current pattern of the pathophysiology of asthma. Thus, recently new cellular and molecular actors in the development of asthma have been demonstrated in animal models and in humans. Among these are components of the innate immune system such as type 2 innate lymphoid cells or adaptive imm...
Source: Presse Medicale - March 8, 2019 Category: General Medicine Authors: Klein M, Dijoux E, Dilasser F, Hassoun D, Moui A, Loirand G, Colas L, Magnan A, Sauzeau V, Bouchaud G Tags: Presse Med Source Type: research

[Heart failure in the elderly: A challenge for the health system and a model for the management of chronic diseases].
PMID: 30857808 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 8, 2019 Category: General Medicine Authors: Belmin J, Lafuente-Lafuente C, Hittinger L Tags: Presse Med Source Type: research

[The Jard é law: What does change].
[The Jardé law: What does change]. Presse Med. 2019 Mar 07;: Authors: Lemaire F Abstract The Jardé law has been voted in 2012 but was only enforced in November 2016, after the publication of its decree. Introduction of non-interventional researches in the scope of the "researches involving human beings" and random allocation of ethics committees are the main novelties of the new law. Global consent, which authorizes future researches on existing data without informing the study participant, has also been introduced. Submission of collections of biological samples and genetic st...
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Lemaire F Tags: Presse Med Source Type: research

[PCSK9 inhibitors: What place in the management of dyslipidemia?]
Abstract PCSK9 protein is a key regulator of LDL receptor activity. Gain-of-function mutations in PCSK9 are one of the genetic causes of familial hypercholesterolemia. Conversely, loss-of-function mutations are associated with lower levels of LDL cholesterol and reduced coronary heart disease. Monoclonal antibodies targeting PCSK9 are highly efficacious in lowering LDL-C levels, with a good tolerability and safety profile. Two PCSK9 inhibitors, alirocumab and evolocumab, have demonstrated a cardiovascular benefit in addition to statin therapy in patients with established cardiovascular disease. A recent European c...
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Sabouret P, Farnier M, Puymirat E Tags: Presse Med Source Type: research

[Isolated splenomegaly during congenital cytomegalovirus infection].
PMID: 30853282 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Kojmane W, Hmami F, Atmani S Tags: Presse Med Source Type: research

[Only good therapeutic strategies! Response to the letter about the special issue: "All the truth about benzodiapz épines"].
[Only good therapeutic strategies! Response to the letter about the special issue: "All the truth about benzodiapzépines"]. Presse Med. 2019 Mar 07;: Authors: Aouizerate B, El-Hage W PMID: 30853283 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Aouizerate B, El-Hage W Tags: Presse Med Source Type: research

A co-infection with malaria and visceral leishmaniasis in Eastern state of India.
PMID: 30853284 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Topno RK, Kumar R, Pandey K, Verma N, Das VR, Sahoo GC, Siddiqui NA, Sinha AK, Kumar R, Kumar R, Agrawal K, Das P Tags: Presse Med Source Type: research

[Dyspnoea in asthma: diagnostic approach].
Abstract Dyspnoea is a cardinal symptom of asthma and an essential part of assessing control of the disease. Its intensity is variable for the same level of bronchial obstruction, which suggests the involvement of other mechanisms. Therefore, it is extremely important to characterize and measure dyspnoea in asthmatic patients because its profile can be quantitatively and qualitatively modified by disease control, comorbidities and anxiety. Hence the value of using additional tools to ACT and ACQ because the latter do not characterize nor measure specifically dyspnoea in asthma. Different tools can be used in this ...
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Laveneziana P, Beurnier A Tags: Presse Med Source Type: research

[Medical publications: The multiple flaws of the system].
PMID: 30853286 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Lorin de la Grandmaison G Tags: Presse Med Source Type: research

Hepatitis C treatment with all-oral direct-acting antivirals: Effectiveness and tolerance in a multicenter, prospective, observational study from French general hospitals (APROVVIE, ANGH).
ondat B, Ripault MP, Zanditenas D, de Montigny-Lenhardt S, Labadie H, Tissot B, Maringe E, Cadranel JF, Hagège H, Lesgourgues B, Association nationale des gastroentérologues des hôpitaux (ANGH) Abstract BACKGROUND AND AIMS: According to clinical trials, the treatment of patients with chronic hepatitis C (CHC) with second-generation direct acting antiviral agents (DAAs) is highly efficient and well tolerated. The goal of this study was to investigate the effectiveness and safety of various combinations of these drugs during their first 2 years of use in the real-world practice of French general ...
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Pariente A, Arpurt JP, Rémy AJ, Rosa-Hézode I, Causse X, Heluwaert F, Macaigne G, Henrion J, Renou C, Schnee M, Salloum H, Hommel S, Pilette C, Arotcarena R, Barjonet G, Lison H, Bourhis F, Jouannaud V, Pauwels A, Le eaBricquir Y, Geagea E, Condat B, Ri Tags: Presse Med Source Type: research

[Rosai-Dorfman disease of maxillary sinuses].
PMID: 30853288 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Smail K Tags: Presse Med Source Type: research

[Strongyloidiasis, a sexually transmitted disease].
mon D PMID: 30853289 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Bourée P, Usubillaga R, Viard JP, Slama L, Salmon D Tags: Presse Med Source Type: research

[Ovarian or tubal ?]
PMID: 30853290 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Toufga Z, Ayouche O, Dafiri R, Chat L Tags: Presse Med Source Type: research

Oral health in schizophrenia patients: A French Multicenter Cross-Sectional Study.
CONCLUSIONS: PWS describe a poor OHrQoL. The dental and hygiene index scores are poor. We observed a lack of brushing and of dental visit for these persons and a gap in oral health between PWS and general population. PMID: 30853291 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Denis F, Milleret G, Wallenhorst T, Carpentier M, Rude N, Trojak B Tags: Presse Med Source Type: research

[Haematidrosis responding favorably to propranolol].
PMID: 30853292 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Mahamat Abderraman G, Djidita Hagre Y, Mahamat Hissein A, Boudalia A, Sauvage J, Ibrahim H, Glenn R, Brahim N, Achta AF, Tara F, Charfadine S, Aboubacar A, Haddoum F Tags: Presse Med Source Type: research

[Gerontological evaluation benefits for very older people with cardiovascular disease].
Abstract The multidimensional, multiprofessional gerontological evaluation helps identify geriatric syndromes and situations of fragility. This is a first step to establish a plan of care and assistance, to reduce the risk of falls, hospitalization, entry into institutions and to prevent a decline in independence. Older people with cardiovascular disease such as heart failure are at very high risk of repeated hospitalizations, with an average of 45% of patients re-hospitalized in the year following all-cause hospitalization. In the context of heart failure, frailty is an independent risk factor for mortality withi...
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Broussier A, Valembois L, Lafuente-Lafuente C, David JP, Pariel S Tags: Presse Med Source Type: research

["Hospital hotels": One more step towards short stay and ambulatory surgery].
["Hospital hotels": One more step towards short stay and ambulatory surgery]. Presse Med. 2019 Mar 07;: Authors: Theissen A, Pujol N, Raspado O, Slim K PMID: 30853294 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - March 7, 2019 Category: General Medicine Authors: Theissen A, Pujol N, Raspado O, Slim K Tags: Presse Med Source Type: research

[Benzodiaz épines misuse and limited access to cognitive-behavioral therapy. Letter on the special issue: "All the truth about benzodiazépines"].
[Benzodiazépines misuse and limited access to cognitive-behavioral therapy. Letter on the special issue: "All the truth about benzodiazépines"]. Presse Med. 2019 Feb 21;: Authors: Braillon A, Taiebi F PMID: 30799149 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - February 21, 2019 Category: General Medicine Authors: Braillon A, Taiebi F Tags: Presse Med Source Type: research

[Comparison between endoscopic stenting and colostomy in the management of obstructing cancer of the left colon: Literature review].
CONCLUSION: In case of neoplastic occlusion of the left colon, the choice between colostomy or colonic stent depends on the therapeutic strategy. Indeed, for curative strategy or administration of anti-angiogenics, it is recommended to practice a colostomy. However, for palliative treatment, colonic stenting is the treatment to follow. PMID: 30799150 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - February 21, 2019 Category: General Medicine Authors: Trigui A, Rejab H, Akrout A, Harbi H, Kachaou A, Fendri S, Frikha MF, Mzali R Tags: Presse Med Source Type: research

[Heart failure in patients over 80 years old].
Abstract Heart failure (HF) is a clinical syndrome that associates clinical signs in people over 80 years of age, an increase in natriuretic peptides and abnormal cardiac structures that result from cardiac aging in many cases. The most common symptoms are grouped according to the acronym "EPOF" (shortness of breath, weight gain, edema, fatigue). Over the age of 80, comorbidities must be taken into account. The incidence and prevalence of HF significantly increases with age and makes HF the most common reason for hospitalization for people over 80, and an important health expense. The management of HF, n...
Source: Presse Medicale - February 21, 2019 Category: General Medicine Authors: Berthelot E, Nouhaud C, Lafuente-Lafuente C, Assayag P, Hittinger L Tags: Presse Med Source Type: research

[Health students quality of life: A challenge for universities].
cute; PMID: 30773252 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - February 14, 2019 Category: General Medicine Authors: Diot P, Arnault É Tags: Presse Med Source Type: research

[Prevalence and risk markers of anxiety and depression among health students].
lon L PMID: 30770277 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - February 12, 2019 Category: General Medicine Authors: Hermetet C, Arnault É, Gaborit C, Coillot H, Florence AM, Diot P, Colombat P, Rusch E, Grammatico-Guillon L Tags: Presse Med Source Type: research

Intervention psychoth érapeutique brève (activation comportementale) pour le traitement de la dépression d’intensité légère à modérée en soins primaires : proposition d’un guide pour la pratique clinique.
Intervention psychothérapeutique brève (activation comportementale) pour le traitement de la dépression d’intensité légère à modérée en soins primaires : proposition d’un guide pour la pratique clinique. Presse Med. 2019 Feb 12;: Authors: Sarron PY, Palma J, Lemaire M, Camus V, ElHage W PMID: 30770278 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - February 12, 2019 Category: General Medicine Authors: Sarron PY, Palma J, Lemaire M, Camus V, ElHage W Tags: Presse Med Source Type: research

[An high level diagnosis!]
PMID: 30737074 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - February 6, 2019 Category: General Medicine Authors: Kauffmann P, Le Borgne P, Lemaitre EL, Quoirin E, Bilbault P Tags: Presse Med Source Type: research

[Hypotensions in the elderly: Clinical and therapeutic features].
Abstract Hypotension and especially very low diastolic blood pressure could be an at-risk situation in very old and frail patients and in those with coronary heart disease. Chronic hypotension in people with heart failure is an indicator of poor prognosis and hinders the management of therapy. Orthostatic hypotension is a decrease in blood pressure>20mmHg for systolic and/or>10mmHg for diastolic within 3minutes after transition from supine to upright. Orthostatic hypotension may be symptomatic or not. The search for orthostatic hypotension is part of the clinical examination of elderly patients with hyperten...
Source: Presse Medicale - February 3, 2019 Category: General Medicine Authors: Magny E, Donadio C, Maronnat F, Nghiem D, Berthelot E, Belmin J, Lafuente-Lafuente C Tags: Presse Med Source Type: research

[Childhood trauma in subjects at ultra high risk for psychosis].
Abstract Childhood adversity rates would be higher in subjects at ultra-high risk of psychosis than in the general population. In addition to reference ideas, magical thoughts and social dysfunction, subjects at ultra-high risk of psychosis with a history of childhood trauma would experience more severe and specific symptoms. Childhood trauma, especially sexual abuse, was associated with the transition to psychosis. Several models have been cited to explain the link between trauma and the subsequent onset of psychosis or prepsychotic states: dysfunctional cognitive patterns, affective dysregulation, attachment sty...
Source: Presse Medicale - January 30, 2019 Category: General Medicine Authors: Fekih-Romdhane F, Ben Fadhel S, Hakiri A, Cheour M Tags: Presse Med Source Type: research

[Update of French guidelines for the use of positron emission tomography (PET) in gastro-intestinal cancer (Part of the InCa guidelines)].
PMID: 30709559 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - January 29, 2019 Category: General Medicine Authors: Wartski M, Coriat R Tags: Presse Med Source Type: research

Familial Mediterranean Fever.
Abstract Familial Mediterranean Fever (FMF) is the oldest and the most frequent of all described hereditary periodic fever syndromes. The populations originating from Mediterranean basin carry the highest risk for FMF however it is being increasingly recognized in many parts of the world. It is an autoinflammatory disease with an autosomal recessive transmission. In the majority of the patients it is related with mutations in the MEFV gene that encodes a protein named pyrin. This protein has been shown to act as a regulator of inflammation mediated by IL-1β, which plays a major role in the pathogenesis of FMF...
Source: Presse Medicale - January 24, 2019 Category: General Medicine Authors: Ozdogan H, Ugurlu S Tags: Presse Med Source Type: research