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A Multi-Center, Open-Label, Prospective Study of Cannula Injection of Small-Particle Hyaluronic Acid Plus Lidocaine (SPHAL) for Lip Augmentation.
CONCLUSION: SPHAL was well tolerated and effective following injection with a blunt-tipped microcannula. No unanticipated safety concerns were identified in the study population. J Drugs Dermatol. 2018;17(1):10-16.. PMID: 29320583 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Male Aesthetic Patient: Facial Anatomy, Concepts of Attractiveness, and Treatment Patterns.
CONCLUSIONS: Approaches to aesthetic consultation and treatment should differ between men and women based on the fundamental dissimilarities between the sexes. Educating men about available aesthetic treatments and about the safety and side effects associated with each treatment, as well as addressing concerns about their treatment results looking natural, are key considerations. J Drugs Dermatol. 2018;17(1):19-28.. PMID: 29320584 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Liposuction of the Neck: Low Incidence of Nerve Injury and Other Complications in 987 Patients.
We present a large case series (n=987) performed by three dermatologic surgeons. Five patients developed temporary post-operative marginal mandibular dysfunction, one patient had submandibular gland ptosis and one patient had arterial bleeding. Seroma, skin necrosis, scarring, and hyperpigmentation did not occur following neck liposuction. Neck liposuction performed with tumescent local anesthesia is a safe procedure associated with a low incidence of nerve injury and other complications. J Drugs Dermatol. 2018;17(1):30-34.. PMID: 29320585 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Safety and Efficacy of a 1550nm/1927nm Dual Wavelength Laser for the Treatment of Photodamaged Skin.
CONCLUSION: Treatments using both wavelengths associated with the combined 1550/1927 Laser System were well tolerated with limited, transient anticipated side effects and no serious AEs. Clinical efficacy in the appearance of photodamage and pigmentation was greatest following a series of up to 3 treatments. J Drugs Dermatol. 2018;17(1):41-46.. PMID: 29320586 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Randomized Study to Assess the Efficacy of Skin Rejuvenation Therapy in Combination With Neurotoxin and Full Facial Filler Treatments.
CONCLUSIONS: Our study confirms that facial rejuvenation therapy involving hyaluronic acid filler and neurotoxin injections combined with a topical skin treatment regimen leads to improvement in skin quality and aesthetic appearance as well as to patient satisfaction. Additional larger studies are needed to better delineate the most ideal combination facial rejuvenation therapy for optimizing patient appearance and satisfaction. J Drugs Dermatol. 2018;17(1):48-54.. PMID: 29320587 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Guide to Tissue-Engineered Skin Substitutes.
Authors: Kallis PJ, Friedman AJ, Lev-Tov H Abstract Wounds that exhibit delayed healing have a tremendous impact on health care expenditures and place patients at serious risk for severe complications including death. The healing of a chronic wound requires the restoration of multiple factors that normally work in concert to repair the damaged skin barrier. Skin substitutes have shown great promise for use as adjunctive therapies for refractory wounds by providing cells, soluble mediators, and extracellular matrix materials needed to stimulate healing. There are a growing variety of skin substitutes available on th...
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Multicenter, Double-Blinded, Randomized, Split-Face Study of the Safety and Efficacy of a Novel Hyaluronic Acid Gel for the Correction of Nasolabial Folds.
CONCLUSION: The Test Product is safe and non-inferior to the Comparator for the correction of nasolabial folds. The Test Product was associated with less swelling, pain, and overall severity of treatment-emergent adverse events than the Comparator. J Drugs Dermatol. 2018;17(1):66-73.. PMID: 29320589 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Treatment of D écolletage Photoaging With Fractional Microneedling Radiofrequency.
CONCLUSIONS: Subjects in this study demonstrated an overall improvement in décolletage appearance in regard to skin tightening, wrinkles, and skin texture suggested by overall patient satisfaction (80%) and physician-rated GAIS improvement (67%). This study suggests that fractional microneedling radiofrequency devices are a safe and efficacious way to improve overall décolletage appearance with little down time. J Drugs Dermatol. 2018;17(1):74-76.. PMID: 29320590 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Use of an Over-the-Counter Hand Cream With Sweet Almond Oil for the Treatment of Hand Dermatitis.
In this study, a moisturizer with 7% sweet almond oil and 2% colloidal oatmeal was found to be both safe and effective in treating patients with moderate to severe hand dermatitis. J Drugs Dermatol. 2018;17(1):78-82.. PMID: 29320591 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Injectable Non-Animal Stabilized Hyaluronic Acid as a Skin Quality Booster: An Expert Panel Consensus.
Authors: Belmontesi M, De Angelis F, Di Gregorio C, Iozzo I, Romagnoli M, Salti G, Clementoni MT Abstract Hyaluronic acid (HA) is used extensively in aesthetic medicine thanks to its documented role in skin rejuvenation. The specific applications of HA-based products are not always fully acknowledged due to a lack of consistent recommendations. In this paper, the authors have summarized available published data on the range of applications of non-animal stabilized hyaluronic acid (NASHA®) gel skin boosters (NSBs) in several anatomical areas and types of patient, as well as their own recommendations. Overall, th...
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Injection Depth in Intradermal Therapy: Update and Correction of Published Data.
CONCLUSION: Whilst examining our study results, two different possibilities come to mind. We must either: 1) review and correct the existing histological classification; and/or 2) better learn to correctly inject in the superficial-dermis, mid-dermis, and deep-dermis. In other words, a perfect control over the needle penetration angle and implanted part appears urgently required. J Drugs Dermatol. 2018;17(1):89-96.. PMID: 29320593 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Pivotal Trial of the Efficacy and Safety of Oxymetazoline Cream 1.0% for the Treatment of Persistent Facial Erythema Associated With Rosacea: Findings from the First REVEAL Trial.
Authors: Kircik LH, DuBois J, Draelos ZD, Werschler P, Grande K, Cook-Bolden FE, Weng E, Berk DR, Ahluwalia G Abstract An unmet need exists for a safe, tolerable, effective treatment for moderate to severe persistent facial erythema in patients with rosacea. This pivotal phase 3, multicenter, double-blind study evaluated the efficacy and safety of topical oxymetazoline in patients with facial erythema associated with moderate to severe rosacea. Patients were randomly assigned to treatment with oxymetazoline hydrochloride cream 1.0% or vehicle applied once daily for 29 days, and were followed for 28 days posttreatme...
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Safety and Efficacy of a Non-Invasive 1060 nm Diode Laser for Fat Reduction of the Abdomen.
CONCLUSION: 1060 nm based laser treatment can consistently reduce the fat contour in the abdomen with an excellent safety profile in all skin types. The study met all three of its prospectively defined endpoints of success. J Drugs Dermatol. 2018;17(1):106-112. THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL TEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEASE CONTACT THE PUBLISHER WITH ANY QUESTIONS.. PMID: 29320595 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Double Blind, Placebo Controlled Evaluation of a Novel Skin Lightening Agent.
In this study, a unique combination of ingredients with non-irritating properties was tested for treatment of melasma. In a double blind, placebo controlled, split face trial, 17 patients with melasma were treated on one half of the face, left or right, while the other received placebo control. All patients used sunscreen on both sides. Measurement with a colorimeter (Mexameter) was taken at baseline and after 8 weeks of daily use. The active side showed an objective decrease in hyperpigmentation of 14.60% while the control side showed a decrease of 9.82%. We conclude the product provides a non-irritating effective therapy...
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Realistic Sunscreen Durability: A Randomized, Double-blinded, Controlled Clinical Study.
CONCLUSION: This study demonstrates that current sunscreens may be durable on skin even following significant exercise and water exposure, suggesting that reapplication intervals may be longer than currently recommended. In addition, the higher SPF sunscreen maintained a skin cancer-protective level of SPF following extended use. J Drugs Dermatol. 2018;17(1):116-117.. PMID: 29320597 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Eruptive Sebaceous Hyperplasia: A Rare Consequence of Systemic Corticosteroids.
CONCLUSION: To our knowledge, this is the first reported case of eruptive sebaceous hyperplasia secondary to the use of prednisone in a patient with Crohn's disease. This case brings awareness to the unique side effect of prednisone induced sebaceous hyperplasia, and demonstrates the importance of educating patients with Crohn's disease of this potential side effect when prescribing this medication. J Drugs Dermatol. 2018;17(1):118-120.. PMID: 29320598 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 12, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Upregulation of Extracellular Matrix Genes Corroborates Clinical Efcacy of Human Fibroblast-Derived Growth Factors in Skin Rejuvenation.
Authors: Kadoya K, Makino ET, Jiang LI, Bachelor M, Chung R, Tan P, Cheng T, Naughton GK, Mehta RC Abstract Skin care products may use various active ingredients to support skin rejuvenation including growth factors and other molecules that help to regenerate extracellular matrix (ECM) and promote skin repair. The biological effect of skin care products with a strong anti-aging claim was assessed in gene expression analyses using an in vitro human skin model. Application of products containing human fbroblast-derived growth factors resulted in signifcant upregulation of genes encoding ECM components including colla...
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Lawrence Transfer Factor: Transference of Specifc Immune Memory by Dialyzable Leukocyte Extract from a CD8+ T Cell Line.
Authors: Wang JF, Park AJ, Rendini T, Levis WR Abstract Lawrence transfer factor (TF) is defned as dialyzable leukocyte extract (DLE) that can transfer antigen-specifc cell-mediated immunity from a person testing positive for the antigen in a delayed type hypersensitivity skin test manner to a person negative for the same antigen. A recent article by Myles et al1 has identifed a DLE isolated from an established CD8+ T cell line capable of transferring antigen-specifc immunity. The DLE contains a portion of the beta chain of the T cell receptor and additional nucleotide and protein factors that are being subjected t...
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Combining Topical Psoriasis Treatment to Enhance Systemic and Phototherapy: A Review of the Literature.
This article reviews the most recently published clinical evidence of adjunctive use of topical agents with biologics, conventional systemic agents, and phototherapy, to better establish the role of topical agents in combination therapy for the treatment of psoriasis. J Drugs Dermatol. 2017;16(12):1209-1222.. PMID: 29240856 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Latest Drugs and Small Molecule Inhibitors for Skin and Hair.
Authors: Kalhun V, Sadick N Abstract Biologic drugs, a novel class of agents engineered to target specifc mediators of infammation, and small-molecule inhibitors that pen-etrate the cell membrane to interact with targets inside a cell represent the cutting-edge of pharmacological biomedical therapeutics. Clinical studies have already demonstrated the effectiveness of this new generation of drugs in treating a variety of medical illnesses and conditions that were refractory to traditional treatments. This review aims to describe the latest available or currently in-develop-ment drugs, biologic agents, and small mole...
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Novel Multifactorial Approach to Developing Mild Laundry Detergents and Assessing Their Relative Mildnes.
Discussion: The Detergent Mildness Index provides dermatologists with an objective method to compare commercial laundry deter-gents. Currently the only method available is patch testing, this new test is able to more finely differentiate between products and thus enables more informed recommendations on laundry detergent choices for their patients with sensitive skin. J Drugs Dermatol. 2017;16(12):1235-1239.. PMID: 29240858 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Real-World Clinical Experience With Apremilast in a Large US Retrospective Cohort Study of Patients With Moderate to Severe Plaque Psoriasis.
Conclusions: Findings support the effectiveness of apremilast in patients with moderate to severe psoriasis in dermatology clinical practices. Patients perceived apremilast to be effective. J Drugs Dermatol. 2017;16(12):1240-1245.. PMID: 29240859 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Cost Per Additional Responder Associated With Ixekizumab and Etanercept in the Treatment of Moderate-to-Severe Psoriasis.
CONCLUSIONS: Twelve-week costs per additional responder were lower for ixekizumab Q2W than for etanercept BIW across all levels of clearance (PASI 75, PASI 90, and PASI 100) in the pooled UNCOVER-2/UNCOVER-3 overall and US subgroup ITT populations. J Drugs Dermatol. 2017;16(12):1246-1252.. PMID: 29240860 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Systematic Review of Lower Lip Anatomy, Mechanics of Local Flaps, and Special Considerations for Lower Lip Reconstruction.
In conclusion, knowledge of the static and dynamic structural support of the lower lip, as well as the characteristics of different reconstructive options, is imperative for optimal functional and aesthetic outcomes. J Drugs Dermatol. 2017;16(12):1254-1261.. PMID: 29240861 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

"Deep Heating" Noninvasive Skin Tightening Devices: Review of Efectiveness and Patient Satisfaction.
This study is intended to review available peer reviewed literature about Ultherapy, ThermaCool, and Exilis Ultra 360 non-invasive skin tightening devices to compare their treatment effcacy and patient subjective satisfaction. J Drugs Dermatol. 2017;16(12):1262-1266.. PMID: 29240862 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Long-Term Follow-up of Onychomycosis Patients Treated With Efinaconazole.
CONCLUSIONS: This single-center phase 4 study supports previous data showing good efficacy and tolerability of efinaconazole in moderately severe onychomycosis. Continued reduction in disease severity post-treatment suggest that a longer follow-up of patients treated with efinaconazole would afford better efficacy results, as indicated by greater treatment success, and increase in number of subjects who became complete cures. J Drugs Dermatol. 2017;16(12):1269-1273.. PMID: 29240863 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Patient Awareness of Local Drug Price Variation and the Factors That Influence Pharmacy Choice: A Cross-sectional Survey Study.
Conclusion: In this study, pharmacy choice was more influenced by convenience than cost prior to drug price education. However, price education ultimately impacted intent to research prescription drug prices before selecting a pharmacy. Thus, knowledge of drug pricing may be useful in creating cost savings for patients. J Drugs Dermatol. 2017;16(12):1274-1280.. PMID: 29240864 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Mast Cell Burden in a Patient With Cutaneous Disease.
In this report, we present a case of cutaneous mast cell disease with associated findings of elevated serum tryptase and mast cell infiltration of the bone marrow consistent with indolent systemic mastocytosis. J Drugs Dermatol. 2017;16(12):1285-1287.. PMID: 29240865 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Pityriasis Folliculorum: Response to Topical Ivermectin.
We present the case of a woman with pityriasis folliculorum who showed significant improvement from using topical ivermectin with no adverse events related to treatment. J Drugs Dermatol. 2017;16(12):1290-1292.. PMID: 29240866 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Management of Late-Onset, Recurrent Facial Nodular Reaction After Poly-L-Lactic (PLLA) Injections.
Authors: O'Daniel G Abstract Despite a well-established safety profile for poly-L-lactic acid (PLLA), known complications of nodules, papules and granulomas can occur. The author presents a case of late-onset facial nodules after treatment with PLLA dermal filler for facial volumization. The late-onset nodules appeared 16 months post-initial injection and were initially treated with intralesional steroids followed by 5-fluorouracil, and oral corticosteroids. It took over a year of treatment with oral corticosteroids and periodic intralesional steroid injections for the nodules to resolve. The author describes in de...
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Effectiveness of the Mohs and Close Technique in Increasing the Efficiency of a Mohs Micrographic Surgery.
Authors: Konda S, Francis J, Patel VA Abstract Editor's note: JDD welcomes Letters to the Editor that discuss controversy surrounding a recently published article. Letters being considered for publication may be sent to the authors of the original article, who may be given the opportunity to reply. Letters will be published at the discretion of the Editors. PMID: 29240868 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Recalcitrant Diffuse Cutaneous Sarcoidosis With Perianal Involvement Responding to Adalimumab.
Authors: Cohen GF, Wolfe CM Abstract Recalcitrant cutaneous sarcoidosis with perianal involvement is rare. To our knowledge we present the first documented case of cutaneous sarcoidosis with perianal involvement successfully treated with adalimumab. J Drugs Dermatol. 2017;16(12):1305-1306.. PMID: 29240869 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Practitioners Take Huge Risks Dealing With Rogue Drug Compounders.
Authors: Bradshaw S Abstract . PMID: 29240870 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Major Win for the Treatment of Nail Psoriasis.
Authors: Lipner SR Abstract . PMID: 29220417 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 10, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Managing Seborrheic Keratoses: Evolving Strategies for Optimizing Patient Outcomes.
Authors: Ranasinghe GC, Friedman AJ Abstract The seborrheic keratosis is the most common benign skin tumor of middle-aged and elderly adults, affecting nearly 83 million individuals in the US alone. Although these are benign lesions, many patients still undergo some form of treatment. Clinicians are frequently presented with a challenge when determining whether to remove a seborrheic keratosis, and which treatment modality to use when doing so. The most commonly used method of removal is cryotherapy, however there are numerous other options that can be employed with varying degrees of efficacy. In this article, we ...
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Treatment of Photoaging With a Dual-Wavelength, 532 nm and 1,064 nm Picosecond-Domain Laser Producing a Fractionated Treatment Beam Using a Holographic Optic.
CONCLUSION: The fractionated, picosecond-domain, 532 nm and 1,064 nm laser is safe and effective for improvement of facial photodamage. The laser was well tolerated with mild erythema, edema, and petechiae as the most common side-effects. J Drugs Dermatol. 2017;16(11):1077-1082.. PMID: 29141055 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

In-Vivo Histological Analysis of a Fractional CO2 Laser System Intended for Treatment of Soft Tissue.
CONCLUSION: Treatment of the skin using the fractional CO2 device leads to skin resurfacing via ablation and coagulation of the treated area at a depth proportional to the delivered energy. The higher the energy used, the greater the degree of ablation and coagulation in tissue, which can lead to a greater tissue response in terms of fibroblast activity, collagen remodeling, and new collagen formation. J Drugs Dermatol. 2017;16(11):1085-1090.. PMID: 29141056 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Lasers, Light, and the Treatment of Acne: A Comprehensive Review of the Literature.
DISCUSSION: These treatments do and will continue to play an important and enlarging role in the management of acne. Larger scale studies with standardization of treatment protocols are warranted. J Drugs Dermatol. 2017;16(11):1095-1102.. PMID: 29141057 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Disparity in Cutaneous Pigmentary Response to LED vs Halogen Incandescent Visible Light: Results from a Single Center, Investigational Clinical Trial Determining a Minimal Pigmentary Visible Light Dose.
CONCLUSION: This study is the first to report a distinct difference in cutaneous pigmentary response to different sources of visible light, and the first to demonstrate cutaneous pigment darkening from visible LED light exposure. Our findings raise the concern that our increasing daily artificial light surroundings may have clandestine effects on skin biology. J Drugs Dermatol. 2017;16(11):1105-1110.. PMID: 29141058 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Retrospective Study on Efficacy of Pulsed Dye Laser and Intense Pulsed Light for the Treatment of Facial Telangiectasia.
In this study, we performed a retrospective analysis to compare the efficacy of PDL and IPL systems for the treatment of facial telangiectasia. A total of 416 patients with facial telangiectasia who were treated by PDL or IPLs in our department from August 2012 to March 2015 were included in this study. The subjects received one of the following five treatments: PDL 595 nm (9-12 J/cm2), MaxG (500-670 nm & 870-1200 nm, 30-46 J/cm2), IPL (560-1200 nm, 18-24 J/cm2), M22 560 (560-1200 nm, 15-18 J/cm2), and M22 590 (590-1200 nm, 15-20 J/cm2). Each treatment had two sessions with 6-week intervals. The improvement percentage ...
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Efficacy of Low-Fluence Nd:YAG 1064 nm Laser for the Treatment of Post-Inflammatory Hyperpigmentation in the Axillary Area.
CONCLUSION: A low-fluence Q-switched 1064-nm Nd:YAG laser provided safe and effective treatment for post-inflammatory hyperpigmentation in the axillary area, with good-to-excellent improvement after a minimum of 3 sessions. J Drugs Dermatol. 2017;16(11):1118-1123.. PMID: 29141060 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Randomized, Investigator-Blinded Comparison of Two Topical Regimens in Fitzpatrick Skin Types III-VI With Moderate to Severe Facial Hyperpigmentation.
CONCLUSION: Both a new HQ-free skincare system and a widely-available HQ-based system improved hyperpigmentation in Fitzpatrick skin types III to VI. Though the HQ-based system produced greater improvement in hyperpigmentation when compared to the HQ-free system, there was no difference in MoPASI scores between the treatment groups. Subjects were satisfied with both treatments and reported only mild to moderate irritation using either system. J Drugs Dermatol. 2017;16(11):1127-1132.. PMID: 29141061 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Management of Severe Acne Vulgaris With Topical Therapy.
Authors: Stein Gold L, Baldwin HE, Lin T Abstract Acne vulgaris (acne) is the most common skin disease we see in dermatology practice. Although rare in childhood, severe acne can affect up to 12% of the adolescent population. A chronic disease, it requires both aggressive management and effective maintenance strategies. Oral antibiotics, in combination with topical agents are recommended for treatment, with topical agents being continued as maintenance therapy to minimize resistance and recurrence. However, concerns with systemic side effects have recently resulted in a greater focus on the potential of fixed combi...
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris.
Authors: Strazzulla LC, Avila L, Lo Sicco K, Shapiro J Abstract Lichen planopilaris (LPP) is a variant of lichen planus that affects the scalp causing scarring hair loss. Patients also frequently experience symptoms of scalp itch, pain, and burning. To date, there are no long-term remittive nor curative therapies available. Low-dose naltrexone has anti-inflammatory properties and has recently been described in the context of treating autoimmune conditions. This retrospective medical record review describes four LPP patients treated with low-dose (3 milligrams per day) naltrexone. This medication provided benefit in...
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Port-Wine Stains: A Focused Review on Their Management.
Authors: Updyke KM, Khachemoune A Abstract Port-wine stain (PWS) is the second most common congenital vascular malformation characterized as ectatic capillaries and venules in the dermis that clinically appears as a deep red to purple patch on the skin. Typically, PWS progressively darken and may become hypertrophic or nodular without treatment. There are several treatment options available for PWS from topical antiangiogenic agents to laser therapies. Vascular-specific lasers are the gold standard in treating PWS and classically pulsed dye lasers are usually the treatment of choice. However, some patients with PWS...
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Use of Isoquercetin in the Treatment of Prurigo Nodularis.
Authors: Pennesi CM, Neely J, Marks AG, Basak SA Abstract Atopic dermatitis and prurigo nodularis result from complex interactions between the skin, the immune system, and the external environment. The pruritus associated with these conditions greatly impacts patients' quality of life and lacks uniformly effective treatment. A 57-year-old patient presented with severe atopic dermatitis and subsequent prurigo nodularis refractory to numerous standard therapies. The supplement isoquercetin was initiated and he noted significant, sustained reduction in his pruritus after only four weeks. Isoquercetin is a glycoside de...
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Vancomycin Infiltrate-Induced Dermatitis Mimicking Bullous Cellulitis.
Authors: Nanjappa S, Snyder M, Greene JN Abstract Extravasation of medications can manifest as tenderness, pain, tissue necrosis, and thrombophlebitis and lead to infection and severe long-term complications. Risk factors for leakage of medications include mechanical and pharmacologic mechanisms such as cannulation technique, vasoconstriction, and cytotoxicity. Well-known vesicants like anthracyclines, vinca alkaloids, and vasopressors are usually administered with proper caution. Often overlooked are many antimicrobial agents, which typically act via differences in osmolality and pH. Vancomycin harms the vascular ...
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

An Elusive Amelanotic Melanoma and Review of Dermoscopic Findings.
We present a new case of AM in an 84-year-old woman with a history of non-melanoma skin cancer. She had a thin pink plaque that was initially misdiagnosed as a basal cell carcinoma. We also discuss dermoscopy and its valuable role to improve diagnostic accuracy. A review of dermoscopic features that favor and oppose the clinical diagnosis of AM is discussed. Even with dermoscopy, it is still important to have a high index of suspicion and a low threshold to biopsy when the clinical diagnosis is unclear. J Drugs Dermatol. 2017;16(11):1164-1165.. PMID: 29141067 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

New Insight Into the Pathophysiology of Hair Loss Trigger a Paradigm Shift in the Treatment Approach.
Authors: Sadick NS, Callender VD, Kircik LH, Kogan S Abstract Hair loss affects millions of men and women of all ages and ethnicities, impacting appearance, social interactions, and psycho-emotional well-being. Although a number of options are available, they are limited, carry a potential risk of side effects, and none have proven to be comprehensive for treatment of hair loss. Across the spectrum of hair loss disorders, there has long been a segmentation into distinct mechanisms, driving the main trend in current therapeutics to focus on targeting single molecules or pathways. However, research points to similar ...
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Novel Multi-Targeting Approach to Treating Hair Loss, Using Standardized Nutraceuticals.
Authors: Farris PK, Rogers N, McMichael A, Kogan S Abstract Hair loss is a complicated problem that causes significant concern for those who are affected. Patients seeking medical treatment have limited options that include topical minoxidil and oral finasteride. While these treatments are backed by long term clinical use and research outcomes, many patients find topical minoxidil difficult to incorporate into their daily routine and some are concerned with the side effects associated with finasteride. In the office setting, patients may be treated with more invasive procedures such as platelet-rich plasma injectio...
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research