Novel Polymeric Lotion Formulation of Once-Daily Tazarotene (0.045%) for Moderate-to-Severe Acne: Pooled Phase 3 Analysis.
The objective was to assess efficacy, safety, and tolerability of tazarotene 0.045% lotion in patients with moderate-to-severe acne in a pooled analysis of data from two identical phase 3, double-blind, random-ized, vehicle-controlled 12-week clinical studies. Methods: Patients aged ≥9 years with moderate-to-severe acne were randomized (1:1) to tazarotene 0.045% lotion or vehicle lotion applied once daily. Inflammatory and noninflammatory lesion counts and Evaluator's Global Severity Score (EGSS) were assessed. Treatment success was defined as a ≥2-grade improvement in EGSS and a score of 'clear'/'almost clear'. Adve...
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Basal Cell Carcinoma in the Nasal Vestibule.
We present a case of a basal cell carcinoma located in the nasal vestibule. In presenting this case, we would like to emphasize the importance of attentive full skin examinations, both by physicians and patients, that include observation of sun-protected areas, as skin cancers such as basal cell carcinomas may occur in these unusual areas. In addition, BCCs have been reported in the literature to have occurred in the interdigital area of the foot, the female and male nipples, the axillae, and the genital and perianal areas.3,4,5,6,7,8 J Drugs Dermatol. 2020;19(3):333-334 doi:10.36849/JDD.2020.4517. PMID: 32550683 [PubM...
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Pityriasis Lichenoides Chronica in a Patient With Ankylosing Spondylitis Treated With Etanercept.
Authors: Goldust M, Weinberg JM, Kircik LH, Sonthalia S, Di Lernia V, Rathod D Abstract Pityriasis lichenoides is a scarce cutaneous disorder with unknown etiology. It contains a range of clinical manifestations including acute papular lesions that quickly grow into pseudo vesicles and central necrosis to small, scaling, benign-appearing papules.1,2. PMID: 32550684 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Lichen Myxedematosus: Case Report and Review of Literature.
We present the case of a 66-year-old Hispanic male referred by his primary care physician for evaluation of asymptomatic dark spots on his trunk and extremities present for about one-year. Physical exam revealed smooth, brown hyperpigmented papules coalescing into plaques on the trunk. Multiple well-demarcated oval dark brown plaques measuring 3 cm in size were located on the upper back, peri-umbilical area, bilateral lower extremities, and buttocks. A diagnosis of lichen myxedematosus was made based on histologic features observed in the dermis. There are 5 subtypes of LM: a discrete papular form, acral persistent papular...
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Real World SB4 (Etanercept Biosimilar) Use in Patients With Psoriasis: Data from the British Association of Dermatologists Biologic Interventions Register (BADBIR).
Authors: Egeberg A, Girolomoni G, Feldman SR, Radtke MA, Carrascosa JM, Ghil J, Keum JW, Lee J, Seo H Abstract Psoriasis is a chronic, systemic, inflammatory skin disease with a risk of comorbidities and a potential high impact on patients’ quality of life. PMID: 32550686 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Efficacy and Safety of Systemic Treatments for Skin and Joint Manifestations in Patients With Psoriasis.
Authors: Abramovits W, Schlessinger J Abstract Psoriasis is a chronic, systemic disease with features suggestive of autoimmune dysregulation. Patients with psoriasis vulgaris frequently experience systemic comorbidities, including cardiovascular and metabolic diseases, and approximately 30% develop psoriatic arthritis (PsA), which requires treatment. It is important that physicians and patients are aware of the breadth of treatment options available to treat the complete spectrum of psoriasis manifestations. This narrative review summarizes clinical information from approved systemic psoriasis therapies relevant to...
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Supersaturated Oxygen Emulsion for Wound Care and Skin Rejuvenation.
Authors: Gold MH, Nestor MS Abstract Although oxygen is essential for proper wound healing, wounds are often hypoxic with diminished oxygen delivery to the healing tissue. Since oxygenation of the outer layers of skin is almost exclusively provided by the atmosphere, increasing the presence of external oxygen enhances the healing process. Hyperbaric oxygen therapy is beneficial for treating nonhealing wounds, such as diabetic ulcers, and has been used to speed post-treatment recovery following aesthetic procedures; however, it is not suitable for home use. Recently, perfluorocarbon emulsions have been developed tha...
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Atopic Dermatitis: A Review of Current Diagnostic Criteria and a Proposed Update to Management.
Authors: Reynolds M, Gorelick J, Bruno M Abstract The diagnosis of atopic dermatitis (AD) remains primarily a clinical diagnosis, in which several clinical signs and symptoms including pruritus, the presence and location of skin lesions, and a personal or family history of atopic conditions are used to facilitate a diagnosis. In recent decades, several well-established sets of criteria have been developed to aid diagnosis. With increased awareness of AD and the recent development of systemic immunomodulators to treat the condition, there exists a need to further define and consolidate the current diagnostic criteri...
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Treatment of Impetigo in the Pediatric Population: Consensus and Future Directions.
CONCLUSION: Bacterial resistance to antimicrobials commonly used in treating impetigo has been reported. Antimicrobial stewardship is critical to optimize patient outcomes and to prevent the development of resistance. Healthcare providers should be aware of local resistance patterns in impetigo to help guide therapy. The use of newer safe and effective topical antibiotic alternatives as a first-line treatment should be an important step in antimicrobial stewardship.J Drugs Dermatol. 2020;19(3): doi:10.36849/JDD.2020.4679. PMID: 32550690 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Nail Surgery Myths and Truths.
DISCUSSION: Randomized controlled trials for nail surgery are lacking. Data from similar fields may guide dermatologists in performing nail surgery. J Drugs Dermatol. 2020;19(3): 230-234 doi:10.36849/JDD.2020.4861. PMID: 32550691 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Long-Term Benefits of Daily Photo-Protection With a Broad-Spectrum Sunscreen in United States Hispanic Female Population.
Authors: Grimes P, Halder R, Verschoore M, Wangari-Talbot J, Pillai K, Foltis P, Bouez C, Galdi A, Abdelhalim D, Liao IC, Zheng Q Abstract aThe Vitiligo and Pigmentation Institute of Southern California, Los Angeles, CA bDepartment of Dermatology, Howard University, Washington, DC cL’Oreal Research and Innovation, Paris, France dL’Oreal Research and Innovation, Clark, NJ. PMID: 32550692 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Real-World Utility of a Non-Invasive Gene Expression Test to Rule Out Primary Cutaneous Melanoma: A Large US Registry Study.
Authors: Brouha B, Ferris LK, Skelsey MK, Peck G, Moy R, Yao Z, Jansen B PMID: 32550693 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Tumor Necrosis Factor Inhibitor-Induced Psoriasis in a Pediatric Crohn's Disease Patient Successfully Treated with Ustekinumab.
CONCLUSION: This is the first reported case of a school-age pediatric patient with TNF inhibitor-induced psoriasis treated with ustekinumab. Controlled trials are warranted to fully assess the safety and efficacy of ustekinumab for treating TNF inhibitor-induced psoriasis in the pediatric population.J Drugs Dermatol. 2020;19(3): doi:10.36849/JDD.2020.2106. PMID: 32550694 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Field Therapy in Solid Organ Transplant Recipients: Are We Initiating Early Enough?
Authors: Topham C, Haynes D, Hopkins RS, Leitenberger J Abstract Organ transplant recipients (OTRs) are at increased risk for more aggressive non-melanoma skin cancer (NMSC). Recent emphasis on field therapy has complimented the canonical surgical treatment paradigm. This retrospective analysis of survey responses by patients seen at Oregon Health and Science University from 2013-2018 offers insights into patient trends and practice gaps in caring for OTRs. All patients completed a 57-point questionnaire at their first clinic visit, which included questions regarding demographics, transplant history, dermatologic h...
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Rosacea Treatment Satisfaction: Matching Adjusted Indirect Treatment Comparison Analysis of Metronidazole Gel or Cream vs Azelaic Acid Foam.
CONCLUSIONS: MG- and MC-treated patients more frequently reported treatment concerns and side effects than AAF-treated patients, and tolerability of those side effects was higher for patients treated with AAF. While treatment cost is a more frequent concern in patients treated with AAF, these patients less frequently reported concerns with treatment efficacy and reported similar or greater tolerance to side effects than patients treated with either MC or MG. J Drugs Dermatol. 2020;19(3): doi:10.36849/JDD.2020.3679. PMID: 32550696 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Effects of Primary Defect Characteristics on Reconstruction Type and Adjunctive Intervention in Mohs Micrographic Surgery: A Retrospective Review.
CONCLUSIONS: Both defect subunit and closure type were independently associated with adjunctive cosmetic intervention following MMS. Defect size was not significantly associated with an adjunctive intervention in our study. Understanding the factors affecting the need for adjunctive cosmetic interventions may improve patient counseling prior to Mohs repair. J Drugs Dermatol. 2020;19(3): doi:10.36849/JDD.2020.4701. PMID: 32550697 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Game Changer in Acne Treatment.
Authors: Kircik LH Abstract Of the four primary pathogenic factors that drive acne vulgaris—androgen excess, increased sebum production, faulty keratinization, and overgrowth of C. acnes—androgen excess has been the most elusive therapeutic target. Oral contraceptive pills (OCPs) have direct effect on circulating hormones, but their potential use is limited to a subset of women. As such, a sizable portion of the population affected by acne vulgaris cannot even consider treatment with OCPs. While these systemic agents are generally associated with a low risk profile and have a history of safe and...
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Androgens, Androgen Receptors, and the Skin: From the Laboratory to the Clinic With Emphasis on Clinical and Therapeutic Implications.
Authors: Del Rosso JQ, Kircik LH, Stein Gold L, Thiboutot D Abstract The effects of androgens on human skin include growth and differentiation of sebaceous glands, terminal hair growth, epidermal barrier function, wound healing, and modification of the cutaneous microbiome. Androgens exert their activities via ligand formation with intracytoplasmic androgen receptors which can then translocate to the nucleus and interact with genetic androgen response elements to influence signaling cascades. Differences in tissue distribution and activities of enzymes that modify androgen synthesis and catabolism, variations relat...
Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Utilization of an Online Cash-Pay Pharmacy for Topical 5-Fluorouracil Prescriptions in Older Patients.
CONCLUSIONS: Lower-cost medications from the online pharmacy site may improve adherence and outcomes in older adults and decrease total cost associated with AK treatment. However, the online pharmacy is underutilized by this population. J Drugs Dermatol. 2020;19(4): doi:10.36849/JDD.2020.4690. PMID: 32484613 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Risk of Non-Melanoma Skin Cancer in Connective Tissue Disease and The Impact of Immunosuppressive Therapy.
The objective of this study is to investigate the risk of non-melanoma skin cancer in patients with connective tissue disease and to assess the impact of immunosuppressive therapy on this risk. This is a retrospective case control cohort study of 8281 patients with connective tissue disease (systemic lupus erythematosus, Sjogren’s disease and scleroderma) and 8281 age, race, and gender matched controls followed for a 5-year period between 2002-2012, who obtained their care from a large integrated multispecialty group practice in Northern California. The odds ratio for developing squamous cell skin cancer among pa...
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Analysis of Wait Times for Online Dermatology Appointments in Most and Least Dermatologist-Dense Cities.
Authors: Xiang L, Lipner SR PMID: 32484615 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Pityriasis Lichenoides Chronica in a Patient With Ankylosing Spondylitis Treated With Etanercept.
CONCLUSION: Pityriasis lichenoides chronica should be included among the broad clinical spectrum of chronic inflammatory skin diseases which may occur during treatment with TNF-alpha antagonists. J Drugs Dermatol. 2020;19(5): doi:10.36849/JDD.2020.2191. PMID: 32484616 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Topical Fluorouracil Therapy for Residual Superficial Basal Cell Carcinoma Following Mohs Micrographic Surgery.
Authors: Pederson H, Staples CJ, Housewright C Abstract When treating invasive basal cell carcinoma (BCC) with Mohs micrographic surgery (MMS), including infiltrative and nodular subtypes, the goal is complete surgical removal of the tumor. In some cases, after several stages of MMS, residual foci of superficial BCC are noted with no dermal invasive components apparent. Some patients and surgeons have opted for halting surgery and treating residual superficial BCC with adjuvant topical fluorouracil. In this retrospective study, this treatment method is shown to be effective with a recurrence rate of BCC of 3.7% ove...
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Successful Treatment of Painful Cutaneous Vasculopathy With Rivaroxaban in a Patient With Systemic Lupus Erythematosus.
Authors: Leisenring NH, Rogers JL, Telloni S, Mansoori P, Al-Rohil RN, Marano AL Abstract Novel oral anticoagulant (NOAC) medications have revolutionized hematology and cardiology. Recently, NOACs have demonstrated additional promise in dermatology. Specifically, rivaroxaban, a direct factor Xa inhibitor NOAC, has been shown to be successful in the treatment of livedoid vasculopathy. Herein, we describe a patient with systemic lupus erythematosus who presented with painful cutaneous vasculopathy, demonstrated on biopsy with occlusive microvascular fibrin thrombi without evidence of concurrent vasculitis. Interestin...
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Influence of Dermatologists' Use of Social Media on Attracting Patients.
CONCLUSION: Given the majority of patients reported that social media is not important or only slightly important, dermatologists should consider means other than social media to attract new patients to their practices. For dermatologists who use social media, they should highlight patient reviews, experience level, and original medical content. J Drugs Dermatol. 2020;19(5):   doi:10.36849/JDD.2020.4849. PMID: 32484619 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Combined Triple-Wavelength (755nm, 810nm, and 1064nm) Laser Device for Hair Removal: Efficacy and Safety Study.
CONCLUSION: Simultaneous triple-wavelength laser device is a safe and effective hair removal modality. J Drugs Dermatol. 2020;19(5): doi:10.36849/JDD.2020.4735. PMID: 32484620 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Treatment of Sebaceous Hyperplasia by Laser Modalities: A Review of the Literature and Presentation of Our Experience With Erbium-doped Yttrium Aluminium Garnet (Er:YAG).
CONCLUSIONS: Laser modalities can provide satisfactory results for removing SH. It is crucial that the laser is being used by an expert who is familiar with the device as well as understand the laser tissue interaction to minimize patient adverse effects while providing the best cosmetic outcome. In our experience, Er:YAG laser can provide a safe and highly effective solution for SH. J Drugs Dermatol. 2020;19(5)   doi:10.36849/JDD.2020.3971. PMID: 32484621 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

MRI Assessment of Arm and Calf Muscle Toning With High-Intensity Focused Electromagnetic Technology: Case Study.
Authors: Katz B Abstract Arms and calves have long been a subject of interest in aesthetic medicine. Current surgical and non-invasive procedures focus on sagging skin and fat deposits without targeting the muscles. The aim of this study is to investigate the feasibility of high-intensity focused electromagnetic (HIFEM) technology for arm and calf toning through simultaneous fat reduction and muscle strengthening. In this case study, two subjects received four 20-minute HIFEM treatments of biceps, triceps, and calves, with the outcomes assessed by MRI. The analysis of MRI images showed an average increase in all th...
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Effects of Colloidal Oatmeal Topical Atopic Dermatitis Cream on Skin Microbiome and Skin Barrier Properties.
Authors: Capone K, Kirchner F, Klein SL, Tierney NK Abstract Atopic dermatitis is characterized by dry, itchy, inflamed skin with a dysbiotic microbiome. In this clinical study (NCT03673059), we compared the effects of an eczema cream containing 1% colloidal oat and a standard moisturizer on the skin microbiome and skin barrier function of patients with mild to moderate eczema. Patients were randomly assigned to treatment with 1% colloidal oat eczema cream or a standard, non-fragranced daily moisturizer. Treatment lasted 14 days, followed by a 7-day regression period. Of 61 patients who completed the study, 30 rece...
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

COVID-19 Pandemic: Are There Unique Cutaneous Manifestations in Patients Infected With SARS-CoV-2?
Authors: Wei C, Friedman AJ PMID: 32484624 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Influence of Supportive Oncodermatology Interventions on Patient Quality of Life: A Cross-Sectional Survey.
Conclusion: Enrollment was significantly associated with improved QOL. Dermatologic care also resulted in overall satisfied patient outcomes, although many patients were unsure if these dermatologic interventions aided in anticancer treatment adherence, highlighting the need for evidence-based management strategies for dAEs. J Drugs Dermatol. 2020;19(5):  doi:10.36849/JDD.2020.5040. PMID: 32484625 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Antibiotic Practices in Mohs Micrographic Surgery.
CONCLUSION: Disparity exists in antibiotic prescribing practices amongst Mohs surgeons. There may be under-prescription of antibiotics for high risk factors like nasal flaps, wedge excisions, skin grafts, anogenital/lower extremity site, and extensive inflammatory disease. Conversely, there may be over-prescription for prosthetic joints or cardiac valves. Increased guideline awareness may reduce post-operative infections and costs/side effects from antibiotic over-prescription. J Drugs Dermatol. 2020;19(5): doi:10.36849/JDD.2020.4695. PMID: 32484626 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Multiple Primary Melanomas Occurring Around the Same Time: A Review of Terminology and Implications.
This study conducted a review of the literature to elucidate the definitions of terminology used to describe MPMs that were diagnosed in close temporal proximity as well as explore common risk factors. Terminology found in the literature included “concurrent”, “simultaneous” and “synchronous” with varying definitions that ranged from 0-6 months between diagnoses of the first and subsequent melanomas. Eight cases are described in chronological order, and the incidence of MPMs diagnosed around the same time were reported as 22-39%. Nevus spilus was identified as a p...
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Importance of Complete Skin Clearance in Psoriasis as a Treatment Goal: Implications for Patient-Reported Outcomes.
Authors: Blauvelt A, Wu JJ, Armstrong A, Menter A, Liu C, Jacobson A Abstract Psoriasis is associated with physical, psychological, social, and economic burdens that lead to substantial impairment over a patient’s lifetime. It is important to understand how different skin clearance levels may relate to patient perceptions of psoriasis symptoms and health-related quality of life. Here, we highlight notable advantages to complete skin clearance relative to high levels of efficacy without complete skin clearance, including meaningful improvements in patient-reported signs and symptoms of psoriasis, a higher ...
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Halobetasol 0.01%/Tazarotene 0.045% Lotion for Moderate-to-Severe Psoriasis: Pooled Phase 3 Analysis of Males and Females.
CONCLUSION: HP/TAZ lotion was highly effective and safe in both males and females with moderate-to-severe psoriasis over 8 weeks of once-daily use. J Drugs Dermatol. 2020;19(5): doi:10.36849/JDD.2020.5021. PMID: 32484629 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Randomized Trial of Broad Area ALA-PDT for Field Cancerization Mitigation in High-Risk Patients.
CONCLUSION: 2 or 3 ALA–PDT treatments with 1-hour incubation can significantly reduce occurrence of AKs after 1 year in patients at high risk of NMSC versus VEH–PDT (NCT02239679). J Drugs Dermatol. 2020;19(5):452-458. doi:10.36849/JDD.2020.4930. PMID: 32484630 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Safety, Tolerability, and Efficacy of Repeat-Dose Injections of IncobotulinumtoxinA in the Treatment of Upper Facial Lines: Results from a Prospective, Open-Label, Phase III Study.
The objective of this study was to investigate the safety, tolerability, and efficacy of repeat-dose injections of incobotulinumtoxinA in the combined treatment of moder-ate to severe upper facial lines (UFL) [glabellar frown lines (GFL), horizontal forehead lines (HFL), and lateral periorbital lines (LPL)]. Healthy subjects (≥18 years) with moderate to severe GFL, HFL, and LPL on the Merz Aesthetics Scales (MAS) at maximum contrac-tion were administered 54 to 64 U of incobotulinumtoxinA (GFL, 20 U; HFL, 10 to 20 U; LPL, 24 U) in up to four, 120-day treatment cycles. Adverse events (AE) were recorded for each cycle ...
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Long-term Facial and Body Hair Removal With a Combined Radiofrequency and Optical Home-Use Device for All Skin Types.
CONCLUSIONS: Long term persistent hair reduction was achieved using an RF/IPL home-use hair reduction device. The combination of RF and optical energies allowed for the effective application of low energy usage. All skin types and both facial and body anatomical regions tolerated the procedures very well. J Drugs Dermatol. 2020;19(5):498-503. doi:10.36849/JDD.2020.4741. PMID: 32484632 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 4, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Exacerbation of Pediatric Periorificial Dermatitis: A Novel Adverse Reaction.
Authors: Parker J, Neill B, Whitsitt J, Rajpara A, Aires D PMID: 32401455 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 14, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Is It Time to Redefine Lidocaine Administration Guidelines in Mohs Surgery?
Authors: Flanagan K, McLean R, Goldberg D PMID: 32401456 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 14, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

CME: Re-examining the Optimal Use of Neuromodulators and the Changing Landscape: A Consensus Panel Update.
Authors: Kaminer MS, Cox SE, Fagien S, Kaufman J, Lupo MP, Shamban A Abstract Since initial US Food and Drug Administration approval of botulinum toxin type A (BoNT-A) for aesthetic use in 2002, clinical evidence and experience with BoNT-A and understanding of facial anatomy have greatly increased, leading to rapid advances in treatment planning and implementation. BoNT-A use has expanded from the upper face to the midface, lower face, and neck, so that BoNT-A injection is the most common cosmetic procedure worldwide. Trends in facial aesthetics reflect growing patient diversity with respect to age, gender, and eth...
Source: Journal of Drugs in Dermatology - May 14, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Cash Pharmacy Model May Effectively Lower Prescription Drug Prices.
Authors: Johnson MC, Hamid RN, Feldman SR PMID: 32401458 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 14, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Survey Study of Human Papillomavirus Vaccination Practices by Dermatologists.
Authors: Cartron AM, Raiciulescu S, Trinidad JC PMID: 32401459 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 14, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Is the Coronavirus (COVID-19) Pandemic an Indication to Temporarily Modify Dermatological Management Plans?
Authors: Shanshal M PMID: 32401460 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 14, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

CME/CE: ABOUT FACE: Navigating Neuromodulators and Injection Techniques for Optimal Results.
Authors: Yoelin SG, Bay Aguilera S, Cohen JL, Gold MH, Kaufman J, Maas CS Abstract Interest in the cosmetic use of neuromodulators for facial rejuvenation is increasing among physicians, other practitioners, and patients alike, and an expanding array of formulations and reported applications might be helping to drive this trend. Safety, efficacy, and a high level of patient satisfaction can be achieved with all the available botulinum neurotoxin type A (BTXA) products. With any of the formulations, optimal results require knowledge of the individual product’s unique properties and dosing, along with an un...
Source: Journal of Drugs in Dermatology - May 14, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Minimally Invasive Facial Cosmetic Procedures for the Millennial Aesthetic Patient.
Authors: Mobayed N, Nguyen JK, Jagdeo J Abstract Millennials, defined as the generation of individuals born between 1981 and 1996, have emerged as one of the leading patient demographics seeking minimally invasive cosmetic procedures. Worldwide, millennials are more likely to consider preventative treatments compared to any other age-group. The three most popular minimally invasive facial procedures in this demographic include botulinum toxin, dermal fillers (eg, hyaluronic acid, calcium hydroxylapatite, facial fat-fillers), and microdermabrasion. Given their impact on the expanding aesthetic medicine market and th...
Source: Journal of Drugs in Dermatology - May 13, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Treatment of Plaque Psoriasis With an Excimer Laser Utilizing an Optimal Therapeutic UVB Dose Protocol.
Conclusion: The OTDTM protocol with the MMD® tip allows determining the optimal dose locally on the psoriatic plaque itself. Consequently, ineffectual dosing levels and treatments are minimized. The OTD protocol reduces treatment frequency from 2-3 times per week to once weekly. J Drugs Dermatol. 2020;19(4):349-354. doi:10.36849/JDD.2020.4891. PMID: 32272510 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 12, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Light Emitting Diode Phototherapy for Skin Aging.
Authors: Huang A, Nguyen JK, Ho D, Jagdeo J Abstract Skin aging is associated with changes that include atrophy, pigmentation, decreased ability for wound healing, and rhytides. Recently, there has been growing research interest and consumer demand for minimally invasive cosmetic procedures involving light and energy-based devices, particularly for facial skin rejuvenation. Light emitting diode (LED) phototherapy is a promising treatment modality for photorejuvenation as it is safe, noninvasive, accessible, and can be easily combined with other treatment options. LED irradiation alters intrinsic cellular activity v...
Source: Journal of Drugs in Dermatology - April 12, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Safety of Combining Facial Lifting With Suspension Threads and Microfocused Ultrasound With Visualization.
The objective of this study was to assess the safety of combining suspension threads with MFU in the face and neck. The structure and integrity of suspension threads was tested in an ex vivo animal model, an in vitro hot water bath and clinically in a human subject. Safety and subject satisfaction was assessed in a retrospective study. The structure and integrity of poly-L-lactic acid, polyethylene and polyamide threads was confirmed in an in vitro hot water bath and exposure to MFU in an ex vivo animal model. Clinically, exposure of poly-L-lactic acid threads to MFU resulted in greater neocollagenesis after 3 months compa...
Source: Journal of Drugs in Dermatology - April 12, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Effect of a Ceramide-Containing Product on Stratum Corneum Lipid Levels in Dry Legs.
This study explored the relationship between the improvement in the signs of dry skin and the amounts of ceramides in the SC by combining clinical observations with a biochemical analysis to quantify the level of SC intercellular lipids. The efficacy of a multilamellar vesicular emulsion (MVE), ceramide-containing moisturizing cream was evaluated in a randomized, investigator-blinded, split-leg study on female subjects with dry, itchy skin. The cream increased skin hydration and demonstrated an immediate and sustained reduction in the visible signs of dry skin and subject perceived sensory discomfort. Additionally, ceramid...
Source: Journal of Drugs in Dermatology - April 12, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research