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Demographic and Tumor Characteristics of Patients Younger Than 50 Years With Nonmelanoma Skin Cancer Referred for Mohs Micrographic Surgery.
CONCLUSION: Patients
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Vismodegib and the Hedgehog Pathway Inhibitors: A Historical Perspective to Current Clinical Application.
Authors: Tang JC, Hanke CW, Caro I Abstract Vismodegib (Erivedge, Genentech-Roche) is the first in class of Hedgehog pathway inhibitors approved for treatment of metastatic basal cell carcinoma (BCC), or locally advanced BCC that has recurred after surgery or is not amenable to surgery or radiation. Its path to discovery has been unique and traces its origin to corn lilies, sheep, Drosophila flies, and the Hedgehog signaling pathway. J Drugs Dermatol. 2018;17(5):506-508. PMID: 29742180 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Retrospective Analysis of Complication Rates in Mohs Micrographic Surgery Patients With Clinically Large Tumors and Tumors With Aggressive Subclinical Extension.
CONCLUSION: Clinically, large tumors may be at higher risk for complications following MMS due to their increased size and need for repair with methods other than linear closures. Tumors with ASE were not found to be at higher risk for postoperative complications. J Drugs Dermatol. 2018;17(5):511-515. PMID: 29742181 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Dermatologist Practices During Total Body Skin Examinations: A Survey Study.
Authors: Rieder EA, Mu EW, Wang J, Cohen DE, Rigel DS, Stevenson ML Abstract Though screening for skin cancer is an essential practice in dermatology, limited data are published on dermatologists' total body skin examination (TBSE) behaviors. We surveyed 6500 dermatologists on their TBSE practices, including questions about less commonly examined body sites. We found varied TBSE practices among all dermatologists and discrepancies in examinations between dermatologists of opposite genders. J Drugs Dermatol. 2018;17(5):516-520. PMID: 29742182 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Facial Basal Cell Carcinoma in Patients Younger Than 40.
DISCUSSION: There may be underlying differences in the pathogenesis and natural history of basal cell carcinoma in the younger population, and between males and females; alternatively, lifestyle factors may also play a role. J Drugs Dermatol. 2018;17(5):525-530. PMID: 29742183 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Complex Regional Pain Syndrome: What the Dermatologist Should Know.
Authors: Qureshi AA, Friedman AJ Abstract Reflex sympathetic dystrophy is a subtype of complex regional pain syndrome, a condition characterized by persistent post-injury extremity pain. Temperature and sweating changes, edema, mobility changes, and a variety of hair, nail, and skin sequelae have been described. Only 23 articles published since 1990 describe dermatologic changes in CRPS. Given this paucity of literature, we present a case to further elucidate cutaneous manifestations of CRPS. Our patient is a 52-year-old Caucasian woman with a 19-year history of reflex sympathetic dystrophy who has presented with s...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Role of IL-17 in the Human Immune System and Its Blockage as a Treatment of Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis.
Authors: Jaller Char JJ, Jaller JA, Waibel JS, Bhanusali DG, Bhanusali N Abstract Interleukin 17 (IL-17) functions as a bridge between the innate and adaptive immunity. In addition to being a crucial defense mechanism against extracellular pathogens, it plays a significant role in inflammation, therefore considered a decisive factor in inflammatory conditions; hence the importance of its understanding for the treatment of autoimmune diseases. Animal models have demonstrated that blockage of the IL-17 receptor (IL-17R) may prevent these pathologies. For instance, there is evidence that IL-17R-deficient mice may be p...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Factors Affecting Dermatologists' Use of a 31-Gene Expression Profiling Test as an Adjunct for Predicting Metastatic Risk in Cutaneous Melanoma.
CONCLUSIONS AND RELEVANCE: Ulceration appears to be the most important factor impacting clinicians when deciding to order the 31-GEP test to assess risk for melanoma metastasis. J Drugs Dermatol. 2018;17(5):544-547. THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL TEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEASE CONTACT THE PUBLISHER WITH ANY QUESTIONS.. PMID: 29742186 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Degradation of Hylauronic Acid Fillers Using Hyaluronidase in an In Vivo Model.
DISCUSSION: This standardized animal model proved efficient in the study of in vivo degradation of HA fillers using injected hyaluronidase where products manufactured with different technologies were evaluated. J Drugs Dermatol. 2018;17(5):548-553. PMID: 29742187 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Chlorine Dioxide Complex Cleanser: A New Agent With Rapid Efficacy for Keratosis Pilaris.
Authors: Zirwas MJ, Fichtel J Abstract Chlorine dioxide complex™ is a new molecule to dermatology that is a unique, non-toxic, broad spectrum anti-microbial and keratolytic compound. Chlorine dioxide has been used as an antiseptic in industrial settings for decades, primarily in water treatment facilities for municipal water supplies and food preparation. The compound has exceptional antiseptic properties with no known potential for development of resistance. It is a true keratolytic and anti-inflammatory, but is non-toxic to human tissue due to its unique mechanism of action. Chlorine dioxide's use in consum...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Six-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self-Perceived Thinning Hair.
CONCLUSION: This nutraceutical supplement safely and effectively promoted hair growth in women with self-perceived thinning. It provides a multi-targeted therapeutic approach to hair loss by addressing micro-inflammation, stress, and oxidative damage with clinically tested, standardized, and bio-optimized phytoactive ingredients. ClinicalTrials.gov: NCT03206567 J Drugs Dermatol. 2018;17(5):558-565. PMID: 29742189 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Natural Cream-to-Powder Formulation Developed for the Prevention of Diaper Dermatitis in Diaper-Wearing Infants and Children: Barrier Property and In-Use Tolerance Studies.
Authors: Gunt HB, Levy SB, Lutrario CA Abstract INTRODUCTION: Diaper dermatitis is a common condition that develops in the diaper area due to factors such as elevated moisture, increased skin surface pH, and exposure to irritants from urine and feces. These factors suggest interventions to prevent or treat diaper dermatitis such as exposing the skin to air, frequent diaper changes, and thorough cleansing of the diaper area. Barrier creams and powders also have a role in preventing and treating diaper dermatitis. We developed a cream-to-powder product with a formula based on corn starch and other natural ingredients...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Gene Expression Analysis Differentiates Melanomas from Spitz Nevi.
In this study, we investigate gene expression patterns of pigmented lesions from FFPE tissue block samples (n=23, 9 male, 14 female patients, median age 12) with a focus on differentiating Spitz nevi from melanomas in children and young adults. RESULTS: PRAME levels were significantly (P less than 0.001) increased based on normalized Ct cycle counts (lower cycle counts indicate higher expression levels) in melanomas (mean Ct 33.83 + 0.54, 95% CI 32.85-34.80) when compared to Spitz nevi (mean Ct 37.21 + 0.98, 95% CI 35.41-39.01) or common nevi (mean Ct 36.94 + 0.80, 95% CI 35.47-38.40), respectively. LINC and 4 control ...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Chronic Nasolabial Fold Seborrheic Dermatitis Successfully Controlled With Crisaborole.
Authors: Liu D, Chow P, Strawn S, Rajpara A, Wang T, Aires D Abstract . PMID: 29742192 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Nodule Formation Following Treatment With Hyaluronic Acid Fillers: A Report of Two Challenging Cases.
Authors: Orseth ML, Lee N, Ibrahim O, Arndt KA, Kaminer M Abstract Nodule formation can be a potentially disfiguring adverse event of soft tissue fillers. Limited treatment consensus exists regarding the optimal approach for addressing recurrent and persistent nodules. Here we describe two challenging cases of nodules that developed following injection with Restylane and Juvéderm Voluma. We review suspected pathophysiology and discuss our treatment approach. J Drugs Dermatol. 2018;17(5):580-581. PMID: 29742193 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Widespread Skin Necrosis Secondary to Gemcitabine Therapy.
Authors: Zito PM, Gonzalez AM, Fox JD, Cronin M, Mackrides N, Kirsner RS, Nichols AJ Abstract Gemcitabine, a pyrimidine nucleoside analogue, is an oncologic agent used in the treatment of cutaneous T-cell lymphoma (CTCL). Common dermatologic reactions associated with gemcitabine include alopecia, mild skin rash, and mucositis but skin necrosis is exceptional. Herein we present an unusual case of widespread skin necrosis mimicking toxic epidermal necrolysis in a 45-year-old woman receiving gemcitabine therapy for stage IIIA cutaneous T-cell lymphoma. This is the first reported case of a TEN-like reaction subsequent ...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Longitudinal Melanonychia Biopsy: What Not to Do.
Authors: Ocampo-Garza J, Bretas JM, Matana D, Sobral PJ, Thompson CT, Zaiac M, Tosti A Abstract The nail matrix biopsy is an important technique in confirming or excluding a diagnosis of melanoma in a patient with longitudinal melanonychia. Dermatologists are the first-line diagnosticians for these pigmented lesions of the nail unit, however, for different reasons, some are reluctant to perform a nail biopsy. This case demonstrates how a poor biopsy technique resulted in a misdiagnosis in a patient with melanoma in situ. J Drugs Dermatol. 2018;17(5):587-588. PMID: 29742195 [PubMed - in process] (Source: Journal...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

An Acne Survey from the World's Largest Annual Gathering of Twins.
CONCLUSIONS AND REVELANCE: This twin study further supports that there may be a genetic phenotypic link, though social and environmental factors may also have an influence in the disease process. J Drugs Dermatol. 2018;17(4):380-382.. PMID: 29601613 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Dihydroxyacetone: A Review.
Authors: Braunberger TL, Nahhas AF, Katz LM, Sadrieh N, Lim HW Abstract The sunless tanning industry has experienced rapid growth due to public education on the dangers of ultraviolet radiation on skin and improvements in products. Dihydroxyacetone (DHA) is a 3-carbon sugar allowed by the Food and Drug Administration (FDA) as a color additive in sunless tanning products. Bronzers, a product removed with soap and water, may also contain DHA. We aim to review the literature on DHA. DHA is intended for external application, not including the mucous membranes or in or around the eye area. DHA has been used in spray-tan...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Understanding Patient Experience With Hyperhidrosis: A National Survey of 1,985 Patients.
Authors: Glaser DA, Hebert A, Pieretti L, Pariser D Abstract Hyperhidrosis affects 4.8% of the US population, and despite the well documented negative impact of hyperhidrosis on patients' lives, data are generally lacking on the patient experience with this condition. The International Hyperhidrosis Society (IHHS) conducted a study in 2014, and initial results confirmed the multifaceted impact of hyperhidrosis on quality of life and underscored the need for disease awareness and effective management. To provide further insight into the hyperhidrosis patient experience, additional results focusing on family history,...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Frontal Fibrosing Alopecia and Concomitant Lichen Planus Pigmentosus: A Case Series of Seven African American Women.
Authors: Uwakwe LN, Cardwell LA, Dothard EH, Baroudi BI, McMichael AJ Abstract The association of frontal fibrosing alopecia (FFA) and lichen planus pigmentosus (LPPigm) is rare. Prior reports suggest that FFA and LPPigm are on the same spectrum of disease, and a diagnosis of LPPigm may predict the future development of FFA. We aim to further characterize the association between FFA and LPPigm by reviewing the clinical cases of seven African American women. Seven patients with FFA were diagnosed clinically by recession of frontotemporal hairline and confirmed by histopathologic examination showing lymphocyte-mediat...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Collagen Powder in Wound Healing.
This article critically reviews the current evidence for collagen powder as an adjunctive therapy for chronic wounds and presents indications, limitations, and principles of use. In general, there is a need for high quality studies and randomized control trials to support its use in clinical practice. J Drugs Dermatol. 2018;17(4):403-408.. PMID: 29601617 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Use of a Self-Occluding Topical Anasthetic in Daily Practice: A Non-Interventional Study.
CONCLUSION: Pliaglis was well-tolerated and provided adequate pain reduction prior to dermatological procedures. www.clinicaltrials.gov (NCT01800474). J Drugs Dermatol. 2018;17(4):413-418. Partial study data have been presented at the Anti-Aging Medicine European Congress (AMEC), Paris; October, 24-25, 2014, and the European Academy of Dermatology and Venereology (EADV), Istanbul; October 2-6, 2013.. PMID: 29601618 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Topical Agents for Scar Management: Are They Effective?
Authors: Zoumalan CI Abstract Scar formation is the body's natural healing response to reestablish dermal integrity following an injury. Excessive scarring, however, can cause significant cosmetic, functional, and psychological problems. A wide variety of topical creams, lotions, and oils are available for scar treatment or wound healing. Sieving through the options and selecting the best option for their patients can be challenging for clinicians, especially given that clinical evidence for many of the active agents in commonly used topical treatments is lacking. The goal of this review is to provide an overview o...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Multi-Center, Double-Blind, Vehicle-Controlled Clinical Trial of an Alpha and Beta Defensin-Containing Anti-Aging Skin Care Regimen With Clinical, Histopathologic, Immunohistochemical, Photographic, and Ultrasound Evaluation.
CONCLUSIONS: A 3-product skin care regimen containing alpha and beta defensins globally improves the visual appearance and structure of aging skin without irritation, dryness, or inflammation. Specifically, this regimen increases epidermal thickness, reduces appearance of pores, reduces wrinkles, and reduces melanin. This skin care regimen stimulates rejuvenation without evidence of increase of a marker of carcinogenic stimulation. This data is consistent with the hypothesis that a defensin-containing skin care regimen activates the body's own dormant stem cells to generate healthy new epidermal cells. J Drugs Dermatol. 20...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Prospective, Randomized, Investigator-Blinded, Split-Face Evaluation of a Topical Crosslinked Hyaluronic Acid Serum for Post-Procedural Improvement of Skin Quality and Biomechanical Attributes.
CONCLUSIONS: When initiated post-procedurally, topical RHA serum was well-tolerated and enhanced biomechanical properties, quality, and clinical appearance of the skin. Based on these data, RHA serum may be of value in improving patient outcomes and satisfaction following minimally invasive aesthetic procedures. The availability of the same hyaluronic acid technology also as a cohesive, tissue-integrating injectable filler enables synergistic, multi-level treatment plans to be devised. J Drugs Dermatol. 2018;17(4):442-450.. PMID: 29601621 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women.
CONCLUSION: Preliminary results on the use of topical FNS are limited, but safe and promising. Continued research into drug-delivery, ideal topical concentration and application frequency, side effects, and use for other alopecias will help to elucidate the full extent of topical FNS' use. J Drugs Dermatol. 2018;17(4):457-463.. PMID: 29601622 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Dynamic Changes of Facial Supporting Cornerstones (Pillars): Considerations in Aesthetic Approach.
Authors: Avelar LET, Cazerta CEP, Avè MN, Shitara DI Abstract The bony structures of the face provide the framework upon which the soft-tissue envelope rests, such that facial symmetry and proportionality usually depend upon the morphological patterns and anthropometrical measurements of a symmetrical skull. Facial bony pillars are dynamic and variable according to the demands placed upon them, as well as gender and aging differences. Thus, a more profound knowledge of facial supporting pillars and their dynamic behavior by physicians who practice minimally cosmetic procedures would allow for a more natural ...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Psoriasiform Pemphigus Foliaceus in an African American Female: An Important Clinical Manifestation.
Authors: Austin E, Millsop JW, Ely H, Jagdeo J, Schulman JM Abstract A 50-year-old African-American woman presented to the dermatology clinic with a pruritic eruption of 3 years' duration. On clinical examination, the patient had well-demarcated, pink, atrophic plaques and superficial erosions over the inframammary folds and mid-chest. She also had well-demarcated, hyperpigmented, hyperkeratotic scaly plaques over the abdomen, suprapubic region, elbows, knees, and back with sporadic small superficial blisters. A punch biopsy of the right abdomen was performed and revealed psoriasiform epidermal hyperplasia, focal p...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Proximal Subungual Onychomycosis in the Immunocompetent: A Case Report and Review of the Literature.
We present a case of a healthy 51-year-old man, who presented with a three-month history of white discoloration of multiple toenails. Physical examination revealed white, opaque patches on the proximal third nail plates of multiple toenails. The affected digits also demonstrated proximal onycholysis, subungual debris, and mild paronychia. Laboratory examinations, including routine serologic studies as well as human immunodeficiency virus and antinuclear antibodies, were within normal limits. Proximal nail fragments of the left hallux showed sections of dystrophic nail plate with mounds of parakeratosis, collections of neut...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Successful Therapy of Severe Oro-Labial Herpes Simplex With Muco-Adhesive Acyclovir.
Authors: Rosen T Abstract Although muco-adhesive acyclovir 50mg tablets are only approved for the management of recurrent oro-labial HSV-1 infections, their ability to achieve extremely high concentrations in saliva and oral tissues suggests the potential for other uses. In this case, the agent was successfully utilized as a single tablet monotherapy leading to rapid clinical resolution of severe post-operative oro-labial infection. J Drugs Dermatol. 2018;17(4):479-480.. PMID: 29601626 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Dermatology on Instagram: An Analysis of Hashtags.
Authors: Park JH, Christman MP, Linos E, Rieder EA Abstract Forty-two percent of Americans search for health-related information on social media platforms, and forty-five percent of consumers report that social media health information influences their decision to seek care. PMID: 29601627 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Controversy: Mohs and Close.
Authors: Sarnoff DS, Gotkin RH Abstract . PMID: 29601628 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Skin Type Classification: A Decennial Perspective.
Authors: Roberts WE Abstract The intent of this brief communication is to revisit the Roberts Skin Type Classification System published by Journal of Drugs in Dermatology (JDD) in 2008 with a 2018 lens and provide additional information for its wider acceptance and implementation. PMID: 29601629 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Onset of Action of Biologics in Patients With Moderate-to-Severe Psoriasis.
CONCLUSIONS: Brodalumab may have the most rapid onset of action of any biologic therapy used in psoriasis. Similar results were seen with both outcome measures and will have important implications in psoriasis management. J Drugs Dermatol. 2018;17(3):247-250.. PMID: 29537442 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Clinical Insights About Onychomycosis and Its Treatment: A Consensus.
CONCLUSIONS: The current treatment paradigm for onychomycosis may have shifted from mainly oral antifungals to topical treatment, improving patient-focused quality of care. J Drugs Dermatol. 2018;17(3):253-262.. PMID: 29537443 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Efficacy and Safety of Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel Plus Oral Doxycycline in Subjects With Severe Inflammatory Acne Who Are Candidates for Oral Isotretinoin.
CONCLUSION: 0.3% A/BPO + DOX is an effective and safe treatment option for severe inflammatory AV, before starting OI treatment, or as an alternative when OI cannot be used. ClinicalTrials.gov identifier: NCT02899000 J Drugs Dermatol. 2018;17(3):264-273.. PMID: 29537444 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Intralesional and Laser-Assisted 5-Fluorouracil in Dermatologic Disease: A Systematic Review.
DISCUSSION: Intralesional and laser-assisted 5-fluorouracil are used in a variety of dermatologic disease processes with a wide range of efficacy and levels of evidence. Based on extent and level of evidence, our disease-specific systematic review found that the evidence is strongest for intralesional 5-FU use in the treatment of keloids, hypertrophic scars, and keratoacanthomas. This review serves as a comprehensive summary of intralesional and laser-assisted 5-fluorouracil use in dermatology. J Drugs Dermatol. 2018;17(3):274-280.. PMID: 29537445 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Dermal Microflora Restoration With Ammonia-Oxidizing Bacteria Nitrosomonas Eutropha in the Treatment of Keratosis Pilaris: A Randomized Clinical Trial.
Authors: Lee NY, Ibrahim O, Khetarpal S, Gaber M, Jamas S, Gryllos I, Dover JS Abstract Keratosis pilaris (KP) is a common skin finding that presents as follicular hyperkeratotic papules on the proximal extremities in patients with a propensity for atopy. Although often asymptomatic, the stippled appearance is cosmetically disturbing to patients and difficult to treat as current therapies are limited in availability and efficacy. Nitric oxide (NO) has been found to be essential in basic systemic and cutaneous physiologic function, specifically in terms of its anti-microbial and anti-inflammatory properties, which e...
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Pivotal Trial of the Efficacy and Safety of Oxymetazoline Cream 1.0% for the Treatment of Persistent Facial Erythema Associated With Rosacea: Findings from the Second REVEAL Trial.
Authors: Baumann L, Goldberg DJ, Stein Gold L, Tanghetti EA, Lain E, Kaufman J, Weng E, Berk DR, Ahluwalia G Abstract Rosacea is a chronic dermatologic condition with limited treatment options, particularly for persistent erythema. This pivotal phase 3 study evaluated oxymetazoline, an a1A-adrenoceptor agonist, for the treatment of moderate to severe persistent erythema of rosacea. Eligible patients were randomly assigned 1:1 to receive oxymetazoline cream 1.0% or vehicle applied topically to the face once daily for 29 days. The primary efficacy outcome was ≥2-grade improvement from baseline on both Clinician Er...
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Addressing Male Facial Skin Concerns: Clinical Efficacy of a Topical Skincare Treatment Product for Men.
Authors: Makino ET, Jiang LI, Tan P, Cheng T, Mehta RC Abstract The growing male skincare market reflects the increased interest of men in addressing facial aging concerns and maintaining a healthy youthful appearance. Because of differences in skin structure and aging as well as in lifestyle and behavior, male facial skin presents unique challenges that may result in different priorities or treatment strategies compared to female skin. A clinical study was conducted to assess clinical efficacy and tolerability of a topical skincare treatment product that was developed to address several male facial skin concerns r...
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Phase 2 Randomized, Dose-Ranging Study of Oxymetazoline Cream for Treatment of Persistent Facial Erythema Associated With Rosacea.
CONCLUSION: Oxymetazoline 1.0% QD provided the optimal dosing regimen and was selected for evaluation in phase 3 clinical studies. J Drugs Dermatol. 2018;17(3):308-316. PMID: 29537449 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Intramuscular Steroids in the Treatment of Dermatologic Disease: A Systematic Review.
CONCLUSIONS AND RELEVANCE: We conclude that intramuscular steroids can be regarded as having comparable efficacy to other steroid modalities in the treatment of steroid responsive dermatoses; and also appear to be safer in most instances with the exception of dysmenorrhea in females. Additional studies are greatly needed. J Drugs Dermatol. 2018;17(3):323-329.. PMID: 29537450 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Efficacy and Safety of Sarecycline, a Novel, Once-Daily, Narrow Spectrum Antibiotic for the Treatment of Moderate to Severe Facial Acne Vulgaris: Results of a Phase 2, Dose-Ranging Study.
CONCLUSION: Once-daily sarecycline 1.5 mg/kg significantly reduced inflammatory lesions versus placebo and was safe and well tolerated with low rates of AEs, including gastrointestinal AEs. Sarecycline 3.0 mg/kg did not result in additional efficacy versus 1.5 mg/kg. Sarecycline may represent a novel, once-daily treatment for patients with moderate to severe acne. It offers a narrow antibacterial spectrum relative to other tetracycline options, which may lead to less selective pressure on enteric Gram-negative bacteria, resulting in less disruption of commensal organisms and less potential for antibiotic resistance. J Drug...
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Clobetasol Emulsion Foam and Calcipotriene 0.005% Foam Combination Therapy for the Maintenance of Treatment Response in Patients With Moderate Plaque Psoriasis.
Authors: Bhatia N, Kircik L Abstract Optimizing combinations for psoriasis means asking patients to take control of their disease. It means balancing potency of steroids for the short-run to put out the fire and bring relief and maintaining the clearance for the long-run to reduce recurrence potential. Successful combinations are built on tolerability, ease of application, and the efficacy demonstrated by the synergy of the sum of the parts over being used separately. J Drugs Dermatol. 2018;17(3):342-346.. PMID: 29537452 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Topical Tavaborole in the Treatment of Onychomycosis Complicated by Dermatophytoma: A Post-hoc Assessment of Phase II Subjects.
We present 5 cases of dermatophytoma identified in Phase II trials that responded in a positive manner following treatment with tavaborole solution for onychomycosis of the great toenail. Although not representative of all subject outcomes, these findings provide insight into the use of topical tavaborole for dermatophytoma, a condition previously thought to respond only to oral or combination therapy. J Drugs Dermatol. 2018;17(3):347-354.. PMID: 29537453 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Dupilumab in the Treatment of Dyshidrosis: A Report of Two Cases.
We report two cases of recalcitrant dyshidrotic eczema treated successfully with dupilumab at standard dosing. Further studies to establish the efficacy of dupilumab in the treatment of dyshidrosis are warranted. J Drugs Dermatol. 2018;17(3):355-356.. PMID: 29537454 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Locally Advanced Basal Cell Carcinoma: Two Severe Case Presentations and Review.
Authors: Brown L, David J, Skopit S Abstract Basal cell carcinoma (BCC) is a common skin malignancy comprising 80% of non-melanoma skin cancers.1 Over 2.8 million cases are estimated to be diagnosed in the United States alone each year. Advanced BCCs are comprised of BCCs that have metastasized to local or distant lymph nodes or organs, or locally invasive BCCs that are extensive and infiltrate vital structures such as eyes, nose, or brain. Advanced BCC tumors represent roughly 1-10% of BCCs today. Two severe case presentations and treatment options will be discussed in this case report series and review. J Drugs D...
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Injection Site Necrosis and Ulceration Following Vaccination in an Adult Patient.
Authors: Donaldson S, Canavan T, Pavlidakey PG, Cantrell WC, Elewski BE Abstract Local adverse reactions to vaccination are typically mild and often quickly resolve. Vaccine adjuvants such as aluminum salts in combination with improper vaccination technique may result in severe local adverse reactions. As far as we know, there is only one prior case of frankly necrotic rapidly progressing vaccine site necrosis, which occurred in a pediatric patient.1 To our knowledge, this is the first adult case of vaccine site necrosis to be reported. The presumed etiology has been aluminum salt adjuvants and improper vaccination...
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Reply to Letter: Effectiveness of Mohs and Close.
Authors: Gloster HM Abstract The following is a response to the Letter to the Editor by Konda, Francis, and Patel regarding the article "Mohs and Close" Technique (MCT) for selected cases to increase the efficiency of Mohs micrographic surgery.1,2 The letter raises questions about our utilization of MCT that require clarification. PMID: 29537457 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 17, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research