Therapeutic Insights in Melasma and Hyperpigmentation Management
Authors: Huerth KA, Hassan S, Callender VD Abstract Melasma and postinflammatory hyperpigmentation (PIH) are the most common forms of dyschromia in patients with skin of color. Both are associated with a high psychological burden of disease. To exacerbate this burden, the need for treatment is chronic, and the results are often suboptimal in the eyes of the patient. Successful treatment is therefore contingent upon a correct diagnosis, patient education, and a carefully considered therapeutic approach. The latter is often multimodal in its design, incorporating sun protection, topical and systemic medications, and ...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Combination Use of Systemic Therapies in Psoriasis: Baseline Characteristics from the Corrona Psoriasis Registry
CONCLUSIONS: Various demographic and socioeconomic factors are associated with use of combination systemic therapy compared to use of systemic monotherapy for psoriasis. An association with commonly used disease severity indices was not observed. RELEVANCE: An understanding of which patients are more likely to be prescribed combination systemic therapy will provide important context for long-term efficacy and safety data as they become available. PMID: 31424705 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Prescribing Patterns Associated With Biologic Therapies for Psoriasis from a United States Medical Records Database
The objective of this study was to use data from electronic health records to understand prescribing patterns associated with biologic therapies for psoriasis and utilization of concomitant non-biologic psoriasis therapies in patients on biologics. METHODS: A retrospective cohort study was performed using OptumInSight’s electronic health records database. Patients were classified as having psoriasis if they had 2 diagnosis codes for psoriasis or 1 diagnosis for psoriasis and a subsequent prescription for a systemic psoriasis therapy or phototherapy on a separate day. Only patients with at least 1 prescription for a ...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Review of Topical Corticosteroid Foams
Authors: Payne J, Habet KA, Pona A, Feldman SR Abstract BACKGROUND: Topical corticosteroids are efficacious treatment options for multiple dermatoses. However, ointments and cream corticosteroid vehicles can be cumbersome to patients and may act as a barrier to adherence. Foam vehicles may be preferred by some patients. OBJECTIVE: To evaluate the efficacy and safety of topical corticosteroid foams. METHODS: A literature review was conducted using the keywords “clobetasol,” “betamethasone,” “propionate,” “valerate,” “topical,” “foam,” “v...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Comparison of the Safety and Efficacy of Tumor Necrosis Factor Inhibitors and Interleukin-17 Inhibitors in Patients With Psoriasis
Authors: Green LJ, Yamauchi PS, Kircik LH Abstract Psoriasis (PsO) is a common, systemic, chronic inflammatory disease characterized by key clinical symptoms, including itching, pain, and scaling, and is associated with substantial physical, psychosocial, and economic health burdens. Currently, there is no cure for PsO; however, the introduction of biologic therapies has revolutionized the clinical management of patients with PsO by expanding treatment options to include multiple therapies with different mechanisms of action targeting cytokines, including tumor necrosis factor inhibitors (TNFis), interleukin (IL)-1...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Two Multicenter, Randomized, Double-Blind, Parallel Group Comparison Studies of a Novel Foam Formulation of Halobetasol Propionate, 0.05% vs Its Vehicle in Adult Subjects With Plaque Psoriasis
Authors: Bhatia N, Stein Gold L, Kircik LH, Schreiber R Abstract BACKGROUND: A novel foam formulation of halobetasol propionate, 0.05% (HBP-Foam) has been developed to treat plaque psoriasis in patients who prefer a thermostable topical foam with low application shear that allows for easier coverage over large and/or hirsute areas than existing formulations. OBJECTIVE: To determine the safety and effectiveness of HBP-Foam in subjects with plaque psoriasis. METHODS: Two randomized, double-blind, vehicle-controlled clinical studies were conducted in 560 adult subjects with moderate to severe plaque psoriasis. Subje...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Use of In-Office Preparations by Dermatologists for the Diagnosis of Cutaneous Fungal Infections
Authors: Murphy EC, Friedman AJ Abstract Cutaneous fungal infections account for millions of office visits per year, yet their varied presentations often lead to misdiagnosis. If dermatology clinics are Clinical Laboratory Improvement Amendment (CLIA) certified, direct microscopy with potassium hydroxide or other stains can be used to inexpensively and rapidly diagnose fungal infections. In this survey, we examined dermatologists’ perceptions of fungal preparations and CLIA certification to identify barriers that prevent the use of these bedside diagnostics. The response rate was 13% (n=308, based on the numb...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Efficacy of Dupilumab in Different Racial Subgroups of Adults With Moderate-to-Severe Atopic Dermatitis in Three Randomized, Placebo-Controlled Phase 3 Trials
Authors: Alexis AF, Rendon M, Silverberg JI, Pariser DM, Lockshin B, Griffiths CE, Weisman J, Wollenberg A, Chen Z, Davis JD, Li M, Eckert L, Gadkari A, Shumel B, Rossi AB, Graham NM, Ardeleanu M Abstract Dupilumab, a monoclonal antibody that blocks the shared receptor subunit for interleukin (IL)-4 and IL-13, is currently approved for the treatment of adults with inadequately controlled moderate-to-severe atopic dermatitis (AD). The efficacy and safety of dupilumab for AD among racial subgroups is unknown. This post hoc analysis from three phase 3 trials assessed the efficacy and safety of dupilumab vs placebo by ...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Halobetasol 0.01%/Tazarotene 0.045% Lotion in the Treatment of Moderate-to-Severe Plaque Psoriasis: Maintenance of Therapeutic Effect After Cessation of Therapy
Authors: Abstract BACKGROUND: Psoriasis is a chronic, immune-mediated disease that varies widely in its clinical expression. Topical corticosteroids (TCS) are the mainstay of treatment. Long-term safety remains a concern, limiting use and recurrence is common. Tazarotene has also been shown to be effective in psoriasis, with efficacy maintained several weeks posttreatment. Fixed combination therapy with TCS and tazarotene may improve psoriasis signs and maintain efficacy between treatment sessions. OBJECTIVE: To investigate the maintenance of effect posttreatment with a once-daily application of halobetasol propi...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Resolution of Guttate Psoriasis Plaques After One-time Administration of Guselkumab
Authors: Hall SL, Haidari W, Feldman SR Abstract Guttate psoriasis is an acute subtype of plaque psoriasis characterized by eruption of small, scaly plaques, and papules, 5 to 10 mm in size over the trunk and proximal extremities.1 It often arises in children and young adults concomitantly with or shortly after a streptococcal throat infection or tonsillitis. Patients with chronic plaque psoriasis can also experience guttate flares following streptococcal throat infections.1,2 Controlling guttate psoriasis with topical corticosteroids is difficult to achieve due to numerous widespread lesions. Other treatment optio...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Ostraceous Psoriasis Presenting as Koebner Phenomenon in a Tattoo
Authors: Reinhart J, Willett M, Gibbs N Abstract Psoriasis is a common dermatologic condition with a variety of morphologic presentations. These variations include the less common hyperkeratotic form, psoriasis ostracea, defined as having pronounced adherent scales resembling an oyster shell. Of the ostraceous cases that have been reported in the literature, many occur as generalized outbreaks in patients with long-standing history of psoriasis. Rarely does this remarkable variant occur as a direct flare from a cutaneous insult. In these situations, when a pre-existing dermatosis appears in response to a traumatic ...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Clinical Pathologic Mismatch in a TNF- α Inhibitor-Associated Drug Reaction
Clinical Pathologic Mismatch in a TNF-α Inhibitor-Associated Drug Reaction J Drugs Dermatol. 2019 Aug 01;18(8):828-830 Authors: O’Brien KF, Maiman RE, DeWitt CA Abstract A 56-year-old Caucasian male with a history of chronic plaque psoriasis, primary sclerosing cholangitis status-post liver transplant on tacrolimus, and ulcerative colitis on infliximab developed a progressive erythematous eruption with associated fatigue, anorexia, myalgias, and arthralgias. On two separate occasions, his skin biopsy demonstrated a lichenoid interface dermatitis (LID). Despite multiple courses of oral predn...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Paradoxical Induction of Crohn ’s Disease Following Treatment of Psoriatic Arthritis With Etanercept
We describe the case of a 37-year-old man with a 20-year history of psoriatic arthritis. The patient presented with abdominal pain, watery diarrhea with mild hematochezia, and a reported 24-pound unintentional weight loss over the past five months. Of note, the patient began treatment with etanercept five months earlier after discontinuation of infliximab for his psoriatic arthritis symptoms. Colonoscopy with terminal ileum intubation revealed active colitis and intestinal biopsy results showed marked ulcerations and non-caseating granulomas, indicative of CD. Etanercept was subsequently discontinued and the patient was st...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Eskata (40% Hydrogen Peroxide Solution) for the Treatment of Seborrheic Keratoses
Authors: Keaney T Abstract “Barnacles”, “liverspots”, “age spots": Seborrheic keratoses (SKs) have many different names, sizes, and clinical presentations in our patients. The only commonality among SKs is that patients despise them. While patients are initially concerned about their malignant potential, once they are reassured, most patients quickly transition from relief to request: “Can you get rid of them?” An observational study conducted across multiple dermatology practices found that SKs have a significant impact on quality of life, causing patients to adopt st...
Source: Journal of Drugs in Dermatology - July 26, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Clinical Experience With 40% Hydrogen Peroxide Topical Solution for the Treatment of Seborrheic Keratosis
In this study, we present two patients with SKs located on their face and neck who received in-office treatment with 40% Hydrogen Peroxide Topical Solution (Eskata™, HP40), a new FDA-approved topical therapy that has demonstrated efficacy in phase 3 trials. Compared to non-topical, more invasive techniques, HP40 may lead to less pigmentary changes, and may be more efficacious for SKs on the face and neck. Both patients received two treatment courses of HP40, which resulted in positive therapeutic outcomes, including the absence of scarring and pigmentary changes. In addition to the case presentations, we will discuss...
Source: Journal of Drugs in Dermatology - July 26, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Enhancing Outcomes in Seborrheic Keratosis: Using a Novel Treatment Solution
Authors: Schlesinger TE, Favre C Abstract Seborrheic keratosis (SK) is an extremely common benign cutaneous lesion that often appears on individuals older than the age of 50. SK lesions can appear in numerous clinical variations, but typically, SKs present with a well-demarcated, “stuck-on” appearance having a waxy or keratotic surface. Even though SK lesions are usually benign, many individuals elect for SK treatment or removal due to cosmetic concerns. One study regarding SK appearance reported that 61% of women tried to conceal the appearance of the SKs by using certain hairstyles, make-up, and cloth...
Source: Journal of Drugs in Dermatology - July 26, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Patient-focused Solutions in Rosacea Management: Treatment Challenges in Special Patient Groups
Authors: Cices A, Alexis AF Abstract Rosacea is among the most common facial skin conditions diagnosed by dermatologists. Typical clinical features include erythema, flushing, telangiectasia, papules, and pustules distributed on the central face. While the prevalence of rosacea is highest among white populations of Northern European descent, recent reports have found that rosacea frequently occurs in people from a broad range of racial/ethnic backgrounds and skin types. When rosacea presents in darker skin types, the diagnosis is often more challenging due to masking of features by increased epidermal melanin. As s...
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Global Perspectives of the Patient of Color
Authors: Burgess CM Abstract Many cultures associate beauty with an even complexion. It has been shown in many reported references, the major cosmetic concern in patients of color is discoloration. This issue addresses discoloration of individuals of color and the use of a multitude of preparations that can blend the complexion. Authors in Asia, Sweden, France, and Brazil discuss the use of injectable deoxycholic acid in nonsubmental regions and hyaluronic acid for skin boosting, an off-label usage or procedures in the United States. Skin boosting improves hydration and the smoothness of the skin. Additionally, int...
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Myths and Knowledge Gaps in the Aesthetic Treatment of Patients With Skin of Color
Conclusions: Knowledge gaps and myths concerning facial aesthetic treatment in individuals with SOC exist. These patients may undergo various facial aesthetic procedures safely and effectively, as long as nuances in treatment approaches are recognized. J Drugs Dermatol. 2019;18(7):616-622. PMID: 31329382 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Understanding the Female Hispanic and Latino American Facial Aesthetic Patient
Conclusion: An understanding of the facial aesthetic concerns and treatment priorities specific to Hispanic/Latino women will enhance the practitioner’s patient-centric treatment approach. J Drugs Dermatol. 2019;18(7):623-632. PMID: 31329400 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Understanding the Female Asian American Facial Aesthetic Patient
Conclusion: Understanding the aesthetic concerns and priorities specific to Asian American women may help guide treatment plans more aligned with the goals and expectations of this patient population. J Drugs Dermatol. 2019;18(7):633-641. PMID: 31329401 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

In Vitro and In Vivo Efficacy and Tolerability of a Non-Hydroquinone, Multi-Action Skin Tone Correcting Cream
Authors: Grimes PE, McDaniel DH, Wortzman M, Nelson D Abstract Background: Pigmentation disorders are therapeutically challenging to treat, requiring complicated regimens. Objectives: Alternatives to hydroquinone (HQ) are desired. We evaluated the efficacy and tolerability of a non-HQ multi-action skin tone corrector (ETCS) developed to inhibit melanin production and improve skin quality. Design and Methods: Twice-daily use of ETCS and ETCS + AHA-Ret, a retinoid-based alpha hydroxy acid cream, was evaluated in subjects with mild to severe dyschromia. Digital images were obtained at baseline, 4, 8, and 12 weeks an...
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Survey-Based Comparison of Sun Safety Practices in a Representative Cohort of the General Public Versus Attendees of a Skin Cancer Screening
Authors: Murphy EC, Kao S, Wang H, Nguyen H, Friedman AJ Abstract A large proportion of data on photoprotective practices is yielded from free skin cancer screenings. However, the sun safety practices of populations who seek these skin cancer screenings may differ from the general public. To examine differences in skin cancer prevention practices and risk factors, we surveyed pedestrians at six locations in Washington, DC (public group, n=285) and attendees of a free skin cancer screening (screening group, n=144) using an IRB-approved survey. The screening group was older and included more individuals with fair ski...
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Survey-Based Comparison of Sun Safety Practices in a Representative Cohort of the General Public Versus Attendees of a Skin Cancer Screening
Authors: Murphy EC, Kao S, Wang H, Chen D, Nguyen H, Friedman AJ Abstract A large proportion of data on photoprotective practices is yielded from free skin cancer screenings. However, the sun safety practices of populations who seek these skin cancer screenings may differ from the general public. To examine differences in skin cancer prevention practices and risk factors, we surveyed pedestrians at six locations in Washington, DC (public group, n=285) and attendees of a free skin cancer screening (screening group, n=144) using an IRB-approved survey. The screening group was older and included more individuals with ...
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Topical Ozenoxacin Cream 1% for Impetigo: A Review
Conclusions: Resistance patterns in a wide range of pathogens against oral or topical antibiotics and antiseptics used for the treatment of dermatological conditions, such as impetigo have been observed. When making treatment decisions for impetigo MRSA and other antimicrobial resistance has to be taken into account. Ozenoxacin 1% cream offers a potent bactericidal activity and has demonstrated clinical efficacy and safety. Combined with its favorable features, such as a low dosing frequency and a 5 days treatment regimen, ozenoxacin 1% cream is an important option for the treatment of impetigo for pediatric and adult popu...
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Laser-Assisted Delivery of Topical Cidofovir in the Treatment of Plantar Warts
We report the use of an erbium:yttrium-aluminum-garnet (Er:YAG) ablative fractional laser (AFL) followed by topical cidofovir in treating recalcitrant plantar warts. Two patients were treated with a 2940-nm Er:YAG laser at depths of 1.2-1.5 mm followed by topical application of cidofovir 75 mg/mL. Both patients exhibited a significant reduction in lesion size and improvement in symptoms. AFL-assisted delivery of topical cidofovir represents a promising therapeutic option for recalcitrant plantar warts. J Drugs Dermatol. 2019;18(7):663-665. PMID: 31334626 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Head-to-Head Comparison of Topical Collagen Powder to Primary Closure for Acute Full-Thickness Punch Biopsy-Induced Human Wounds: An Internally Controlled Pilot Study
Conclusion: These data suggest that collagen powder is non-inferior to primary closure at the macro- and microscopic levels, while possibly leading to superior early cosmetic outcomes and accelerated histologic wound maturation. Ethics/Clinical Trials Registration: Study was approved by the George Washington University Institutional Review Board (IRB protocol #121745). ClinicalTrials.gov: NCT03481907. J Drugs Dermatol. 2019;18(7):667-673. PMID: 31334925 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Non-Submental Applications of Injectable Deoxycholic Acid: A Systematic Review
Conclusion: Off-label use of injectable DCA demonstrate a similar safety profile, effectiveness, and overall patient satisfaction compared to FDA-approved use for persistent SMF. DCA appears to be a safe and efficacious alternative to surgical reduction of unwanted adipose tissue in non-submental areas. Larger-scale studies are warranted to explore further cosmetic and potential medical applications. J Drugs Dermatol. 2019;18(7):675-680. PMID: 31334926 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Effective and Safe Repeated Full-Face Treatments With AbobotulinumtoxinA, Hyaluronic Acid Filler, and Skin Boosting Hyaluronic Acid
Conclusion: Aesthetic improvement and subject satisfaction was high and increased with each treatment. All treatments were well tolerated. These data may be used as support when establishing individual treatment plans. J Drugs Dermatol. 2019;18(7):682-689. PMID: 31334927 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

An Atypical Presentation of PLEVA: Case Report and Review of the Literature
We report the case of a patient who presented with multiple erythematous papules and plaques on the palms, forearms, and dorsal feet. J Drugs Dermatol. 2019;18(7):690-691. PMID: 31334928 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Treatment of Solitary Keratoacanthoma of the Nose With Intralesional Methotrexate and Review of the Literature
We report a patient with a solitary KA of the skin of the right ala successfully treated with intralesional (IL) injections of methotrexate (MTX). We also provide a review of the literature on IL-MTX as a treatment modality for KA. J Drugs Dermatol. 2019;18(7):693-696. PMID: 31334929 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Giant Cutaneous Horn: One of the Largest Recorded
We present a case of one of the largest cutaneous horns recorded in the known literature as an opportunity to explore diagnostic considerations and treatment options. Cutaneous horns are common exophytic neoplasms composed of dense keratin that are always secondary to primary lesions, which can be benign or malignant. Due to the variance of the primary lesion, diagnostic biopsies are necessary to rule out a malignant origin. Several case reports of giant cutaneous horns may suggest that a larger size indicates a verrucous origin, although a biopsy is necessary as this association has only been noted in very few cases. If t...
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

What Is PFE? It May Just Be Time You Found Out....
Authors: Del Rosso JQ Abstract With all the literature and research we have on acne and rosacea, there are still many unanswered questions. Over time, as we uncover more information on both preexisting and newly recognized pathophysiologic pathways, modes of drug action, alternative therapies, caveats related to basic skin care, and the potential roles for physical modalities, we often find that specific information that we thought was fact, is later altered, expanded, or corrected. What is interesting, and sometimes perplexing to me personally, is how difficult it is for the clinical dermatology community at large...
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Use of Oral Antibiotics in the Management of Rosacea
Authors: Nagler AR, Del Rosso J Abstract Rosacea is common inflammatory facial dermatosis. Rosacea has variable manifestations including facial flushing, central facial erythema, telangiectasias, and papulopustular lesions. Treatment of rosacea is challenging given the varied manifestations and incompletely understood etiology, but the treatment of papulopustular presentations often relies on oral antibiotics. Tetracyclines, specifically doxycycline, are the most commonly prescribed antibiotics for rosacea. Other antibiotics that can be used include macrolides, commonly azithromycin, and rarely, metronidazole. This...
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Patient-Reported Outcomes in Acne Patients With Skin of Color Using Adapalene 0.3%-Benzoyl Peroxide 2.5%: A Prospective Real-World Study
Conclusion: Patients with SOC and moderate or severe facial acne reported high satisfaction with 0.3% A/BPO treatment and experienced good tolerability, improved QoL, treatment efficacy, and improvement in PIH. Clinicaltrials.gov number: NCT02932267 J Drugs Dermatol. 2019;18(6):514-520. PMID: 31251543 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Safety and Effectiveness of Microfocused Ultrasound for Treating Erythematotelangiectatic Rosacea
Conclusion: The results of this study demonstrated that a single, high-density MFU-V treatment may be effective for treating erythematotelangiectatic rosacea. Based on these results, a large, randomized controlled study of single, high-density MFU-V treatment for erythematotelangiectatic rosacea is warranted. J Drugs Dermatol. 2019;18(6):522-531. PMID: 31251544 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Clinical Validation of the Surface Volume Coefficient for Minimally Invasive Treatment of the Temple
Authors: Cotofana S, Koban K, Pavicic T, Yankonva M, Frank K, Green JB, Gotkin RH, Etzel L, Giunta RE, Schenck TL Abstract Objective: The aim of the present study is to compare the temporal surface volume coefficient obtained in the cadaveric model from subdermal and supraperiosteal injections to the clinical setting when treating temporal hollowing. Material and Methods: A total of 36 subjects were included in this investigation, 17 patients (16 females, 1 male; 46.3 ± 8.9 years; 25.5 ± 2.8 kg/m2) and 19 cadaveric specimens (11 females, 8 males; 76.4 ± 11.5 years; 24.0 ± 5.1 kg/m2). Su...
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Phase 2, Multicenter, Double-Blind, Randomized, Vehicle-Controlled Clinical Study to Compare the Safety and Efficacy of a Novel Tazarotene 0.045% Lotion and Tazarotene 0.1% Cream in the Treatment of Moderate-to-Severe Acne Vulgaris
Authors: Tanghetti EA, Kircik LH, Green LJ, Guenin E, Harris S, Martin G, Pillai R Abstract Background: Tazarotene has been extensively studied in clinical trials and is widely used to treat acne vulgaris (acne). Irritation potential has limited its use. Objective: To compare efficacy, safety, and tolerability of a novel formulation tazarotene 0.045% lotion based on polymeric emulsion technology, and tazarotene 0.1% cream in patients with moderate-to-severe acne. Methods: A total of 210 patients, 12 years and older were randomized to receive tazarotene 0.045% lotion, tazarotene 0.1% cream, or respective vehicle i...
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Update on the Treatment of Scars
Conclusion: Review of the literature revealed a myriad of options for the treatment of different scar types. Although there is not vast evidence in the literature in regard to combination treatments, these are becoming more popular, and it is the author’s opinion that combination treatments yield better overall results. J Drugs Dermatol. 2019;18(6):550-555. PMID: 31251547 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Validation of Botanical Treatment Efficiency for Adults and Children Suffering from Mild to Moderate Atopic Dermatitis
Conclusion: The study results approve and validate that the botanical combination is the key factor for the efficacy and improvement of the AD symptoms within this study population. J Drugs Dermatol. 2019;18(6):557-561. PMID: 31251548 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Pharmacokinetic Profile, Safety, and Tolerability of Clascoterone (Cortexolone 17-alpha propionate, CB-03-01) Topical Cream, 1% in Subjects With Acne Vulgaris: An Open-Label Phase 2a Study
This study was an open-label, multicenter study in 42 subjects ≥12 years of age with moderate-to-severe acne (Grade 3-4 on the Investigator’s Global Assessment [IGA]), on the face, chest and/or back. Cohort 1(>18 years of age) and Cohort 2 (12-18 years of age) applied clascoterone topical cream, 1% twice daily (BID) for 14 days. Primary safety endpoints included hypothalamic-pituitary-adrenal (HPA) axis response to cosyntropin via a Cosyntropin Stimulation Test (CST) upon screening (day 1) and at day 14 (HPA axis suppression was defined as a post-stimulation serum cortisol level
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Phase 2b, Randomized, Double-Blind Vehicle Controlled, Dose Escalation Study Evaluating Clascoterone 0.1%, 0.5%, and 1% Topical Cream in Subjects With Facial Acne
Conclusions: All clascoterone cream concentrations were well tolerated with no clinically relevant safety issues noted. Clascoterone 1% BID treatment had the most favorable results and was selected as the best candidate for further clinical study and development. Two Phase 3 investigations of clascoterone topical cream, 1% for the treatment of moderate-to-severe acne vulgaris in individuals ≥9 years recently concluded. J Drugs Dermatol. 2019;18(6):570-575. PMID: 31251550 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

DNA Repair Enzyme Containing Lip Balm for the Treatment of Actinic Cheilitis: A Pilot Study
Authors: Abstract Background: DNA repair enzymes have been shown to reduce actinic keratoses and non-melanoma skin cancers, but their use for the treatment of actinic cheilitis has not been studied. Objective: The purpose of this pilot study was to examine the efficacy of a DNA repair enzyme lip balm containing T4 endonuclease in reducing the severity of actinic cheilitis in patients who applied the lip balm twice daily for 3 months. Methods: We performed a prospective study in which 29 patients with a diagnosis of actinic cheilitis underwent a 3-month trial using a topical DNA repair enzyme lip balm containing ...
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Connecting the Dots: From Skin Barrier Dysfunction to Allergic Sensitization, and the Role of Moisturizers in Repairing the Skin Barrier
The objective of this review is to provide an update on current knowledge about the relationship between skin barrier function and how dysfunction at each level of the skin barrier can lead to allergic sensitization, contact dermatitis, and the atopic march, and examine how to best repair and maintain this barrier through the use of moisturizers. J Drugs Dermatol. 2019;18(6):581-586. PMID: 31251552 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Arterial Occlusion and Necrosis Following Hyaluronic Acid Injection and a Review of the Literature
We report a case of vascular occlusion successfully managed using high dose hyaluronidase and provide a review of the literature including incidence, management, and techniques to prevent vascular complications. J Drugs Dermatol. 2019;18(6):587-591. PMID: 31251553 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Cortexolone 17 α-propionate (Clascoterone) Is a Novel Androgen Receptor Antagonist that Inhibits Production of Lipids and Inflammatory Cytokines from Sebocytes In Vitro
Cortexolone 17α-propionate (Clascoterone) Is a Novel Androgen Receptor Antagonist that Inhibits Production of Lipids and Inflammatory Cytokines from Sebocytes In Vitro J Drugs Dermatol. 2019 May 01;18(5):412-418 Authors: Rosette C, Agan FJ, Mazzetti A, Moro L, Gerloni M Abstract Cortexolone 17α-propionate (clascoterone) is a novel topical androgen antagonist that is being analyzed for its ability to treat acne. The pathogenesis of acne is attributed to multiple factors, including altered sebum production, inflammatory processes, dysregulation of the hormone microenvironment, and the prolife...
Source: Journal of Drugs in Dermatology - June 2, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Silicone-Based Scar Cream for Post Upper Eyelid Blepharoplasty-associated Cicatricial and Hypertrophic Scarring
CONCLUSION: The use of a topical silicone-based scar cream has been shown to be safe and effective in decreasing the incidence of intralesional injections of triamcinolone and 5-FU for postoperative cicatricial and hypertrophic changes in upper eyelid blepharoplasty incisions. J Drugs Dermatol. 2019;18(5):440-446. PMID: 31141848 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Skin Cancer Epidemiology and Sun Protection Behaviors Among Native Americans
Discussion: Sunscreen use among Native Americans (36.4%) appears to be greater than other skin of color users, but less than that of non-Hispanic Whites (40.4%). We postulate that this may be due to the respondents living in states with high UV burden, or an intrinsically greater propensity to burn. Native American populations tend to lack skin cancer screenings by dermatologists and understanding of skin cancer etiology. Efforts are needed to encourage education and dermatologic services to Native American reservations. J Drugs Dermatol. 2019;18(5):420-423. PMID: 31141849 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Non-Invasive Buccal Swab Gene Testing for Skin Cancer Risk
Conclusion: This data supports that 4 of the 7 SNP’s studied had similar associations and could potentially be predictive tool of NMSC risk in this patient population. The remaining three SNP’s did not have a definitive association with malignancy. Larger studies are needed to further elucidate the specific roles of these SNPs collectively and ultimately to develop a genetic profile for those patients at increased risk of developing skin cancer. J Drugs Dermatol. 2019;18(5):448-453. PMID: 31141850 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Optimizing Patient Outcomes by Customizing Treatment With Microfocused Ultrasound With Visualization: Gold Standard Consensus Guidelines from an Expert Panel
Conclusion: Supported by a large body of clinical evidence, a well-characterized mechanism of action, and high patient satisfaction, MFU-V is considered by the expert panel of physicians to be a key foundation of aesthetic treatment and the gold standard for nonsurgical lifting and skin tightening. PMID: 31141851 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research