Beyond Liposuction: Evolving Applications for Tumescent Anesthesia
J Drugs Dermatol. 2022 Jan 1;21(1):86-89. doi: 10.36849/JDD.2022.6279.ABSTRACTTumescent anesthesia was initially developed as a safer and more effective alternative to general anesthesia in performing liposuction. Today, it is used extensively for a wide variety of surgical procedures performed by various specialties. As more surgeons have become exposed to tumescent anesthesia with its associated advantages over general anesthesia, the number of applications for this unique form of local anesthesia has skyrocketed. In this article, we will briefly discuss the basics of tumescent anesthesia, followed by a discussion of the...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: C Hanke Michael Dent Source Type: research

Clinical Evaluation of Fractional Radiofrequency for the Treatment and Reduction of Wrinkles: A Prospective Study
CONCLUSION: A statistically significant reduction in rhytids of the upper lip and the perioral area, was found, as evaluated by independent blinded evaluators. There were no adverse events. Treatment pain was low and tolerable, and subjects had high levels of satisfaction with the results at last follow-up. J Drugs Dermatol. 2022;21(1):43-48. doi:10.36849/JDD.6492.PMID:35005858 | DOI:10.36849/JDD.2022.6492 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Alison Kang Suzanne Kilmer Source Type: research

Treatment of Alopecia in Children
J Drugs Dermatol. 2022 Jan 1;21(1):49-53. doi: 10.36849/JDD.2022.6096.ABSTRACTAlopecia or hair loss in children is an important and often challenging problem to diagnose and treat. Early diagnosis and treatment is the key because hair loss in children has a significant physical as well as psychological impact on their development. Alopecia in children are mainly non-scarring, but cicatricial alopecia can also be seen. The diagnosis can usually be made by direct examination of the scalp. Potassium hydroxide (KOH) examination of plucked hair and scalp scrapings, woods lamp examination and trichoscopy are useful diagnostic ai...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Pranshu Mishra Anant Patil Rodney Sinclair Michael Gold Lidia Rudnicka Stephan Grabbe Mohamad Goldust Source Type: research

Safety and Efficacy of Deoxycholic Acid for Reduction of Upper Inner Thigh Fat
CONCLUSION: Deoxycholic acid injection was safe and effective for reduction of upper inner thigh fat in this Phase I study. J Drugs Dermatol. 2022;21(1):66-70. doi:10.36849/JDD.5919.PMID:35005860 | DOI:10.36849/JDD.2022.5919 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Joyce Yuan Faiza Shafiq Arisa Ortiz Source Type: research

The Lip Flip for Beautification and Rejuvenation of the Lips
CONCLUSIONS: The lip flip technique is a novel, safe and effective additive for perioral rejuvenation. J Drugs Dermatol. 2022;21(1):71-76. doi:10.36849/JDD.6344R1.PMID:35005861 | DOI:10.36849/JDD.2022.6344 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Sahar Ghannam Fotini Bageorgou Source Type: research

Efficacy and Tolerability of a Double-Conjugated Retinoid and Alpha Hydroxy Acid Cream in Subjects With Mild to Moderate Blemish-Prone Skin
CONCLUSIONS: A double-conjugated retinoid/AHA cream specifically developed for individuals with blemish-prone skin demonstrated early improvements in the appearance of skin clarity and pores over 12 weeks. AEs were mild and transient. Subjects reported high levels of satisfaction in the overall appearance and quality of skin. J Drugs Dermatol. 2022;21(1):54-59. doi:10.36849/JDD.6415.PMID:35005862 | DOI:10.36849/JDD.2022.6415 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Deanne Robinson Daniel Friedmann Jennifer Gordon Mitchell Wortzman Diane Nelson Source Type: research

Use of Topical Calcipotriol Plus 5-Fluorouracil in the Treatment of Actinic Keratosis: A Systematic Review
CONCLUSION: Calcipotriol plus 5-FU reduced greater number of AKs in the treated area (25 cm2) when compared to 5-FU plus petroleum jelly, but only 27% of participants had complete clearance on the face at week-8. Calcipotriol plus 5-FU lowered the risk of cSCC on the face and scalp area over a 3-year period. Adequate and well-controlled studies are needed to compare the efficacy of calcipotriol plus 5-FU to 5-FU monotherapy, and other FDA-approved topical drugs such as imiquimod cream and tirbanibulin ointment. J Drugs Dermatol. 2022;21(1):60-65. doi:10.36849/JDD.6632.PMID:35005863 | DOI:10.36849/JDD.2022.6632 (Source: Jou...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Lindsey Mohney Rohan Singh Ayman Grada Steven Feldman Source Type: research

A Genderfluid Approach to Aesthetic Language in Dermatology
J Drugs Dermatol. 2022 Jan 1;21(1):96-99. doi: 10.36849/JDD.2022.6486.ABSTRACTDermatologists are in a unique position to help transgender and non-binary individuals achieve an appearance that corresponds to their identity. Minimally invasive procedures for gender affirmation are relatively safe and customizable, providing an increasingly favorable treatment niche for these patients.1-4.PMID:35005864 | DOI:10.36849/JDD.2022.6486 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Marc Beuttler Jennifer MacGregor Source Type: research

Combination Facial Aesthetic Treatment in Millennials
CONCLUSION: Combination botulinum toxin and dermal filler treatment is a safe and effective means of improving millennial satisfaction with overall facial appearance and various facial areas, decreasing self-perceived age, and improving aspects of psychosocial functioning. J Drugs Dermatol. 2022;21(1)37-42. doi:10.36849/JDD.6425.PMID:35005865 | DOI:10.36849/JDD.2022.6425 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Alana Kurtti Cassandra Charles Jared Jagedo Source Type: research

Consumer Perspectives on and Utilization of Medical Cannabis to Treat Dermatologic Conditions
CONCLUSION: Consumers are interested in and are using MCPs for dermatologic indications, most commonly for inflammatory skin disorders. Targeted education for dermatologists is recommended. J Drugs Dermatol. 2022;21(1):31-36. doi:10.36849/JDD.6540.PMID:35005866 | DOI:10.36849/JDD.2022.6540 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Samuel Yeroushalmi Daniel Nemirovsky Mira Mamlouk Dovid Feldman Kamaria Nelson Andrew Sparks Adam Freidman Source Type: research

Treatment of Hyperpigmented Discoid Lupus Erythematosus With Jessner's Peel: A Case Report
J Drugs Dermatol. 2022 Jan 1;21(1):92-93. doi: 10.36849/JDD.2022.5521.ABSTRACTDiscoid lupus erythematosus (DLE) is the most common type of chronic cutaneous lupus erythematosus and is categorized by well-demarcated, often hyper or hypopigmented macules or papules that gradually progress into discoid plaques. Lesions are most commonly found above the neck, particularly on the face, scalp, and ears.1.PMID:35005867 | DOI:10.36849/JDD.2022.5521 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Nkemjika Ugonabo Melissa Levin Source Type: research

Improvement of Facial Skin Laxity by a Combined Technique With Hyaluronic Acid and Calcium Hydroxylapatite Fillers: A Clinical and Ultrasonography Analysis
CONCLUSION: In conclusion, the combined technique with HA and CaHA fillers was well-tolerated and yielded high satisfaction and safe improve in facial skin laxity and dermal thickness in women with mild midface aging. J Drugs Dermatol. 2022;21(1): 102-106. doi:10.36849/JDD.633.PMID:35005868 | DOI:10.36849/JDD.2022.6333 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Bruna Felix Bravo La ís Bezerra de Menezes Penedo Raquel de Melo Carvalho H élio Amante Miot Mariana Calomeni Elias Source Type: research

Combined Calcium Hydroxylapatite Plus Microfocused Ultrasound for Treating Skin Laxity of the Chest and Buttocks
J Drugs Dermatol. 2022 Jan 1;21(1):27-30. doi: 10.36849/JDD.2022.6368.ABSTRACTMicrofocused ultrasound with visualization (MFU-V) and a calcium hydroxylapatite dermal filler (CaHA) were both developed to meet the patient demand for a noninvasive but effective means for lifting and tightening of lax skin. Recently, there has been growing interest in the use of dilute (1:1) and hyperdilute (1:≥2) CaHA to achieve skin tightening and stimulating neocollagenesis, and the combined use of difference techniques to obtain optimum aesthetic outcomes. Here, two patients with Grade 3 chest laxity on the Décollet&e...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Gabriela Casabona Source Type: research

Expert Recommendations on the Use of Injectable Poly-L-lactic Acid for Contour Deficiencies of the Buttocks
This report reflects consensus recommendations for the use of PLLA in non-invasive buttock contouring, including patient selection, PLLA preparation, dosing, injection and, efficacy and safety assessments. Recommendations were provided by the collective author group, comprising international leaders in the field of aesthetics, dermatology, and plastic surgery. J Drugs Dermatol. 2022;21(1):21-26. doi:10.36849/JDD.6180.PMID:35005870 | DOI:10.36849/JDD.2022.6180 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Justin Harper Luiz Avelar Alessandra Haddad Juliana Novello Douglas Mest Christine Guarnieri-Munia Sean Rice Janelle Vega Bill Andriopolous Alessandra Nogueria Neil Sadick Source Type: research

Safety and Effectiveness of a Novel Hyaluronic Acid Gel for Lip Augmentation
CONCLUSION: For lip augmentation, the efficacy and safety of the test device is non-inferior to comparator. J Drugs Dermatol. 2022;21(1):13-20 doi:10.36849/JDD.6548.PMID:35005871 | DOI:10.36849/JDD.2022.6548 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Jeffery Adelglass Javier Alonso-Llamazares Jeremy Fenton Michael Gold Joel Schlessinger Stacy Smith Source Type: research

Alteration to the Skin Ceramide Profile Following Broad-Spectrum UV Exposure
This study investigated the effects of ultraviolet (UV) radiation on the ceramide profile using both an ex vivo skin and a clinical model. Lipidomic analysis of UV-exposed skin showed shifts to the composition of ceramide subclasses essential in repairing and strengthening the SC barrier (including CER1[EOS], CER3[NP], and CER6[AP]) and reduced very long-chain acyl moieties. Gene expression analysis and immunohistochemical staining of key enzymes (aSMase, DES1, CerS5, CerS3) suggested that lipid alterations can be attributed to changes within the ceramide biosynthesis process. Topical application of ceramide-containing sun...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Rebecca Barresi Hawasatu Dumbuya I-Chien Liao Ying Chen Xi Yan Janet Wangari-Olivero Nada Baalbaki Stephen Lynch Patricia Brieva Miao Wang Qian Zheng Charbel Bouez Source Type: research

Beyond Liposuction: Evolving Applications for Tumescent Anesthesia
J Drugs Dermatol. 2022 Jan 1;21(1):86-89. doi: 10.36849/JDD.2022.6279.ABSTRACTTumescent anesthesia was initially developed as a safer and more effective alternative to general anesthesia in performing liposuction. Today, it is used extensively for a wide variety of surgical procedures performed by various specialties. As more surgeons have become exposed to tumescent anesthesia with its associated advantages over general anesthesia, the number of applications for this unique form of local anesthesia has skyrocketed. In this article, we will briefly discuss the basics of tumescent anesthesia, followed by a discussion of the...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: C Hanke Michael Dent Source Type: research

Clinical Evaluation of Fractional Radiofrequency for the Treatment and Reduction of Wrinkles: A Prospective Study
CONCLUSION: A statistically significant reduction in rhytids of the upper lip and the perioral area, was found, as evaluated by independent blinded evaluators. There were no adverse events. Treatment pain was low and tolerable, and subjects had high levels of satisfaction with the results at last follow-up. J Drugs Dermatol. 2022;21(1):43-48. doi:10.36849/JDD.6492.PMID:35005858 | DOI:10.36849/JDD.2022.6492 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Alison Kang Suzanne Kilmer Source Type: research

Treatment of Alopecia in Children
J Drugs Dermatol. 2022 Jan 1;21(1):49-53. doi: 10.36849/JDD.2022.6096.ABSTRACTAlopecia or hair loss in children is an important and often challenging problem to diagnose and treat. Early diagnosis and treatment is the key because hair loss in children has a significant physical as well as psychological impact on their development. Alopecia in children are mainly non-scarring, but cicatricial alopecia can also be seen. The diagnosis can usually be made by direct examination of the scalp. Potassium hydroxide (KOH) examination of plucked hair and scalp scrapings, woods lamp examination and trichoscopy are useful diagnostic ai...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Pranshu Mishra Anant Patil Rodney Sinclair Michael Gold Lidia Rudnicka Stephan Grabbe Mohamad Goldust Source Type: research

Safety and Efficacy of Deoxycholic Acid for Reduction of Upper Inner Thigh Fat
CONCLUSION: Deoxycholic acid injection was safe and effective for reduction of upper inner thigh fat in this Phase I study. J Drugs Dermatol. 2022;21(1):66-70. doi:10.36849/JDD.5919.PMID:35005860 | DOI:10.36849/JDD.2022.5919 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Joyce Yuan Faiza Shafiq Arisa Ortiz Source Type: research

The Lip Flip for Beautification and Rejuvenation of the Lips
CONCLUSIONS: The lip flip technique is a novel, safe and effective additive for perioral rejuvenation. J Drugs Dermatol. 2022;21(1):71-76. doi:10.36849/JDD.6344R1.PMID:35005861 | DOI:10.36849/JDD.2022.6344 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Sahar Ghannam Fotini Bageorgou Source Type: research

Efficacy and Tolerability of a Double-Conjugated Retinoid and Alpha Hydroxy Acid Cream in Subjects With Mild to Moderate Blemish-Prone Skin
CONCLUSIONS: A double-conjugated retinoid/AHA cream specifically developed for individuals with blemish-prone skin demonstrated early improvements in the appearance of skin clarity and pores over 12 weeks. AEs were mild and transient. Subjects reported high levels of satisfaction in the overall appearance and quality of skin. J Drugs Dermatol. 2022;21(1):54-59. doi:10.36849/JDD.6415.PMID:35005862 | DOI:10.36849/JDD.2022.6415 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Deanne Robinson Daniel Friedmann Jennifer Gordon Mitchell Wortzman Diane Nelson Source Type: research

Use of Topical Calcipotriol Plus 5-Fluorouracil in the Treatment of Actinic Keratosis: A Systematic Review
CONCLUSION: Calcipotriol plus 5-FU reduced greater number of AKs in the treated area (25 cm2) when compared to 5-FU plus petroleum jelly, but only 27% of participants had complete clearance on the face at week-8. Calcipotriol plus 5-FU lowered the risk of cSCC on the face and scalp area over a 3-year period. Adequate and well-controlled studies are needed to compare the efficacy of calcipotriol plus 5-FU to 5-FU monotherapy, and other FDA-approved topical drugs such as imiquimod cream and tirbanibulin ointment. J Drugs Dermatol. 2022;21(1):60-65. doi:10.36849/JDD.6632.PMID:35005863 | DOI:10.36849/JDD.2022.6632 (Source: Jou...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Lindsey Mohney Rohan Singh Ayman Grada Steven Feldman Source Type: research

A Genderfluid Approach to Aesthetic Language in Dermatology
J Drugs Dermatol. 2022 Jan 1;21(1):96-99. doi: 10.36849/JDD.2022.6486.ABSTRACTDermatologists are in a unique position to help transgender and non-binary individuals achieve an appearance that corresponds to their identity. Minimally invasive procedures for gender affirmation are relatively safe and customizable, providing an increasingly favorable treatment niche for these patients.1-4.PMID:35005864 | DOI:10.36849/JDD.2022.6486 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Marc Beuttler Jennifer MacGregor Source Type: research

Combination Facial Aesthetic Treatment in Millennials
CONCLUSION: Combination botulinum toxin and dermal filler treatment is a safe and effective means of improving millennial satisfaction with overall facial appearance and various facial areas, decreasing self-perceived age, and improving aspects of psychosocial functioning. J Drugs Dermatol. 2022;21(1)37-42. doi:10.36849/JDD.6425.PMID:35005865 | DOI:10.36849/JDD.2022.6425 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Alana Kurtti Cassandra Charles Jared Jagedo Source Type: research

Consumer Perspectives on and Utilization of Medical Cannabis to Treat Dermatologic Conditions
CONCLUSION: Consumers are interested in and are using MCPs for dermatologic indications, most commonly for inflammatory skin disorders. Targeted education for dermatologists is recommended. J Drugs Dermatol. 2022;21(1):31-36. doi:10.36849/JDD.6540.PMID:35005866 | DOI:10.36849/JDD.2022.6540 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Samuel Yeroushalmi Daniel Nemirovsky Mira Mamlouk Dovid Feldman Kamaria Nelson Andrew Sparks Adam Freidman Source Type: research

Treatment of Hyperpigmented Discoid Lupus Erythematosus With Jessner's Peel: A Case Report
J Drugs Dermatol. 2022 Jan 1;21(1):92-93. doi: 10.36849/JDD.2022.5521.ABSTRACTDiscoid lupus erythematosus (DLE) is the most common type of chronic cutaneous lupus erythematosus and is categorized by well-demarcated, often hyper or hypopigmented macules or papules that gradually progress into discoid plaques. Lesions are most commonly found above the neck, particularly on the face, scalp, and ears.1.PMID:35005867 | DOI:10.36849/JDD.2022.5521 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Nkemjika Ugonabo Melissa Levin Source Type: research

Improvement of Facial Skin Laxity by a Combined Technique With Hyaluronic Acid and Calcium Hydroxylapatite Fillers: A Clinical and Ultrasonography Analysis
CONCLUSION: In conclusion, the combined technique with HA and CaHA fillers was well-tolerated and yielded high satisfaction and safe improve in facial skin laxity and dermal thickness in women with mild midface aging. J Drugs Dermatol. 2022;21(1): 102-106. doi:10.36849/JDD.633.PMID:35005868 | DOI:10.36849/JDD.2022.6333 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Bruna Felix Bravo La ís Bezerra de Menezes Penedo Raquel de Melo Carvalho H élio Amante Miot Mariana Calomeni Elias Source Type: research

Combined Calcium Hydroxylapatite Plus Microfocused Ultrasound for Treating Skin Laxity of the Chest and Buttocks
J Drugs Dermatol. 2022 Jan 1;21(1):27-30. doi: 10.36849/JDD.2022.6368.ABSTRACTMicrofocused ultrasound with visualization (MFU-V) and a calcium hydroxylapatite dermal filler (CaHA) were both developed to meet the patient demand for a noninvasive but effective means for lifting and tightening of lax skin. Recently, there has been growing interest in the use of dilute (1:1) and hyperdilute (1:≥2) CaHA to achieve skin tightening and stimulating neocollagenesis, and the combined use of difference techniques to obtain optimum aesthetic outcomes. Here, two patients with Grade 3 chest laxity on the Décollet&e...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Gabriela Casabona Source Type: research

Expert Recommendations on the Use of Injectable Poly-L-lactic Acid for Contour Deficiencies of the Buttocks
This report reflects consensus recommendations for the use of PLLA in non-invasive buttock contouring, including patient selection, PLLA preparation, dosing, injection and, efficacy and safety assessments. Recommendations were provided by the collective author group, comprising international leaders in the field of aesthetics, dermatology, and plastic surgery. J Drugs Dermatol. 2022;21(1):21-26. doi:10.36849/JDD.6180.PMID:35005870 | DOI:10.36849/JDD.2022.6180 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Justin Harper Luiz Avelar Alessandra Haddad Juliana Novello Douglas Mest Christine Guarnieri-Munia Sean Rice Janelle Vega Bill Andriopolous Alessandra Nogueria Neil Sadick Source Type: research

Safety and Effectiveness of a Novel Hyaluronic Acid Gel for Lip Augmentation
CONCLUSION: For lip augmentation, the efficacy and safety of the test device is non-inferior to comparator. J Drugs Dermatol. 2022;21(1):13-20 doi:10.36849/JDD.6548.PMID:35005871 | DOI:10.36849/JDD.2022.6548 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Jeffery Adelglass Javier Alonso-Llamazares Jeremy Fenton Michael Gold Joel Schlessinger Stacy Smith Source Type: research

Alteration to the Skin Ceramide Profile Following Broad-Spectrum UV Exposure
This study investigated the effects of ultraviolet (UV) radiation on the ceramide profile using both an ex vivo skin and a clinical model. Lipidomic analysis of UV-exposed skin showed shifts to the composition of ceramide subclasses essential in repairing and strengthening the SC barrier (including CER1[EOS], CER3[NP], and CER6[AP]) and reduced very long-chain acyl moieties. Gene expression analysis and immunohistochemical staining of key enzymes (aSMase, DES1, CerS5, CerS3) suggested that lipid alterations can be attributed to changes within the ceramide biosynthesis process. Topical application of ceramide-containing sun...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Rebecca Barresi Hawasatu Dumbuya I-Chien Liao Ying Chen Xi Yan Janet Wangari-Olivero Nada Baalbaki Stephen Lynch Patricia Brieva Miao Wang Qian Zheng Charbel Bouez Source Type: research

Beyond Liposuction: Evolving Applications for Tumescent Anesthesia
J Drugs Dermatol. 2022 Jan 1;21(1):86-89. doi: 10.36849/JDD.2022.6279.ABSTRACTTumescent anesthesia was initially developed as a safer and more effective alternative to general anesthesia in performing liposuction. Today, it is used extensively for a wide variety of surgical procedures performed by various specialties. As more surgeons have become exposed to tumescent anesthesia with its associated advantages over general anesthesia, the number of applications for this unique form of local anesthesia has skyrocketed. In this article, we will briefly discuss the basics of tumescent anesthesia, followed by a discussion of the...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: C Hanke Michael Dent Source Type: research

Clinical Evaluation of Fractional Radiofrequency for the Treatment and Reduction of Wrinkles: A Prospective Study
CONCLUSION: A statistically significant reduction in rhytids of the upper lip and the perioral area, was found, as evaluated by independent blinded evaluators. There were no adverse events. Treatment pain was low and tolerable, and subjects had high levels of satisfaction with the results at last follow-up. J Drugs Dermatol. 2022;21(1):43-48. doi:10.36849/JDD.6492.PMID:35005858 | DOI:10.36849/JDD.2022.6492 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Alison Kang Suzanne Kilmer Source Type: research

Treatment of Alopecia in Children
J Drugs Dermatol. 2022 Jan 1;21(1):49-53. doi: 10.36849/JDD.2022.6096.ABSTRACTAlopecia or hair loss in children is an important and often challenging problem to diagnose and treat. Early diagnosis and treatment is the key because hair loss in children has a significant physical as well as psychological impact on their development. Alopecia in children are mainly non-scarring, but cicatricial alopecia can also be seen. The diagnosis can usually be made by direct examination of the scalp. Potassium hydroxide (KOH) examination of plucked hair and scalp scrapings, woods lamp examination and trichoscopy are useful diagnostic ai...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Pranshu Mishra Anant Patil Rodney Sinclair Michael Gold Lidia Rudnicka Stephan Grabbe Mohamad Goldust Source Type: research

Safety and Efficacy of Deoxycholic Acid for Reduction of Upper Inner Thigh Fat
CONCLUSION: Deoxycholic acid injection was safe and effective for reduction of upper inner thigh fat in this Phase I study. J Drugs Dermatol. 2022;21(1):66-70. doi:10.36849/JDD.5919.PMID:35005860 | DOI:10.36849/JDD.2022.5919 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Joyce Yuan Faiza Shafiq Arisa Ortiz Source Type: research

The Lip Flip for Beautification and Rejuvenation of the Lips
CONCLUSIONS: The lip flip technique is a novel, safe and effective additive for perioral rejuvenation. J Drugs Dermatol. 2022;21(1):71-76. doi:10.36849/JDD.6344R1.PMID:35005861 | DOI:10.36849/JDD.2022.6344 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Sahar Ghannam Fotini Bageorgou Source Type: research

Efficacy and Tolerability of a Double-Conjugated Retinoid and Alpha Hydroxy Acid Cream in Subjects With Mild to Moderate Blemish-Prone Skin
CONCLUSIONS: A double-conjugated retinoid/AHA cream specifically developed for individuals with blemish-prone skin demonstrated early improvements in the appearance of skin clarity and pores over 12 weeks. AEs were mild and transient. Subjects reported high levels of satisfaction in the overall appearance and quality of skin. J Drugs Dermatol. 2022;21(1):54-59. doi:10.36849/JDD.6415.PMID:35005862 | DOI:10.36849/JDD.2022.6415 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Deanne Robinson Daniel Friedmann Jennifer Gordon Mitchell Wortzman Diane Nelson Source Type: research

Use of Topical Calcipotriol Plus 5-Fluorouracil in the Treatment of Actinic Keratosis: A Systematic Review
CONCLUSION: Calcipotriol plus 5-FU reduced greater number of AKs in the treated area (25 cm2) when compared to 5-FU plus petroleum jelly, but only 27% of participants had complete clearance on the face at week-8. Calcipotriol plus 5-FU lowered the risk of cSCC on the face and scalp area over a 3-year period. Adequate and well-controlled studies are needed to compare the efficacy of calcipotriol plus 5-FU to 5-FU monotherapy, and other FDA-approved topical drugs such as imiquimod cream and tirbanibulin ointment. J Drugs Dermatol. 2022;21(1):60-65. doi:10.36849/JDD.6632.PMID:35005863 | DOI:10.36849/JDD.2022.6632 (Source: Jou...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Lindsey Mohney Rohan Singh Ayman Grada Steven Feldman Source Type: research

A Genderfluid Approach to Aesthetic Language in Dermatology
J Drugs Dermatol. 2022 Jan 1;21(1):96-99. doi: 10.36849/JDD.2022.6486.ABSTRACTDermatologists are in a unique position to help transgender and non-binary individuals achieve an appearance that corresponds to their identity. Minimally invasive procedures for gender affirmation are relatively safe and customizable, providing an increasingly favorable treatment niche for these patients.1-4.PMID:35005864 | DOI:10.36849/JDD.2022.6486 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Marc Beuttler Jennifer MacGregor Source Type: research

Combination Facial Aesthetic Treatment in Millennials
CONCLUSION: Combination botulinum toxin and dermal filler treatment is a safe and effective means of improving millennial satisfaction with overall facial appearance and various facial areas, decreasing self-perceived age, and improving aspects of psychosocial functioning. J Drugs Dermatol. 2022;21(1)37-42. doi:10.36849/JDD.6425.PMID:35005865 | DOI:10.36849/JDD.2022.6425 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Alana Kurtti Cassandra Charles Jared Jagedo Source Type: research

Consumer Perspectives on and Utilization of Medical Cannabis to Treat Dermatologic Conditions
CONCLUSION: Consumers are interested in and are using MCPs for dermatologic indications, most commonly for inflammatory skin disorders. Targeted education for dermatologists is recommended. J Drugs Dermatol. 2022;21(1):31-36. doi:10.36849/JDD.6540.PMID:35005866 | DOI:10.36849/JDD.2022.6540 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Samuel Yeroushalmi Daniel Nemirovsky Mira Mamlouk Dovid Feldman Kamaria Nelson Andrew Sparks Adam Freidman Source Type: research

Treatment of Hyperpigmented Discoid Lupus Erythematosus With Jessner's Peel: A Case Report
J Drugs Dermatol. 2022 Jan 1;21(1):92-93. doi: 10.36849/JDD.2022.5521.ABSTRACTDiscoid lupus erythematosus (DLE) is the most common type of chronic cutaneous lupus erythematosus and is categorized by well-demarcated, often hyper or hypopigmented macules or papules that gradually progress into discoid plaques. Lesions are most commonly found above the neck, particularly on the face, scalp, and ears.1.PMID:35005867 | DOI:10.36849/JDD.2022.5521 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Nkemjika Ugonabo Melissa Levin Source Type: research

Improvement of Facial Skin Laxity by a Combined Technique With Hyaluronic Acid and Calcium Hydroxylapatite Fillers: A Clinical and Ultrasonography Analysis
CONCLUSION: In conclusion, the combined technique with HA and CaHA fillers was well-tolerated and yielded high satisfaction and safe improve in facial skin laxity and dermal thickness in women with mild midface aging. J Drugs Dermatol. 2022;21(1): 102-106. doi:10.36849/JDD.633.PMID:35005868 | DOI:10.36849/JDD.2022.6333 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Bruna Felix Bravo La ís Bezerra de Menezes Penedo Raquel de Melo Carvalho H élio Amante Miot Mariana Calomeni Elias Source Type: research

Combined Calcium Hydroxylapatite Plus Microfocused Ultrasound for Treating Skin Laxity of the Chest and Buttocks
J Drugs Dermatol. 2022 Jan 1;21(1):27-30. doi: 10.36849/JDD.2022.6368.ABSTRACTMicrofocused ultrasound with visualization (MFU-V) and a calcium hydroxylapatite dermal filler (CaHA) were both developed to meet the patient demand for a noninvasive but effective means for lifting and tightening of lax skin. Recently, there has been growing interest in the use of dilute (1:1) and hyperdilute (1:≥2) CaHA to achieve skin tightening and stimulating neocollagenesis, and the combined use of difference techniques to obtain optimum aesthetic outcomes. Here, two patients with Grade 3 chest laxity on the Décollet&e...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Gabriela Casabona Source Type: research

Expert Recommendations on the Use of Injectable Poly-L-lactic Acid for Contour Deficiencies of the Buttocks
This report reflects consensus recommendations for the use of PLLA in non-invasive buttock contouring, including patient selection, PLLA preparation, dosing, injection and, efficacy and safety assessments. Recommendations were provided by the collective author group, comprising international leaders in the field of aesthetics, dermatology, and plastic surgery. J Drugs Dermatol. 2022;21(1):21-26. doi:10.36849/JDD.6180.PMID:35005870 | DOI:10.36849/JDD.2022.6180 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Justin Harper Luiz Avelar Alessandra Haddad Juliana Novello Douglas Mest Christine Guarnieri-Munia Sean Rice Janelle Vega Bill Andriopolous Alessandra Nogueria Neil Sadick Source Type: research

Safety and Effectiveness of a Novel Hyaluronic Acid Gel for Lip Augmentation
CONCLUSION: For lip augmentation, the efficacy and safety of the test device is non-inferior to comparator. J Drugs Dermatol. 2022;21(1):13-20 doi:10.36849/JDD.6548.PMID:35005871 | DOI:10.36849/JDD.2022.6548 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Jeffery Adelglass Javier Alonso-Llamazares Jeremy Fenton Michael Gold Joel Schlessinger Stacy Smith Source Type: research

Alteration to the Skin Ceramide Profile Following Broad-Spectrum UV Exposure
This study investigated the effects of ultraviolet (UV) radiation on the ceramide profile using both an ex vivo skin and a clinical model. Lipidomic analysis of UV-exposed skin showed shifts to the composition of ceramide subclasses essential in repairing and strengthening the SC barrier (including CER1[EOS], CER3[NP], and CER6[AP]) and reduced very long-chain acyl moieties. Gene expression analysis and immunohistochemical staining of key enzymes (aSMase, DES1, CerS5, CerS3) suggested that lipid alterations can be attributed to changes within the ceramide biosynthesis process. Topical application of ceramide-containing sun...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Rebecca Barresi Hawasatu Dumbuya I-Chien Liao Ying Chen Xi Yan Janet Wangari-Olivero Nada Baalbaki Stephen Lynch Patricia Brieva Miao Wang Qian Zheng Charbel Bouez Source Type: research

Beyond Liposuction: Evolving Applications for Tumescent Anesthesia
J Drugs Dermatol. 2022 Jan 1;21(1):86-89. doi: 10.36849/JDD.2022.6279.ABSTRACTTumescent anesthesia was initially developed as a safer and more effective alternative to general anesthesia in performing liposuction. Today, it is used extensively for a wide variety of surgical procedures performed by various specialties. As more surgeons have become exposed to tumescent anesthesia with its associated advantages over general anesthesia, the number of applications for this unique form of local anesthesia has skyrocketed. In this article, we will briefly discuss the basics of tumescent anesthesia, followed by a discussion of the...
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: C Hanke Michael Dent Source Type: research

Clinical Evaluation of Fractional Radiofrequency for the Treatment and Reduction of Wrinkles: A Prospective Study
CONCLUSION: A statistically significant reduction in rhytids of the upper lip and the perioral area, was found, as evaluated by independent blinded evaluators. There were no adverse events. Treatment pain was low and tolerable, and subjects had high levels of satisfaction with the results at last follow-up. J Drugs Dermatol. 2022;21(1):43-48. doi:10.36849/JDD.6492.PMID:35005858 | DOI:10.36849/JDD.2022.6492 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 10, 2022 Category: Dermatology Authors: Alison Kang Suzanne Kilmer Source Type: research