Bridging the Gap: Integrating Gene Expression Profiling into Clinical Practice
J Drugs Dermatol. 2021 Jun 1;20(6):s4. doi: 10.36849/JDD.2021.6068.NO ABSTRACTPMID:34076384 | DOI:10.36849/JDD.2021.6068 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Aaron S Farberg Teo Soleymani Desiree Ratner Source Type: research

Clinical Considerations for Integrating Gene Expression Profiling into Cutaneous Squamous Cell Carcinoma Management
J Drugs Dermatol. 2021 Jun 1;20(6):5s-s11. doi: 10.36849/JDD.2021.6068.ABSTRACTGene expression profile (GEP) testing is now commercially available for metastatic risk prediction in patients with cutaneous squamous cell carcinoma (CSCC) and one or more high-risk factors. The purpose of this article is to provide an early framework for healthcare providers looking to integrate patient-specific tumor biology into their clinical practice using GEP testing. To develop a framework for clinical use, an expert panel was convened to identify CSCC management decision points where GEP testing may be immediately incorporated into prac...
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Sarah T Arron Travis W Blalock J Michael Guenther David M Hyams Sherrif F Ibrahim Shlomo A Koyfman Ashley Wysong Source Type: research

Management of Truncal Acne With Oral Sarecycline: Pooled Results from Two Phase-3 Clinical Trials
Conclusion: Sarecycline efficacy for truncal acne was observed within 3 weeks after treatment, supporting sarecycline as an optimal choice for oral treatment of moderate to severe truncal acne. J Drugs Dermatol. 2021;20(6):634-640. doi:10.36849/JDD.6204.PMID:34076386 | DOI:10.36849/JDD.2021.6204 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: James Q Del Rosso Linda Stein Gold Hilary Baldwin Julie C Harper Joshua Zeichner Sabine Obagi Emmy Graber Xochitl Jimenez Francisco Hernandez Vicente Ayman Grada Source Type: research

Parametric Acne Severity (PAS) Score and Lesion Counts From Multi-Modality Facial Image Analysis Correlates Strongly with Investigator Assessment
J Drugs Dermatol. 2021 Jun 1;20(6):642-647. doi: 10.36849/JDD.2021.6165.ABSTRACTVariability in acne lesion counting and assessing global severity necessitates large sample sizes that increase trial costs. Lack of standardized measures for these outcomes precludes the conduct of meta-analyses needed to compare efficacy of acne treatments. The goal of this study was to evaluate objective measures of lesion counts and global severity using analysis of multimodal photography. An algorithm for counting lesions was trained and validated in 30 acne subjects and compared to parallel assessments by 2 expert raters. A composite of p...
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Diane Thiboutot Amy Longenecker Douglas Canfield Sachin V Patwardhan Source Type: research

Cell-Free Blood Cell Secretome (BCS) Counteracts Skin Aging and Restores Firmness and Elasticity
CONCLUSION: BCS treatment resulted in increased firmness and hydration, usually attributed to younger skin. BCS is potentially the first cell-free autologous therapy for skin rejuvenation derived from patients’ own blood. J Drugs Dermatol. 2021;20(6):682-688. doi:10.36849/JDD.5018.PMID:34076388 | DOI:10.36849/JDD.2021.5018 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Martina Kerscher Dominique Hertz-Kleptow Attyla Drabik Tanju Kaptan Julio Reinecke Source Type: research

Vehicle Effects on the Rosacea Skin Barrier
CONCLUSION: The investigational topical 3% minocycline anhydrous gel decreases TEWL, indicating barrier repair, while increasing corneometry measurements, indicating improved skin hydration. J Drugs Dermatol. 2021;20(6):630-632. doi:10.36849/JDD.6105Visit the rosacea resource center.PMID:34076389 | DOI:10.36849/JDD.2021.6105 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Zoe Diana Draelos Source Type: research

Botulinum Neurotoxin Type A as an Adjuvant to Reduce Scarring After Dermatological Surgery
J Drugs Dermatol. 2021 Jun 1;20(6):677-680. doi: 10.36849/JDD.2021.5807.ABSTRACTBotulinum neurotoxin type A (BoNTA) is thought to have biological effects beyond muscle paralysis, including direct effects on wound healing. This provides a potential rationale for adjuvant intradermal BoNTA injection in selected patients undergoing minor dermatological surgeries, such as sebaceous cyst or intradermal naevus excision, which often lead to problematic scarring. Case studies are presented showing that BoNTA treatment may be associated with more rapid post-procedural healing and less visible scarring. These case reports of adjuvan...
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Dinesh Maini Source Type: research

Seeing the Treatment of Psoriasis in a New Light: A Novel Medical Device Utilizing Localized Coal Tar and Narrowband UVB for Targeted Treatment of Plaque Psoriasis
J Drugs Dermatol. 2021 Jun 1;20(6):701-702. doi: 10.36849/JDD.2021.5760.ABSTRACTGiven the high costs of systemic psoriasis therapies, studies have also shown that phototherapy achieves significant cost savings by replacing or delaying drug-based systemic treatment in patients with moderate to severe disease. However, this modality is often underutilized mainly due to the lack of phototherapy treatment centers across the country. Home phototherapy was designed to fill this treatment gap and allow patients to be treated with phototherapy despite living in areas that may not have a formal treatment facility. Inspired by the G...
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Nicholas D Brownstone Alina Bridges Tina Bhutani Evan Anderson Jeffrey Sugarman Source Type: research

A Multi-Centered Case-Control Study of Vitiligo Support Groups and Quality of Life
CONCLUSIONS: Vitiligo support group membership is associated with worse QoL. Individuals with vitiligo who have worse QoL, chronic, and/or untreated vitiligo may be more likely to seek out vitiligo support groups. Support group referral should be considered in the therapeutic management of vitiligo, particularly in patients whose QoL is more significantly impacted, who fail or are who are without access to treatment or have longstanding disease. J Drugs Dermatol. 2021;20(6):672-675. doi:10.36849/JDD.5706.PMID:34076392 | DOI:10.36849/JDD.2021.5706 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Zo ë I Smith Jason F Wang Nada Elbuluk Richard H Huggins Mathew R Birnbaum Alexandra Rzepecki Bhavnit K Bhatia Christina Kratschmer Beth McLellan Allison Kutner Source Type: research

Acne Vulgaris: The Majority of Patients Do Not Achieve Success According to FDA Guidance
CONCLUSIONS: The majority of acne patients are not likely to achieve success according to FDA guidance. We propose that the FDA guidance may be too rigorous. An alternative hypothesis is that most acne patients are undertreated. J Drugs Dermatol. 2021;20(6):648-651. doi:10.36849/JDD.5727.PMID:34076393 | DOI:10.36849/JDD.2021.5727 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Keshav Patel Katherine Baquerizo Nole Alan Fleischer Source Type: research

Analysis of Reddit Reveals Atopic Dermatitis Patient Questions
CONCLUSION: This analysis demonstrates that atopic dermatitis patients require greater management guidance, especially non-pharmacologic strategies, and more comprehensive discussions regarding the range of symptoms, trigger avoidance, and mental health resources. Addressing these gaps in knowledge may lead to improved outcomes and more informed, empowered patients. J Drugs Dermatol. 2021;20(6):653-658. doi:10.36849/JDD.5734Visit the Atopic Dermatitis Resource Center.PMID:34076394 | DOI:10.36849/JDD.2021.5734 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Alana Kurtti Jared Jagdeo Source Type: research

Efficacy of a Non-Comedogenic Hair Care Regimen for the Reduction of Mild-to-Moderate Truncal and Facial Acne: A Single-Arm 8-Week Study
CONCLUSION: This non-comedogenic hair care regimen showed efficacy in improving mild to moderate truncal and facial acne, both by dermatologist grading and subject self-assessment. Hair care products should be considered as a possible contributor to acne. J Drugs Dermatol. 2021;20(6):690-693. doi:10.36849/JDD.5772.PMID:34076395 | DOI:10.36849/JDD.2021.5772 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Iris K Rubin Source Type: research

Revisiting the Skin Health and Beauty Pyramid: A Clinically Based Guide to Selecting Topical Skincare Products
This article updates the original pyramid with these new concepts. J Drugs Dermatol. 2021;20(6):695-699. doi:10.36849/JDD.5883 THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL fTEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEASE CONTACT THE PUBLISHER WITH ANY QUESTIONS.PMID:34076396 | DOI:10.36849/JDD.2021.5883 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Zoe Diana Draelos Source Type: research

Vitiligo Health Education: A Study of Accuracy and Engagement of Online Educational Materials
CONCLUSION: Inaccurate videos on vitiligo are prevalent on social media. Misinformation can lead to potentially harmful interventions and delay in seeking evidence-based care. Videos from healthcare sources were more accurate but were viewed less than those from non-healthcare sources. Further efforts are needed to improve the visibility and viewer experience of accurate healthcare content on social media. J Drugs Dermatol. 2021;20(6):623-629. doi:10.36849/JDD.5835.PMID:34076397 | DOI:10.36849/JDD.2021.5835 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Charlotte Read Kevin K Wu Paulina M Young April W Armstrong Source Type: research

Concerns, Expectations, and Management Gaps Relating to Acne and Associated Scarring Identified from Survey Data
CONCLUSION: AcnePop are often dissatisfied with the information they receive from healthcare providers and more comprehensive information should be provided to help them understand their condition and available treatment options. J Drugs Dermatol. 2021;20(6):600-606. doi:10.36849/JDD.5920.PMID:34076398 | DOI:10.36849/JDD.2021.5920 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Jerry Tan Anna L Chien Jean Philippe York Alison M Layton Source Type: research

Applications of Gold and Silver Nanoparticles in the Treatment of Acne Vulgaris: A Systematic Review
CONCLUSION: This review found gold and silver nanoparticles to be a promising treatment for acne vulgaris. Further randomized controlled studies are needed to determine clinical efficacy and the role of gold and silver nanoparticles in the treatment algorithm for acne. J Drugs Dermatol. 2021;20(6):666-670. doi:10.36849/JDD.5762.PMID:34076399 | DOI:10.36849/JDD.2021.5762 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Kimberly Artounian Nour Bundogji Elika Hoss Monica Boen Source Type: research

Tazarotene 0.045% Lotion for Moderate-to-Severe Acne Patients: Pooled Phase 3 Analysis by Age and Sex
CONCLUSIONS: Tazarotene 0.045% lotion is efficacious and well tolerated in female and male adolescents and adults with moderate-to-severe acne. J Drugs Dermatol. 2021;20(6):608-615. doi:10.36849/JDD.6070.PMID:34076400 | DOI:10.36849/JDD.2021.6070 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Lawrence J Green James Q Del Rosso Emil A Tanghetti Eric Guenin Source Type: research

Evaluation of a First-in-Class Proteasome Inhibitor in Patients With Moderate to Severe Rosacea
CONCLUSION: This study demonstrates that topical ACU-D1 is safe and well-tolerated by patients in the study and demonstrates efficacy in reducing inflammatory lesions and erythema in patients with rosacea. Improvement was also noted on Canfield imaging, and this modality is likely to be used as an objective measure in the future. Further studies are warranted based on these initial positive results. ClinicalTrials.gov Identifier: NCT03064438 J Drugs Dermatol. 2021;20(6):660-664. doi:10.36849/JDD.5925.PMID:34076401 | DOI:10.36849/JDD.2021.5925 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: J Mark Jackson Rick Coulon Jack L Arbiser Source Type: research

Bridging the Gap: Integrating Gene Expression Profiling into Clinical Practice
J Drugs Dermatol. 2021 Jun 1;20(6):s4. doi: 10.36849/JDD.2021.6068.NO ABSTRACTPMID:34076384 | DOI:10.36849/JDD.2021.6068 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Aaron S Farberg Teo Soleymani Desiree Ratner Source Type: research

Clinical Considerations for Integrating Gene Expression Profiling into Cutaneous Squamous Cell Carcinoma Management
J Drugs Dermatol. 2021 Jun 1;20(6):5s-s11. doi: 10.36849/JDD.2021.6068.ABSTRACTGene expression profile (GEP) testing is now commercially available for metastatic risk prediction in patients with cutaneous squamous cell carcinoma (CSCC) and one or more high-risk factors. The purpose of this article is to provide an early framework for healthcare providers looking to integrate patient-specific tumor biology into their clinical practice using GEP testing. To develop a framework for clinical use, an expert panel was convened to identify CSCC management decision points where GEP testing may be immediately incorporated into prac...
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Sarah T Arron Travis W Blalock J Michael Guenther David M Hyams Sherrif F Ibrahim Shlomo A Koyfman Ashley Wysong Source Type: research

Management of Truncal Acne With Oral Sarecycline: Pooled Results from Two Phase-3 Clinical Trials
Conclusion: Sarecycline efficacy for truncal acne was observed within 3 weeks after treatment, supporting sarecycline as an optimal choice for oral treatment of moderate to severe truncal acne. J Drugs Dermatol. 2021;20(6):634-640. doi:10.36849/JDD.6204.PMID:34076386 | DOI:10.36849/JDD.2021.6204 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: James Q Del Rosso Linda Stein Gold Hilary Baldwin Julie C Harper Joshua Zeichner Sabine Obagi Emmy Graber Xochitl Jimenez Francisco Hernandez Vicente Ayman Grada Source Type: research

Parametric Acne Severity (PAS) Score and Lesion Counts From Multi-Modality Facial Image Analysis Correlates Strongly with Investigator Assessment
J Drugs Dermatol. 2021 Jun 1;20(6):642-647. doi: 10.36849/JDD.2021.6165.ABSTRACTVariability in acne lesion counting and assessing global severity necessitates large sample sizes that increase trial costs. Lack of standardized measures for these outcomes precludes the conduct of meta-analyses needed to compare efficacy of acne treatments. The goal of this study was to evaluate objective measures of lesion counts and global severity using analysis of multimodal photography. An algorithm for counting lesions was trained and validated in 30 acne subjects and compared to parallel assessments by 2 expert raters. A composite of p...
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Diane Thiboutot Amy Longenecker Douglas Canfield Sachin V Patwardhan Source Type: research

Cell-Free Blood Cell Secretome (BCS) Counteracts Skin Aging and Restores Firmness and Elasticity
CONCLUSION: BCS treatment resulted in increased firmness and hydration, usually attributed to younger skin. BCS is potentially the first cell-free autologous therapy for skin rejuvenation derived from patients’ own blood. J Drugs Dermatol. 2021;20(6):682-688. doi:10.36849/JDD.5018.PMID:34076388 | DOI:10.36849/JDD.2021.5018 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Martina Kerscher Dominique Hertz-Kleptow Attyla Drabik Tanju Kaptan Julio Reinecke Source Type: research

Vehicle Effects on the Rosacea Skin Barrier
CONCLUSION: The investigational topical 3% minocycline anhydrous gel decreases TEWL, indicating barrier repair, while increasing corneometry measurements, indicating improved skin hydration. J Drugs Dermatol. 2021;20(6):630-632. doi:10.36849/JDD.6105Visit the rosacea resource center.PMID:34076389 | DOI:10.36849/JDD.2021.6105 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Zoe Diana Draelos Source Type: research

Botulinum Neurotoxin Type A as an Adjuvant to Reduce Scarring After Dermatological Surgery
J Drugs Dermatol. 2021 Jun 1;20(6):677-680. doi: 10.36849/JDD.2021.5807.ABSTRACTBotulinum neurotoxin type A (BoNTA) is thought to have biological effects beyond muscle paralysis, including direct effects on wound healing. This provides a potential rationale for adjuvant intradermal BoNTA injection in selected patients undergoing minor dermatological surgeries, such as sebaceous cyst or intradermal naevus excision, which often lead to problematic scarring. Case studies are presented showing that BoNTA treatment may be associated with more rapid post-procedural healing and less visible scarring. These case reports of adjuvan...
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Dinesh Maini Source Type: research

Seeing the Treatment of Psoriasis in a New Light: A Novel Medical Device Utilizing Localized Coal Tar and Narrowband UVB for Targeted Treatment of Plaque Psoriasis
J Drugs Dermatol. 2021 Jun 1;20(6):701-702. doi: 10.36849/JDD.2021.5760.ABSTRACTGiven the high costs of systemic psoriasis therapies, studies have also shown that phototherapy achieves significant cost savings by replacing or delaying drug-based systemic treatment in patients with moderate to severe disease. However, this modality is often underutilized mainly due to the lack of phototherapy treatment centers across the country. Home phototherapy was designed to fill this treatment gap and allow patients to be treated with phototherapy despite living in areas that may not have a formal treatment facility. Inspired by the G...
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Nicholas D Brownstone Alina Bridges Tina Bhutani Evan Anderson Jeffrey Sugarman Source Type: research

A Multi-Centered Case-Control Study of Vitiligo Support Groups and Quality of Life
CONCLUSIONS: Vitiligo support group membership is associated with worse QoL. Individuals with vitiligo who have worse QoL, chronic, and/or untreated vitiligo may be more likely to seek out vitiligo support groups. Support group referral should be considered in the therapeutic management of vitiligo, particularly in patients whose QoL is more significantly impacted, who fail or are who are without access to treatment or have longstanding disease. J Drugs Dermatol. 2021;20(6):672-675. doi:10.36849/JDD.5706.PMID:34076392 | DOI:10.36849/JDD.2021.5706 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Zo ë I Smith Jason F Wang Nada Elbuluk Richard H Huggins Mathew R Birnbaum Alexandra Rzepecki Bhavnit K Bhatia Christina Kratschmer Beth McLellan Allison Kutner Source Type: research

Acne Vulgaris: The Majority of Patients Do Not Achieve Success According to FDA Guidance
CONCLUSIONS: The majority of acne patients are not likely to achieve success according to FDA guidance. We propose that the FDA guidance may be too rigorous. An alternative hypothesis is that most acne patients are undertreated. J Drugs Dermatol. 2021;20(6):648-651. doi:10.36849/JDD.5727.PMID:34076393 | DOI:10.36849/JDD.2021.5727 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Keshav Patel Katherine Baquerizo Nole Alan Fleischer Source Type: research

Analysis of Reddit Reveals Atopic Dermatitis Patient Questions
CONCLUSION: This analysis demonstrates that atopic dermatitis patients require greater management guidance, especially non-pharmacologic strategies, and more comprehensive discussions regarding the range of symptoms, trigger avoidance, and mental health resources. Addressing these gaps in knowledge may lead to improved outcomes and more informed, empowered patients. J Drugs Dermatol. 2021;20(6):653-658. doi:10.36849/JDD.5734Visit the Atopic Dermatitis Resource Center.PMID:34076394 | DOI:10.36849/JDD.2021.5734 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Alana Kurtti Jared Jagdeo Source Type: research

Efficacy of a Non-Comedogenic Hair Care Regimen for the Reduction of Mild-to-Moderate Truncal and Facial Acne: A Single-Arm 8-Week Study
CONCLUSION: This non-comedogenic hair care regimen showed efficacy in improving mild to moderate truncal and facial acne, both by dermatologist grading and subject self-assessment. Hair care products should be considered as a possible contributor to acne. J Drugs Dermatol. 2021;20(6):690-693. doi:10.36849/JDD.5772.PMID:34076395 | DOI:10.36849/JDD.2021.5772 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Iris K Rubin Source Type: research

Revisiting the Skin Health and Beauty Pyramid: A Clinically Based Guide to Selecting Topical Skincare Products
This article updates the original pyramid with these new concepts. J Drugs Dermatol. 2021;20(6):695-699. doi:10.36849/JDD.5883 THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL fTEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEASE CONTACT THE PUBLISHER WITH ANY QUESTIONS.PMID:34076396 | DOI:10.36849/JDD.2021.5883 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Zoe Diana Draelos Source Type: research

Vitiligo Health Education: A Study of Accuracy and Engagement of Online Educational Materials
CONCLUSION: Inaccurate videos on vitiligo are prevalent on social media. Misinformation can lead to potentially harmful interventions and delay in seeking evidence-based care. Videos from healthcare sources were more accurate but were viewed less than those from non-healthcare sources. Further efforts are needed to improve the visibility and viewer experience of accurate healthcare content on social media. J Drugs Dermatol. 2021;20(6):623-629. doi:10.36849/JDD.5835.PMID:34076397 | DOI:10.36849/JDD.2021.5835 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Charlotte Read Kevin K Wu Paulina M Young April W Armstrong Source Type: research

Concerns, Expectations, and Management Gaps Relating to Acne and Associated Scarring Identified from Survey Data
CONCLUSION: AcnePop are often dissatisfied with the information they receive from healthcare providers and more comprehensive information should be provided to help them understand their condition and available treatment options. J Drugs Dermatol. 2021;20(6):600-606. doi:10.36849/JDD.5920.PMID:34076398 | DOI:10.36849/JDD.2021.5920 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Jerry Tan Anna L Chien Jean Philippe York Alison M Layton Source Type: research

Applications of Gold and Silver Nanoparticles in the Treatment of Acne Vulgaris: A Systematic Review
CONCLUSION: This review found gold and silver nanoparticles to be a promising treatment for acne vulgaris. Further randomized controlled studies are needed to determine clinical efficacy and the role of gold and silver nanoparticles in the treatment algorithm for acne. J Drugs Dermatol. 2021;20(6):666-670. doi:10.36849/JDD.5762.PMID:34076399 | DOI:10.36849/JDD.2021.5762 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Kimberly Artounian Nour Bundogji Elika Hoss Monica Boen Source Type: research

Tazarotene 0.045% Lotion for Moderate-to-Severe Acne Patients: Pooled Phase 3 Analysis by Age and Sex
CONCLUSIONS: Tazarotene 0.045% lotion is efficacious and well tolerated in female and male adolescents and adults with moderate-to-severe acne. J Drugs Dermatol. 2021;20(6):608-615. doi:10.36849/JDD.6070.PMID:34076400 | DOI:10.36849/JDD.2021.6070 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Lawrence J Green James Q Del Rosso Emil A Tanghetti Eric Guenin Source Type: research

Evaluation of a First-in-Class Proteasome Inhibitor in Patients With Moderate to Severe Rosacea
CONCLUSION: This study demonstrates that topical ACU-D1 is safe and well-tolerated by patients in the study and demonstrates efficacy in reducing inflammatory lesions and erythema in patients with rosacea. Improvement was also noted on Canfield imaging, and this modality is likely to be used as an objective measure in the future. Further studies are warranted based on these initial positive results. ClinicalTrials.gov Identifier: NCT03064438 J Drugs Dermatol. 2021;20(6):660-664. doi:10.36849/JDD.5925.PMID:34076401 | DOI:10.36849/JDD.2021.5925 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: J Mark Jackson Rick Coulon Jack L Arbiser Source Type: research

Bridging the Gap: Integrating Gene Expression Profiling into Clinical Practice
J Drugs Dermatol. 2021 Jun 1;20(6):s4. doi: 10.36849/JDD.2021.6068.NO ABSTRACTPMID:34076384 | DOI:10.36849/JDD.2021.6068 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Aaron S Farberg Teo Soleymani Desiree Ratner Source Type: research

Clinical Considerations for Integrating Gene Expression Profiling into Cutaneous Squamous Cell Carcinoma Management
J Drugs Dermatol. 2021 Jun 1;20(6):5s-s11. doi: 10.36849/JDD.2021.6068.ABSTRACTGene expression profile (GEP) testing is now commercially available for metastatic risk prediction in patients with cutaneous squamous cell carcinoma (CSCC) and one or more high-risk factors. The purpose of this article is to provide an early framework for healthcare providers looking to integrate patient-specific tumor biology into their clinical practice using GEP testing. To develop a framework for clinical use, an expert panel was convened to identify CSCC management decision points where GEP testing may be immediately incorporated into prac...
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Sarah T Arron Travis W Blalock J Michael Guenther David M Hyams Sherrif F Ibrahim Shlomo A Koyfman Ashley Wysong Source Type: research

Management of Truncal Acne With Oral Sarecycline: Pooled Results from Two Phase-3 Clinical Trials
Conclusion: Sarecycline efficacy for truncal acne was observed within 3 weeks after treatment, supporting sarecycline as an optimal choice for oral treatment of moderate to severe truncal acne. J Drugs Dermatol. 2021;20(6):634-640. doi:10.36849/JDD.6204.PMID:34076386 | DOI:10.36849/JDD.2021.6204 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: James Q Del Rosso Linda Stein Gold Hilary Baldwin Julie C Harper Joshua Zeichner Sabine Obagi Emmy Graber Xochitl Jimenez Francisco Hernandez Vicente Ayman Grada Source Type: research

Parametric Acne Severity (PAS) Score and Lesion Counts From Multi-Modality Facial Image Analysis Correlates Strongly with Investigator Assessment
J Drugs Dermatol. 2021 Jun 1;20(6):642-647. doi: 10.36849/JDD.2021.6165.ABSTRACTVariability in acne lesion counting and assessing global severity necessitates large sample sizes that increase trial costs. Lack of standardized measures for these outcomes precludes the conduct of meta-analyses needed to compare efficacy of acne treatments. The goal of this study was to evaluate objective measures of lesion counts and global severity using analysis of multimodal photography. An algorithm for counting lesions was trained and validated in 30 acne subjects and compared to parallel assessments by 2 expert raters. A composite of p...
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Diane Thiboutot Amy Longenecker Douglas Canfield Sachin V Patwardhan Source Type: research

Cell-Free Blood Cell Secretome (BCS) Counteracts Skin Aging and Restores Firmness and Elasticity
CONCLUSION: BCS treatment resulted in increased firmness and hydration, usually attributed to younger skin. BCS is potentially the first cell-free autologous therapy for skin rejuvenation derived from patients’ own blood. J Drugs Dermatol. 2021;20(6):682-688. doi:10.36849/JDD.5018.PMID:34076388 | DOI:10.36849/JDD.2021.5018 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Martina Kerscher Dominique Hertz-Kleptow Attyla Drabik Tanju Kaptan Julio Reinecke Source Type: research

Vehicle Effects on the Rosacea Skin Barrier
CONCLUSION: The investigational topical 3% minocycline anhydrous gel decreases TEWL, indicating barrier repair, while increasing corneometry measurements, indicating improved skin hydration. J Drugs Dermatol. 2021;20(6):630-632. doi:10.36849/JDD.6105Visit the rosacea resource center.PMID:34076389 | DOI:10.36849/JDD.2021.6105 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Zoe Diana Draelos Source Type: research

Botulinum Neurotoxin Type A as an Adjuvant to Reduce Scarring After Dermatological Surgery
J Drugs Dermatol. 2021 Jun 1;20(6):677-680. doi: 10.36849/JDD.2021.5807.ABSTRACTBotulinum neurotoxin type A (BoNTA) is thought to have biological effects beyond muscle paralysis, including direct effects on wound healing. This provides a potential rationale for adjuvant intradermal BoNTA injection in selected patients undergoing minor dermatological surgeries, such as sebaceous cyst or intradermal naevus excision, which often lead to problematic scarring. Case studies are presented showing that BoNTA treatment may be associated with more rapid post-procedural healing and less visible scarring. These case reports of adjuvan...
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Dinesh Maini Source Type: research

Seeing the Treatment of Psoriasis in a New Light: A Novel Medical Device Utilizing Localized Coal Tar and Narrowband UVB for Targeted Treatment of Plaque Psoriasis
J Drugs Dermatol. 2021 Jun 1;20(6):701-702. doi: 10.36849/JDD.2021.5760.ABSTRACTGiven the high costs of systemic psoriasis therapies, studies have also shown that phototherapy achieves significant cost savings by replacing or delaying drug-based systemic treatment in patients with moderate to severe disease. However, this modality is often underutilized mainly due to the lack of phototherapy treatment centers across the country. Home phototherapy was designed to fill this treatment gap and allow patients to be treated with phototherapy despite living in areas that may not have a formal treatment facility. Inspired by the G...
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Nicholas D Brownstone Alina Bridges Tina Bhutani Evan Anderson Jeffrey Sugarman Source Type: research

A Multi-Centered Case-Control Study of Vitiligo Support Groups and Quality of Life
CONCLUSIONS: Vitiligo support group membership is associated with worse QoL. Individuals with vitiligo who have worse QoL, chronic, and/or untreated vitiligo may be more likely to seek out vitiligo support groups. Support group referral should be considered in the therapeutic management of vitiligo, particularly in patients whose QoL is more significantly impacted, who fail or are who are without access to treatment or have longstanding disease. J Drugs Dermatol. 2021;20(6):672-675. doi:10.36849/JDD.5706.PMID:34076392 | DOI:10.36849/JDD.2021.5706 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Zo ë I Smith Jason F Wang Nada Elbuluk Richard H Huggins Mathew R Birnbaum Alexandra Rzepecki Bhavnit K Bhatia Christina Kratschmer Beth McLellan Allison Kutner Source Type: research

Acne Vulgaris: The Majority of Patients Do Not Achieve Success According to FDA Guidance
CONCLUSIONS: The majority of acne patients are not likely to achieve success according to FDA guidance. We propose that the FDA guidance may be too rigorous. An alternative hypothesis is that most acne patients are undertreated. J Drugs Dermatol. 2021;20(6):648-651. doi:10.36849/JDD.5727.PMID:34076393 | DOI:10.36849/JDD.2021.5727 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Keshav Patel Katherine Baquerizo Nole Alan Fleischer Source Type: research

Analysis of Reddit Reveals Atopic Dermatitis Patient Questions
CONCLUSION: This analysis demonstrates that atopic dermatitis patients require greater management guidance, especially non-pharmacologic strategies, and more comprehensive discussions regarding the range of symptoms, trigger avoidance, and mental health resources. Addressing these gaps in knowledge may lead to improved outcomes and more informed, empowered patients. J Drugs Dermatol. 2021;20(6):653-658. doi:10.36849/JDD.5734Visit the Atopic Dermatitis Resource Center.PMID:34076394 | DOI:10.36849/JDD.2021.5734 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Alana Kurtti Jared Jagdeo Source Type: research

Efficacy of a Non-Comedogenic Hair Care Regimen for the Reduction of Mild-to-Moderate Truncal and Facial Acne: A Single-Arm 8-Week Study
CONCLUSION: This non-comedogenic hair care regimen showed efficacy in improving mild to moderate truncal and facial acne, both by dermatologist grading and subject self-assessment. Hair care products should be considered as a possible contributor to acne. J Drugs Dermatol. 2021;20(6):690-693. doi:10.36849/JDD.5772.PMID:34076395 | DOI:10.36849/JDD.2021.5772 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Iris K Rubin Source Type: research

Revisiting the Skin Health and Beauty Pyramid: A Clinically Based Guide to Selecting Topical Skincare Products
This article updates the original pyramid with these new concepts. J Drugs Dermatol. 2021;20(6):695-699. doi:10.36849/JDD.5883 THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL fTEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEASE CONTACT THE PUBLISHER WITH ANY QUESTIONS.PMID:34076396 | DOI:10.36849/JDD.2021.5883 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Zoe Diana Draelos Source Type: research

Vitiligo Health Education: A Study of Accuracy and Engagement of Online Educational Materials
CONCLUSION: Inaccurate videos on vitiligo are prevalent on social media. Misinformation can lead to potentially harmful interventions and delay in seeking evidence-based care. Videos from healthcare sources were more accurate but were viewed less than those from non-healthcare sources. Further efforts are needed to improve the visibility and viewer experience of accurate healthcare content on social media. J Drugs Dermatol. 2021;20(6):623-629. doi:10.36849/JDD.5835.PMID:34076397 | DOI:10.36849/JDD.2021.5835 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 2, 2021 Category: Dermatology Authors: Charlotte Read Kevin K Wu Paulina M Young April W Armstrong Source Type: research