Vitamin K2 Awareness in Sun-Protected Patients Supplementing With Vitamin D.
Authors: Abouodah H, Douglas LM, Ho BV, Bhattacharya R, Wolf E, Wang-Weinman T, Liu D, Aires D Abstract Dermatologists often recommend vitamin D for sun-protected patients. Most patients are not aware of the key role vitamin K2 plays in vitamin D metabolism and do not receive sufficient dietary vitamin K2. A survey of 50 sun-protecting patients shows 4/50 understood the role of vitamin K2 and 1/50 was supplementing vitamin K2. Therefore, counseling on vitamin K2 supplementation may be of benefit to sun-protected dermatology patients. J Drugs Dermatol. 2021;20(2):228-229. doi:10.36849/JDD.2021.5829. PMID: 335385...
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Retrospective Chart Review of Inflamed Epidermal Inclusion Cysts.
CONCLUSIONS: Almost half of cases of mild inflamed EIC (lacking systemic symptoms) cultured will not grow pathogenic bacteria, therefore incision and drainage with culture and appropriate therapy is a viable therapeutic option in uncomplicated inflamed EIC lesions. In this way, over prescription of antibiotics can be minimized. J Drugs Dermatol. 2021;20(2):199-202. doi:10.36849/JDD.2021.5014. PMID: 33538555 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Response to "Assessing a Paradigm Shift: Perceptions of the USMLE Step 1 Scoring Change to Pass/Fail".
Response to "Assessing a Paradigm Shift: Perceptions of the USMLE Step 1 Scoring Change to Pass/Fail". J Drugs Dermatol. 2021 Feb 01;20(2):230 Authors: Militello M, Presley CL, Rundle CW, Pulsipher KJ, Dellavalle RP Abstract We commend Wei et al1 for highlighting the fundamental shift that dermatology program directors (PDs) and students alike will experience following the change of the USMLE Step 1 to pass/fail. PMID: 33538556 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Intense Pulsed Light: A Methodical Approach to Understanding Clinical Endpoints.
CONCLUSION: Greatest clinical endpoint response at 4-week follow-up was observed with more robust initial responses. This was most apparent at higher fluence levels and fewer pulse counts. However, when the IPL is pushed to aggressive parameters, there is risk of hypopigmentation and hair loss as seen in this case study. Skin type is an important consideration when using IPL and MSP adds to its safety profile. J Drugs Dermatol. 2021;20(2):203-207. doi:10.36849/JDD.2020.5638. PMID: 33538557 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Dermatologists' Perspectives on Defining Moderate Psoriasis: The Canadian Moderate Psoriasis Survey.
CONCLUSIONS: This is the first survey of Canadian dermatologists on moderate psoriasis. Efforts are needed to implement a clinically useful definition of moderate plaque psoriasis to improve patient care and to raise awareness of the definition among regulatory agencies and reimbursement authorities. J Drugs Dermatol. 2021;20(2):126-132. doi:10.36849/JDD.2021.5531. PMID: 33538558 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Do Antimicrobial Resistance Patterns Matter? An Algorithm for the Treatment of Patients With Impetigo.
CONCLUSIONS: When prescribing antibiotics, it is essential to know the local trends in antibiotic resistance. Ozenoxacin cream 1% is highly effective against S. pyogenes and S. aureus, including methycyllin-susceptible and resistant strains (MRSA), and may be a suitable option for localized impetigo.J Drugs Dermatol. 2021;20(2):134-142. doi:10.36849/JDD.2021.5475 THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL TEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEASE CONTACT THE PUBLISHER WITH ANY QUESTIONS. PMID: 33538559 [PubMed - as supplied by publisher] (Sour...
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Hospitalization in Patients with Psoriasis: Impact of Biological Therapies on Temporal Evolution.
CONCLUSIONS: In our study population hospitalizations for psoriasis descended progressively and significantly from 2004. So far there are no extensive data on the impact of biological therapies on psoriasis hospitalization. J Drugs Dermatol. 2021;20(2):208-214. doi:10.36849/JDD.2021.4931. PMID: 33538560 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Ingenol Mebutate as Treatment of Squamous Cell Carcinoma In Situ: A Case Series.
Authors: Khalfe Y, Rosen T Abstract Ingenol mebutate (IM) is a novel drug currently only FDA-approved for the treatment of actinic keratosis. However, it has been extensively used off-label to treat multiple other skin disorders. In recent years, literature has emerged providing evidence for IM’s use as treatment for dermatologic disorders beyond actinic keratosis, including squamous cell carcinoma in situ. Here, we report a case series in which topical 0.05% ingenol mebutate was used to treat squamous cell carcinoma in situ, with five of six patients demonstrating successful results. J Drugs Dermatol. 20...
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Acitretin for Secondary Prevention of Keratinocyte Cancers in a Veteran Population: A Retrospective Cohort Study.
Authors: Lim RK, Weinstock MA, Landow SM Abstract Acitretin, a vitamin A derivative used for psoriasis, can prevent keratinocyte carcinoma (KC). It induced regression of keratoacanthomas (KA) in animal models, presumably by activating retinoic acid and retinoid X receptors that regulate gene expression for growth and proliferation.1,2. PMID: 33538562 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Patient Perceptions and Satisfaction With Teledermatology During the COVID-19 Pandemic: A Survey-Based Study.
CONCLUSION: Dermatology patients likely perceive telehealth visits as a convenient and safe method for quality care during the COVID-19 pandemic. The lack of physical touch, inability to provide close inspection and/or procedural intervention can be frustrating for patients and therefore meaningful selection of appropriate cases for telehealth visits can optimize the patient experience. Overall, telemedicine represents an effective and safe vehicle for delivering care especially during a global pandemic. J Drugs Dermatol. 2021;20(2):178-183. doi:10.36849/JDD.2021.5714. PMID: 33538563 [PubMed - as supplied by publisher]...
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

New Protocol for Long-Term Results With a Multi-Pulse Nd:YAG Laser for Melasma Treatment: A Descriptive Cohort Study.
CONCLUSION: Results of this study indicate that the four-step Fotona laser protocol is a safe and effective treatment option for melasma. J Drugs Dermatol. 2021;20(2):150-154. doi:10.36849/JDD.2021.1221. PMID: 33538564 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Differences in Depression and Distress Between Acne Patients on Isotretinoin vs Oral Antibiotics.
CONCLUSION: Acne patients on isotretinoin experienced less depressive symptoms and psychological distress as compared to oral antibiotics. J Drugs Dermatol. 2021;20(2):172-177. doi:10.36849/JDD.2021.5559. PMID: 33538565 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Efficacy and Tolerability of a Novel Topical Treatment for Neck: A Randomized, Double-blind, Regimen-Controlled Study.
Authors: Makino ET, Kadoya K, Chung R, Jiang L, Mikati M, Mehta RC Abstract The neck plays a telling role as an age indicator. Due to its anatomy and function, neck skin ages differently than facial skin and special considerations need to be taken when providing treatment. A randomized, double-blind, regimen-controlled study was conducted to assess the efficacy and tolerability of a novel topical cosmetic cream (NCC) specifically tailored to address the signs of skin aging of the neck and décolletage. Twice daily application of NCC significantly improved skin sagging/laxity of the neck as well as the app...
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Review of Hedgehog Inhibitors Sonidegib and Vismodegib for Treatment of Advanced Basal Cell Carcinoma.
Authors: Migden M, Farberg AS, Dummer R, Squittieri N, Hanke CW Abstract Basal cell carcinoma (BCC) is the most common malignancy in fair-skinned populations. Most cases are successfully treated with surgery, but in advanced BCC—including locally advanced BCC and metastatic BCC—surgery is likely to result in substantial morbidity or unlikely to be effective. In those patients, the systemic Hedgehog inhibitors (HHIs) sonidegib and vismodegib are the only approved pharmacologic treatment option. Although a number of clinical studies highlight the similarities and differences between the two HHIs, ...
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Impact of the COVID-19 Pandemic on Physician-Pharmaceutical Office-Based Interactions.
CONCLUSION: PPRI materially decreased during the initial COVID-19 peak but will likely return to baseline volume moving forward with a significant component being hybrid PPRI. Further studies may better elucidate the economic and clinical impact associated with these changes and their effect on dermatologists’ ability to provide patients with samples and educational materials. J Drugs Dermatol. 2021;20(2):215-223. doi:10.36849/JDD.2021.5651. PMID: 33538568 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Intralesional 5-Fluorouracil for Treatment of Non-Melanoma Skin Cancer: A Systematic Review.
CONCLUSION: While majority of data is derived from individual cases, IL 5-FU achieved higher clearance rate in SCC and BCC groups than in KA group. J Drugs Dermatol. 2021;20(2):192-198. doi:10.36849/JDD.2021.5518. PMID: 33538569 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Inflammaging in Dermatology: A New Frontier for Research.
Authors: Haque A, Woolery-Lloyd H Abstract As humans age, our ability to manage certain types of inflammation is reduced. As a result, we experience chronic, low-grade inflammation, which has been termed “inflammaging”. This type of low-level inflammation is driven by a progressive increase in pro- inflammatory systemic cytokines over time. Inflammaging is thought to contribute to many age-related chronic diseases including cardiovascular disease, diabetes, Alzheimer’s disease, and even certain cancers. Recent studies suggest that the human microbiome may play a critical role in inflam...
Source: Journal of Drugs in Dermatology - February 6, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Relevance of Vitamin D Supplementation for People of Color in the Era of COVID-19.
Authors: Grimes PE, Elbuluk N, Alexis AF PMID: 33528149 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - February 4, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

COVID-19 Vaccine and Biologics: An Impending Dilemma.
Authors: Hauptman M, Vasic J, Krase J Abstract The COVID-19 pandemic has forced healthcare providers across all specialties to adjust their methods of clinical practice. In Dermatology, focus on the continued safe usage of immunomodulating biologic therapies has attracted particular interest as the COVID-19 virus represents a novel infection risk. While guidance on biologic initiation and continuation has been established,1 the return to normalcy will likely involve a safe and effective vaccine. This vaccine(s) will represent a new clinical hurdle for prescribers who have continued patients on biologic therapy thro...
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Ingenol Mebutate and the Treatment of Actinic Keratosis.
Authors: Heron CE, Feldman SR Abstract Actinic keratoses (AKs) are common skin lesions association with increased exposure to ultraviolet radiation; these lesions have the potential to transform into squamous cell carcinomas (SCCs).1. PMID: 33400406 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Men's Attitudes and Behaviors About Skincare and Sunscreen Use Behaviors.
CONCLUSIONS AND RELEVANCE: This survey shows lapses in evidenced-based sunscreen behaviors to reduce skin cancer among men. Campaigns to reduce skin cancer should focus on increasing men’s interest in daily sunscreen use and adherence to wearing sun-protective products. J Drugs Dermatol. 2021;20(1):88-93. doi:10.36849/JDD.2021.5470. PMID: 33400407 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Prescribing Isotretinoin for Transgender Patients: A Call to Action and Recommendations.
Authors: Sanchez DP, Brownstone N, Thibodeaux Q, Reddy V, Myers B, Chan S, Bhutani T Abstract Case Scenerio: A 26-year-old patient presents to the dermatology clinic with severe nodulocystic scarring acne. The patient identifies as a transgender male and notes that he has been receiving hormone replacement therapy for the past 4 years with weekly intramuscular testosterone injections. PMID: 33400408 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Leveraging Virtual Boot Camp to Alleviate First Year Dermatology Resident Anxiety.
Authors: Adusumilli NC, Hausmann K, Friedman AJ, Maiberger M Abstract The coronavirus disease 2019 pandemic has quickly and abruptly altered workflow and education across medical specialties. As the health crisis persists in the United States, change will be the norm for the foreseeable future. Dermatology residents report high levels of anxiety, with concerns ranging from redeployment to career prospects.1. PMID: 33400409 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Psychosocial Stress and Mechanisms of Skin Health: A Comprehensive Update.
Authors: Sun MD, Rieder EA Abstract Although the relationship between psychosocial stress and skin health is commonly invoked in both the scientific and popular literature, its underlying mechanisms are still not well understood. In this review, we provide a comprehensive update on the pathophysiology of stress and its clinical impact on skin homeostasis. The recent characterization of a bidirectional HPA stress axis in the skin has illuminated peripheral stress pathways, with effects spanning inflammation, atopy, barrier function, dermal thinning, wound healing, and melanogenesis. Additionally, new research into t...
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Intradermal Microdroplet Injection of Diluted Incobotulinumtoxin-A for Sebum Control, Face Lifting, and Pore Size Improvement.
CONCLUSION: This study showed that intradermal injection with Incobotulinumtoxin-A could be effective for face lifting, reduced sebum production, and improved facial pores. J Drugs Dermatol. 2021;20(1):49-54. doi:10.36849/JDD.2021.5616. PMID: 33400411 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Phase 2 Open-Label Study to Evaluate VP-102 for the Treatment of Molluscum Contagiosum.
CONCLUSIONS: VP-102 treatment resulted in a reduction in lesion counts and improved QoL. Treated subjects had a 48.5% rate of complete clearance of molluscum lesions. Negligible systemic cantharidin exposure was observed in the systemic exposure group. This data demonstrates safety and efficacy of treatment with VP-102 in MC; a widespread viral infection that does not have any current FDA-approved treatments. Significant Finding: Treatment of subjects with MC using VP-102 resulted in negligible systemic cantharidin exposure, as well as a reduction in lesion counts, improved QoL, and a demonstrated efficacy in clearance of ...
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Chart Review Presenting Safety of Injectable PLLA Used With Alternative Reconstitution Volume for Facial Treatments.
CONCLUSION: The low number of AEs reported in this retrospective chart review suggests that facial aesthetic treatment with PLLA reconstituted to a final volume of 8–10 mL, including anesthetics, is associated with a favorable risk benefit ratio. J Drugs Dermatol. 2021;20(1):18-22. doi:10.36849/JDD.2021.5631. PMID: 33400413 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Absorbable Suspension Sutures: Recommendations for Use in a Multimodal Nonsurgical Approach to Facial Rejuvenation.
CONCLUSIONS: By combining nonsurgical modalities that address each of the four Rs (Repositioning tissue, Relaxation of hyperkinetic musculature, Resurfacing, and Revolumization),1 nonsurgical patient outcomes can be further improved. Absorbable suspension sutures represent a unique technology in that they are able to provide significant support to ptotic tissue in the face and neck. J Drugs Dermatol. 2021;20(1):23-29. doi:10.36849/JDD.2021.5684. PMID: 33400414 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Laboratory Testing in Telogen Effluvium.
Authors: Kakpovbia E, Ogbechie-Godec OA, Shapiro J, Lo Sicco KI Abstract Telogen effluvium (TE) – a common cause of non- scarring hair loss – is managed with varying clinical protocols given the paucity of evidence-based practices. PMID: 33400415 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The ABC Topical Management of Atopic Dermatitis in Philippines: Expert Recommendations.
Authors: Lavadia AM, Cumagun AT, Palmero L, Ramos NS, Tan CJ Abstract Atopic dermatitis (AD) has been shown to have an increasing incidence in Asia, congruous with the trends observed worldwide. The severity of the condition has been associated with challenges in disease control. Moreover, a significant number of patients do not adhere to their physicians’ recommendations correctly and prefer alternative treatments. Better education regarding the nature of the disease and its appropriate management may improve patient compliance and lead to better control. An ABC scheme of AD management entails anti-infla...
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Presentation and Management of Cutaneous Manifestations of COVID-19.
CONCLUSIONS: Cutaneous symptoms are part of the COVID-19 disease spectrum. Early identification, diagnosis, and management through a multidisciplinary approach can facilitate safe disease resolution for patients. J Drugs Dermatol. 2021;20(1):76-83. doi:10.36849/JDD.2021.5676. PMID: 33400417 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Successful Treatment of Periorificial Dermatitis With Novel Narrow Spectrum Sarecycline.
Authors: Graber E, Kay CR Abstract Broad spectrum tetracyclines are a well-known, widely used, and often successful treatment for use in inflammatory skin pathologies such as acne and rosacea. However, the steady rise of antibiotic resistance and gut dysbiosis associated with broad spectrum tetracyclines emphasizes the importance and responsibility of antibiotic stewardship. Narrow spectrum antibiotics have become increasingly important therapies to slow the progression of resistance as well as decrease negative side effect profiles, particularly those associated with broad spectrum tetracyclines. This case shows t...
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Aesthetic Office Disaster Preparedness and Response Plan.
Authors: Cohen JL, Dayan SH, Avram MM, Saltz R, Kilmer S, Maas CS, Schlessinger J Abstract The coronavirus pandemic (COVID-19) has served as a call-to-arms in preparing practices for the next disaster whether it is another infectious disease or a flood, hurricane, earthquake, a sustained power outage, or something else. A group of predominantly core aesthetic physicians discussed the various aspects of their office procedures that warrant consideration in a proactive approach to the next pandemic/disaster-related event. This guide does not set a standard of practice but contains recommendations that may avoid some ...
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Pyoderma Gangrenosum Occurring in the Setting of Hypercortisolism Associated With Adrenocortical Adenoma: A Pathophysiological Paradox.
We present a 25-year old previously healthy female with a 1.5-year history of treatment refractory PG. Features of Cushing’s syndrome such as facial plethora, striae, and lipodystrophy were noted on exam, which prompted several studies that ultimately revealed an adrenal adenoma. Following surgical excision of the adenoma, symptoms rapidly resolved and systemic immunosuppressants were discontinued. This rare case highlights the importance that adrenal adenoma and resultant Cushing’s syndrome may be a driver of PG despite the pathophysiologic paradox. J Drugs Dermatol. 2021;20(1):95-97. doi:10.36849/JDD....
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Randomized, Double-Blind, Placebo-Controlled Study of a Nutraceutical Supplement for Promoting Hair Growth in Perimenopausal, Menopausal, and Postmenopausal Women With Thinning Hair.
The objective of this 6-month, randomized, double-blind, placebo-controlled study was to assess the safety and efficacy of this oral supplement to promote hair growth in perimenopausal, menopausal, and postmenopausal women with self-perceived thinning. Subjects were randomized to the study supplement (n=40) or placebo (n=30). The primary endpoint was a statistically significant increase in the number of terminal and vellus hairs based on phototrichogram analysis. Daily intake of the nutraceutical supplement resulted in progressive and significant increase in terminal and total hair counts on days 90 (P<0.01) and 180...
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Aesthetic ONE21 Technique for Injecting IncobotulinumtoxinA into the Forehead: Initial Experience With 86 Patients.
CONCLUSION: INCO injection using the ONE21 technique is effective and safe in treating forehead wrinkles, providing a natural result, with a customized treatment and a predictable eyebrow shape. J Drugs Dermatol. 2021;20(1):31-37. doi:10.36849/JDD.2021.5617. PMID: 33400422 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Needle Manufacturing, Quality Control, and Optimization for Patient Comfort.
CONCLUSION: There is extensive consideration that goes into needle manufacturing, quality control, and optimization for hyaluronic acid filler. Understanding the technical process helps inform the clinician and guide patient care for maximum comfort. J Drugs Dermatol. 2021;20(1):44-48. doi:10.36849/JDD.2021.5591. PMID: 33400423 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 7, 2021 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Predicting Secukinumab Fast-Responder Profile in Psoriatic Patients: Advanced Application of Artificial-Neural-Networks (ANNs).
CONCLUSIONS: The present study is possibly the first approach employing ANNs to predict drug efficacy in dermatology; a wider use of ANNs may be conducive to useful both theoretical and clinical insight. J Drugs Dermatol. 2020;19(12) doi:10.36849/JDD.2020.5006. PMID: 33346505 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin.
CONCLUSION: A bakuchiol nature-based anti-aging moisturizer is well tolerated and effective in individuals with sensitive skin.J Drugs Dermatol. 2020;19(12): doi:10.36849/JDD.2020.5522. PMID: 33346506 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Teledermatology: Improving Access or Widening Healthcare Disparities?
Authors: Hadeler EK, Beer J, Nouri K Abstract Teledermatology, the form of telemedicine directed toward dermatology patients, is one of the earliest technological innovations that advanced remote medical care. Developed in 1995, teledermatology was established with the mission of increasing healthcare access among patients in rural geographic locations who had limited access to specialist care.1. PMID: 33346507 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Optimizing the Trial Design for a Comparative Effectiveness Study of Spironolactone versus Oral Antibiotics for Women With Acne: A Delphi Consensus Panel.
Authors: Barbieri JS, Margolis DJ Abstract For women with acne, their acne often persists into adulthood, with over 50% of women reporting acne between 20–29 years of age and over 35% of women reporting acne between 30–39 years of age.1 While mild acne can usually be managed with topical medications, moderate to severe acne often requires treatment with systemic medications such as oral antibiotics, spironolactone, and isotretinoin.2 Although oral antibiotics are the most common systemic medication prescribed for women with moderate to severe acne, spironolactone may represent a safe and effecti...
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Apremilast with Add-On Calcipotriene/Betamethasone Dipropionate for Treating Moderate to Severe Plaque Psoriasis.
CONCLUSION: We show that most week-8 partial apremilast responders can achieve PASI 75 at week 12 with combination C/BD topical therapy, and maintain PASI 75 through week 16 with apremilast monotherapy. J Drugs Dermatol. 2020;19(12): doi:10.36849/JDD.2020.5435. PMID: 33346509 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Tolerability of Six Months Indirect Cold (Physical) Plasma Treatment of the Scalp for Hair Loss.
Authors: Khan A, Malik S, Walia J, Fridman G, Fridman A, Friedman PC Abstract Androgenetic alopecia (AGA) is a chronic form of hair loss. Cold atmospheric (physical) plasma (CAP) is partly ionized gas with various widely researched effects on living tissues. CAP is an emerging treatment modality in dermatology with uses for chronic leg ulcer, actinic keratosis, warts, and other applications. Its previously demonstrated ability to induce stem cell differentiation in various cell types makes CAP a possible treatment option for AGA. Directly creating CAP on the scalp surface has drawbacks, but indirect CAP treatment&a...
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Oxytocin Levels Inversely Correlate With Skin Age Score and Solar Damage.
CONCLUSIONS: This study links previously published evidence of oxytocin’s protective role against inflammatory cytokine release in the skin with clinical evidence of OT levels correlating with SAS scores. Furthermore, it shows OT is likely inducing a protective function in the epidermis in the case of sun exposure and possibly with intrinsic aging. J Drugs Dermatol. 2020;19(12): doi:10.36849/JDD.2020.5063. PMID: 33346511 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

An Observational Study of the Application of a Topical Cannabinoid Gel on Sensitive Dry Skin.
Authors: Maghfour J, Rietcheck HR, Rundle CW, Runion TM, Jafri ZA, Dercon S, Lio P, Fernandez J, Fujita M, Dellavalle RP, Yardley H Abstract Atopic dermatitis (AD) is a chronic skin disorder characterized by pruritus, erythema and excoriation. While AD has a multifactorial etiology, neuro-signaling pathways are now recognized to play an essential role in the pathogenesis of AD, particularly pruritus. Neuromodulators, such as topical naltrexone, are being utilized in AD treatment. Another class of neuromodulator, Palmitoylethanolamide (PEA), has demonstrated effectiveness in the treatment of itch, excoriation and er...
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Update on Biotin Therapy in Dermatology: Time for a Change.
Authors: Lipner SR Abstract Biotin (vitamin B7 or H) is found in milk, nuts, egg yolks, cereals, supplements, synthesized by intestinal bacteria, and is required for gluconeogenesis, fatty acid synthesis and amino acid catabolism. PMID: 33346513 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Pinch Stitch: A Pearl for Suturing Wounds Under Tension.
Authors: Abstract Closing defects under tension in areas such as the scalp and back may be challenging during dermatologic surgery. Different techniques have been advocated to ease the placement of the first deep suture under tension, including the slip-knot stitch, pully stitch, horizontal mattress suture, pulley set-back dermal suture, and tandem pulley stitch. PMID: 33346514 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Racial Differences in Treatment Preferences of Acne Vulgaris: A Cross-Sectional Study.
The objective of this study was to determine how perception, treatment preferences, and treatment valuation of acne vulgaris vary across different races. This was a cross-sectional study run from June 2017–February 2018. Participants with self-identified acne completed a one-time 31 question online survey distributed through ResearchMatch (national research registry) and campus recruitment. 217 English-speaking participants with self-identified acne who were over 18 years-old attempted the survey, and 3 participants were excluded for failing to complete it. Response rate of this study was 10.5%. Compared to White...
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Hispanic/Latinos and Skincare: Disparities in Product Development, Marketing, and Toxicity.
Authors: Dow AA, Murphy MJ Abstract “Hispanic” and “Latino” (also known as Mestizo) describe a diverse racial and ethnic group, with a range of cultures, languages, and biological ancestry. It includes individuals of Mexican, Central-to-South American, and Spanish-Caribbean (eg, Cuban, Puerto Rican, and Dominican) descent.1 Individuals of Hispanic/Latino race and ethnicity represent a heterogenous group of people with different skin tones and Fitzpatrick phototypes. Hispanic/Latinos are the fastest growing population in the United States (US) - projected to increase from 55 m...
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Time Intervals Until the First Return Office Visit After New Medications.
CONCLUSIONS AND RELEVANCE: The time for a first return visit is frequently more than two months after a new medication is prescribed. Incorporating an earlier visit when prescribing a medication may be a means to improve adherence. J Drugs Dermatol. 2020;19(12): doi:10.36849/JDD.2020.5542. PMID: 33346517 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research