Who Is Accountable When Patients Do Not Achieve Successful Treatment for Their Acne?
Authors: Del Rosso JQ Abstract Acne vulgaris (AV) is a very common inflammatory facial disorder that is complex in its pathophysiology, heterogenous in clinical presentation, and affects children and adults of all ethnicities, races, and skin types. PMID: 29879246 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Clinical Experience With Once-Daily Dapsone Gel, 7.5% Monotherapy in Patients With Acne Vulgaris.
CONCLUSION: Photographs, dermatologist reports, and patient commentary in an office-based practice demonstrated that 12 weeks of treatment with only topical dapsone gel, 7.5%, applied once daily, was effective and well tolerated as a stand-alone treatment in 8 patients with facial acne vulgaris, with results that are consistent with the phase 3 pivotal trials. J Drugs Dermatol. 2018;17(6):602-608. PMID: 29879247 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Biologically Based Approach to Acne and Rosacea.
Authors: Kallis PJ, Price A, Dosal JR, Nichols AJ, Keri J Abstract Complementary and alternative medicine (CAM) therapies are increasing in popularity in the field of dermatology. Natural products and holistic approaches are in high demand among patients and research has begun to support their roles in acne and rosacea pathophysiology. In this article, commonly utilized biologically based complementary and alternative therapies for acne and rosacea are reviewed from an evidence-based perspective. Therapies discussed include vitamin C, nicotinamide, zinc, tea tree oil, green tea, resveratrol, curcumin, feverfew, lic...
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Clinically Relevant Reduction in Persistent Facial Erythema of Rosacea on the First Day of Treatment With Oxymetazoline Cream 1.0.
CONCLUSIONS: A ≥1-grade improvement in persistent erythema achieved after the first dose of once-daily topical oxymetazoline demonstrated clinically meaningful improvement from the beginning of therapy. J Drugs Dermatol. 2018;17(6):621-626. PMID: 29879249 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Frequency of Treatment Switching for Spironolactone Compared to Oral Tetracycline-Class Antibiotics for Women With Acne: A Retrospective Cohort Study 2010-2016.
CONCLUSIONS: Based on the observation of similar switching between the two groups, spironolactone may have similar clinical effectiveness to that of oral tetracycline-class antibiotics. While ultimately large clinical trials are needed to determine the optimal management strategy for women with moderate to severe acne, these results provide additional support that spironolactone represents an effective treatment for women with acne. J Drugs Dermatol. 2018;17(6):632-638. PMID: 29879250 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Efficacy and Safety of Azelaic Acid 15% Foam in the Treatment of Facial Acne Vulgaris.
CONCLUSION: Azelaic acid 15% foam is effective and safe in the treatment of facial acne vulgaris. Given the convenience of foam vehicles, azelaic acid 15% foam should be considered as a viable treatment option for this condition. J Drugs Dermatol. 2018;17(6):641-645. PMID: 29879251 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Expert Consensus on Achieving Optimal Outcomes With Absorbable Suspension Suture Technology for Tissue Repositioning and Facial Recontouring.
Authors: Lorenc ZP, Ablon G, Few J, Gold MH, Goldberg DJ, Mandy S, Nestor MS, Weinkle SH Abstract A complete approach to facial rejuvenation includes restoration of the skin's surface, relaxation of muscles that contribute to hyperkinetic movement, revolumization, and repositioning/recontouring of descended tissues and fat pads. After receiving 510(k) clearance from the US Food and Drug Administration (FDA) in 2015, the Silhouette InstaLift™ absorbable suspension suture became the only available non-surgical technique for repositioning of facial tissue. In January 2017, a consensus paper presented a review of...
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

From Probiotic to Prebiotic Using Thermal Spring Water.
CONCLUSIONS: Enhancement of skin microbiota diversity using topical LRP-TSW may offer a valuable option for the treatment and maintenance of inflammatory skin diseases. J Drugs Dermatol. 2018;17(6):657-662. THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL TEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEASE CONTACT THE PUBLISHER WITH ANY QUESTIONS.. PMID: 29879253 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Single-Center, Double-Blind, Randomized, Placebo-Controlled, Study of the Efficacy and Safety of a Cream Formulation for Improving Facial Wrinkles and Skin Quality.
CONCLUSION: Nimni Cream by Hydropeptide is safe and effective for improving skin quality in the face and can be considered a satisfactory therapeutic option adjuvant to aesthetic procedures. J Drugs Dermatol. 2018;17(6):664-669. PMID: 29879254 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Effect of an Anti-Inflammatory Botanical Cleanser/Night Mask Combination on Facial Redness Reduction.
Authors: Draelos ZD, Donald A Abstract Facial redness is a common difficult to control cosmetic problem representing various phases of rosacea. Using anti-inflammatory/antioxidant botanicals in moisturizer formulations is a possible approach to minimizing the erythema. This research utilized a common facial cleanser, but only applied the botanically based moisturizer to one half face to properly assess efficacy. 30 female subjects Fitzpatrick skin types I-IV 30-55 years of age with mild to moderate chronic facial redness, defined as a redness score of 3-6 on a 10-point scale, were enrolled. By the end of week 4, st...
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A National Survey of Medical Coding and Billing Training in United States Dermatology Residency Programs.
CONCLUSIONS: The majority of dermatology residents have opportunities to learn medical coding and billing through didactics and clinical experiences. Many residents were able to answer correctly questions that tested their basic knowledge of E&M coding. These results are encouraging and reflect the recognition of the importance of medical coding and billing training during residency. J Drugs Dermatol. 2018;17(6):678-682. PMID: 29879256 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Naturopathic Self-Treatment of an Atypical Fibroxanthoma: Lessons for Dermatologic Surgery.
CONCLUSION: For patients who desire to use alternative medicine, communication is all important. Integrative approaches to use traditional therapy while reconciling patient beliefs in natural medicine can improved oncologic, functional, and psychosocial outcomes. J Drugs Dermatol. 2018;17(6):683-685. PMID: 29879257 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Currently Constrained, Dermatologists Are Ready for New Acne Therapies.
Authors: Nagler AR Abstract Acne is the most common skin condition in the United States, affecting 50 million Americans annually. The disease's severity can range from mild to severe, with approximately 20% of people with acne experiencing moderate to severe disease. PMID: 29879258 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Beyond Traditional Treatment: The Importance of Psychosocial Therapy in Vitiligo.
Authors: Rzepecki AK, McLellan BN, Elbuluk N Abstract Vitiligo is an acquired depigmentation disorder of the skin. Patients with vitiligo often face a challenging disease course, having to cope with a condition that is known to be physically disfiguring, psychologically devastating, and socially stigmatizing. Although an extensive amount of research has been directed towards the dermatologic treatment of vitiligo, an overall lack of data exists investigating treatment of the psychological and emotional burden of patients with vitiligo. This paper reviews the literature for treatment options in patients with vitilig...
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Fifteen Minute Test May Save 15% or More on Rosacea Treatment.
Authors: Darwin E, Cervantes J, Lev-Tov H Abstract Rosacea is a common inflammatory skin condition that impacts a large portion of fair-skinned populations. The redness associated with rosacea can be a significant challenge. Brimonidine sulfate and oxymetazoline HCL were both recently approved by the FDA for the management of facial redness. These agents, however, are costly, and not all patients respond to the medication. Herein, we describe a clinical pearl that helps to optimize patient selection for the medications. This saves the patient and the health care system both time and money. J Drugs Dermatol. 2018;17...
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Vehicles Matter.
Authors: Kircik L Abstract Acne vulgaris (AV) is one of the most common diseases that we encounter in our clinics every day. PMID: 29879261 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Topical Vehicle Formulations in the Treatment of Acne.
This article will review the goals of topical therapy for the treatment of acne, in addition to common therapies and their challenges. Advanced formulations and combination formulations of benzoyl peroxide, clindamycin, and tretinoin will also be discussed. J Drugs Dermatol. 2018;17(6 Suppl):s6-10. PMID: 29879262 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 9, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Demographic and Tumor Characteristics of Patients Younger Than 50 Years With Nonmelanoma Skin Cancer Referred for Mohs Micrographic Surgery.
CONCLUSION: Patients
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Vismodegib and the Hedgehog Pathway Inhibitors: A Historical Perspective to Current Clinical Application.
Authors: Tang JC, Hanke CW, Caro I Abstract Vismodegib (Erivedge, Genentech-Roche) is the first in class of Hedgehog pathway inhibitors approved for treatment of metastatic basal cell carcinoma (BCC), or locally advanced BCC that has recurred after surgery or is not amenable to surgery or radiation. Its path to discovery has been unique and traces its origin to corn lilies, sheep, Drosophila flies, and the Hedgehog signaling pathway. J Drugs Dermatol. 2018;17(5):506-508. PMID: 29742180 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Retrospective Analysis of Complication Rates in Mohs Micrographic Surgery Patients With Clinically Large Tumors and Tumors With Aggressive Subclinical Extension.
CONCLUSION: Clinically, large tumors may be at higher risk for complications following MMS due to their increased size and need for repair with methods other than linear closures. Tumors with ASE were not found to be at higher risk for postoperative complications. J Drugs Dermatol. 2018;17(5):511-515. PMID: 29742181 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Dermatologist Practices During Total Body Skin Examinations: A Survey Study.
Authors: Rieder EA, Mu EW, Wang J, Cohen DE, Rigel DS, Stevenson ML Abstract Though screening for skin cancer is an essential practice in dermatology, limited data are published on dermatologists' total body skin examination (TBSE) behaviors. We surveyed 6500 dermatologists on their TBSE practices, including questions about less commonly examined body sites. We found varied TBSE practices among all dermatologists and discrepancies in examinations between dermatologists of opposite genders. J Drugs Dermatol. 2018;17(5):516-520. PMID: 29742182 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Facial Basal Cell Carcinoma in Patients Younger Than 40.
DISCUSSION: There may be underlying differences in the pathogenesis and natural history of basal cell carcinoma in the younger population, and between males and females; alternatively, lifestyle factors may also play a role. J Drugs Dermatol. 2018;17(5):525-530. PMID: 29742183 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Complex Regional Pain Syndrome: What the Dermatologist Should Know.
Authors: Qureshi AA, Friedman AJ Abstract Reflex sympathetic dystrophy is a subtype of complex regional pain syndrome, a condition characterized by persistent post-injury extremity pain. Temperature and sweating changes, edema, mobility changes, and a variety of hair, nail, and skin sequelae have been described. Only 23 articles published since 1990 describe dermatologic changes in CRPS. Given this paucity of literature, we present a case to further elucidate cutaneous manifestations of CRPS. Our patient is a 52-year-old Caucasian woman with a 19-year history of reflex sympathetic dystrophy who has presented with s...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Role of IL-17 in the Human Immune System and Its Blockage as a Treatment of Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis.
Authors: Jaller Char JJ, Jaller JA, Waibel JS, Bhanusali DG, Bhanusali N Abstract Interleukin 17 (IL-17) functions as a bridge between the innate and adaptive immunity. In addition to being a crucial defense mechanism against extracellular pathogens, it plays a significant role in inflammation, therefore considered a decisive factor in inflammatory conditions; hence the importance of its understanding for the treatment of autoimmune diseases. Animal models have demonstrated that blockage of the IL-17 receptor (IL-17R) may prevent these pathologies. For instance, there is evidence that IL-17R-deficient mice may be p...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Factors Affecting Dermatologists' Use of a 31-Gene Expression Profiling Test as an Adjunct for Predicting Metastatic Risk in Cutaneous Melanoma.
CONCLUSIONS AND RELEVANCE: Ulceration appears to be the most important factor impacting clinicians when deciding to order the 31-GEP test to assess risk for melanoma metastasis. J Drugs Dermatol. 2018;17(5):544-547. THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL TEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEASE CONTACT THE PUBLISHER WITH ANY QUESTIONS.. PMID: 29742186 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Degradation of Hylauronic Acid Fillers Using Hyaluronidase in an In Vivo Model.
DISCUSSION: This standardized animal model proved efficient in the study of in vivo degradation of HA fillers using injected hyaluronidase where products manufactured with different technologies were evaluated. J Drugs Dermatol. 2018;17(5):548-553. PMID: 29742187 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Chlorine Dioxide Complex Cleanser: A New Agent With Rapid Efficacy for Keratosis Pilaris.
Authors: Zirwas MJ, Fichtel J Abstract Chlorine dioxide complex™ is a new molecule to dermatology that is a unique, non-toxic, broad spectrum anti-microbial and keratolytic compound. Chlorine dioxide has been used as an antiseptic in industrial settings for decades, primarily in water treatment facilities for municipal water supplies and food preparation. The compound has exceptional antiseptic properties with no known potential for development of resistance. It is a true keratolytic and anti-inflammatory, but is non-toxic to human tissue due to its unique mechanism of action. Chlorine dioxide's use in consum...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Six-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self-Perceived Thinning Hair.
CONCLUSION: This nutraceutical supplement safely and effectively promoted hair growth in women with self-perceived thinning. It provides a multi-targeted therapeutic approach to hair loss by addressing micro-inflammation, stress, and oxidative damage with clinically tested, standardized, and bio-optimized phytoactive ingredients. ClinicalTrials.gov: NCT03206567 J Drugs Dermatol. 2018;17(5):558-565. PMID: 29742189 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Natural Cream-to-Powder Formulation Developed for the Prevention of Diaper Dermatitis in Diaper-Wearing Infants and Children: Barrier Property and In-Use Tolerance Studies.
Authors: Gunt HB, Levy SB, Lutrario CA Abstract INTRODUCTION: Diaper dermatitis is a common condition that develops in the diaper area due to factors such as elevated moisture, increased skin surface pH, and exposure to irritants from urine and feces. These factors suggest interventions to prevent or treat diaper dermatitis such as exposing the skin to air, frequent diaper changes, and thorough cleansing of the diaper area. Barrier creams and powders also have a role in preventing and treating diaper dermatitis. We developed a cream-to-powder product with a formula based on corn starch and other natural ingredients...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Gene Expression Analysis Differentiates Melanomas from Spitz Nevi.
In this study, we investigate gene expression patterns of pigmented lesions from FFPE tissue block samples (n=23, 9 male, 14 female patients, median age 12) with a focus on differentiating Spitz nevi from melanomas in children and young adults. RESULTS: PRAME levels were significantly (P less than 0.001) increased based on normalized Ct cycle counts (lower cycle counts indicate higher expression levels) in melanomas (mean Ct 33.83 + 0.54, 95% CI 32.85-34.80) when compared to Spitz nevi (mean Ct 37.21 + 0.98, 95% CI 35.41-39.01) or common nevi (mean Ct 36.94 + 0.80, 95% CI 35.47-38.40), respectively. LINC and 4 control ...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Chronic Nasolabial Fold Seborrheic Dermatitis Successfully Controlled With Crisaborole.
Authors: Liu D, Chow P, Strawn S, Rajpara A, Wang T, Aires D Abstract . PMID: 29742192 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Nodule Formation Following Treatment With Hyaluronic Acid Fillers: A Report of Two Challenging Cases.
Authors: Orseth ML, Lee N, Ibrahim O, Arndt KA, Kaminer M Abstract Nodule formation can be a potentially disfiguring adverse event of soft tissue fillers. Limited treatment consensus exists regarding the optimal approach for addressing recurrent and persistent nodules. Here we describe two challenging cases of nodules that developed following injection with Restylane and Juvéderm Voluma. We review suspected pathophysiology and discuss our treatment approach. J Drugs Dermatol. 2018;17(5):580-581. PMID: 29742193 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Widespread Skin Necrosis Secondary to Gemcitabine Therapy.
Authors: Zito PM, Gonzalez AM, Fox JD, Cronin M, Mackrides N, Kirsner RS, Nichols AJ Abstract Gemcitabine, a pyrimidine nucleoside analogue, is an oncologic agent used in the treatment of cutaneous T-cell lymphoma (CTCL). Common dermatologic reactions associated with gemcitabine include alopecia, mild skin rash, and mucositis but skin necrosis is exceptional. Herein we present an unusual case of widespread skin necrosis mimicking toxic epidermal necrolysis in a 45-year-old woman receiving gemcitabine therapy for stage IIIA cutaneous T-cell lymphoma. This is the first reported case of a TEN-like reaction subsequent ...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Longitudinal Melanonychia Biopsy: What Not to Do.
Authors: Ocampo-Garza J, Bretas JM, Matana D, Sobral PJ, Thompson CT, Zaiac M, Tosti A Abstract The nail matrix biopsy is an important technique in confirming or excluding a diagnosis of melanoma in a patient with longitudinal melanonychia. Dermatologists are the first-line diagnosticians for these pigmented lesions of the nail unit, however, for different reasons, some are reluctant to perform a nail biopsy. This case demonstrates how a poor biopsy technique resulted in a misdiagnosis in a patient with melanoma in situ. J Drugs Dermatol. 2018;17(5):587-588. PMID: 29742195 [PubMed - in process] (Source: Journal...
Source: Journal of Drugs in Dermatology - May 10, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

An Acne Survey from the World's Largest Annual Gathering of Twins.
CONCLUSIONS AND REVELANCE: This twin study further supports that there may be a genetic phenotypic link, though social and environmental factors may also have an influence in the disease process. J Drugs Dermatol. 2018;17(4):380-382.. PMID: 29601613 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Dihydroxyacetone: A Review.
Authors: Braunberger TL, Nahhas AF, Katz LM, Sadrieh N, Lim HW Abstract The sunless tanning industry has experienced rapid growth due to public education on the dangers of ultraviolet radiation on skin and improvements in products. Dihydroxyacetone (DHA) is a 3-carbon sugar allowed by the Food and Drug Administration (FDA) as a color additive in sunless tanning products. Bronzers, a product removed with soap and water, may also contain DHA. We aim to review the literature on DHA. DHA is intended for external application, not including the mucous membranes or in or around the eye area. DHA has been used in spray-tan...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Understanding Patient Experience With Hyperhidrosis: A National Survey of 1,985 Patients.
Authors: Glaser DA, Hebert A, Pieretti L, Pariser D Abstract Hyperhidrosis affects 4.8% of the US population, and despite the well documented negative impact of hyperhidrosis on patients' lives, data are generally lacking on the patient experience with this condition. The International Hyperhidrosis Society (IHHS) conducted a study in 2014, and initial results confirmed the multifaceted impact of hyperhidrosis on quality of life and underscored the need for disease awareness and effective management. To provide further insight into the hyperhidrosis patient experience, additional results focusing on family history,...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Frontal Fibrosing Alopecia and Concomitant Lichen Planus Pigmentosus: A Case Series of Seven African American Women.
Authors: Uwakwe LN, Cardwell LA, Dothard EH, Baroudi BI, McMichael AJ Abstract The association of frontal fibrosing alopecia (FFA) and lichen planus pigmentosus (LPPigm) is rare. Prior reports suggest that FFA and LPPigm are on the same spectrum of disease, and a diagnosis of LPPigm may predict the future development of FFA. We aim to further characterize the association between FFA and LPPigm by reviewing the clinical cases of seven African American women. Seven patients with FFA were diagnosed clinically by recession of frontotemporal hairline and confirmed by histopathologic examination showing lymphocyte-mediat...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Collagen Powder in Wound Healing.
This article critically reviews the current evidence for collagen powder as an adjunctive therapy for chronic wounds and presents indications, limitations, and principles of use. In general, there is a need for high quality studies and randomized control trials to support its use in clinical practice. J Drugs Dermatol. 2018;17(4):403-408.. PMID: 29601617 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Use of a Self-Occluding Topical Anasthetic in Daily Practice: A Non-Interventional Study.
CONCLUSION: Pliaglis was well-tolerated and provided adequate pain reduction prior to dermatological procedures. www.clinicaltrials.gov (NCT01800474). J Drugs Dermatol. 2018;17(4):413-418. Partial study data have been presented at the Anti-Aging Medicine European Congress (AMEC), Paris; October, 24-25, 2014, and the European Academy of Dermatology and Venereology (EADV), Istanbul; October 2-6, 2013.. PMID: 29601618 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Topical Agents for Scar Management: Are They Effective?
Authors: Zoumalan CI Abstract Scar formation is the body's natural healing response to reestablish dermal integrity following an injury. Excessive scarring, however, can cause significant cosmetic, functional, and psychological problems. A wide variety of topical creams, lotions, and oils are available for scar treatment or wound healing. Sieving through the options and selecting the best option for their patients can be challenging for clinicians, especially given that clinical evidence for many of the active agents in commonly used topical treatments is lacking. The goal of this review is to provide an overview o...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Multi-Center, Double-Blind, Vehicle-Controlled Clinical Trial of an Alpha and Beta Defensin-Containing Anti-Aging Skin Care Regimen With Clinical, Histopathologic, Immunohistochemical, Photographic, and Ultrasound Evaluation.
CONCLUSIONS: A 3-product skin care regimen containing alpha and beta defensins globally improves the visual appearance and structure of aging skin without irritation, dryness, or inflammation. Specifically, this regimen increases epidermal thickness, reduces appearance of pores, reduces wrinkles, and reduces melanin. This skin care regimen stimulates rejuvenation without evidence of increase of a marker of carcinogenic stimulation. This data is consistent with the hypothesis that a defensin-containing skin care regimen activates the body's own dormant stem cells to generate healthy new epidermal cells. J Drugs Dermatol. 20...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Prospective, Randomized, Investigator-Blinded, Split-Face Evaluation of a Topical Crosslinked Hyaluronic Acid Serum for Post-Procedural Improvement of Skin Quality and Biomechanical Attributes.
CONCLUSIONS: When initiated post-procedurally, topical RHA serum was well-tolerated and enhanced biomechanical properties, quality, and clinical appearance of the skin. Based on these data, RHA serum may be of value in improving patient outcomes and satisfaction following minimally invasive aesthetic procedures. The availability of the same hyaluronic acid technology also as a cohesive, tissue-integrating injectable filler enables synergistic, multi-level treatment plans to be devised. J Drugs Dermatol. 2018;17(4):442-450.. PMID: 29601621 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women.
CONCLUSION: Preliminary results on the use of topical FNS are limited, but safe and promising. Continued research into drug-delivery, ideal topical concentration and application frequency, side effects, and use for other alopecias will help to elucidate the full extent of topical FNS' use. J Drugs Dermatol. 2018;17(4):457-463.. PMID: 29601622 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Dynamic Changes of Facial Supporting Cornerstones (Pillars): Considerations in Aesthetic Approach.
Authors: Avelar LET, Cazerta CEP, Avè MN, Shitara DI Abstract The bony structures of the face provide the framework upon which the soft-tissue envelope rests, such that facial symmetry and proportionality usually depend upon the morphological patterns and anthropometrical measurements of a symmetrical skull. Facial bony pillars are dynamic and variable according to the demands placed upon them, as well as gender and aging differences. Thus, a more profound knowledge of facial supporting pillars and their dynamic behavior by physicians who practice minimally cosmetic procedures would allow for a more natural ...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Psoriasiform Pemphigus Foliaceus in an African American Female: An Important Clinical Manifestation.
Authors: Austin E, Millsop JW, Ely H, Jagdeo J, Schulman JM Abstract A 50-year-old African-American woman presented to the dermatology clinic with a pruritic eruption of 3 years' duration. On clinical examination, the patient had well-demarcated, pink, atrophic plaques and superficial erosions over the inframammary folds and mid-chest. She also had well-demarcated, hyperpigmented, hyperkeratotic scaly plaques over the abdomen, suprapubic region, elbows, knees, and back with sporadic small superficial blisters. A punch biopsy of the right abdomen was performed and revealed psoriasiform epidermal hyperplasia, focal p...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Proximal Subungual Onychomycosis in the Immunocompetent: A Case Report and Review of the Literature.
We present a case of a healthy 51-year-old man, who presented with a three-month history of white discoloration of multiple toenails. Physical examination revealed white, opaque patches on the proximal third nail plates of multiple toenails. The affected digits also demonstrated proximal onycholysis, subungual debris, and mild paronychia. Laboratory examinations, including routine serologic studies as well as human immunodeficiency virus and antinuclear antibodies, were within normal limits. Proximal nail fragments of the left hallux showed sections of dystrophic nail plate with mounds of parakeratosis, collections of neut...
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Successful Therapy of Severe Oro-Labial Herpes Simplex With Muco-Adhesive Acyclovir.
Authors: Rosen T Abstract Although muco-adhesive acyclovir 50mg tablets are only approved for the management of recurrent oro-labial HSV-1 infections, their ability to achieve extremely high concentrations in saliva and oral tissues suggests the potential for other uses. In this case, the agent was successfully utilized as a single tablet monotherapy leading to rapid clinical resolution of severe post-operative oro-labial infection. J Drugs Dermatol. 2018;17(4):479-480.. PMID: 29601626 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Dermatology on Instagram: An Analysis of Hashtags.
Authors: Park JH, Christman MP, Linos E, Rieder EA Abstract Forty-two percent of Americans search for health-related information on social media platforms, and forty-five percent of consumers report that social media health information influences their decision to seek care. PMID: 29601627 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Controversy: Mohs and Close.
Authors: Sarnoff DS, Gotkin RH Abstract . PMID: 29601628 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 31, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research