Dermatologists' Perspectives on Biosimilars
Conclusion: Biosimilars are safe and effective for treating approved dermatological conditions and may lower patient costs compared to their reference products. Patients are not always offered biosimilar therapy as an option, which may be due to unfamiliarity among dermatologists. This survey suggests a need for more research and educational initiatives, such as modules and workshops that focus on biosimilar safety, efficacy, and interchangeability guidelines. J Drugs Dermatol. 2024;23(4):doi:10.36849/JDD.7755.PMID:38564397 | DOI:10.36849/JDD.7755 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Priscila Arellano Zameza Christina Kontzias Keith Flanders Peter Sonnenreich Steven R Feldman Source Type: research
Expression of IL-4 in Tumors: A Safety Surrogate to Predict Cancer Survival Associated With Biologic Therapies
J Drugs Dermatol. 2024 Apr 1;23(4):e118-e119. doi: 10.36849/JDD.7941.NO ABSTRACTPMID:38564398 | DOI:10.36849/JDD.7941 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Nikolai Klebanov Carly Grant Jeffrey S Smith Lourdes M Perez-Chada Joseph F Merola Source Type: research
Treatments for Moderate-to-Severe Acne Vulgaris: A Systematic Review and Network Meta-analysis
CONCLUSIONS: Based on this SLR/NMA, topical triple-agent FDC gel was the most efficacious and safe treatment for moderate-to-severe acne. J Drugs Dermatol. 2024;23(4): doi:10.36849/JDD.8148.PMID:38564399 | DOI:10.36849/JDD.8148 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Julie C Harper Hilary Baldwin Saswata Paul Choudhury Deepti Rai Bikramaditya Ghosh Md Sohai Aman Abhra R Choudhury Sekhar Kumar Dutta Debalina Dey Subrata Bhattacharyya Tina Lin George Joseph Ankur A Dashputre Jerry K L Tan Source Type: research
A Practical Algorithm Integrating Skin Care With Nonenergy and Injectable Dermatologic Procedures to Improve Patient Outcomes and Satisfaction
CONCLUSION: Nonenergy and injectable procedures combined with skin care or topical treatments may improve outcomes and patient satisfaction. Topical antioxidants and free radical quenchers can combat photodamage and may offer a safe alternative to topical hydroquinone. J Drugs Dermatol. 2024;23(4): doi:10.36849/JDD.7918.PMID:38564400 | DOI:10.36849/JDD.7918 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Edward Lain Anneke Andriessen Valeria Barreto Campos Sabrina Guillen Fabi Lisa Ginn Ariel Haus Valerie M Harvey Jean-Fran çois Tremblay Source Type: research
Aesthetic Improvement With Topical Body Skin Treatment as a Complement to Cryolipolysis
Conclusion: This pilot study suggests that FTB may complement skin improvements seen post-NIBC.J Drugs Dermatol. 2024;23(4): doi:10.36849/JDD.7917.PMID:38564401 | DOI:10.36849/JDD.7917 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Craig Teller Harmony Saqr Elizabeth Makino Priscilla Huang Rahul Mehta Source Type: research
Human Clinical Trials Using Topical Bakuchiol Formulations for the Treatment of Skin Disorders: A Systematic Review
Conclusion: Trials lack methodologic rigor, which introduces a high risk of bias in reported outcomes. The use of combination topical formulations containing bakuchiol limits the comparison of bakuchiol’s efficacy with retinoids. Continued research with an improved trial design is needed.J Drugs Dermatol. 2024;23(4): doi:10.36849/JDD.7763.PMID:38564402 | DOI:10.36849/JDD.7763 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: James E Fanning Shayan A McGee Omer I Ibrahim Source Type: research
The Two-Stage Folded Paramedian Forehead Flap Without Cartilage Grafts for Full Thickness Distal Nasal Defects: A Review of 35 Patients
CONCLUSION: The two-stage FPFF without cartilage grafts is a reliable, cosmetically elegant repair that can provide optimal functional and aesthetic results for complex unilateral distal nose defects.J Drugs Dermatol. 2024;23(4): doi:10.36849/JDD.7358.PMID:38564403 | DOI:10.36849/JDD.7358 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Brett C Neill Brett Shaffer Spyros M Siscos Edward W Seger Stanislav N Tolkachjov Thomas L H Hocker Source Type: research
INDIVIDUAL ARTICLE: Update on Combined Topical Products for Treating Acne: Leaping From Dyads
This article discusses formulation strategies that allow for the coadministration of active drugs and reviews all commercially available fixed-combination topical acne treatments. J Drugs Dermatol. 2024;23:4(Suppl 2):s4-10.PMID:38564404 | DOI:10.36849/JDD.SF378083b (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Naiem T Issa Leon Kircik Source Type: research
INDIVIDUAL ARTICLE: Sugar Sag: What Is Skin Glycation and How Do You Combat It?
J Drugs Dermatol. 2024 Apr 1;23(4):SF378083s5-SF378083s10. doi: 10.36849/JDD.SF378083.ABSTRACTSkin aging is influenced by various exogenous and endogenous factors, ranging from ultraviolet (UV) light exposure and environmental toxins to biological sources, such as those that arise from normal metabolic processes (eg, free radicals). Glycation is the normal process by which glucose and other reducing sugars react with proteins to form an array of heterogeneous biomolecular structures known as advanced glycation end-products (AGEs) over time. However, AGEs are toxic to human cells and are implicated in the acceleration of in...
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Zoe Diana Draelos Source Type: research
Topical Human Mesenchymal Stem Cell-Derived Exosomes for Acceleration of Wound Healing Following Tissue Trauma and Aesthetic Procedures: A Case Series
J Drugs Dermatol. 2024 Apr 1;23(4):281-284. doi: 10.36849/JDD.C7395.ABSTRACTIn the aesthetics practice, measures to accelerate wound healing and minimize downtime following procedures have been largely restricted to topical serums and platelet-rich plasma (PRP), which can have varying levels of success. Here, the authors present a case series of patients treated in clinical practice with cell-free exosomes derived from human placental mesenchymal stem cells (Exovex, Exocelbio, Doylestown, PA). Topical administration of exosomes after either aesthetic treatment or traumatic injury (a dog bite) had a marked effect on healing...
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Marina Peredo Shanthala Shivananjappa Source Type: research
Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis
CONCLUSIONS: This pooled analysis of 6 vehicle-controlled clinical studies provides new evidence for the efficacy of 0.1% stabilized bioactive retinol in improving signs of photoaging without causing major irritation. Topical 0.1% stabilized bioactive retinol was well tolerated with only a few reported cases of skin irritation. J Drugs Dermatol. 2024;23(4): doi:10.36849/JDD.8124.PMID:38564380 | DOI:10.36849/JDD.8124 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Patricia Farris Diane Berson Neal Bhatia David Goldberg Edward Lain Kavita Mariwalla Joshua Zeichner Dara Miller Tony McGuire Menas Kizoulis Source Type: research
Functional and Cutaneous Treatment Outcomes With Intravenous Immunoglobulin for Eosinophilic Fasciitis: A Retrospective Study
CONCLUSION: Adverse effects of IVIG included headaches in 1 patient (14.3%) and rash in 2 patients (28.6%). There were no reported veno-occlusive or thromboembolic events associated with IVIG. J Drugs Dermatol. 2024;23(4):8017. doi:10.36849/JDD.8017e.PMID:38564381 | DOI:10.36849/JDD.8017 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Bianca Obiakor Winnie Fan Rebecca Jacobson Jocelyn Gandelman Anna Haemel Source Type: research
Molecular Insights Into the Effects of PLLA-SCA on Gene Expression and Collagen Synthesis in Human 3D Skin Models Containing Macrophages
J Drugs Dermatol. 2024 Apr 1;23(4):285-288. doi: 10.36849/JDD.7791.ABSTRACTInjectable poly-L-lactic acid (PLLA-SCA) is used for the correction of shallow to deep nasolabial fold contour deficiencies, cheek wrinkles, and other facial wrinkles. In contrast to hyaluronan (HA) fillers, PLLA-SCA has a biostimulatory effect by activating resident fibroblasts to produce collagen, but the mechanisms are not known in detail at the molecular level. Therefore, our aim was to investigate the molecular effects of PLLA-SCA in a comprehensive in vitro study. Since PLLA-SCA-dependent collagen production in fibroblasts depends on the inter...
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Sebastian Huth Laura Huth Yvonne Marquardt Manuela Jansen Cheng Lin Matthias Bartneck Jens Malte Baron Source Type: research
Mitogen-Activated Protein Kinase Inhibitor-Induced Inflammatory Alopecia in Woman With Ovarian Cancer
J Drugs Dermatol. 2024 Apr 1;23(4):e102-e103. doi: 10.36849/JDD.7802.ABSTRACTInflammatory alopecia is an increasingly reported side effect of targeted cancer therapies. Here we report one case of inflammatory alopecia secondary to mitogen-activated protein kinase kinase (MEK) inhibitor agent Trametinib in a woman with ovarian cancer. Biopsies of the scalp were consistent with early scarring alopecia compatible with drug-induced alopecia. Significant improvement in hair loss occurred after treatment with intralesional Kenalog (ILK) injections and oral isotretinoin. Though acute alopecia has been described in patients using ...
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Lucy Rose Abena Minta Jose Plaza David E Cohn Brittany Dulmage Source Type: research
Oral Lichen Planus Successfully Treated With Upadacitinib
J Drugs Dermatol. 2024 Apr 1;23(4):e104-e106. doi: 10.36849/JDD.7859.ABSTRACTWith the rise of Janus kinase (JAK) and Signal Transducer and Activator of Transcription (STAT) inhibitor use in dermatologic conditions, there has been increasing hope in treating extensive and difficult-to-treat inflammatory cutaneous conditions. Today we report a case of oral lichen planus successfully treated with an oral JAK1 inhibitor, upadacitinib. This case had been unresponsive by several standard methods but responded with 70% improvement within 1 month when treated with upadacitinib. J Drugs Dermatol. 2024;23(4):7859. ...
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Kristin Slater Katelyn Halash Francisca Kartono Source Type: research
