Remifentanil does not inhibit sugammadex reversal after rocuronium-induced neuromuscular block in the isolated hemidiaphragm of the rat: an ex vivo study
ConclusionClinical concentration of remifentanil does not inhibit sugammadex reversal after rocuronium-induced neuromuscular block. Sugammadex can be used safely without worrying about the interaction with remifentanil. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - September 18, 2019 Category: Anesthesiology Source Type: research

Medical cannabis for chronic pain: can it make a difference in pain management?
AbstractGlobally, chronic pain is a major therapeutic challenge and affects more than 15% of the population. As patients with painful terminal diseases may face unbearable pain, there is a need for more potent analgesics. Although opioid-based therapeutic agents received attention to manage severe pain, their adverse drug effects and mortality rate associated with opioids overdose are the major concerns. Evidences from clinical trials showed therapeutic benefits of cannabis, especially delta-9-tetrahydrocannabinol and cannabinoids reduced neuropathic pain intensity in various conditions. Also, there are reports on using co...
Source: Journal of Anesthesia - September 18, 2019 Category: Anesthesiology Source Type: research

Association between treatment-related early changes in psychological factors and development of postherpetic neuralgia
ConclusionCatastrophizing was associated with acute pain intensity, and lower pain-related catastrophizing among patients with acute herpes zoster was associated with less risk of PHN development, independent of acute pain intensity. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - September 11, 2019 Category: Anesthesiology Source Type: research

Response on: predictive performance of transcranial Doppler for post-dural puncture headache
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - September 4, 2019 Category: Anesthesiology Source Type: research

Predictive performance of transcranial Doppler for PDPH
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - September 3, 2019 Category: Anesthesiology Source Type: research

Lipid emulsion, but not propofol, induces skeletal muscle damage and lipid peroxidation
ConclusionLipofundin induces skeletal muscle damage via lipid peroxidation, and 1% propofol (Maruishi) conversely suppresses the muscle damage via antioxidant effects. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - August 31, 2019 Category: Anesthesiology Source Type: research

Use of a curved needle to facilitate lateral sagittal infraclavicular block performance: a randomized clinical trial
ConclusionThe use of a curved needle reduces the time required to perform the lateral sagittal infraclavicular block. The curved needle provides less procedure pain and higher satisfaction levels among anesthetists than the non-curved needle.Trial registrationThe trial was registered (04/26/2016) with the ClinicalTrials.gov ID: NCT02799576. Approval Number: #2543. Board Name: Research Ethics Committee. Board Affiliation: Suez Canal University, Faculty of Medicine, Suez Canal University hospital, Ismailia, Egypt, 41522. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - August 29, 2019 Category: Anesthesiology Source Type: research

Pre-anesthetic ultrasonographic assessment of the internal jugular vein for prediction of hypotension during the induction of general anesthesia
ConclusionIJV-A in the Trendelenburg position was an independent predictor of hypotension during induction. Further study is required to examine the diagnostic accuracy of IJV-A as a predictor for hypotension during induction. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - August 26, 2019 Category: Anesthesiology Source Type: research

Rocuronium Bromide Intravenous Solution Maruishi ® is more suitable than ESLAX Intravenous® during rapid-sequence induction of anesthesia
ConclusionCompared with rocuronium MSD, rocuronium Maruishi is more suitable than conventional rocuronium formulations, for rapid-sequence induction of anesthesia. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - August 21, 2019 Category: Anesthesiology Source Type: research

Effects of the nontourniquet combined with controlled hypotension technique on pain and long-term prognosis in elderly patients after total knee arthroplasty: a randomized controlled study
ConclusionThe nontourniquet combined with controlled hypotension technique can alleviate chronic pain and promote the long-term rehabilitation of patients after TKA. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - August 19, 2019 Category: Anesthesiology Source Type: research

Resting pupil size is a predictor of hypotension after induction of general anesthesia
ConclusionMeasurement of maximum pupil size is useful to identify patients at risk for intraoperative hypotension. The influence of age must be considered during measurement of the pupil response.Clinical trial numberUMIN000023729Registry URLhttps://www.umin.ac.jp (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - August 17, 2019 Category: Anesthesiology Source Type: research

Response to letter to the editor
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - August 16, 2019 Category: Anesthesiology Source Type: research

Hypnotic potency differs between desflurane and sevoflurane
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - August 14, 2019 Category: Anesthesiology Source Type: research

Relationship between changes in regional cerebral blood volume and oxygenation and changes in cardiac output and systemic vascular resistance during spinal anesthesia in women undergoing cesarean section
We examined the relationships between changes in the systemic circulatory parameters, cardiac output (CO) and systemic vascular resistance (SVR), and rCBV and rCBO after induction of spinal anesthesia, evaluated by near-infrared spectroscopy (NIRS) and an arterial pressure-based cardiac output monitoring system (APCOs).MethodsSeventeen patients undergoing elective cesarean section under spinal anesthesia were monitored every 1  min for mean arterial pressure (MAP), heart rate (HR), end-tidal carbon dioxide (EtCO2) and oxygen saturation (SpO2), and at 20  s intervals for CO, SVR, concentrations of oxy-hemoglobin (...
Source: Journal of Anesthesia - August 7, 2019 Category: Anesthesiology Source Type: research

Propofol inhibits the local activity and connectivity of nuclei in the cortico-reticulo-thalamic loop in rats
ConclusionsThe cortex rather than the subcortical structures, and the cortex –subcortical connectivity instead of subcortical connectivity might be the more vulnerable targets of propofol during anesthesia. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - July 30, 2019 Category: Anesthesiology Source Type: research

Cerebral oxygenation in hemodialysed patients
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - July 23, 2019 Category: Anesthesiology Source Type: research

Phospholipase C-related inactive protein type-1 deficiency affects anesthetic electroencephalogram activity induced by propofol and etomidate in mice
ConclusionsThe lack of PRIP-1 disrupted the EEG power distribution, but did not affect the depth of anesthesia after etomidate administration. Our analyses suggest that PRIP-1 is differentially involved in anesthetic EEG activity with the regulation of GABAA-R activity. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - July 22, 2019 Category: Anesthesiology Source Type: research

A laser mount probe holder facilitates fixation of the optimized ultrasound image and needle alignment in-plane to the ultrasound beam during ultrasound-guided peripheral nerve block
AbstractLaser guidance facilitates needle alignment in-plane to the ultrasound beam. Once the ultrasound image is optimized, there is no further need to maneuver the probe. Therefore, we designed a laser mount probe holder prototype, and examined the ease of visualization of the needle tip using the laser mount probe holder. The needle brightness was quantitatively measured using an image analysis software. We found that the laser mount probe holder is useful, not only to visualize the needle tip in the ultrasound plane, but also to fix the best ultrasound image. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - July 19, 2019 Category: Anesthesiology Source Type: research

Response to letter to the editor
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - July 19, 2019 Category: Anesthesiology Source Type: research

Isoflurane induces c-Fos expression in the area postrema of the rat
ConclusionOverall, these results suggest that isoflurane activates AP neurons and may be involved in the emetic mechanism of isoflurane. This study further suggests the feasibility of using rats as a model for studying emetic mechanisms of drugs, despite their lack of vomit action. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - July 17, 2019 Category: Anesthesiology Source Type: research

Smoking is associated with greater pain intensity and pain-related occupational disability in Japanese workers
ConclusionSmoking and pain were associated with pain-related occupational disability, partially through greater pain intensity, among Japanese workers. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - July 5, 2019 Category: Anesthesiology Source Type: research

Preoperative management and postoperative delirium
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - July 4, 2019 Category: Anesthesiology Source Type: research

The effects of transmuscular quadratus lumborum blocks on postoperative pain in arthroscopic hip surgery: a cohort analysis
ConclusionThe present study did not find the preoperative TQLB to be an effective analgesic technique for patients who underwent arthroscopic hip surgery for FAI. A randomized clinical trial may further validate these results. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - July 1, 2019 Category: Anesthesiology Source Type: research

Measuring suction pressure via a scavenging system
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - June 24, 2019 Category: Anesthesiology Source Type: research

Comparison between hemodynamic effects of propofol and thiopental during general anesthesia induction with remifentanil infusion: a double-blind, age-stratified, randomized study
ConclusionsThiopental is a more suitable agent than propofol for avoiding hypotension during GA induction under remifentanil infusion in the middle and elderly patients. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - June 21, 2019 Category: Anesthesiology Source Type: research

Preoperative sleep disruption and postoperative functional disability in lung surgery patients: a prospective observational study
ConclusionsOur results showed a high prevalence of acute sleep disturbance. Patients with acute sleep disruption had low postoperative sleep efficiency and impaired functional ability three months after surgery. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - June 12, 2019 Category: Anesthesiology Source Type: research

Presser point of chest compression by non-medical personnel
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - May 22, 2019 Category: Anesthesiology Source Type: research

Neuroprotective effects of neurotropin in a mouse model of hypoxic –ischemic brain injury
AbstractPurposeIschemic –hypoxic insult leads to detrimental effects on multiple organs. The brain is especially vulnerable, and it is hard to regenerate once damaged. Currently, therapeutic options are very limited. Previous studies have reported neuroprotective effects of neurotropin, a non-protein extract derived from the inflamed skin of rabbits inoculated with vaccinia virus, using a murine model of peripheral nerve injury and cultured cell lines. However, whether neurotropin might have protective effects against brain injuries remains unclear. We, therefore, investigated the neuroprotective effect of neurotro p...
Source: Journal of Anesthesia - May 21, 2019 Category: Anesthesiology Source Type: research

Perioperative point of care ultrasound in pediatric anesthesiology: a case series highlighting real-time intraoperative diagnosis and alteration of management augmenting physical examination
AbstractUse of diagnostic point of care ultrasound, has come to the forefront of interest within anesthesiology. Much data on the use of point of care ultrasound in emergency medicine and critical care medicine for diagnosis and treatment in acute situations exists. While use of point of care ultrasound has become more prevalent in anesthesia practice, documentation of its use and especially alteration in management based on real-time ultrasound findings in the perioperative period remains scarce. This case series discusses six pediatric patients in which real-time intra-operative use of point of care ultrasound resulted i...
Source: Journal of Anesthesia - May 10, 2019 Category: Anesthesiology Source Type: research

Infraclavicular brachial plexus block in adults: a comprehensive review based on a unified nomenclature system
AbstractOver the last decade, considerable progress has been made regarding infraclavicular brachial plexus block (ICB) in adults, especially since the introduction of ultrasound guidance. The advancements in ICB have been attributed to the development of various approaches to improve the success rate and reduce complications. This has also necessitated a unified nomenclature system to facilitate comparison among different approaches. This review aimed to propose an anatomical nomenclature system by classifying ICB approaches into proximal and distal ones to aid future research and provide practice advisories according to ...
Source: Journal of Anesthesia - May 10, 2019 Category: Anesthesiology Source Type: research

Transcranial Doppler role in prediction of post-dural puncture headache in parturients undergoing elective cesarean section: prospective observational study
This study was performed to investigate if TCD can be used to predict the occurrence of PDPH in high-risk patients.MethodsThis prospective observational study was conducted on ninety ASA I and II pregnant females undergoing elective cesarean section (CS) under spinal anesthesia. TCD was performed to all patients within 24  h before the operation, at 24 h and 48 h in the post-operative period to measure mean velocity (MV) and Gosling pulsatility index (PI) in the right middle cerebral artery. For 5 days postoperatively, all patients were assessed and the PDPH patients were identified, their pre- and post...
Source: Journal of Anesthesia - May 9, 2019 Category: Anesthesiology Source Type: research

Fascial plane blocks: anatomical structures that affect the spread of local anesthetic
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - May 9, 2019 Category: Anesthesiology Source Type: research

Perioperative management of patients with atrial fibrillation receiving anticoagulant therapy
AbstractThe number of patients with atrial fibrillation (AF) and the number of patients indicated for anticoagulant therapy have been increasing because AF would affect patient survival due to thromboembolism. Once AF develops, following the disappearance of pulsation, the circumstances within the atrium become prothrombotic and thrombus formation within the left atrium occurs in patients with AF. In recent years, not only warfarin but also new oral anticoagulants were introduced clinically and have become used as oral anticoagulants. In the perioperative period, the risk of major hemorrhage needs to be reduced. On the oth...
Source: Journal of Anesthesia - May 8, 2019 Category: Anesthesiology Source Type: research

Post-surgical immune suppression: another target to improve postoperative outcomes
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - May 6, 2019 Category: Anesthesiology Source Type: research

Near-infrared spectroscopy underestimates cerebral oxygenation in hemodialysis patients
This study included 113 patients (7 HD patients and 106 non-HD ones) undergoing cardiac or major aortic surgery between December 2015 and November 2017. We evaluated the validity of rSO2 by comparing it with ipsilateral jugular venous oxygen saturation (SjvO2). In HD and non-HD patients, rSO2 and SjvO2 showed a weak correlation (R2: 0.46 and 0.28 in HD and non-HD patients, respectively). Bland –Altman analysis revealed that bias (95% limits of agreement) of rSO2 compared to SjvO2 was  − 19.2% ( − 41.7–3.3%) in HD patients and − 1.9% (− 19....
Source: Journal of Anesthesia - May 6, 2019 Category: Anesthesiology Source Type: research

Sevoflurane has postconditioning as well as preconditioning properties against hepatic warm ischemia –reperfusion injury in rats
ConclusionPostC and PreC by sevoflurane at a clinically applicable dose have equally protective effects against hepatic IR injury by increasing HO-1 expression. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - May 3, 2019 Category: Anesthesiology Source Type: research

Local anesthetic systemic toxicity: proposed mechanisms for lipid resuscitation and methods of prevention
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - May 3, 2019 Category: Anesthesiology Source Type: research

Acute and long-term effects of haloperidol on surgery-induced neuroinflammation and cognitive deficits in aged rats
ConclusionOur findings indicate that perioperative administration with HAL may have no effects on postoperative neuroinflammation and related cognitive impairment. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - May 2, 2019 Category: Anesthesiology Source Type: research

Morphine inhibits cell viability and growth via suppression of  vascular endothelial growth factor in human oral cancer HSC-3 cells
ConclusionsOur results suggest that in human oral cancer HSC-3 cells, morphine exposure inhibits cell viability and growth via suppression of VEGF in clinical conditions. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - May 2, 2019 Category: Anesthesiology Source Type: research

Intraoperative hemorrhage in revision total hip arthroplasty: a retrospective single-center study
AbstractPurposeThe amount of intraoperative hemorrhages and factors associated with hemorrhages and transfusions during revision total hip arthroplasty (reTHA) have not been identified for Japanese patients. We aimed to clarify the amount of intraoperative hemorrhages, and to elucidate the factors associated with hemorrhages and transfusions during reTHA in Japanese patients.MethodsWe retrospectively reviewed patients who underwent reTHA (n = 48) and primary total hip arthroplasty (pTHA) (n = 615) in a single hospital and extracted data regarding hemorrhage, transfusion, patient comorbidities, a...
Source: Journal of Anesthesia - April 29, 2019 Category: Anesthesiology Source Type: research

The efficacy and safety of prophylactic use of levosimendan on patients undergoing coronary artery bypass graft: a systematic review and meta-analysis
AbstractProphylactic use of levosimendan in cardiac surgery remains controversial and no meta-analysis has been done exclusively about that in patients undergoing coronary artery bypass graft (CABG) surgery. We conducted this systematic review and meta-analysis of levosimendan in CABG using PubMed, Embase, Scopus, and Cochrane Library (till April 20, 2018). Two-hundred and forty manuscripts were identified and 21 randomized trials (1727 patients in total) investigating the effect of levosimendan on the patients undergoing CABG surgery were finally included in this analysis. We found that levosimendan was an effective, well...
Source: Journal of Anesthesia - April 25, 2019 Category: Anesthesiology Source Type: research

Population pharmacokinetics of palonosetron and model-based assessment of dosing strategies
ConclusionLBW-based dosing might be suitable for high-weight patients to avoid possible underdosing. Nevertheless, the current fixed dosing of palonosetron is acceptable for adult patients with normal weight. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - April 11, 2019 Category: Anesthesiology Source Type: research

Characterizing the spectrum of body mass index associated with severe postoperative pulmonary complications in children
ConclusionOverweight pediatric patients have an elevated, previously underappreciated risk of severe PPCs. Contrary to prior studies, the present study found no greater risk in obese children, perhaps due to bias, confounding, or practice migration from “availability bias”. Findings from the present study, taken with prior work describing pulmonary risks of obesity, suggest that both obese and overweight children may be evaluated for tailored perioperative care to improve outcomes. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - April 11, 2019 Category: Anesthesiology Source Type: research

Sleep science in anesthesiology
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - April 6, 2019 Category: Anesthesiology Source Type: research

Three versus five lumbar PVB injections for herniorrhaphy
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - April 5, 2019 Category: Anesthesiology Source Type: research

Response to letter to the editor
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - April 5, 2019 Category: Anesthesiology Source Type: research

Dexmedetomidine and clinical outcomes of non-cardiac surgery
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - April 4, 2019 Category: Anesthesiology Source Type: research

Association of perioperative weight-based fluid balance with 30-day mortality and acute kidney injury among patients in the surgical intensive care unit
This study evaluated the associations of perioperative fluid balance (FB) with 30-day mortality and acute kidney injury (AKI) after postoperative intensive care unit (ICU) admission.MethodsThis retrospective study evaluated data from adult patients who were admitted to the ICU after surgery during 2012 –2016. Weight-based cumulative FB (%) was calculated for 3 time periods [postoperative day (POD) 0 (24 h), 0–1 (48 h), and 0–2 (72 h)] and was categorized as positive (≥ 5%), mild to moderate positive (5–10%), severe positive (>  10%), normal (0–5%), or negative (
Source: Journal of Anesthesia - March 27, 2019 Category: Anesthesiology Source Type: research

Acute postoperative pain exacerbates neuroinflammation and related delirium-like cognitive dysfunction in rats
AbstractThe acute neuroinflammatory response to surgery may play a key pathogenic role in postoperative delirium (POD). Here, we investigated the contribution of acute postoperative pain to neuroinflammation and related delirium-like behaviors after surgery in adult and aged rats. Animals were assigned into four groups: control, abdominal surgery, surgery with analgesia using local ropivacaine, and surgery with analgesia using systemic morphine. Pain was assessed by the Rat Grimace Scale (RGS). Trace and context memory retention was evaluated following trace fear conditioning during the first 2 days after surgery. Pro-infl...
Source: Journal of Anesthesia - March 25, 2019 Category: Anesthesiology Source Type: research