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In reply: Is sugammadex alone enough to cause anaphylaxis?
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 19, 2018 Category: Anesthesiology Source Type: research

Correction to: Attenuation of cortical activity triggering descending pain inhibition in chronic low back pain patients: a functional magnetic resonance imaging study
AbstractInadvertently, the Fig.  7 was published incorrectly in the original publication of the article. The correct figure should be as below: (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 19, 2018 Category: Anesthesiology Source Type: research

Complex issues in new ultrasound-guided nerve blocks: how to name, where to inject, and how to publish
AbstractThe recent development of ultrasound-guide nerve block has led to innovation in anesthesia and pain clinics. However, it has also led to some complex issues, including (1) how to name a new technique, (2) the appropriateness of an intramuscular approach, and (3) how to publicize a new technique. This review addresses naming strategy, feasibility of intramuscular approach block, and methods of publication. First, researchers and authors should pay attention to appropriate nomenclature for the term ‘approach’, ‘compartment block’, and ‘nerve block’ for a new block. Second, it is la...
Source: Journal of Anesthesia - January 18, 2018 Category: Anesthesiology Source Type: research

Impact of intervention time on hospital survival in patients requiring emergent airway management: a preliminary study
This study aimed at determining the impact of the time of ETI on hospital survival in critically ill patients.MethodsBetween January 2014 and December 2016, 151 patients who underwent emergency tracheal intubation (ETI) by the airway response team (ART) in the general wards of a tertiary referral center were retrospectively reviewed. Patients were divided into two groups based on the time of ETI (daytime group, 8:00 a.m. –4:00 p.m.,n = 57, mean age 63.5 ± 14.1 years; nighttime group, 4:00 p.m.–8:00 a.m.,n = 94, mean age 60.4 ± 14.9 years). Data reg...
Source: Journal of Anesthesia - January 18, 2018 Category: Anesthesiology Source Type: research

Genetic and functional analysis of the RYR1 mutation p.Thr84Met revealed a susceptibility to malignant hyperthermia
AbstractPurposeThe aim of this study was to analyze the genetic and functional role of a novel RYR1 variant c.251 C  >  T (p.Thr84Met) identified in a patient with muscle weakness demonstrating MH susceptibility.MethodsDNA testing of family members was conducted for assessment of pathogenicity of the genetic variant. For functional analysis, Ca2+ measurement using patient-derived myotubes and p.Thr84Met RYR1-transfected human embryonic kidney (HEK)-293 cells was performed to evaluate reactivity to RYR1 activators. The half-maximal effective concentration (EC50) values of two RYR1 activators, caffeine and 4-chl...
Source: Journal of Anesthesia - January 17, 2018 Category: Anesthesiology Source Type: research

Neurological prognosis of 6 cases after chest compression during general anesthesia
ConclusionEven if the patients were monitored and immediately managed under GA, ineffective management of preoperative conditions tended to result in the poor neurological prognosis. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 15, 2018 Category: Anesthesiology Source Type: research

Is sugammadex alone sufficient to cause anaphylaxis?
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 15, 2018 Category: Anesthesiology Source Type: research

Vasoactive-inotropic score as a predictor of morbidity and mortality in adults after cardiac surgery with cardiopulmonary bypass
ConclusionsThe amount of cardiovascular support at the end of cardiac surgery may predict morbidity and mortality in adults. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 13, 2018 Category: Anesthesiology Source Type: research

Mallory –Weiss syndrome diagnosed after tracheal extubation
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 13, 2018 Category: Anesthesiology Source Type: research

Changes in tissue and cerebral oxygenation following spinal anesthesia in infants: a prospective study
AbstractUse of spinal anesthesia (SA) in children may address concerns about potential neurocognitive effects of general anesthesia. We used near-infrared spectroscopy (NIRS) to assess the effects of SA on cerebral and tissue oxygenation in 19 patients aged 7  ± 3 months. Prior to SA placement, NIRS monitors were placed on the forehead (cerebral) and the thigh (tissue). Intraoperative cerebral and tissue saturation were 73 ± 7 and 80 ± 11%, respectively, before SA placement. NIRS measurements were monitored every minute for 30 min after SA pla cement and modeled ...
Source: Journal of Anesthesia - January 12, 2018 Category: Anesthesiology Source Type: research

Predictors of severe postoperative hyperglycemia after cardiac surgery in infants: a single-center, retrospective, observational study
ConclusionAdding to hyperglycemia during the operation, longer CPB time younger age and chromosomal abnormality were identified as predictors of high blood glucose levels at ICU admission. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 12, 2018 Category: Anesthesiology Source Type: research

Association between remifentanil and acute kidney injury
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 11, 2018 Category: Anesthesiology Source Type: research

Cytotoxicity of propofol in human induced pluripotent stem cell-derived cardiomyocytes
ConclusionsPropofol-induced cytotoxicity in human iPSC-derived cardiomyocytes may be associated with mitochondrial dysfunction via downregulation of PGC-1alpha-regulated genes associated with mitochondrial energy metabolism. Co-treatment with CoQ10 protected cardiomyocytes from propofol-induced cytotoxicity. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - December 29, 2017 Category: Anesthesiology Source Type: research

Murphy ’s law and Murphy eyes
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - December 29, 2017 Category: Anesthesiology Source Type: research

Postoperative mortality and morbidity following non-cardiac surgery in a healthy patient population
AbstractPurposePerioperative mortality ranges from 0.4% to as high as nearly 12%. Currently, there are no large-scale studies looking specifically at the healthy surgical population alone. The primary objective of this study was to report 30-day mortality and morbidity in healthy patients and define any risk factors.MethodsUsing the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) dataset, all patients assigned an American Society of Anesthesiologists physical status (ASA PS) classification score of 1 or 2 were included. Further patients were excluded if they had a comorbidity or underwent...
Source: Journal of Anesthesia - December 26, 2017 Category: Anesthesiology Source Type: research

Correction to: Cerebrovascular CO 2 reactivity during isoflurane-nitrous oxide anesthesia in patients with chronic renal failure
AbstractIn the original publication of the article, the first sentence was published incorrectly under the section “Patients and preoperative assessment”. The correct sentence should read as, “The Yamaguchi University Graduate School of Medicine Ethics Committee for Human Study approved the study protocol (18th August 2004: H16-71)”. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - December 23, 2017 Category: Anesthesiology Source Type: research

Novel ultrasound-guided inter-semispinal plane block: a comparative pilot study in healthy volunteers
AbstractWe previously reported that a novel multifidus cervicis plane (MCP) block could anesthetize the dorsal rami of the cervical spinal nerves. While MCP sonoanatomy is easily detectable in most patients, it is sometimes difficult to recognize the MCP injection plane, especially in elderly patients. Thus, we proposed the inter-semispinal plane (ISP) block as an alternative for the MCP block. The aim of this study was to evaluate the utility of the ISP block by evaluating the area and duration of anesthesia, compared with that of the MCP block in eight healthy volunteers. Each participant underwent unilateral ultrasound-...
Source: Journal of Anesthesia - December 21, 2017 Category: Anesthesiology Source Type: research

Comparison of TIVA with different combinations of ketamine –propofol mixtures in pediatric patients
ConclusionTIVA with a 1:10 ratio of ketofol admixture with a 90% reduction of McFarlan regimen can provide improved recovery conditions.Trial registrationClinicalTrials.gov identifier: NCT02848963. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - December 16, 2017 Category: Anesthesiology Source Type: research

Does prophylactic ondansetron reduce norepinephrine consumption in patients undergoing cesarean section with spinal anesthesia?
ConclusionEight milligrams of intravenous ondansetron given 5  min before spinal anesthesia attenuated but did not prevent spinal anesthesia-induced hypotension in parturients undergoing elective cesarean delivery. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - December 14, 2017 Category: Anesthesiology Source Type: research

Predictors for incidence of increased time spent in hospital after ambulatory surgery in children: a retrospective cohort study
AbstractPurposeRecently, pediatric ambulatory surgery has become common. However, for some of these patients, unplanned admission or prolonged hospital stay is also necessary, which can increase the mental burden on these patients. The aim of this study was to identify the predictors of the incidence of increased time spent in hospitals associated with pediatric ambulatory surgery.MethodsData were obtained from the medical and anesthetic records of 1087 consecutive patients aged  
Source: Journal of Anesthesia - December 12, 2017 Category: Anesthesiology Source Type: research

Choice of desflurane or propofol for the maintenance of general anesthesia does not affect the risk of periprocedural myocardial damage in patients undergoing transfemoral transcatheter aortic valve implantation
ConclusionsDesflurane does not appear to be more cardioprotective than propofol when used for anesthetic maintenance in patients undergoing transfemoral TAVI. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - December 6, 2017 Category: Anesthesiology Source Type: research

Preoperative pulmonary function tests before low-risk surgery in Japan: a retrospective cohort study using a claims database
ConclusionsOur analysis found that preoperative PFTs were performed before 72% of low-risk surgeries under general anesthesia. Apart from age, preoperative PFTs were determined primarily by non-medical factors. Additionally, we observed substantial institutional variation in the use of preoperative PFTs. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - November 4, 2017 Category: Anesthesiology Source Type: research

Cerebrovascular CO 2 reactivity during isoflurane-nitrous oxide anesthesia in patients with chronic renal failure
ConclusionsCO2R in CRF patients was not significantly different from that in controls. However, in CRF patients with high BUN concentrations, CO2R might be impaired, leading to reduced cerebrovascular reserve capacity. Because DM is a major cause of CRF and we excluded DM patients, our results might not be applicable to patients with DM-induced CRF. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - November 4, 2017 Category: Anesthesiology Source Type: research

Evaluation of pharmacokinetic models of intravenous dexmedetomidine in sedated patients under spinal anesthesia
ConclusionsHannivoort et al. ’s pharmacokinetic model, constructed with a dataset obtained from healthy volunteers, can predict dexmedetomidine concentrations best during continuous infusion under spinal anesthesia. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - November 2, 2017 Category: Anesthesiology Source Type: research

Intraoperative administration of dexmedetomidine reduced the postoperative catheter-related bladder discomfort and pain in patients undergoing lumbar microdiscectomy
ConclusionsIntraoperative administration of DEX is a safe and effective practice for the prevention of CRBD after lumbar microdiscectomy and can reduce postoperative pain. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - November 2, 2017 Category: Anesthesiology Source Type: research

Comparison of the protective effects of direct ischemic preconditioning and remote ischemic preconditioning in a rabbit model of transient spinal cord ischemia
ConclusionsDIPC, but not kidney or limb RIPC, protected against ischemic spinal cord injury in rabbits. Akt2 might contribute to this protective effect. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - November 1, 2017 Category: Anesthesiology Source Type: research

Comparing ultrasound-guided and fiberscope-guided intubation
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - November 1, 2017 Category: Anesthesiology Source Type: research

Effect of remifentanil during cardiopulmonary bypass on incidence of acute kidney injury after cardiac surgery
ConclusionThe use of remifentanil during CPB did not decrease the incidence of postoperative AKI after cardiac surgery. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - October 30, 2017 Category: Anesthesiology Source Type: research

Acknowledgment to Reviewers
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - October 29, 2017 Category: Anesthesiology Source Type: research

Hydroxyethyl starch 130/0.4 versus crystalloid co-loading during general anesthesia induction: a randomized controlled trial
AbstractPurposeHypotension and decreased cardiac output (CO) are common adverse effects during anesthesia induction depending on the patient ’s pre-anesthetic cardiac condition. The aim of this study was to assess the ability of hydroxyethyl starch (HES) 130/0.4 to prevent hypotension and decreased CO during the induction of general anesthesia.MethodsNinety patients undergoing laparoscopic surgery were randomly divided into a HES group and a crystalloid group. Following the insertion of an intravenous line, fluid was administered to each patient at a rate of 25  ml/min using either crystalloid or HES 130/0.4. Fi...
Source: Journal of Anesthesia - October 25, 2017 Category: Anesthesiology Source Type: research

Nitrite administration improves sepsis-induced myocardial and mitochondrial dysfunction by modulating stress signal responses
This study investigated the cardioprotective effects of nitrite on myocardial function, mitochondrial bioenergetics, and its underlying molecular mechanisms in severe septic rats.MethodsSepsis was induced in male Wistar rats by cecal ligation and puncture (CLP). After CLP, we administered normal saline (NS group) or nitrite (nitrite group) subcutaneously. We administered nitrite at different doses (0.1 –10 mg/kg) to ascertain the most effective dose and examined cardiac function in an isolated heart experiment 8 h after CLP. We investigated mitochondrial bioenergetics and molecular mechanisms underlying the...
Source: Journal of Anesthesia - October 23, 2017 Category: Anesthesiology Source Type: research

The role of Journal of Anesthesia as a flagship anesthesia journal in Asia
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - October 16, 2017 Category: Anesthesiology Source Type: research

Three cases of implantation of a SureScan ® system and MRI for investigating causes of pain
We report three cases of implantation of the SureScan® system and magnetic resonance imaging (MRI) for investigating causes of pain. Although there were metal-induced artifacts on the MR images of 2 patients, the artifacts did not affect the images of structures that needed to be assessed to make the diagnosis. The SureScan® system enabled patients implanted with spinal cord stimulation devices to undergo MRI. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - October 16, 2017 Category: Anesthesiology Source Type: research

Is use of glycine-containing drugs in anesthesia safe?
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - October 11, 2017 Category: Anesthesiology Source Type: research

Combined intraoperative paracetamol and preoperative dexamethasone reduces postoperative sore throat: a prospective randomized study
In this study, we evaluated the combined effects of paracetamol and dexamethasone on the prevention of POST in patients after general anesthesia.MethodsA total of 226 patients scheduled for urologic surgery under general anesthesia were randomly assigned to one of two groups. In the DexaPara group (n = 113), dexamethasone (10 mg) and paracetamol (1000 mg) was infused. In the Dexa group (n = 113), dexamethasone (10 mg) alone was given. POST, hoarseness, and dysphagia were monitored. The postoperative wound pain score and perioperative opioid requirements were compared. In addition, complic...
Source: Journal of Anesthesia - October 4, 2017 Category: Anesthesiology Source Type: research

Acute kidney injury after pediatric liver transplantation
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - October 4, 2017 Category: Anesthesiology Source Type: research

The preventive effects of dexmedetomidine on endotoxin-induced exacerbated post-incisional pain in rats
ConclusionOur findings indicate that intraoperative DEX treatment can prevent LPS-induced exacerbated post-incisional pain via the α2-adrenergic receptor signaling pathway. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - October 1, 2017 Category: Anesthesiology Source Type: research

Beta-blockers and perioperative outcomes in vascular surgery
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - October 1, 2017 Category: Anesthesiology Source Type: research

Preoperative flurbiprofen axetil administration for acute postoperative pain: a meta-analysis of randomized controlled trials
ConclusionsPreoperative use of flurbiprofen axetil will result in significantly lower postoperative pain scores, but no difference in nausea, vomiting, and opioid consumption compared to those who did not receive flurbiprofen axetil. However, more homogeneous and well-designed clinical studies are necessary to determine whether preoperative flurbiprofen axetil administration has more efficacy than that given at the end of surgery. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - September 21, 2017 Category: Anesthesiology Source Type: research

Endotracheal intubation: ultrasound-guided versus fiberscope in patients with cervical spine immobilization
ConclusionsUltrasound-guided tracheal intubation showed a lower first attempt success rate in patients with cervical spine immobilization compared to fiberscope-guided tracheal intubation but the overall success rates were comparable. Ultrasound can be an alternative technique for guiding tracheal intubation in patients with cervical spine immobilization.Registry numberPACTR201602001476292. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - September 21, 2017 Category: Anesthesiology Source Type: research

Effects of pregabalin on postoperative pain after hysterectomy under spinal anesthesia with intrathecal morphine: a randomized controlled trial
ConclusionA single preoperative dose of pregabalin 150  mg did not reduce 24-h postoperative morphine consumption or pain scores or prolong the time to first analgesic rescue in spinal anesthesia with intrathecal morphine. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - September 16, 2017 Category: Anesthesiology Source Type: research

In reply: Sevoflurane in patients at risk of ventricular dysrhythmias
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - September 15, 2017 Category: Anesthesiology Source Type: research

Effect of swallowing maneuver on fentanyl-induced coughing
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - September 15, 2017 Category: Anesthesiology Source Type: research

Effects of short-term exposure to sevoflurane on the survival, proliferation, apoptosis, and differentiation of neural precursor cells derived from human embryonic stem cells
ConclusionClinically relevant treatment with sevoflurane for 2  h induces no significant changes in the survival, proliferation, apoptosis, and differentiation of human neural precursor cells, although supraclinical doses of sevoflurane do alter human neurogenesis transiently. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - September 14, 2017 Category: Anesthesiology Source Type: research

Local infiltration analgesia: a 2-year follow-up of patients undergoing total hip arthroplasty
ConclusionAnalysis of functional outcome, quality of life, and post-discharge surgical pain did not reveal significant differences between patients receiving LIA and those receiving ITM. LIA was found to be a safe technique for THA during the long-term follow-up. However, it should be noted that these conclusions are based on a limited number of patients. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - August 30, 2017 Category: Anesthesiology Source Type: research

AMP-activated protein kinase and cAMP response element-binding protein activity are associated with distinct postoperative behavioral changes in rats
AbstractPurposeTo explore the association of AMP-activated protein kinase (AMPK) and cAMP response element-binding protein (CREB) activity with distinct postoperative behavioral changes in rats.MethodsWe performed partial hepatolobectomy in adult rats and aged rats. The learning and memory ability of rats was evaluated by the Barnes maze test on postoperative days 1 –4. The expressions of AMPK and phosphorylated CREB (p-CREB) in the CA1 and DG regions of the hippocampus were detected by immunohistochemical assay at 3, 6, 12 and 24 h postoperatively.ResultsSurgery impaired the memory of aged rats but not that of ...
Source: Journal of Anesthesia - August 28, 2017 Category: Anesthesiology Source Type: research

Contralateral cerebral hemoglobin oxygen saturation changes in patients undergoing thoracotomy with general anesthesia with or without paravertebral block: a randomized controlled trial
AbstractPurposePerioperative analgesia during thoracotomy is often achieved by combining paravertebral block (PVB) with general anesthesia (GA). Functional near-infrared spectroscopy (NIRS) can detect changes in cerebral oxygenation resulting from nociceptive stimuli in the awake state or under sedation. We used NIRS to measure changes in cerebral blood flow provoked by thoracotomy incision made under GA and determine how these changes were influenced by supplementation of GA with PVB.MethodsThirty-four patients undergoing elective thoracotomy were enrolled. Patients were randomly assigned to a group receiving only GA, or ...
Source: Journal of Anesthesia - August 23, 2017 Category: Anesthesiology Source Type: research

Important role of calcium chloride in preventing carbon monoxide generation during desflurane degradation with alkali hydroxide-free carbon dioxide absorbents
AbstractWe investigated whether calcium chloride (CaCl2), a supplementary additive in carbon dioxide (CO2) absorbents, could affect carbon monoxide (CO) production caused by desflurane degradation, using a Japanese alkali-free CO2 absorbent Yabashi Lime®-f (YL-f), its CaCl2-free and 1% CaCl2-added derivatives, and other commercially available alkali-free absorbents with or without CaCl2. The reaction between 1  L of desflurane gas (3–10%) and 20 g of desiccated specimen was performed in an artificial closed-circuit anesthesia system for 3 min at 20 or 40 °C. The CO concentration was measur...
Source: Journal of Anesthesia - August 22, 2017 Category: Anesthesiology Source Type: research

Association between AKI and all-cause mortality after EVAR
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - August 22, 2017 Category: Anesthesiology Source Type: research

Pharmacokinetic and pharmacodynamics of intravenous dexmedetomidine in morbidly obese patients undergoing laparoscopic surgery
This study was designed to investigate the pharmacokinetics and pharmacodynamics of dexmedetomidine in morbidly obese patients undergoing laparoscopic surgery.MethodsMorbidly obese (body mass index ≥40 kg/m2) and normal weight patients scheduled for elective laparoscopic surgery were included (n = 8, each group). After baseline hemodynamic measurement, dexmedetomidine 1 μg/kg was administered over 10 min. General anesthesia was induced with propofol 1.5 mg/kg and fentanyl 4 μg/kg 20 min after completion of dexmedetomidine infusion; the lungs were mechanically ventilated afte...
Source: Journal of Anesthesia - August 21, 2017 Category: Anesthesiology Source Type: research