General purpose propofol target-controlled infusion using the marsh model with adjusted weight input
We report a simple method for adjusting the weight input of the Marsh target-controlled infusion (TCI) model such that the resulting infusion regime closely mimics the behaviour of the Eleveld model, thereby making the Marsh model more precise for patients at the extremes of age and body mass index. To assess the performance of our method, we simulated 2768 subjects with diverse combinations of age, weight, height and sex undergoing a hypothetical four-hour propofol TCI using both the Marsh model with our weight adjustment and the Eleveld model. The weight adjusted Marsh model produced infusion regimes and corresponding ef...
Source: Journal of Anesthesia - February 11, 2024 Category: Anesthesiology Source Type: research
General anesthesia at cesarean section for placenta previa
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - February 5, 2024 Category: Anesthesiology Source Type: research
Targeted local anesthesia: a novel slow-release Fe3O4 –lidocaine–PLGA microsphere endowed with a magnetic targeting function
ConclusionMagnetically responsive lidocaine microspheres can prolong analgesia by slowly releasing lidocaine, which can be immobilized around the nerve by a magnetic field on the body surface, avoiding premature diffusion of the microspheres to surrounding tissues and improving drug targeting. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - February 4, 2024 Category: Anesthesiology Source Type: research
A comparison of invasive arterial blood pressure measurement with oscillometric non-invasive blood pressure measurement in patients with sepsis
ConclusionIBP and NIBP were not interchangeable in septic patients. Clinicians should be aware that non-invasive MAP was clinically and significantly underestimated invasive MAP. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - February 2, 2024 Category: Anesthesiology Source Type: research
Effect of epidural analgesia on cervical ripening using dinoprostone vaginal inserts
ConclusionEpidural analgesia as labor relaxant adversely affected the progression of uterine cervical ripening when dinoprostone vaginal inserts were used, whereas it did not affect cervical ripening when a mechanical cervical dilatation balloon was used. The present results are significant for choosing the appropriate ripening method. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - February 1, 2024 Category: Anesthesiology Source Type: research
Paramedian versus midline approach of spinal anesthesia: a systematic review and meta-analysis with trial sequential analysis
ConclusionsOur meta-analysis of 36 RCTs showed that paramedian approach may result in little to no difference in success rate at the first attempt owing to its very low level of evidence. However, given the low level of evidence and studies with small sample sizes, these findings need to be interpreted with caveat.Clinical Trial Registration Number: CRD42023397781. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 24, 2024 Category: Anesthesiology Source Type: research
Authors ’ response to the letter to the editor
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 24, 2024 Category: Anesthesiology Source Type: research
Reply to a letter to the editor
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 24, 2024 Category: Anesthesiology Source Type: research
Neurosteroids and their potential as a safer class of general anesthetics
AbstractNeurosteroids (NS) are a class of steroids that are synthesized within the central nervous system (CNS). Various NS can either enhance or inhibit CNS excitability and they play important biological roles in brain development, brain function and as mediators of mood. One class of NS, 3 α-hydroxy-pregnane steroids such as allopregnanolone (AlloP) or pregnanolone (Preg), inhibits neuronal excitability; these endogenous NS and their analogues have been therapeutically applied as anti-depressants, anti-epileptics and general anesthetics. While NS have many favorable properties as ane sthetics (e.g. rapid onset, rapid r...
Source: Journal of Anesthesia - January 22, 2024 Category: Anesthesiology Source Type: research
Amplitude at 10 min in thromboelastography predicts maximum amplitude: a single-center observational study
AbstractThromboelastography is a quantitative test widely used to measure the efficiency of blood clotting. However, awaiting the results of maximum amplitude (MA) is necessary for determining the need for platelet- and fibrinogen-containing products. A more rapid prediction of MA could facilitate faster preparation and administration of blood transfusion products, thereby resulting in coagulation improvement. In this retrospective study, we hypothesized that early amplitude at 10 min (A10) could be a predictor of MA. Therefore, we investigated whether MA can be rapidly inferred from thromboelastographic 6 s (TEG6s) mea...
Source: Journal of Anesthesia - January 11, 2024 Category: Anesthesiology Source Type: research
Response to letter to the editor on “Continuous paravertebral block combined with multilevel single-shot intercostal nerve blocks for pain control after thoracotomy”
(Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 11, 2024 Category: Anesthesiology Source Type: research
Video versus ultrasound pupillometry for detecting increased pupillary diameters due to nociceptive stimuli: a prospective observational study
ConclusionDue to the significant constant error, we consider the reproducibility of the measured ΔPD between UP and VP moderate.Trial registry numberUMIN 000047145. Prior to the subjects' enrollment, the trial was registered with the University Hospital Medical Information Network (Principal investigator: Mao Konno, Date of registration: 3.11.2022).https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000053778. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 8, 2024 Category: Anesthesiology Source Type: research
The median effective concentration of ropivacaine for ultrasound-guided caudal block in children: a dose-finding study
ConclusionsThis study showed that children in the preschool group required higher concentrations of ropivacaine than children in the toddler group during ultrasound-guided sacral block combined with non-intubated general anesthesia. At the same time, this method of anesthesia is safe and effective for children undergoing surgery for hypospadias. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 5, 2024 Category: Anesthesiology Source Type: research
Changes in the corrected carotid flow time can predict spinal anesthesia-induced hypotension in patients undergoing cesarean delivery: an observational study
ConclusionsThis study demonstrated that changes in the corrected carotid flow time induced by the Trendelenburg position could serve as a good predictor of spinal anesthesia-induced hypotension for cesarean delivery. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - January 3, 2024 Category: Anesthesiology Source Type: research
