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A New Publisher and New Opportunities for the Journal.
Authors: Lipman AG PMID: 28792804 [PubMed] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - August 11, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Probiotics to Prevent Antibiotic-Related Diarrhea.
Authors: Abernethy AP PMID: 28792805 [PubMed] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - August 11, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

News and Innovations.
Authors: PMID: 28792806 [PubMed] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - August 11, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

The NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT).
This study was designed to determine if glucosamine and chondroitin are effective for osteoarthritis pain. This report was adapted from an online publication by the National Center for Complimentary and Alternative Medicine of the National Institutes of Health to inform the general public about the GAIT trial and its findings. Participants taking the positive control, celecoxib, experienced statistically significant pain relief versus placebo, about 70% of those taking celecoxib had a 20% or greater reduction in pain versus about 60% for placebo. Overall, there were no significant differences between the other treatments t...
Source: Journal of Pain and Palliative Care Pharmacotherapy - August 11, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

So You've Got Chronic Pain-What's Next?
Authors: Collen MR PMID: 28792808 [PubMed] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - August 11, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

A Review of: "The Weeping Willow: Encounters with Grief".
A Review of: "The Weeping Willow: Encounters with Grief". J Pain Palliat Care Pharmacother. 2008;22(1):65-68 Authors: Glajchen M PMID: 28792809 [PubMed] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - August 11, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

IL10 and Neuropathic Pain.
Authors: Fine PG PMID: 28792810 [PubMed] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - August 11, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Randomized Controlled Trial of Acupuncture for Chronic Neck Pain.
Authors: Abernethy AP Abstract Timely and important studies are reviewed and commentaries provided by leading palliative care clinicians. Symptoms, interventions, mechanisms of action, and treatment-related adverse events addressed in this issue are: acupuncture for neck pain, role of IL-10 in neuropathic pain, treatments for diabetic neuropathy, probiotics for antibiotic-related diarrhea, and risk of fatal drug poisoning with opioid analgesics. PMID: 28792811 [PubMed] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - August 11, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Opioids and Fatal Drug Poisoning.
Authors: Davis M PMID: 28792812 [PubMed] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - August 11, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Systematic Comparison of Interventions for Painful Diabetic Neuropathy.
Authors: Peppin JF PMID: 28792813 [PubMed] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - August 11, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Safety Alert for Fentanyl Buccal Tablets.
Authors: U S Food And Drug Administration Abstract On September 13, 2007, the United States Food and Drug Administration posted a safety alert for fentanyl buccal tablets (Fentora). The announcement and hyperlinks to the Dear Doctor and Dear Healthcare Professional Letters that were distributed by the sponsor are presented. PMID: 28792814 [PubMed] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - August 11, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Evidence-Based Pain Management and Palliative Care in Issue Three for 2007 of The Cochrane Library.
Authors: Wiffen PJ Abstract The Cochrane Library of Systematic Reviews is published quarterly. Issue 3 2007 contains 3197 complete reviews, 1744 protocols for reviews in production and 6312 one-page summaries of systematic reviews published in the general medical literature. In addition there are citations of 503,000 randomized controlled trials, and 9628 cited papers in the Cochrane methodology register. The health technology assessment database contains 6817 citations. This edition of the Library contains 103 new reviews of which 11 have potential relevance for practitioners in pain and palliative medicine. P...
Source: Journal of Pain and Palliative Care Pharmacotherapy - August 11, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Indexed Pain Journals.
Authors: National Library Of Medicine Abstract The U.S. National Library of Medicine (NLM) lists only 19 periodicals in its electronic databases (MEDLINE, PubMed) that are classified as pain journals. Only papers published in journals that are indexed in the databases are accessible through electronic literature searches utilizing those databases. Those 19 journals are listed with their NLM abbreviations and their print and electronic ISSNs. PMID: 28792816 [PubMed] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - August 11, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Conversations on Dying: A Palliative Care Pioneer Faces His Own Death.
Authors: Woodruff R Abstract Editor's Note The journal is delighted to continue a collaboration with the International Association for Hospice and Palliative Care (IAHPC) in publication of book reviews relevant to symptom control in advanced disease. These reviews are adapted from the work of Roger Woodruff, MD, FRACP, FAChPM, an internationally recognized oncologist and palliative care specialist physician from Australia. Dr. Woodruff's reviews appear concurrently or did so previously in the IAHPC Newsletter, which is accessible through the IAHPC Web site: http://hospicecare.com . PMID: 28644746 [PubMed - in p...
Source: Journal of Pain and Palliative Care Pharmacotherapy - June 25, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Pain Management and Prescription Opioid-Related Harms: Exploring the State of the Evidence: Proceedings of a Workshop-In Brief.
Authors: Lipman AG PMID: 28644747 [PubMed - in process] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - June 25, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Paediatric Palliative Medicine, 2nd ed.
Authors: Woodruff R Abstract Editor's Note The journal is delighted to continue a collaboration with the International Association for Hospice and Palliative Care (IAHPC) in publication of book reviews relevant to symptom control in advanced disease. These reviews are adapted from the work of Roger Woodruff, MD, FRACP, FAChPM, an internationally recognized oncologist and palliative care specialist physician from Australia. Dr. Woodruff's reviews appear concurrently or did so previously in the IAHPC Newsletter, which is accessible through the IAHPC Web site: http://hospicecare.com . PMID: 28644748 [PubMed - in p...
Source: Journal of Pain and Palliative Care Pharmacotherapy - June 25, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Breakfast, Lunch, and Dinner.
Authors: PMID: 28644749 [PubMed - in process] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - June 25, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Medical Cannabis for Pain: Anecdote or Evidence.
Authors: Lipman AG PMID: 28644751 [PubMed - in process] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - June 25, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Doctor-Related Medication Safety Incidents on a Specialist Palliative Medicine Inpatient Unit: A Retrospective Analysis of Three Years of Voluntary Reporting.
Authors: O'Brien H, Kiely F, Carmichael A Abstract Patients receiving palliative care and those at the end of life are known to be susceptible to medical errors. Errors related to medications are the most avoidable cause of patient harm. This retrospective study examined reported anonymized medication safety incidents, related to physician errors, assessed by the risk committee in a specialist palliative care unit over a 3-year time period. The aim of the study was to describe medication errors, with specific attention paid to what type of errors occurred and when these errors happened. Of the 218 reported medicati...
Source: Journal of Pain and Palliative Care Pharmacotherapy - June 2, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Systematic Reviews Published in the Cochrane Library January-March 2017.
This report attempted to identify all relevant reviews published in the last 3 months to March 30, 2017. The current version contains 7243 complete reviews and 2544 protocols for reviews in production. In addition, there are citations of 1,036,153 randomized controlled trials (first time passing the million mark) and 15,700 cited papers in the Cochrane Methodology Register. The Health Technology Assessment database contains some 17,000 citations. Six reviews have been identified that have potential relevance for practitioners in pain and palliative medicine. The impact factor of the Cochrane Library stands at 6.1. Rea...
Source: Journal of Pain and Palliative Care Pharmacotherapy - May 20, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Propofol-Based Palliative Sedation to Treat Antipsychotic-Resistant Agitated Delirium.
Authors: Covarrubias-Gómez A, López Collada-Estrada M Abstract Delirium is a common problem in terminally ill patients that is associated with significant distress and, hence, considered a palliative care emergency. The three subtypes of delirium are hyperactive, hypoactive, and mixed, depending on the level of psychomotor activity and arousal disturbance. When agitated delirium becomes refractory in the setting of imminent dying, the agitation may be so severe that palliative sedation (PS) is required. Palliative sedation involves the administration of sedative medications with the purpose of reducin...
Source: Journal of Pain and Palliative Care Pharmacotherapy - May 17, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Complications of Psychotropic and Pain Medications in an Ultrarapid Metabolizer Patient at the Upper 1% of Cytochrome P450 (CYP450) Function Quantified by Combinatorial CYP450 Genotyping.
Authors: Ruaño G, Larsen K, Kocherla M, Graydon JS, Kost J Abstract A 44-year-old Caucasian woman presented with a history of empirical treatment with 20 pain and psychotropic medications, as well as dual comorbidity of intractable pain and depression. A multiple gain-of-function profile in the CYP450 family of cytochrome P450 (CYP450) drug metabolism isoenzymes was discovered. The patient was a homozygote of suprafunctional alleles for both CYP2D6 ((*)35/(*)35) and CYP2C19 ((*)17/(*)17) genes and functional alleles for CYP2C9 ((*)1/(*)1), which account for aggregate drug metabolism function at the upper 1% ...
Source: Journal of Pain and Palliative Care Pharmacotherapy - May 17, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Intrathecal Injection of Gadobutrol: A Tale of Caution.
We report a case of an intrathecal gadobutrol injection resulting in neurotoxic manifestations.A 60-year-old female with a history significant for lumbar post-laminectomy syndrome and intrathecal drug delivery implantation was admitted for lumbar fusion and kyphoplasty. Postoperatively, the patient had escalating pain medication requirements. A pump and intrathecal catheter contrast study was completed to assess the integrity and proper placement of the intrathecal catheter. Due to patient.s allergy to iodinated contrast, the physician requested gadolinium contrast dye. Unknown to the staff was that Magnevist had recently ...
Source: Journal of Pain and Palliative Care Pharmacotherapy - May 12, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Benefits of Thoracic Epidural Analgesia in Patients Undergoing an Open Posterior Component Separation for Abdominal Herniorrhaphy.
In conclusion, for patients undergoing an open PCS, the inclusion of TEA in the postoperative analgesic regimen did not by itself hasten the return of bowel function. However, when TEA was utilized and systemic opioids were avoided, bowel recovery occurred significantly sooner and resulted in a shortened hospital LOS. PMID: 28489476 [PubMed - as supplied by publisher] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - May 12, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Combined Sciatic and Lumbar Plexus Nerve Blocks for the Analgesic Management of Hip Arthroscopy Procedures: A Retrospective Review.
Authors: Jaffe JD, Morgan TR, Russell GB Abstract Hip arthroscopy is a minimally invasive alternative to open hip surgery. Despite its minimally invasive nature, there can still be significant reported pain following these procedures. The impact of combined sciatic and lumbar plexus nerve blocks on postoperative pain scores and opioid consumption in patients undergoing hip arthroscopy was investigated. A retrospective analysis of 176 patients revealed that compared with patients with no preoperative peripheral nerve block, significant reductions in pain scores to 24 hours were reported and decreased opioid consumpt...
Source: Journal of Pain and Palliative Care Pharmacotherapy - May 12, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Continuous Intravenous Lidocaine Infusion for the Management of Pain Uncontrolled by Opioid Medications.
The objective of this study was to evaluate the effect of use of continuous lidocaine infusions for pain management at a community teaching hospital. A retrospective chart review was performed that included adult patients receiving continuous systemic lidocaine infusions for the treatment of pain. Twenty-one patients were included in the analysis. Dosing ranged from 0.25 to 2.8 mg/kg/h, with a median infusion time of 64 hours. Eight patients (38%) experienced a response (≥20% reduction in pain score during the infusion compared with prior to the infusion). Among responding patients, there was a decrease in pai...
Source: Journal of Pain and Palliative Care Pharmacotherapy - May 12, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Ischemic Ulcer Pain Is Both Nociceptive and Neuropathic Pain Based on a Discriminant Function Analysis Using the McGill Pain Questionnaire.
Authors: Kogure T, Sumitani M, Abe H, Hozumi J, Inoue R, Mietani K, Kawahara K, Yamada Y Abstract The McGill Pain Questionnaire (MPQ) is composed of 78 words reflecting the mechanisms underlying chronic pain conditions. Ischemic ulcer pain is generally regarded as a nociceptive and inflammatory pain condition. However, it is sometimes refractory to nonsteroidal anti-inflammatory drug (NSAID) and opioid treatment. We categorized ischemic pain into nociceptive/inflammatory pain (NocP) or neuropathic pain (NeP), on the basis of patients' descriptions of their pain using the MPQ. We investigated pain characteristics of...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 26, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Oral Versus Topical Diclofenac Sodium in the Treatment of Osteoarthritis.
Authors: Tieppo Francio V, Davani S, Towery C, Brown TL Abstract Osteoarthritis (OA) is one of the most common causes of joint pain in the United States and non-steroidal anti-inflammatories (NSAIDs), such as Diclofenac sodium, which is currently available in two main routes of administration; oral and topical distribution have been established as one of the standard treatments for OA. Generally, oral NSAIDs are well tolerated; however our narrative review suggests that the topical solution had a better tolerability property than oral Diclofenac sodium, especially due to side effects of gastrointestinal bleeding wi...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 9, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Pain Management of Malignant Psoas Syndrome Under Epidural Analgesia During Palliative Radiotherapy.
Authors: Ota T, Makihara M, Tsukuda H, Kajikawa R, Inamori M, Miyatake N, Tanaka N, Tokunaga M, Hasegawa Y, Tada T, Fukuoka M Abstract Malignant psoas syndrome is a rare malignant condition presenting as lumbosacral plexopathy and painful fixed flexion of the hip. Metastasis to the psoas muscle is observed, which damages the nerve bundles in the lumbosacral plexuses. The syndrome presents as refractory lower back pain with several other neurological symptoms. The pain is difficult to control because it is a mixture of nociceptive and neuropathic pain, which indicates that treatment requires a versatile approach. Th...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 6, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

The Risks of Chronic Corticosteroid Exposure.
This article focuses on the use of corticosteroids to decrease inflammation and treat painful conditions as well as their long-term side effects and risks. Their long-term use can expose the body to side effects and can cause long-term health concerns. It therefore is important to be aware of the risks of long-term corticosteroid use. PMID: 28375794 [PubMed - as supplied by publisher] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 6, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Pathophysiology of Trigger Points in Myofascial Pain Syndrome.
Authors: Money S Abstract Questions from patients about pain conditions and analgesic pharmacotherapy and responses from authors are presented to help educate patients and make them more effective self-advocates. Trigger point pathophysiology in myofascial pain syndrome, which involves muscle stiffness, tenderness, and pain that radiates to other areas of the body, is considered. The causes of trigger points and several theories about how they develop are reviewed, and treatment approaches, including stretching, physical therapy, dry needling, and injections, are offered. PMID: 28379050 [PubMed - as supplied by...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 6, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Intractable Acute Pain Related to Fluoroquinolone-Induced Peripheral Neuropathy.
Authors: Danesh A, Onyima C, Dukewich M, Gupta A Abstract Fluoroquinolones are widely prescribed antibiotics, used for various infectious etiologies. These antibiotics carry the possibility of the serious adverse effect of peripheral neuropathy, with a true incidence not known owing to its rare existence. Recently, the Food and Drug Administration (FDA) has required alterations to drug labels to highlight this adverse effect of fluoroquinolones. This is a case report of a single patient at an inpatient neurology service at an urban academic medical center in the United States. The patient is a 20-year-old male, wit...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 31, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Effectiveness of Corticosteroid Monotherapy for Dyspnea Relief in Patients with Terminal Cancer.
In this study, we retrospectively investigated whether corticosteroid monotherapy was effective for dyspnea palliation. The effectiveness rate of corticosteroid therapy was 45% in nine male and two female study subjects (mean age: 74.5 years; range: 64-86 years). No significant differences were found between responders and nonresponders in the first-day corticosteroid doses (25.5 ± 10.86 vs. 36.1 ± 16.39 mg, P = .29) or doses administered on 2 days (47.7 ± 25.99 vs. 72.2 ± 32.78 mg, P = .25). The mean ± standard error assessment score changed significantly from 2....
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 31, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Strong in the Face of Adversity.
Authors: Binoy S Abstract Palliative care provides holistic care to individuals in life-threatening or life-limiting conditions. This narrative describes the journey of Kanchan. A strong lady and a doting mother, she came to the hospital by choice, in immense pain and with swelling. Her narrative illustrates how the palliative approach draws out the inner strengths of individuals by focusing on their issues and needs. Kanchan was able to benefit from physiotherapy to reduce the risk of lymphoedema after surgery for breast cancer. Her narrative illustrates how she found comfort and relief, ably supported by the dedi...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 28, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

One Needle is Better Than Two: The Philosophy Surrounding Use of Local Anesthesia in Northern India.
Authors: Story M Abstract The author, an internal medicine resident in the United States, participated in an international elective through her postgraduate training program in a rural hospital in northern India. While performing a thoracentesis, she notes that local anesthesia has not been administered, which is seemingly the standard of care at this hospital. Several questionnaire studies about pain services and pain management in India are reviewed, and they reveal insights and severe limitations to effective management of hospitalized patients' pain. PMID: 28346035 [PubMed - as supplied by publisher] (Sourc...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 28, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Book and Media Reviews.
Authors: Woodruff R Abstract Editor's Note The journal is delighted to continue a collaboration with the International Association for Hospice and Palliative Care (IAHPC) in publication of book reviews relevant to symptom control in advanced disease. These reviews are adapted from the work of Roger Woodruff, MD, FRACP, FAChPM, an internationally recognized oncologist and palliative care specialist physician from Australia. Dr. Woodruff's reviews appear concurrently or did so previously in the IAHPC Newsletter, which is accessible through the IAHPC Web site: http://hospicecare.com. PMID: 28287349 [PubMed - in pr...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

FDA Expands List of "Do Not Compound" Drug Products.
FDA Expands List of "Do Not Compound" Drug Products. J Pain Palliat Care Pharmacother. 2017 Mar;31(1):76-78 Authors: Food and Drug Administration, Public Health Service, U.S. Department of Health and Human Services Abstract EDITOR'S ABSTRACT On October 3, 2016, the U.S. Food and Drug Administration published in the Federal Register an expanded list of drug products that are not to be used in compounding extemporaneous dosage forms. This list contains numerous analgesic or anti-inflammatory agents and other chemicals sometimes used to manage pain and related symptoms. Because pharmacies are li...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Zoledronic Acid Treatment in Primary Bone Marrow Edema Syndrome.
Authors: Flores-Robles BJ, Sanz-Sanz J, Sanabria-Sanchinel AA, Huntley-Pascual D, Andréu Sánchez JL, Campos Esteban J, Blanco R, Merino-Argumanez C, Espinosa-Malpartida M, Ramos-Giráldez MC, Godoy-Tundidor H, Jiménez-Palop MM, Barbadillo Mateos C, Villa-Alcázar LF, Isasi CM, Mulero JB Abstract Primary bone marrow edema syndrome (BMES) is characterized by the combination of joint pain and distinctive magnetic resonance imaging changes. It has been suggested that the use of bisphosphonate drugs reduce symptom severity. Our objective was to review cases of patients diagnosed with BME...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

New Online Tool for Exploring Global Opioid Consumption Data.
Authors: Maurer MA Abstract Each year for nearly two decades, the Pain & Policy Studies Group (PPSG) has received from the International Narcotics Control Board, the global monitoring body for the implementation of the United Nations international drug control conventions, consumption data for six principal opioids used to treat moderate and severe pain: fentanyl, hydromorphone, methadone, morphine, oxycodone, and pethidine. To provide these statistics to a wider audience, PPSG developed an extensive section of its Web site featuring these data in the form of global, regional, and individual country graphs. In ...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Systematic Reviews Published in the October 2016 Issue of the Cochrane Library.
Authors: Wiffen PJ Abstract The Cochrane Library of Systematic Reviews has been published quarterly as a DVD and monthly online ( http://www.thecochranelibrary.com ). The final October 2016 issue (4th DVD for 2016) contains 7068 complete reviews and 2467 protocols for reviews in production. In addition, there are citations of 973,000 randomized controlled trials, and 15,700 cited papers in the Cochrane Methodology Register. The Health Technology Assessment database contains some 16,000 citations. One hundred and seventeen new reviews have been published in the previous 3 months, of which three have potential r...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Donepezil, an Acetylcholinesterase Inhibitor, Can Attenuate Gabapentinoid-Induced Somnolence in Patients with Neuropathic Pain: A Retrospective Chart Review.
Authors: Kogure T, Sumitani M, Ikegami K, Abe H, Hozumi J, Inoue R, Kawahara K, Yamada Y Abstract Donepezil, an oral acetylcholinesterase inhibitor, is used to treat Alzheimer's disease and reportedly attenuates opioid-induced sedation in patients with cancer pain. Neuropathic pain is often treated with gabapentinoids (pregabalin, gabapentin), but gabapentinoid-induced somnolence sometimes prevents patients from using these agents. We conducted a retrospective chart review of patients with neuropathic pain to examine whether donepezil is useful for gabapentinoid-induced somnolence. We investigated pain severity in ...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Range of Effective Corticosteroid Doses for Alleviating Dyspnea in Terminal Cancer Patients: A Retrospective Review.
This study aimed to determine the range of mean cumulative corticosteroid doses that could effectively palliate dyspnea in opioid-treated patients with terminal cancer and to investigate the demographic or biochemical factors predictive of corticosteroid responsiveness. To this end, responders and nonresponders were compared with regard to corticosteroid dose and whether they had initiated opioid use before or concomitantly with corticosteroid use. A logistic regression analysis was conducted to assess the impacts of demographic and biochemical factors on corticosteroid effectiveness. The final sample comprised 20 patients...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

A Review of Agents for Palliative Sedation/Continuous Deep Sedation: Pharmacology and Practical Applications.
Authors: Bodnar J Abstract Continuous deep sedation at the end of life is a specific form of palliative sedation requiring a care plan that essentially places and maintains the patient in an unresponsive state because their symptoms are refractory to any other interventions. Because this application is uncommon, many providers may lack practical experience in this specialized area and resources they can access are outdated, nonspecific, and/or not comprehensive. The purpose of this review is to provide an evidence- and experience-based reference that specifically addresses those medications and regimens and their p...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Intractable Neck Pain in an Oncologic Palliative Care Setting: Is Cancer Always the Answer?
Authors: Delfine V, Bernasconi E, Bardelli D, Spataro V, Fusi-Schmidhauser T Abstract Refractory pain is a common manifestation in an oncologic palliative care setting and represents a major challenge for health care professionals involved in care provision. The underlying neoplasm and its dissemination are the foremost pathophysiologic mechanism for the development of pain in patients with advanced cancer. Nonetheless, other etiologies such as trauma and infections need to be considered by clinicians in this particular care setting. The authors present the case of a patient with a recent diagnosis of hepatocellula...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Opioid Prescribing Patterns and Costs in a Large Group of Patients in Colombia.
The objective of this study was to determine prescription patterns of opioid medication in a group of patients through a cross-sectional study on a population database of 3.5 million people. Patients with three months of continuous opioid use were identified. Pharmacological, co-medication and cost variables were analyzed. We conducted a multivariate analysis. A total of 7,457 patients were included; 72.1% were women, the mean age was 65.1 years, and 3.8% had a diagnosis of cancer. 10.2% of the patients received opioids in combination therapy. The most prescribed opioids were codeine (57.7%), tramadol (30.9%), and hydrocod...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

An Educational Intervention to Decrease Drug Costs Related to Terminal Secretions in a Hospice Organization.
Authors: Brock C, Cooper S, Herndon CM Abstract Terminal secretions is a common symptom seen in hospice patients. Antimuscarinic drugs are commonly used to treat this symptom despite a lack of supporting data. Wide variability in cost exists among these treatments. Hospice program data were assessed to identify high-use and high-cost medications. An educational intervention (EI) was developed to target one such medication, transdermal scopolamine. The EI focused on efficacy, safety, and actual cost (by unit and total expenditure) for each possible treatment of terminal secretions. Following the EI, drug utilization...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Believing Jeny About Her Pain.
Authors: Biji MS Abstract A 19-year-old woman with cancer and excruciating pain was not easily responding to morphine. Some of the staff suspected that this pain was not physical, that it was all emotional. But when the palliative care team believed the young woman's report of her pain, they were able to arrive at the right combination of medicines to treat her pain, and to relieve her intolerable suffering. PMID: 28287361 [PubMed - in process] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Drug Costs: The Controversy Continues.
Authors: Lipman AG PMID: 28287362 [PubMed - in process] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Nebulized Fentanyl for Dyspnea in a Hospice Patient with True Allergy to Morphine and Hydromorphone.
Authors: Wahler RG, Smith DB, Mulcahy KB Abstract An 86-year-old white female was admitted to hospice care with lung cancer. Even with optimal medical management, she suffered from dyspnea and required opioid therapy. However, the patient had a true morphine and hydromorphone allergy. She was administered nebulized fentanyl for symptomatic relief of dyspnea with good effect and she did not experience any allergic response. PMID: 28287363 [PubMed - in process] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Food and Drug Administration Requires Strong Warnings for Opioid Analgesics, Prescription Opioid Cough Products, and Benzodiazepine Labeling Related to Serious Risks and Death From Combined Use.
Authors: Food and Drug Administration, U.S. Department of Health and Human Services PMID: 27960626 [PubMed - in process] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - December 16, 2016 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research