Experimental and Molecular Medicine 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.4D nucleome: dynamic three-dimensional genome organization over time
Experimental & Molecular Medicine, Published online: 25 April 2024; doi:10.1038/s12276-024-01248-54D nucleome: dynamic three-dimensional genome organization over time (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Hyoung-Pyo Kim Source Type: research
Author Correction: Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure
Experimental & Molecular Medicine, Published online: 24 April 2024; doi:10.1038/s12276-024-01238-7Author Correction: Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - April 24, 2024 Category: Molecular Biology Authors: Youngbum Yoo MyeongHoon Yeon Won-Kyung Kim Hyeon-Bin Shin Seung-Min Lee Mee-Sup Yoon Hyunju Ro Young-Kyo Seo Source Type: research
Loss of SREBP-1c ameliorates iron-induced liver fibrosis by decreasing lipocalin-2
Experimental & Molecular Medicine, Published online: 16 April 2024; doi:10.1038/s12276-024-01213-2Sterol regulatory element-binding protein (SREBP)-1c plays a role in liver fat regulation and is elevated in nonalcoholic steatohepatitis (NASH). Researchers investigated role of SREBP-1c in NASH using mice models and patient samples, focusing on lipocalin-2 (LCN2) regulation. In NASH mice, LCN2 expression was increased, driven by SREBP-1c. LCN2 treatment increased iron accumulation and fibrosis-related gene expression in hepatic stellate cells, dependent on SREBP-1c. LCN2 expression correlated with inflammation and fibros...
Source: Experimental and Molecular Medicine - April 16, 2024 Category: Molecular Biology Authors: Eun-Ho Lee Jae-Ho Lee Do-Young Kim Young-Seung Lee Yunju Jo Tam Dao Kyung Eun Kim Dae-Kyu Song Ji Hae Seo Young-Kyo Seo Je Kyung Seong Changjong Moon Eugene Han Mi Kyung Kim Seungwan Ryu Minsang Shin Gu Seob Roh Hye Ra Jung Timothy F. Osborne Dongryeol Ry Source Type: research
Overcoming BRAF and CDK4/6 inhibitor resistance by inhibiting MAP3K3-dependent protection against YAP lysosomal degradation
Experimental & Molecular Medicine, Published online: 16 April 2024; doi:10.1038/s12276-024-01210-5Cancer treatment often uses specific drugs, but sometimes the body can resist these, causing the cancer to return. A study led by Yonsei University College of Medicine researchers looked at the role of a protein, yes-associated protein (YAP), in this drug resistance. They found that another protein, MAP3K3, helps keep YAP stable, which then helps the body resist cancer drugs. By stopping MAP3K3, the researchers could lower YAP levels and overcome drug resistance in breast cancer and skin cancer cells. This suggests that fo...
Source: Experimental and Molecular Medicine - April 16, 2024 Category: Molecular Biology Authors: Sanghyun Park Won-Ji Ryu Tae Yeong Kim Yumi Hwang Hyun Ju Han Jeong Dong Lee Gun Min Kim Joohyuk Sohn Sang Kyum Kim Min Hwan Kim Joon Kim Source Type: research
Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression
This study used advanced technology to analyze the genetic makeup of CN. The researchers found that CNs don't have any major repeated changes in their genes, gene combinations, or gene copies that could cause the tumor. Instead, they found that the increase in activity of the PI3K-AKT pathway (a pathway involved in cell growth) and changes in several pathways involved in nerve cell development are controlled by an increase in FGFR3 (a protein that helps cells grow and divide) in CNs. This research provides important information about the genetics of CN and could help guide future research and treatments.This summary was in...
Source: Experimental and Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Yeajina Lee Tamrin Chowdhury Sojin Kim Hyeon Jong Yu Kyung-Min Kim Ho Kang Min-Sung Kim Jin Wook Kim Yong-Hwy Kim So Young Ji Kihwan Hwang Jung Ho Han Jinha Hwang Seong-Keun Yoo Kyu Sang Lee Gheeyoung Choe Jae-Kyung Won Sung-Hye Park Yong Kyu Lee Joo Heon Source Type: research
Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer
Experimental & Molecular Medicine, Published online: 05 April 2024; doi:10.1038/s12276-024-01209-yExtracellular vesicles (EVs)—tiny structures produced by cells that are important for cell-to-cell communication—contain various molecules, a process known as cargo sorting. However, how these molecules are selected and packaged into EVs is not fully understood. This research by Lee, Shin, and Chae provides a detailed analysis of our current knowledge of cargo sorting in exosome biogenesis. They reviewed the literature on the types of molecules in exosome cargo, the factors and machinery controlling cargo selection and...
Source: Experimental and Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Yu Jin Lee Kyeong Jin Shin Young Chan Chae Source Type: research
Entosis: the core mechanism and crosstalk with other cell death programs
In this study, the authors review recent findings uncovering the molecular regulation of entosis and dicuss its potential implications in cancer. They discuss how entosis is controlled by a network of regulations involving cell adhesion, the RhoA–ROCK signaling pathway, and actomyosin contraction. Interestingly, entosis can occur alongside other cell death forms in populations, suggesting it may influence how cell groups respond to stress. The study concludes that entosis may contribute to aggressive cancers’ development by favoring cells with low tension setpoints, promoting the creation of aneuploid cell lineages, an...
Source: Experimental and Molecular Medicine - April 2, 2024 Category: Molecular Biology Authors: Sunghoon Kim Donghyuk Lee Sung Eun Kim Michael Overholtzer Source Type: research
Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure
Experimental & Molecular Medicine, Published online: 01 April 2024; doi:10.1038/s12276-024-01199-xAging often results in a decrease in muscle mass and function, a condition called sarcopenia. This research examines the role of a protein found in mitochondria (the energy factories of cells), cardiolipin synthase 1 (CRLS1), in muscle health and aging. The scientists discovered that levels of CRLS1 and cardiolipin, a fat it produces, decrease in the muscles of older mice. When CRLS1 levels were artificially lowered in young mice, their muscle mass and strength reduced. On the other hand, increasing CRLS1 levels in older m...
Source: Experimental and Molecular Medicine - April 1, 2024 Category: Molecular Biology Authors: Youngbum Yoo MyeongHoon Yeon Won-Kyung Kim Hyeon-Bin Shin Seung-Min Lee Mee-Sup Yoon Hyunju Ro Young-Kyo Seo Source Type: research
Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2
This study could pave the way for new liver disease treatments.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - April 1, 2024 Category: Molecular Biology Authors: Wei Dong Qing Li Xing Lu Jianfeng Lan Zhidong Qiu Xuehong Wang Junnan Wang Xiaojiao Zheng Sifan Chen Chong Zhang Junfei Jin Source Type: research
Transcriptome-based deep learning analysis identifies drug candidates targeting protein synthesis and autophagy for the treatment of muscle wasting disorder
Experimental & Molecular Medicine, Published online: 01 April 2024; doi:10.1038/s12276-024-01189-zScientists used artificial intelligence to find a possible cure for sarcopenia, a disease marked by muscle loss and decreased function. The group, headed by Dr. Jin Woo Choi, used AI to study gene expression patterns in muscle tissues from healthy people and sarcopenia patients. They found a medicine named dimenhydrinate (DH) as a possible cure. The group then experimented with DH on lab-grown muscle cells and mice, discovering that it encouraged muscle cell growth and repair. The scientists concluded that DH could be a ho...
Source: Experimental and Molecular Medicine - April 1, 2024 Category: Molecular Biology Authors: Min Hak Lee Bada Lee Se Eun Park Ga Eul Yang Seungwoo Cheon Dae Hoon Lee Sukyeong Kang Ye Ji Sun Yongjin Kim Dong-sub Jung Wonwoo Kim Jihoon Kang Yi Rang Kim Jin Woo Choi Source Type: research
Cargo specificity, regulation, and therapeutic potential of cytoplasmic dynein
Experimental & Molecular Medicine, Published online: 01 April 2024; doi:10.1038/s12276-024-01200-7This research examines how parts move within a specific type of cell, called eukaryotic cells, focusing on the role of a component called cytoplasmic dynein 1 in moving various items. However, understanding dynein’s function is difficult due to its complexity and the systems that control it. Recent progress in structural, biophysical (relating to the physical properties of biological molecules), and cellular methods are helping us understand these processes. The research also looks at dynein’s role in human diseases, e...
Source: Experimental and Molecular Medicine - April 1, 2024 Category: Molecular Biology Authors: Jin-Gyeong Park Hanul Jeon Kwang Yeon Hwang Sun-Shin Cha Rafael T. Han Hyesung Cho In-Gyun Lee Source Type: research
Recent advances in CRISPR-based functional genomics for the study of disease-associated genetic variants
Experimental & Molecular Medicine, Published online: 01 April 2024; doi:10.1038/s12276-024-01212-3Genetic mutations, changes in our DNA, can cause many human diseases, but it’s hard to understand how they affect our cells. Traditionally, researchers have studied mutations that occur naturally, but this method has its limits. Genome editing methods, like the CRISPR-Cas system, allow for the study of disease-related genetic changes. In this review, Kim et al. outlined the integration of CRISPR-Cas tools with advanced sequencing technologies to explore how genetics influence disease. They comprehensively described both ...
Source: Experimental and Molecular Medicine - April 1, 2024 Category: Molecular Biology Authors: Heon Seok Kim Jiyeon Kweon Yongsub Kim Source Type: research
Methyl-CpG binding domain protein 2 (Mbd2) drives breast cancer progression through the modulation of epithelial-to-mesenchymal transition
Experimental & Molecular Medicine, Published online: 01 April 2024; doi:10.1038/s12276-024-01205-2DNA methylation, a process that regulates how genes work, is often disturbed in cancer. This research looked at the role of Methyl-CpG-Binding Domain Protein 2 (MBD2), a protein that interprets these methylation signals, in breast cancer. It was found that MBD2 is overly active in several kinds of cancer, including breast cancer. In an experiment with mice, it was found that removing MBD2 slowed down the formation of tumors and reduced the spread of cancer. MBD2 was found to control several genes involved in how cancer pro...
Source: Experimental and Molecular Medicine - April 1, 2024 Category: Molecular Biology Authors: Niaz Mahmood Ani Arakelian Moshe Szyf Shafaat A. Rabbani Source Type: research
Correction: TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis
Experimental & Molecular Medicine, Published online: 01 April 2024; doi:10.1038/s12276-024-01215-0Correction: TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - April 1, 2024 Category: Molecular Biology Authors: Eun-Jin Bae Minsun Choi Jeong Tae Kim Dong-Kyu Kim Min Kyo Jung Changyoun Kim Tae-Kyung Kim Jun Sung Lee Byung Chul Jung Soo Jean Shin Ka Hyun Rhee Seung-Jae Lee Source Type: research
Correction: Inflammation promotes synucleinopathy propagation
Experimental & Molecular Medicine, Published online: 01 April 2024; doi:10.1038/s12276-024-01217-yCorrection: Inflammation promotes synucleinopathy propagation (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - April 1, 2024 Category: Molecular Biology Authors: Tae-Kyung Kim Eun-Jin Bae Byung Chul Jung Minsun Choi Soo Jean Shin Sung Jun Park Jeong Tae Kim Min Kyo Jung Ayse Ulusoy Mi-Young Song Jun Sung Lee He-Jin Lee Donato A. Di Monte Seung-Jae Lee Source Type: research
