Experimental and Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The deubiquitinase USP40 preserves endothelial integrity by targeting the heat shock protein HSP90β
Experimental & Molecular Medicine, Published online: 02 February 2024; doi:10.1038/s12276-024-01160-yVascular endothelial cells (ECs - cells that line the interior of blood vessels) play a vital role in maintaining the health of blood vessels and controlling inflammation. Damage or malfunction of these cells can lead to severe inflammatory diseases like acute lung injury and sepsis. The molecular mechanisms (processes at a molecular level) that control these cells’ function are not completely understood. In this research, a new protein, USP40, was identified that helps safeguard ECs from inflammation and maintains th...
Source: Experimental and Molecular Medicine - February 2, 2024 Category: Molecular Biology Authors: Jiaxing Miao Lian Li Nargis Shaheen Jianxin Wei Anastasia M. Jacko Prithu Sundd Sarah J. Taleb Rama K. Mallampalli Yutong Zhao Jing Zhao Source Type: research

HIRA vs. DAXX: the two axes shaping the histone H3.3 landscape
Experimental & Molecular Medicine, Published online: 01 February 2024; doi:10.1038/s12276-023-01145-3Histones are key components of chromain, influencing DNA compaction, gene expression, and genome integrity. Unlike other histones, H3.3 is added to chromatin throughout the cell cycle by specific histone chaperones, namely HIRA and DAXX. This review explores how these two chaperones position H3.3 onto DNA, impacting the cellular management of genetic information and gene activity. Investigating the two axes of H3.3 deposition pathways underscores the delicate balance between HIRA and DAXX in saptial and temporal regulat...
Source: Experimental and Molecular Medicine - February 1, 2024 Category: Molecular Biology Authors: Jinmi Choi Taewan Kim Eun-Jung Cho Source Type: research

Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases
This study explores the process of bone remodeling, particularly the role of osteoclasts (cells that break down bone) and osteoblasts (cells that build new bone). There is a lack of understanding about the biology of the osteoclast differentiation process (the process by which a cell changes from one type to another), which is vital for maintaining bone health. The scientists reviewed how osteoclast differentiation is regulated, focusing on cell signaling (communication between cells) and metabolic adaptation (how cells change their metabolism to survive). They discovered certain molecules could change osteoclast-mediated ...
Source: Experimental and Molecular Medicine - February 1, 2024 Category: Molecular Biology Authors: Noriko Takegahara Hyunsoo Kim Yongwon Choi Source Type: research

Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity
Experimental & Molecular Medicine, Published online: 01 February 2024; doi:10.1038/s12276-024-01161-xExcessive intake of fatty acids can result in a condition known as lipotoxicity (harmful effect of fats on cells), which can harm pancreatic beta cells (cells that produce insulin) and contribute to type 2 diabetes. Researchers have found that this harm is due to a disturbance in the cells' autophagy process (a system used by cells to eliminate unnecessary or dysfunctional parts). Specifically, the research revealed that the autophagy process is hindered by the activation of a protein complex called mTORC1 and the suppr...
Source: Experimental and Molecular Medicine - February 1, 2024 Category: Molecular Biology Authors: Ha Thu Nguyen Andreas Wiederkehr Claes B. Wollheim Kyu-Sang Park Source Type: research

Targeting the m6A RNA methyltransferase METTL3 attenuates the development of kidney fibrosis
This study emphasizes the significance of RNA methylation in kidney fibrosis and its potential as a treatment target.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - February 1, 2024 Category: Molecular Biology Authors: Hae Rim Jung Jeonghwan Lee Seung-Pyo Hong Nayeon Shin Ara Cho Dong-Jin Shin Jin Woo Choi Jong-Il Kim Jung Pyo Lee Sung-Yup Cho Source Type: research

Cathepsin D promotes polarization of tumor-associated macrophages and metastasis through TGFBI-CCL20 signaling
This study focuses on an enzyme called Cathepsin D, which is involved in several cancers and influences how TAMs act within tumors. Researchers conducted an experiment using mice and various cancer cell types to see how Cat D influences TAM behavior and cancer growth. They genetically altered cancer cells to lack Cat D and observed the effects on tumor growth and the immune response in mice. The results showed that removing Cat D from cancer cells led to a decrease in tumor growth and changes in TAMs made them more effective at fighting the tumor.This summary was initially drafted using artificial intelligence, then revise...
Source: Experimental and Molecular Medicine - February 1, 2024 Category: Molecular Biology Authors: Seul Gi Lee Seon Min Woo Seung Un Seo Chan-Hyeong Lee Moon-Chang Baek Se Hwan Jang Zee Yong Park Simmyung Yook Ju-Ock Nam Taeg Kyu Kwon Source Type: research

Synaptotagmin-4 induces anhedonic responses to chronic stress via BDNF signaling in the medial prefrontal cortex
This study advances our understanding of the molecular basis of depression and could lead to new treatments targeting these mechanisms. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - February 1, 2024 Category: Molecular Biology Authors: Jeongseop Kim Sihwan Seol Tae-Eun Kim Joonhee Lee Ja Wook Koo Hyo Jung Kang Source Type: research

Exploring the potential of Toxoplasma gondii in drug development and as a delivery system
Experimental & Molecular Medicine, Published online: 01 February 2024; doi:10.1038/s12276-024-01165-7Immune-mediated inflammatory diseases are a varied set of conditions where the immune system mistakenly attacks the body’s own tissues, causing long-term inflammation. These include illnesses like rheumatoid arthritis, psoriasis, and inflammatory bowel disease. IMIDs have become more common and also raise the risk of certain cancers. They occur due to an imbalance in inflammatory proteins and a misdirected immune response, involving different immune cells and communication pathways, such as the Janus kinase/signal tra...
Source: Experimental and Molecular Medicine - February 1, 2024 Category: Molecular Biology Authors: Chanjin Yoon Yu Seong Ham Woo Jin Gil Chul-Su Yang Source Type: research

Role of UPF1 in lncRNA-HEIH regulation for hepatocellular carcinoma therapy
Experimental & Molecular Medicine, Published online: 01 February 2024; doi:10.1038/s12276-024-01158-6Hepatocellular carcinoma (HCC, a type of liver cancer), has a high death rate due to limited effective treatments. Current medications often result in resistance and only prolong life by a few months. This research investigates the role of UPF1, a crucial component in a process called nonsense-mediated mRNA decay (the elimination of faulty genetic messages), in controlling the expression of a long noncoding RNA (lncRNA, a type of genetic material) known as lncRNA-HEIH. The scientists discovered that reducing UPF1 increa...
Source: Experimental and Molecular Medicine - February 1, 2024 Category: Molecular Biology Authors: Hyunho Cha Minwoo Kim Narae Ahn Seong Dong Jeong Elizaveta Ignatova Sung Wook Chi Hyeon Ho Kim Jungwook Hwang Source Type: research

CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis in lung cancer cells via the PERK-ATF4 and IRE1α-JNK pathways
This study focused on a protein named Cytochrome b5 reductase 3 (CYB5R3 - a protein involved in multiple biological functions, including energy production and fat metabolism). The research discovered that CYB5R3 presence is reduced in lung cancer and that an increase in CYB5R3 can cause cancer cells to die. This implies that CYB5R3 might act as a tumor suppressor (a gene that regulates cell division and prevents tumor formation) and could be a potential treatment target for lung cancer. "This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author." (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - January 22, 2024 Category: Molecular Biology Authors: Joo-Young Im Soo Jin Kim Jong-Lyul Park Tae-Hee Han Woo-il Kim Inhyub Kim Bomin Ko So-Young Chun Mi-Jung Kang Bo-Kyung Kim Sol A. Jeon Seon-Kyu Kim Incheol Ryu Seon-Young Kim Ki-Hoan Nam Inah Hwang Hyun Seung Ban Misun Won Source Type: research

Author Correction: Comparison of the effects of empagliflozin and sotagliflozin on a zebrafish model of diabetic heart failure with reduced ejection fraction
Experimental & Molecular Medicine, Published online: 15 January 2024; doi:10.1038/s12276-023-01154-2Author Correction: Comparison of the effects of empagliflozin and sotagliflozin on a zebrafish model of diabetic heart failure with reduced ejection fraction (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - January 15, 2024 Category: Molecular Biology Authors: Inho Kim Hyun-Jai Cho Soo Lim Seung Hyeok Seok Hae-Young Lee Source Type: research

The multifaceted functions of β-arrestins and their therapeutic potential in neurodegenerative diseases
Experimental & Molecular Medicine, Published online: 11 January 2024; doi:10.1038/s12276-023-01144-4Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis are neurodegenerative diseases impacting millions worldwide. Recent research has identified a significant association between these diseases and beta-arrestin, a regulatory protein that interacts with G-protein-coupled receptors (GPCRs). GPCRs play crucial roles in numerous biological processes and are the focus of many drug therapies. This review article provides a comprehensive summary of the established functions o...
Source: Experimental and Molecular Medicine - January 11, 2024 Category: Molecular Biology Authors: Teresa R. Kee Sophia A. Khan Maya B. Neidhart Brianna M. Masters Victoria K. Zhao Yenna K. Kim Kyle C. McGill Percy Jung-A A. Woo Source Type: research

Maintaining Drosha expression with Cdk5 inhibitors as a potential therapeutic strategy for early intervention after TBI
Experimental & Molecular Medicine, Published online: 10 January 2024; doi:10.1038/s12276-023-01152-4Traumatic brain injury is a leading cause of death and disability in adults, with secondary injuries often causing more damage than the initial trauma. However, the complex series of events leading to these additional injuries is not well understood. A study by Huang et al. found that a protein called Drosha, which is crucial for the biogenesis of microRNA, is decreased in the injuried brain following TBI. This decrease is due to an kinase called Cdk5, which becomes abnormally active after TBI and phosphorylates Drosha, ...
Source: Experimental and Molecular Medicine - January 10, 2024 Category: Molecular Biology Authors: Lu Huang Li Xia Tiejian Nie Bozhou Cui Jianjun Lu Fangfang Lu Feiyan Fan Dongni Ren Yuan Lu Guodong Gao Qian Yang Source Type: research

PRKCSH contributes to TNFSF resistance by extending IGF1R half-life and activation in lung cancer
Experimental & Molecular Medicine, Published online: 10 January 2024; doi:10.1038/s12276-023-01147-1Cancer cells often develop resistance to treatments that stimulate the natural cell death process, including immune therapies that initiate a group of proteins known as tumour necrosis factors (TNFs - proteins that can cause cell death). Researchers at Sungkyunkwan University in South Korea have discovered that a protein named PRKCSH is vital in assisting lung cancer cells to resist TNFs. Through a sequence of lab tests, they found that PRKCSH extends the lifespan of another protein, IGF1R, which subsequently prevents th...
Source: Experimental and Molecular Medicine - January 10, 2024 Category: Molecular Biology Authors: Gu-Choul Shin Hyeong Min Lee Nayeon Kim Sang-Uk Seo Kwang Pyo Kim Kyun-Hwan Kim Source Type: research

Effects of fine particulate matter on bone marrow-conserved hematopoietic and mesenchymal stem cells: a systematic review
Experimental & Molecular Medicine, Published online: 10 January 2024; doi:10.1038/s12276-023-01149-zAir pollution, particularly fine particulate matter (tiny particles in the air, PM2.5), poses major health dangers, including diseases linked to the breathing and heart systems, and cancer. This research by Bhattarai, Shrestha, Sim, Lee, and Kook examines how PM2.5 impacts bone marrow stem cells and hematopoietic stem cells, which are vital for blood creation and immune system operation. The scientists discovered that prolonged exposure to PM2.5 can disturb the bone marrow environment, causing oxidative stress (damage ca...
Source: Experimental and Molecular Medicine - January 10, 2024 Category: Molecular Biology Authors: Govinda Bhattarai Saroj Kumar Shrestha Hyun-Jaung Sim Jeong-Chae Lee Sung-Ho Kook Source Type: research