Experimental and Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Circular RNA cFAM210A, degradable by HBx, inhibits HCC tumorigenesis by suppressing YBX1 transactivation
Experimental & Molecular Medicine, Published online: 01 November 2023; doi:10.1038/s12276-023-01108-8A study has identified a circular RNA, cFAM210A, that inhibits the growth and stemness of hepatocellular carcinoma (HCC) cells. Researchers found that the hepatitis B virus (HBV) protein HBx promotes the degradation of cFAM210A through a process called N6-methyladenosine modification. This leads to increased tumour growth and stemness in HCC cells. By inhibiting the transactivation function of a protein called YBX1 on another protein called MET, cFAM210A suppresses tumour progression. These findings highlight the potent...
Source: Experimental and Molecular Medicine - November 1, 2023 Category: Molecular Biology Authors: Jian Yu Wen Li Guo-jun Hou Da-peng Sun Yuan Yang Sheng-xian Yuan Zhi-hui Dai Hao-zan Yin Shu-han Sun Gang Huang Wei-ping Zhou Fu Yang Source Type: research

Angiotensin receptor blockers, but not angiotensin-converting enzyme inhibitors, inhibit abnormal bone changes in spondyloarthritis
Experimental & Molecular Medicine, Published online: 01 November 2023; doi:10.1038/s12276-023-01103-zResearchers have discovered that the renin-angiotensin system (RAS) plays a key role in bone changes associated with spondyloarthritis, a chronic inflammatory disease. The study found that RAS components were overexpressed in patients with the disease, and that angiotensin receptor blockers (ARBs) significantly reduced bone erosion and increased bone mineral density in an animal model of spondyloarthritis. In contrast, angiotensin-converting enzyme inhibitors (ACEis) increased osteoblast and osteoclast differentiation, ...
Source: Experimental and Molecular Medicine - November 1, 2023 Category: Molecular Biology Authors: Jin Sun Choi Ji-Young Kim Min-Joo Ahn Hanbit Jang Seungtaek Song Sung Hoon Choi Ye-Soo Park Sungsin Jo Tae-Hwan Kim Seung Cheol Shim Source Type: research

SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs
This study reveals that SARS-CoV-2 exhibits distinct profiles of viral gene expression in tissue microenvironments, with lower levels of subgenomic RNAs and subdued expansion compared to cell lines. Researchers discovered pseudoribosomal ribonucleoprotein (RNP) interactions developing in the lungs during SARS-CoV-2 pathogenesis, which may contribute to the accumulation of small Ribo-seq reads and affect translation elongation. Ribosome heterogeneity with compromised 5 S rRNP association was also observed, suggesting a potential strategy for coping with SARS-CoV-2 pathogenesis by resolving RBP complexes. The findings prov...
Source: Experimental and Molecular Medicine - November 1, 2023 Category: Molecular Biology Authors: Junsoo Kim Daehwa Youn Seunghoon Choi Youn Woo Lee Dulguun Sumberzul Jeongeun Yoon Hanju Lee Jong Woo Bae Hyuna Noh Dain On Seung-Min Hong Se-Hee An Hui Jeong Jang Seo Yeon Kim Young Been Kim Ji-Yeon Hwang Hyo-Jung Lee Hong Bin Kim Jun Won Park Jun-Won Yu Source Type: research

Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells
Experimental & Molecular Medicine, Published online: 31 October 2023; doi:10.1038/s12276-023-01100-2Researchers used a mouse model to investigate the impact of multiple pregnancies on long-term metabolic health of female, discovering that pancreatic β cells in multiparous mice lost their proliferative capacity, leading to hyperglycemia. Transcriptomic analyses showed features of senescence and increased cellular stress in these cells. In humans, women with a higher number of pregnancies had reduced glucose tolerance compared to those with fewer deliveries. Multiparous women who gained weight after delivery had impaire...
Source: Experimental and Molecular Medicine - October 31, 2023 Category: Molecular Biology Authors: Joon Ho Moon Joonyub Lee Kyun Hoo Kim Hyun Jung Kim Hyeongseok Kim Hye-Na Cha Jungsun Park Hyeonkyu Lee So-young Park Hak Chul Jang Hail Kim Source Type: research

Trametinib activates endogenous neurogenesis and recovers neuropathology in a model of Alzheimer’s disease
Experimental & Molecular Medicine, Published online: 02 October 2023; doi:10.1038/s12276-023-01073-2“Trametinib, a MEK1/2 inhibitor, promotes adult neurogenesis in an Alzheimer’s disease mouse model and human iPSC-derived neural stem cells." Researchers have discovered that trametinib, a MEK1/2 inhibitor, can enhance adult neurogenesis and replenish neurons in brain areas where neurodegeneration most affects Alzheimer’s disease (AD). The study found that trametinib induced neuronal differentiation of adult neural stem cells and restored impaired neurogenesis in the hippocampus and subventricular zone of the AD mo...
Source: Experimental and Molecular Medicine - October 2, 2023 Category: Molecular Biology Authors: Mi-Yeon Kim Mi Jeong Kim Changyeob Lee Juwon Lee Sang Seong Kim Sungho Hong Hyoung Tae Kim Jinsoo Seo Ki-Jun Yoon Sungho Han Source Type: research

Systemic antibiotics cause deterioration of emphysema associated with exaggerated inflammation and autophagy
Experimental & Molecular Medicine, Published online: 02 October 2023; doi:10.1038/s12276-023-01099-6Antibiotics may aggravate emphysema by disrupting gut microbiota, according to a study on mice. Researchers found that a mixture of antibiotics led to increased alveolar destruction and inflammation in smoking-exposed emphysema models. However, short-chain fatty acids (SCFAs), which are metabolites of gut microbiota, were found to attenuate emphysema development. The study suggests that reasonable prescription of antibiotics and therapeutic potential of gut microbiota restoration and its metabolites could be beneficial f...
Source: Experimental and Molecular Medicine - October 2, 2023 Category: Molecular Biology Authors: Na Hyun Kim Bo-Yun Choi Eun Sil Kim Su Jung Kim Jeong Yeon Hong Sun-Hee Heo Jin-Yong Jeong Kyunggon Kim Hyun Ju Yoo Woo Jun Sul Sei Won Lee Source Type: research

A stepwise activation model for the insulin receptor
Experimental & Molecular Medicine, Published online: 02 October 2023; doi:10.1038/s12276-023-01101-1New insights into insulin receptor activation mechanisms reveal a stepwise process, providing a basis for designing functionally selective insulin receptor agonists. Cryo-EM structures of the insulin receptor in various states, from inactive to fully active, have been analyzed, and a model for insulin-induced activation has been proposed. This model suggests that insulin binding leads to transient intermediate states before reaching the fully active conformation. These intermediate states display functional selectivity b...
Source: Experimental and Molecular Medicine - October 2, 2023 Category: Molecular Biology Authors: Na-Oh Yunn Junhong Kim Sung Ho Ryu Yunje Cho Source Type: research

Phosphocode-dependent glutamyl-prolyl-tRNA synthetase 1 signaling in immunity, metabolism, and disease
Experimental & Molecular Medicine, Published online: 02 October 2023; doi:10.1038/s12276-023-01094-xEPRS1, a vital enzyme for protein synthesis, has been found to play a significant role in various biological processes beyond translation. Researchers have discovered that EPRS1 can act as a molecular switch, regulating inflammation, metabolism, and disease. The enzyme’s phosphorylation at specific sites allows it to dissociate from the multi-tRNA synthetase complex (MSC) and interact with different proteins to perform various functions. For example, EPRS1 regulates inflammation resolution in response to LPS and bacter...
Source: Experimental and Molecular Medicine - October 2, 2023 Category: Molecular Biology Authors: Eun-Young Lee Jungwon Hwang Myung Hee Kim Source Type: research

Targeting E3 ubiquitin ligases and their adaptors as a therapeutic strategy for metabolic diseases
Experimental & Molecular Medicine, Published online: 02 October 2023; doi:10.1038/s12276-023-01087-wThis review highlights the crucial role of E3 ubiquitin ligases and their adaptors in regulating metabolic diseases, such as obesity, diabetes, and nonalcoholic fatty liver disease. The authors discuss the mechanisms controlling E3 ubiquitin ligases and their adaptors, as well as the potential of targeting specific E3 ubiquitin ligases or adaptors for therapeutic interventions. By developing therapeutic approaches that target these proteins, it may be possible to stabilize target proteins without affecting the expression...
Source: Experimental and Molecular Medicine - October 2, 2023 Category: Molecular Biology Authors: Yelin Jeong Ah-Reum Oh Young Hoon Jung HyunJoon Gi Young Un Kim KyeongJin Kim Source Type: research

Vascular regeneration and skeletal muscle repair induced by long-term exposure to SDF-1α derived from engineered mesenchymal stem cells after hindlimb ischemia
Experimental & Molecular Medicine, Published online: 02 October 2023; doi:10.1038/s12276-023-01096-9Researchers have developed a strategy using SDF1α-engineered mesenchymal stem cells (SDF1α-eMSCs) to simultaneously regenerate blood vessels and skeletal muscles in limbs experiencing ischemia. In a mouse model of hindlimb ischemia, intramuscular injection of SDF1α-eMSCs improved blood perfusion, preserved limb function, and prevented amputation. In vitro result showed that SDF1α-eMSCs not only amplified the angiogenic potential and survival of endothelial cells, but also demonstrated enhanced survival and migration ...
Source: Experimental and Molecular Medicine - October 2, 2023 Category: Molecular Biology Authors: Jin-Ju Kim Jae-Hyun Park Hyeok Kim Woo-Sup Sim Seokbeom Hong Yeon-Jik Choi Hyo-Jin Kim Soon Min Lee Dongha Kim Sun-woong Kang Kiwon Ban Hun-Jun Park Source Type: research

Optimization of the optical transparency of bones by PACT-based passive tissue clearing
Experimental & Molecular Medicine, Published online: 02 October 2023; doi:10.1038/s12276-023-01089-8An optimized imaging technique specifically designed for large, hard bones could significantly enhance evaluations of animal models of different bone diseases. To fully visualize and understand the structure of complex biological tissues, scientists use techniques known as ‘optical clearing’ to enhance the resolution and optical clarity of images. One such technique is passive clearing (PACT), which has already produced high-quality, three-dimensional analysis of multiple biological tissues. However, using PACT for l...
Source: Experimental and Molecular Medicine - October 2, 2023 Category: Molecular Biology Authors: Byung-Ho Jin Jiwon Woo Mirae Lee Seockmo Ku Hyung Seok Moon Seung Jun Ryu Young-Min Hyun Jeong-Yoon Park Sung Uk Kuh Yong Eun Cho Source Type: research

Author Correction: Elevated FBXL6 expression in hepatocytes activates VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver cancer metastasis in mice
Experimental & Molecular Medicine, Published online: 02 October 2023; doi:10.1038/s12276-023-01116-8Author Correction: Elevated FBXL6 expression in hepatocytes activates VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver cancer metastasis in mice (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - October 2, 2023 Category: Molecular Biology Authors: Jie Zhang Xiao-Tong Lin Hong-Qiang Yu Lei Fang Di Wu Yuan-Deng Luo Yu-Jun Zhang Chuan-Ming Xie Source Type: research

Author Correction: Diversity and complexity of cell death: a historical review
Experimental & Molecular Medicine, Published online: 20 September 2023; doi:10.1038/s12276-023-01107-9Author Correction: Diversity and complexity of cell death: a historical review (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Wonyoung Park Shibo Wei Bo-Sung Kim Bosung Kim Sung-Jin Bae Young Chan Chae Dongryeol Ryu Ki-Tae Ha Source Type: research

Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice
Experimental & Molecular Medicine, Published online: 13 September 2023; doi:10.1038/s12276-023-01084-zSmall molecular membrane-bound vesicles released by probiotic bacteria can help to counteract the negative effects of amyloid-beta (Aβ), a protein that clumps inside the brain and is associated with the progression of Alzheimer’s disease. A team led by Yoon-Keun Kim from MD Healthcare Inc. and Pyung-Lim Han from Ewha Womans University, both in Seoul, South Korea, showed that these molecular packets — known as extracellular vesicles and derived from Lactobacillus bacteria found in the mouth and gut — can mitigate...
Source: Experimental and Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Hyejin Kwon Eun-Hwa Lee So-Young Park Jin-Young Park Jin-Hwan Hong Eun-Kyung Kim Tae-Seop Shin Yoon-Keun Kim Pyung-Lim Han Source Type: research

CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system
Experimental & Molecular Medicine, Published online: 11 September 2023; doi:10.1038/s12276-023-01053-6Further research is needed into how certain proteins present self and foreign lipid antigens from mucosal tissues (skin, lungs, intestines) to a specific group of T cells, triggering immune responses, and how disruption to that system triggers inflammation and disease. In a review paper, Ji Hyung Kim and colleagues at Korea University in Seoul, South Korea, examined the lipid antigen presentation system mediated by CD1 glycoproteins, and highlighted how finely tuned the system is. A defect or mutation in a single facto...
Source: Experimental and Molecular Medicine - September 11, 2023 Category: Molecular Biology Authors: Seohyun Kim Sumin Cho Ji Hyung Kim Source Type: research