Experimental and Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Histone modifications in drug-resistant cancers: From a cancer stem cell and immune evasion perspective
Experimental & Molecular Medicine, Published online: 03 July 2023; doi:10.1038/s12276-023-01014-zUnderstanding how modification of histones, structural proteins that support chromatin and affect gene expression, helps cancer stem cells interact with immune cells will help fight drug-resistant cancers. An important mechanism of cancer treatment resistance is histone modification. Ming Li Jin and Kwang Won Jeong at Gachon University in Incheon, South Korea, reviewed recent research into histone modifications in drug-resistant cancers. Much is known about how histone-modifying enzymes remodel the tumor micro-environment, ...
Source: Experimental and Molecular Medicine - July 3, 2023 Category: Molecular Biology Authors: Ming Li Jin Kwang Won Jeong Source Type: research

Arginine 65 methylation of Neurogenin 3 by PRMT1 is required for pancreatic endocrine development of hESCs
Experimental & Molecular Medicine, Published online: 03 July 2023; doi:10.1038/s12276-023-01035-8Examination of the endocrine (hormone-producing) cells of the pancreas reveals how the modification of a key regulatory protein acts as a molecular switch to ensure the development of endocrine cells. In the developing pancreas, the transcription factor neurogenin 3 (NGN3) plays a critical role in triggering differentiation of human embryonic stem cells (hESCs) into endocrine cells. NGN3 then degrades rapidly, but the exact details of this process are unclear. Using human cell lines, Yong-Mahn Han and co-workers at the Kore...
Source: Experimental and Molecular Medicine - July 3, 2023 Category: Molecular Biology Authors: Gahyang Cho Kwangbeom Hyun Jieun Choi Eunji Shin Bumsoo Kim Hail Kim Jaehoon Kim Yong-Mahn Han Source Type: research

Genomic characteristics of triple negative apocrine carcinoma: a comparison to triple negative breast cancer
Experimental & Molecular Medicine, Published online: 03 July 2023; doi:10.1038/s12276-023-01030-zA comparative study reveals the distinctive genomic and clinical characteristics of a rare form of breast cancer, with implications for treatment. Apocrine carcinoma accounts for 1–4 percent of breast cancer cases. The molecular characteristics of a subtype known as triple negative apocrine carcinoma (TNAC) remain unclear. Ji-Yeon Kim at Sungkyunkwan University School of Medicine, Seoul, South Korea, and co-workers conducted genomic analysis on tumor samples taken from 73 TNAC patients. They compared the results to sample...
Source: Experimental and Molecular Medicine - July 3, 2023 Category: Molecular Biology Authors: Ji-Yeon Kim Sabin Park Eun Yoon Cho Jeong Eon Lee Hae Hyun Jung Byung Joo Chae Seok Won Kim Seok Jin Nam Soo Youn Cho Yeon Hee Park Jin Seok Ahn Semin Lee Young-Hyuck Im Source Type: research

Immune regulation through tryptophan metabolism
Experimental & Molecular Medicine, Published online: 03 July 2023; doi:10.1038/s12276-023-01028-7The dietary essential amino acid tryptophan is converted by cellular metabolism into breakdown products that play regulatory roles in health and disease, some involving their effects on a gene control protein called the aryl hydrocarbon receptor (AHR). Su-Kil Seo at Inje University, Busan, and Byungsuk Kwon at the University of Ulsan, in South Korea, review recent insights into the role of several catabolites (breakdown products) of tryptophan in regulating the AHR. The effects of aberrant tryptophan metabolism on the AHR c...
Source: Experimental and Molecular Medicine - July 3, 2023 Category: Molecular Biology Authors: Su-Kil Seo Byungsuk Kwon Source Type: research

Decorin: a potential therapeutic candidate for ligamentum flavum hypertrophy by antagonizing TGF-β1
Experimental & Molecular Medicine, Published online: 03 July 2023; doi:10.1038/s12276-023-01023-yA protein called decorin offers a potential therapy for ligamentum flavum hypertrophy (LFH), stiffening of the ligament inside the spinal canal that connects vertebrae. In LFH, fibrosis (deposition of extra collagen) thickens and stiffens the ligament, reducing the space in the spinal column, thereby compressing nerves and causing loss of mobility. Yang Liu and Hua Wu at Huazhong University of Science and Technology in Wuhan, China, investigated whether decorin, known to combat fibrosis in other contexts, could help treat L...
Source: Experimental and Molecular Medicine - July 3, 2023 Category: Molecular Biology Authors: Shanxi Wang Yunkun Qu Xuan Fang Qing Ding Hongqi Zhao Xiaojun Yu Tao Xu Rui Lu Shaoze Jing Chaoxu Liu Hua Wu Yang Liu Source Type: research

Metastatic pattern of ovarian cancer delineated by tracing the evolution of mitochondrial DNA mutations
Experimental & Molecular Medicine, Published online: 03 July 2023; doi:10.1038/s12276-023-01011-2Analysis of mitochondrial DNA offers new insights into cancer spread (metastasis) that could lead to more accurate prognoses and inform selection of better treatment regimens. Mitochondria carry their own DNA, which accumulates mutations at a far higher rate than does chromosomal DNA. These mutations can be extremely useful for tracing cellular lineages. Researchers led by Jinliang Xing and Shujuan Liu at the Fourth Military Medical University in Xi’an, China, have shown that these changes can also provide insights on tum...
Source: Experimental and Molecular Medicine - July 3, 2023 Category: Molecular Biology Authors: Zhiyang Xu Kaixiang Zhou Zhenni Wang Yang Liu Xingguo Wang Tian Gao Fanfan Xie Qing Yuan Xiwen Gu Shujuan Liu Jinliang Xing Source Type: research

Author Correction: SCON—a Short Conditional intrON for conditional knockout with one-step zygote injection
Experimental & Molecular Medicine, Published online: 21 June 2023; doi:10.1038/s12276-023-01039-4Author Correction: SCON—a Short Conditional intrON for conditional knockout with one-step zygote injection (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - June 21, 2023 Category: Molecular Biology Authors: Szu-Hsien Sam Wu Heetak Lee R éka Szép-Bakonyi Gabriele Colozza Ayse Boese Krista R. Gert Natalia Hallay Ji-Hyun Lee Jihoon Kim Yi Zhu Margot M. Linssen Sandra Pilat-Carotta Peter Hohenstein Hans-Christian Theussl Andrea Pauli Bon-Kyoung Koo Source Type: research

piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination
Experimental & Molecular Medicine, Published online: 19 June 2023; doi:10.1038/s12276-023-01010-3A small RNA molecule regulates key cellular processes and promotes the malignancy of renal cell cancer, the most common kidney cancer in adults, in ways that could be targeted by anti-cancer treatments. The incidence of renal cell cancer is steadily increasing, and patients with high levels of piRNA-1742 have poorer outcomes. Wentao Zhang and colleagues at Tongji University, Shanghai, and other research centers in China, found that the cancer-promoting abilities of piRNA-1742 involve its binding to a protein called hnRNPU w...
Source: Experimental and Molecular Medicine - June 19, 2023 Category: Molecular Biology Authors: Wentao Zhang Zongtai Zheng Keyi Wang Weipu Mao Xue Li Guangchun Wang Yuanyuan Zhang Jianhua Huang Ning Zhang Pengfei Wu Ji Liu Haimin Zhang Jianping Che Bo Peng Junhua Zheng Wei Li Xudong Yao Source Type: research

Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications
Experimental & Molecular Medicine, Published online: 19 June 2023; doi:10.1038/s12276-023-01008-xTherapies directed at a key signaling pathway could help reduce the growth of sarcomas, connective tissue cancers that affect fat, muscles, nerves and other tissues. Azucena Esparís-Ogando from the Instituto de Investigación Biomédica de Salamanca (IBSAL), Spain, and colleagues showed that in a genetically engineered mouse model the activation of the MEK5 enzyme activates the ERK5 enzyme, a regulator of genes involved in cell proliferation, differentiation and survival, and promotes the development of soft-tissue sarcoma...
Source: Experimental and Molecular Medicine - June 19, 2023 Category: Molecular Biology Authors: Adri án Sánchez-Fdez Sof ía Matilla-Almazán Sof ía Del Carmen Mar Abad Elena Arconada-Luque Jaime Jim énez-Suárez Luis Miguel Chinchilla-T ábora M ª José Ruíz-Hidalgo Ricardo S ánchez-Prieto Atanasio Pandiella Azucena Espar ís-Ogando Source Type: research

Author Correction: Clinical molecular subtyping reveals intrinsic mesenchymal reprogramming in gastric cancer cells
Experimental & Molecular Medicine, Published online: 16 June 2023; doi:10.1038/s12276-023-01037-6Author Correction: Clinical molecular subtyping reveals intrinsic mesenchymal reprogramming in gastric cancer cells (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - June 16, 2023 Category: Molecular Biology Authors: Eunji Jang Min-Kyue Shin Hyunki Kim Joo Yeon Lim Jae Eun Lee Jungmin Park Jungeun Kim Hyeseon Kim Youngmin Shin Hye-Young Son Yoon Young Choi Woo Jin Hyung Sung Hoon Noh Jin-Suck Suh Ji-Yong Sung Yong-Min Huh Jae-Ho Cheong Source Type: research

Author Correction: Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFβ2/ALK1 axis
Experimental & Molecular Medicine, Published online: 09 June 2023; doi:10.1038/s12276-023-01029-6Author Correction: Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFβ2/ALK1 axis (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - June 9, 2023 Category: Molecular Biology Authors: Yiyang Xu Guping Mao Dianbo Long Zengfa Deng Ruobin Xin Ziji Zhang Ting Xue Weiming Liao Jie Xu Yan Kang Source Type: research

Author Correction: Bystander CD4+ T cells: crossroads between innate and adaptive immunity
Experimental & Molecular Medicine, Published online: 08 June 2023; doi:10.1038/s12276-023-01032-xAuthor Correction: Bystander CD4+ T cells: crossroads between innate and adaptive immunity (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - June 8, 2023 Category: Molecular Biology Authors: Hong-Gyun Lee Min-Ji Cho Je-Min Choi Source Type: research

Author Correction: Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response
Experimental & Molecular Medicine, Published online: 01 June 2023; doi:10.1038/s12276-023-01026-9Author Correction: Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - June 1, 2023 Category: Molecular Biology Authors: Weiwei Jiang Guanghui Jin Fangfang Cai Xiao Chen Nini Cao Xiangyu Zhang Jia Liu Fei Chen Feng Wang Wei Dong Hongqin Zhuang Zi-Chun Hua Source Type: research

Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABAA receptor transport in a murine model
Experimental & Molecular Medicine, Published online: 01 June 2023; doi:10.1038/s12276-023-01000-5Studies using a mouse model of epilepsy implicate a protein inside cells called Toll-like receptor 7 (TLR7) in susceptibility to epileptic seizures, suggesting the protein could be a target for antiepileptic drugs. TLR7 is part of the immune system and is found in the external and internal membranes of some cells, recognizing molecules associated with infection and disease. It can, however, lead to damaging over-reactions, including auto-immune responses. Fei Xiao, Xuefeng Wang, and colleagues at Chongqing Medical Universit...
Source: Experimental and Molecular Medicine - June 1, 2023 Category: Molecular Biology Authors: Jing Liu Pingyang Ke Haokun Guo Juan Gu Yan Liu Xin Tian Xuefeng Wang Fei Xiao Source Type: research

SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence
Experimental & Molecular Medicine, Published online: 01 June 2023; doi:10.1038/s12276-023-01012-1Two opposing molecular mechanisms determine the stability of SIRT1, a protein that prevents cells from prematurely entering the ‘retirement’ state known as senescence. This state, in which cell division is halted and tissue repair and regeneration impeded, is a natural endpoint of aging but also arises from cellular damage and other stressors. South Korean researchers led by Eun-Joo Kim at Dankook University, Cheonan, and Soo-Jong Um at Sejong University, Seoul, have identified two proteins that govern the onset of sene...
Source: Experimental and Molecular Medicine - June 1, 2023 Category: Molecular Biology Authors: Sang Hyup Lee Ji-Hye Yang Ui-Hyun Park Hanbyeul Choi Yoo Sung Kim Bo-Eun Yoon Hye-Jeong Han Hyun-Taek Kim Soo-Jong Um Eun-Joo Kim Source Type: research