Experimental and Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis
Experimental & Molecular Medicine, Published online: 23 August 2023; doi:10.1038/s12276-023-01077-yA new study reveals the role of lipid metabolism in ferroptosis and its potential implications for cancer treatment. The researchers found that certain lipids, such as polyunsaturated fatty acids (PUFAs), are more susceptible to lipid peroxidation, leading to ferroptosis. By manipulating lipid metabolism pathways, the researchers were able to increase or decrease the sensitivity of cancer cells to ferroptosis, offering new therapeutic strategies for overcoming drug resistance and improving cancer treatment outcomes. Futur...
Source: Experimental and Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Jong Woo Kim Ji-Yoon Lee Mihee Oh Eun-Woo Lee Source Type: research

Mitochondria-associated programmed cell death as a therapeutic target for age-related disease
Experimental & Molecular Medicine, Published online: 23 August 2023; doi:10.1038/s12276-023-01046-5Therapies directed at the quality control systems of mitochondria have the potential to preserve cellular health in individuals with age-related diseases. Dongryeol Ryu from Gwangju Institute of Science and Technology in South Korea, Riekelt Houtkooper from the Amsterdam University Medical Center in The Netherlands, and colleagues review how dysfunctional mitochondria, which are responsible for producing energy in cells, contribute to cancer and many neurodegenerative, cardiovascular and metabolic conditions. When mitocho...
Source: Experimental and Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Thanh T. Nguyen Shibo Wei Thu Ha Nguyen Yunju Jo Yan Zhang Wonyoung Park Karim Gariani Chang-Myung Oh Hyeon Ho Kim Ki-Tae Ha Kyu Sang Park Raekil Park In-Kyu Lee Minho Shong Riekelt H. Houtkooper Dongryeol Ryu Source Type: research

Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis
Experimental & Molecular Medicine, Published online: 23 August 2023; doi:10.1038/s12276-023-01069-yThe different pathways that cause cell death, which are activated under different conditions, have complex relationships and sometimes act together to fight infection or cancer. All the pathways eliminate cells damaged by disease or mutation and are important for development and disease resistance, but can affect immune responses to infection or cause damage if dysregulated. Rajendra Karki at Seoul National University in South Korea and co-workers review recent evidence revealing links, including common molecules, between...
Source: Experimental and Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Ein Lee Chang-Hyun Song Sung-Jin Bae Ki-Tae Ha Rajendra Karki Source Type: research

Diversity and complexity of cell death: a historical review
Experimental & Molecular Medicine, Published online: 23 August 2023; doi:10.1038/s12276-023-01078-xCell death is a complex and interconnected process that plays a crucial role in maintaining tissue homeostasis and preventing disease. There are various types of cell death, including necrosis, apoptosis, autophagy, and others, each with distinct morphological features and molecular mechanisms. Understanding the diverse processes underlying cell death is essential for understanding diseases and developing new therapies. Recent research has focused on characterizing and distinguishing various forms of cell death, thereby a...
Source: Experimental and Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Wonyoung Park Shibo Wei Bo-Sung Kim Bosung Kim Sung-Jin Bae Young Chan Chae Dongryeol Ryu Ki-Tae Ha Source Type: research

After cell death: the molecular machinery of efferocytosis
Experimental & Molecular Medicine, Published online: 23 August 2023; doi:10.1038/s12276-023-01070-5Vast numbers of cells die every day in a healthy adult and are cleared away in a process called efferocytosis in which ‘phagocyte’ cells engulf and degrade the remains. Daeho Park and colleagues at Gwangju Institute of Science and Technology in South Korea review the current understanding of efferocytosis at the molecular level. Research over several decades has discovered many of the molecules involved in the multiple stages of efferocytosis, which include finding, recognizing, engulfing, and degrading a wide variety...
Source: Experimental and Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Byeongjin Moon Susumin Yang Hyunji Moon Juyeon Lee Daeho Park Source Type: research

Recent advances in cell death
Experimental & Molecular Medicine, Published online: 23 August 2023; doi:10.1038/s12276-023-01083-0Recent advances in cell death (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Ki-Tae Ha Source Type: research

A single-cell atlas of in vitro multiculture systems uncovers the in vivo lineage trajectory and cell state in the human lung
Experimental & Molecular Medicine, Published online: 15 August 2023; doi:10.1038/s12276-023-01076-zA new atlas of single cell profiles from human lungs provides a powerful platform for comparing immune responses in vitro and in vivo. The COVID-19 pandemic highlighted the usefulness of growing mini human organ cultures, called organoids, to understand the pathogenesis of diseases, especially in the epithelial cells that line the lungs. However, it is vital to confirm that these model systems accurately replicate the gene expression of real tissues. Jong-Il Kim at Seoul National University and co-workers established a bi...
Source: Experimental and Molecular Medicine - August 15, 2023 Category: Molecular Biology Authors: Woochan Lee Seyoon Lee Jung-Ki Yoon Dakyung Lee Yuri Kim Yeon Bi Han Rokhyun Kim Sungji Moon Young Jun Park Kyunghyuk Park Bukyoung Cha Jaeyong Choi Juhyun Kim Na-young Ha Kwhanmien Kim Sukki Cho Nam-Hyuk Cho Tushar J. Desai Jin-Haeng Chung Joo-Hyeon Lee Source Type: research

Microbiota influences host exercise capacity via modulation of skeletal muscle glucose metabolism in mice
Experimental & Molecular Medicine, Published online: 04 August 2023; doi:10.1038/s12276-023-01063-4Gut microbes alter metabolism and enhance exercise performance in mice. Gut microbes are known to produce beneficial metabolites and improve health, but how they affect exercise is not well understood. Je Kyung Seong at Seoul National University in South Korea and co-workers compared how mice with a healthy microbiome and germ-free (GF) mice responded to exercise. Although GF mice became exhausted much sooner than non-GF mice, spent one-third less time running, and ate 1.5 times more than non-GF mice, they did not gain we...
Source: Experimental and Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Hye Jin Kim Youn Ju Kim Yong Jae Kim Ji Hyeon Baek Hak Su Kim Il Yong Kim Je Kyung Seong Source Type: research

Impact of the circadian nuclear receptor REV-ERBα in dorsal raphe 5-HT neurons on social interaction behavior, especially social preference
Experimental & Molecular Medicine, Published online: 03 August 2023; doi:10.1038/s12276-023-01052-7Daily fluctuation of serotonin levels during the day, controlled by a nuclear receptor called REV-ERBα, is important in social behavior and may offer insights into conditions such as autism spectrum disorder (ASD). The neurotransmitter serotonin influences behavior and mood, but how its circadian fluctuations affect social behavior is not fully understood. Kyungjin Kim at the Daegu Gyeongbuk Institute of Science & Technology in Daegu, South Korea, and co-workers used mice lacking REV-ERBα to investigate links between br...
Source: Experimental and Molecular Medicine - August 3, 2023 Category: Molecular Biology Authors: Sangwon Jang Inah Park Mijung Choi Jihoon Kim Seungeun Yeo Sung-Oh Huh Ji-Woong Choi Cheil Moon Han Kyoung Choe Youngshik Choe Kyungjin Kim Source Type: research

Olfactory modulation of stress-response neural circuits
Experimental & Molecular Medicine, Published online: 01 August 2023; doi:10.1038/s12276-023-01048-3Research into the mechanisms through which the sense of smell controls stress responses provides insights into how stress-related environmental cues are perceived in the brain. Smells are important signals enabling animals to sense and cope with environmental changes. A major nervous system associated with stress responses involves corticotropin-releasing hormone neurons (CRHNs) in the hypothalamus. Eun Jeong Lee and colleagues at Ajou University, Suwon, South Korea, and Kunio Kondoh at the National Institute of Natural S...
Source: Experimental and Molecular Medicine - August 1, 2023 Category: Molecular Biology Authors: Min-Gi Shin Yiseul Bae Ramsha Afzal Kunio Kondoh Eun Jeong Lee Source Type: research

Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair
Experimental & Molecular Medicine, Published online: 01 August 2023; doi:10.1038/s12276-023-01064-3Drugs that alleviate a molecular blockade against wound healing and vessel growth could offer effective therapies for diabetic foot ulcers (DFU). Such chronic wounds are a serious consequence of type 2 diabetes, and current therapies only manage the symptoms without providing recovery. Researchers led by Kang-Yell Choi of Yonsei University, Seoul, South Korea, have determined that DFU from human patients and animal models exhibit elevated levels of CXXC5, a protein that inhibits genes associated with healing and angiogene...
Source: Experimental and Molecular Medicine - August 1, 2023 Category: Molecular Biology Authors: Eunhwan Kim Seol Hwa Seo Yumi Hwang Yeong Chan Ryu Heejene Kim Kyoung-Mi Lee Jin Woo Lee Kwang Hwan Park Kang-Yell Choi Source Type: research

Genome editing in the treatment of ocular diseases
Experimental & Molecular Medicine, Published online: 01 August 2023; doi:10.1038/s12276-023-01057-2Using gene editing tools to correct gene mutations and manipulate specific tissues in the eye could revolutionize treatment for multiple eye diseases. Krzysztof Palczewski and co-workers at the University of California in Irvine, USA, reviewed the current status of gene editing tools such as CRISPR-Cas9 for eye diseases. The eye’s special ‘immune privilege’ status means it can tolerate therapeutic interventions without excessive inflammatory responses. The eye is also easy to image for monitoring. Recent successful ...
Source: Experimental and Molecular Medicine - August 1, 2023 Category: Molecular Biology Authors: Elliot H. Choi Susie Suh Avery E. Sears Rafa ł Hołubowicz Sanjay R. Kedhar Andrew W. Browne Krzysztof Palczewski Source Type: research

Reg3γ: current understanding and future therapeutic opportunities in metabolic disease
Experimental & Molecular Medicine, Published online: 01 August 2023; doi:10.1038/s12276-023-01054-5An antimicrobial peptide, Reg3γ found in the small intestine may be a vital link between gut microbiota and metabolic regulation, and understanding its activity may inform future therapeutics. Reg3γ protects the host by keeping gut bacteria from passing into other organs. Questions remain regarding the role of Reg3γ in metabolic disorders. Randy Seeley at the University of Michigan, Ann Arbor, USA, and co-workers reviewed understanding of the biological roles of Reg3γ. Its production is boosted in infections as part o...
Source: Experimental and Molecular Medicine - August 1, 2023 Category: Molecular Biology Authors: Jae Hoon Shin Nadejda Bozadjieva-Kramer Randy J. Seeley Source Type: research

The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis
Experimental & Molecular Medicine, Published online: 01 August 2023; doi:10.1038/s12276-023-01066-1Researchers investigating idiopathic pulmonary fibrosis (IPF), a chronic and potentially fatal lung disease of unknown cause, have identified increased levels of the epigenetic regulator protein p300 in lung cells from IPF patients and in a mouse model of the disease. The team led by Hyo Sup Shim and Ho-Geun Yoon at Yonsei University, Seoul, South Korea, also found that lung fibrosis (scar tissue formation) was significantly reduced in mice lacking the gene for p300. Chemically inhibiting p300 activity promoted the reprog...
Source: Experimental and Molecular Medicine - August 1, 2023 Category: Molecular Biology Authors: Soo Yeon Lee Soo-Yeon Park Seung-Hyun Lee Hyunsik Kim Jae-Hwan Kwon Jung-Yoon Yoo Kyunggon Kim Moo Suk Park Chun Geun Lee Jack A. Elias Myung Hyun Sohn Hyo Sup Shim Ho-Geun Yoon Source Type: research

Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy
Experimental & Molecular Medicine, Published online: 01 August 2023; doi:10.1038/s12276-023-01047-4A protein that interferes with a critical cellular housekeeping mechanism offers a promising drug target for non-alcoholic fatty liver disease (NAFLD), a condition that can lead to liver failure. Jang Hyun Choi of the Ulsan National Institute of Science and Technology, South Korea, and colleagues previously demonstrated that a protein called Thrap3 contributes to obesity-related insulin resistance. They have now investigated Thrap3 function in the liver and found that levels were significantly elevated in tissues from NAF...
Source: Experimental and Molecular Medicine - August 1, 2023 Category: Molecular Biology Authors: Hyun-Jun Jang Yo Han Lee Tam Dao Yunju Jo Keon Woo Khim Hye-jin Eom Ju Eun Lee Yi Jin Song Sun Sil Choi Kieun Park Haneul Ji Young Chan Chae Kyungjae Myung Hongtae Kim Dongryeol Ryu Neung Hwa Park Sung Ho Park Jang Hyun Choi Source Type: research