An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis

Experimental & Molecular Medicine, Published online: 23 August 2023; doi:10.1038/s12276-023-01077-yA new study reveals the role of lipid metabolism in ferroptosis and its potential implications for cancer treatment. The researchers found that certain lipids, such as polyunsaturated fatty acids (PUFAs), are more susceptible to lipid peroxidation, leading to ferroptosis. By manipulating lipid metabolism pathways, the researchers were able to increase or decrease the sensitivity of cancer cells to ferroptosis, offering new therapeutic strategies for overcoming drug resistance and improving cancer treatment outcomes. Future research will focus on understanding the precise molecular mechanisms of ferroptosis and how they can be targeted for more effective cancer therapies.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research