Experimental and Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders
Experimental & Molecular Medicine, Published online: 01 June 2023; doi:10.1038/s12276-023-01005-0Identifying genetic variants associated with irritability, a heritable condition, has revealed some variants that are also associated with major psychiatric disorders. Researchers in Seoul, South Korea, led by Hong-Hee Won at Sungkyunkwan University and Woojae Myung at Seoul National University, performed a genome-wide association study with 379,506 individuals of European ancestry from the UK Biobank database. The study compared millions of genetic variants between 105,975 people with self-reported irritability and 273,531...
Source: Experimental and Molecular Medicine - June 1, 2023 Category: Molecular Biology Authors: Kyeongmin Jung Joohyun Yoon Yeeun Ahn Soyeon Kim Injeong Shim Hyunwoong Ko Sang-Hyuk Jung Jaeyoung Kim Hyejin Kim Dong June Lee Soojin Cha Hyewon Lee Beomsu Kim Min Young Cho Hyunbin Cho Dan Say Kim Jinho Kim Woong-Yang Park Tae Hwan Park Kevin S. O ` Con Source Type: research

TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1
Experimental & Molecular Medicine, Published online: 01 June 2023; doi:10.1038/s12276-023-01007-yKey aspects of the role of the multi-functional protein TRIM22 in promoting the proliferation of glioblastoma, the most common malignant brain tumor in adults, have been identified in human glioblastoma cells and laboratory mice. Xiaofan Jiang, Zhou Fei and colleagues at the Air Force Medical University in Xi’an, China, revealed how TRIM22 activates MAPK signaling, a pathway of interacting proteins that controls cell growth and development. TRIM22 was also found to accelerate the degradation of a cell-regulating protein c...
Source: Experimental and Molecular Medicine - June 1, 2023 Category: Molecular Biology Authors: Xiaowei Fei Ya-nan Dou Kai Sun Jialiang Wei Qingdong Guo Li Wang Xiuquan Wu Weihao Lv Xiaofan Jiang Zhou Fei Source Type: research

The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression
Experimental & Molecular Medicine, Published online: 01 June 2023; doi:10.1038/s12276-023-00997-zUnderstanding the links between glucose metabolism and bladder cancer (BC) may help find novel therapies. High blood sugar and cancer are linked—abundant energy fuels rapid tumor growth—but the mechanisms are not completely understood, especially in BC. Bin Yan at Central South University, Changsha, China, and co-workers investigated how YTHDC1, a protein known to be suppressed by high blood sugar, affects BC. They found that BC tissues had low levels of YTHDC1 which was associated with a poor prognosis. Boosting YTHDC1...
Source: Experimental and Molecular Medicine - June 1, 2023 Category: Molecular Biology Authors: Bin Yan Xurui Li Mou Peng Yali Zuo Yinhuai Wang Pian Liu Weigang Ren Xin Jin Source Type: research

Comparison of the effects of empagliflozin and sotagliflozin on a zebrafish model of diabetic heart failure with reduced ejection fraction
Experimental & Molecular Medicine, Published online: 01 June 2023; doi:10.1038/s12276-023-01002-3Two existing drugs used to lower glucose in patients with diabetes also reduce the chances of heart failure by blocking the excessive activity of a protein involved in transport of molecules across membranes. The drugs empagliflozin and sotagliflozin, which inhibit sodium-glucose transporters in diabetes, also help protect against heart failure, but the mechanisms are unclear. Hae-Young Lee and Seung Hyeok Seok at Seoul National University, South Korea, and co-workers examined the cardio-protective effects of the drugs on z...
Source: Experimental and Molecular Medicine - June 1, 2023 Category: Molecular Biology Authors: Inho Kim Hyun-Jai Cho Soo Lim Seung Hyeok Seok Hae-Young Lee Source Type: research

Peptides as multifunctional players in cancer therapy
Experimental & Molecular Medicine, Published online: 01 June 2023; doi:10.1038/s12276-023-01016-xTargeted drug delivery systems using tiny, non-toxic guiding molecules could transform cancer treatment and reduce chemotherapy resistance. Peptides are small molecules consisting of two or more amino acids. While they degrade quickly in the body, they show promise as guiding molecules for targeted drug delivery, with deep tissue penetration and low toxicity. Byungheon Lee at Kyungpook National University in Daegu, South Korea, and co-workers reviewed progress into novel therapeutic systems that use ‘tumour-homing’ pept...
Source: Experimental and Molecular Medicine - June 1, 2023 Category: Molecular Biology Authors: Sri Murugan Poongkavithai Vadevoo Smriti Gurung Hyun-Su Lee Gowri Rangaswamy Gunassekaran Seok-Min Lee Jae-Won Yoon Yun-Ki Lee Byungheon Lee Source Type: research

Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation
Experimental & Molecular Medicine, Published online: 01 June 2023; doi:10.1038/s12276-023-01009-wAn enzyme implicated in innate immunity offers a potential new target for treating liver injury due to acetaminophen, a common painkiller also known as paracetamol in many countries. A team from South Korea led by Seok Hee Park from Sungkyunkwan University in Suwon and Seong-Jin Kim from the GILO Foundation in Seoul showed that an enzyme called Pellino3 plays a critical role in triggering liver damage caused by acetaminophen. The researchers found that mice lacking Pellino3, an enzyme that marks proteins with chemical tags ...
Source: Experimental and Molecular Medicine - June 1, 2023 Category: Molecular Biology Authors: Jaewon Lee Jihoon Ha Jun-Hyeong Kim Dongyeob Seo Minbeom Kim Yerin Lee Seong Shil Park Dahee Choi Jin Seok Park Young Jae Lee Siyoung Yang Kyung-Min Yang Su Myung Jung Suntaek Hong Seung-Hoi Koo Yong-Soo Bae Seong-Jin Kim Seok Hee Park Source Type: research

Mesenchymal stem cell-derived extracellular vesicles protect against abdominal aortic aneurysm formation by inhibiting NET-induced ferroptosis
Experimental & Molecular Medicine, Published online: 01 May 2023; doi:10.1038/s12276-023-00986-2Tiny membrane-bound packets of biomolecules secreted by stem cells in the bone marrow umbilical cord can reduce the development of dangerous bulges or ballooning in the aorta, the body’s largest artery. Liang Chen of China’s Shanghai Jiao Tong University School of Medicine and colleagues report that these stem cell-derived vesicles help to prevent such bulges, known as aneurysms, in mice through their effects on a type of immune cell called neutrophils, which release networks of DNA and protein at sites of inflammation. ...
Source: Experimental and Molecular Medicine - May 1, 2023 Category: Molecular Biology Authors: Liang Chen Yuting Liu Zheyu Wang Leiyang Zhang Yi Xu Yinan Li Lan Zhang Guiming Wang Shuofei Yang Guanhua Xue Source Type: research

An MRTF-A–ZEB1–IRF9 axis contributes to fibroblast–myofibroblast transition and renal fibrosis
Experimental & Molecular Medicine, Published online: 01 May 2023; doi:10.1038/s12276-023-00990-6Targeting a signalling pathway involving several proteins could help treat renal fibrosis in chronic kidney disease. Renal fibrosis, regulated by a network of transcription factors, involves the accumulation of extracellular matrix proteins in the kidneys and significantly affects kidney function and prognosis of kidney diseases. Previous studies have revealed that loss of myocardin-related transcription factor A (MRTF-A) reduces renal fibrosis. Investigators in China led by Tao Zhang, Nanjing Medical University, and Xiaoyan...
Source: Experimental and Molecular Medicine - May 1, 2023 Category: Molecular Biology Authors: Qianwen Zhao Tinghui Shao Yuwen Zhu Gengjie Zong Junjie Zhang Shifan Tang Yanshan Lin Hongzhen Ma Zhifan Jiang Yong Xu Xiaoyan Wu Tao Zhang Source Type: research

Steady-state memory-phenotype conventional CD4+ T cells exacerbate autoimmune neuroinflammation in a bystander manner via the Bhlhe40/GM-CSF axis
Experimental & Molecular Medicine, Published online: 01 May 2023; doi:10.1038/s12276-023-00995-1An antigen independent function of T cells, known as bystander-activated T cell, contributes to autoimmune disease in the CNS (Central Nervous System), and could be targeted therapeutically to help suppress neuroinflammation. A team led by Je-Min Choi from Hanyang University in Seoul, South Korea, showed in mice that different subgroups of memory-phenotype T cells naturally arising without immunization. These cells become activated in response to different immune-stimulating cytokines, even without antigen-specific immune re...
Source: Experimental and Molecular Medicine - May 1, 2023 Category: Molecular Biology Authors: Min-Ji Cho Hong-Gyun Lee Jae-Won Yoon Gil-Ran Kim Ja-Hyun Koo Reshma Taneja Brian T. Edelson You Jeong Lee Je-Min Choi Source Type: research

Insulin signaling is critical for sinoatrial node maintenance and function
Experimental & Molecular Medicine, Published online: 01 May 2023; doi:10.1038/s12276-023-00988-0The hormone insulin and the related protein insulin-like growth factor-1 (IGF-1) have previously unrecognized significance in regulating heart rate through cell signaling activities affecting the pacemaker region of the heart. Researchers in South Korea led by Wang-Soo Lee and Jaetaek Kim at Chung-Ang University, Seoul, investigated the role of receptor proteins that bind to insulin and IGF-1 in the heart’s pacemaker sinoatrial node in mice. They explored the effects of genetic interventions altering the normal levels of t...
Source: Experimental and Molecular Medicine - May 1, 2023 Category: Molecular Biology Authors: Sangmi Ock Seong Woo Choi Seung Hee Choi Hyun Kang Sung Joon Kim Wang-Soo Lee Jaetaek Kim Source Type: research

Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity
Experimental & Molecular Medicine, Published online: 01 May 2023; doi:10.1038/s12276-023-00980-8Cell signaling processes are affected by the varying ways that sections of messenger RNA (mRNA), the molecule that carries genetic instructions copied from a gene, are spliced together to generate several different proteins from a single gene. Kee K. Kim et al. at Chungnam National University in Daejeon, South Korea, review the significance for cell signaling of the alternative splicing of mRNAs. Mutations or abnormal expression of splicing factors that lead to the splicing processes going awry are implicated in human diseas...
Source: Experimental and Molecular Medicine - May 1, 2023 Category: Molecular Biology Authors: Si Shi Huijie Gu Jinyuan Xu Wan Sun Caiyin Liu Tong Zhu Juan Wang Furong Gao Jieping Zhang Qingjian Ou Caixia Jin Jingying Xu Hao Chen Jiao Li Guotong Xu Haibin Tian Lixia Lu Source Type: research

Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation
Experimental & Molecular Medicine, Published online: 01 May 2023; doi:10.1038/s12276-023-00992-4Resolving the crystal structure of a multifunctional protein suggests possible routes to alleviating symptoms of advanced diabetes. Leucine-rich α-2-glycoprotein 1 (LRG1) plays both positive and negative roles in health and disease. LRG1 glycosylation, where carbohydrate-based polymers known as glycans bind to the protein, alters LRG1’s properties and functions. Aberrant LRG1 glycosylation is recognised in multiple diseases, including diabetes. Jimin Yang at the Institute for Basic Science, Daejeon, South Korea, and co-wo...
Source: Experimental and Molecular Medicine - May 1, 2023 Category: Molecular Biology Authors: Jimin Yang Guo Nan Yin Do-Kyun Kim Ah-reum Han Dong Sun Lee Kwang Wook Min Yaoyao Fu Jeongwon Yun Jun-Kyu Suh Ji-Kan Ryu Ho Min Kim Source Type: research

Trends and prospects in mitochondrial genome editing
Experimental & Molecular Medicine, Published online: 01 May 2023; doi:10.1038/s12276-023-00973-7Applying gene editing techniques to the DNA found within mitochondria, the intracellular energy-producing organelles, is being explored as an approach to treating various diseases. Most of the cell’s genetic information is found in the nucleus, but mitochondria carry their own set of genes. Hong Thi Lam Phan Korea University, Seoul, South Korea, and coworkers review current trends and prospects in mitochondrial gene editing. Genetic defects in mitochondria have been implicated in many diseases, mainly affecting muscle and ...
Source: Experimental and Molecular Medicine - May 1, 2023 Category: Molecular Biology Authors: Hong Thi Lam Phan Hyunji Lee Kyoungmi Kim Source Type: research

Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation
Experimental & Molecular Medicine, Published online: 01 May 2023; doi:10.1038/s12276-023-00982-6A drug usually used to treat high blood pressure (hypertension) shows great promise in preventing insulin resistance, where cells no longer respond to insulin thereby increasing the risk of type 2 diabetes, by reducing intracellular calcium overload in cells. High intracellular calcium levels associated with obesity have been strongly linked to insulin resistance. Byung-Chul Oh and Ok-Hee Kim at Gachon College of Medicine in Incheon, South Korea, and co-workers investigated the effects of several anti-hypertension drugs in t...
Source: Experimental and Molecular Medicine - May 1, 2023 Category: Molecular Biology Authors: Jin Wook Lee Hyun-Oh Gu Yunshin Jung YunJae Jung Seung-Yong Seo Jeong-Hee Hong In-Sun Hong Dae Ho Lee Ok-Hee Kim Byung-Chul Oh Source Type: research

Author Correction: Mesenchymal stem cell-derived extracellular vesicles subvert Th17 cells by destabilizing RORγt through posttranslational modification
Experimental & Molecular Medicine, Published online: 26 April 2023; doi:10.1038/s12276-023-01001-4Author Correction: Mesenchymal stem cell-derived extracellular vesicles subvert Th17 cells by destabilizing RORγt through posttranslational modification (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - April 26, 2023 Category: Molecular Biology Authors: Sunyoung Jung Sunho Lee Hyun Je Kim Sueon Kim Ji Hwan Moon Hyunwoo Chung Seong-Jun Kang Chung-Gyu Park Source Type: research