Experimental and Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions
Experimental & Molecular Medicine, Published online: 09 February 2023; doi:10.1038/s12276-023-00945-xStudies of inflammatory bowel disease (IBD) in mice reveal the role of an enzyme that assists the degradation of mis-folded proteins in the ‘goblet’ cells involved in producing the mucus barrier that lines and protects the interior of the gut. The most common forms of IBD are ulcerative colitis and Crohn’s disease. Researchers in South Korea led by Hyun-Jeong Ko at Kangwon National University, Chuncheon, and Sun-Young Chang at Ajou University, Suwon, compared goblet cell biology in normal mice with mice in which t...
Source: Experimental and Molecular Medicine - February 9, 2023 Category: Molecular Biology Authors: Hyunjin Jeong Eun-Hye Hong Jae-Hee Ahn Jaewon Cho Jae-Hyeon Jeong Chae-Won Kim Byung-Il Yoon Ja Hyun Koo Yun-Yong Park Yoon Mee Yang Takao Iwawaki Bruce A. Vallance Sun-Young Chang Hyun-Jeong Ko Source Type: research

Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver
Experimental & Molecular Medicine, Published online: 07 February 2023; doi:10.1038/s12276-023-00941-1Drugs directed at a receptor protein implicated in the body’s inflammatory responses could help protect the liver against fibrosis, cancer and other disorders. Youngmi Jung and Chanbin Lee from Pusan National University, South Korea, review how the formyl peptide receptor (FPR) family of proteins plays important roles in mediating immune responses to infection, injury and stress. One such family member, FPR2, is particularly active in certain liver diseases, including non-alcoholic fatty liver disease and hepatocellul...
Source: Experimental and Molecular Medicine - February 7, 2023 Category: Molecular Biology Authors: Chanbin Lee Jinsol Han Youngmi Jung Source Type: research

Adipokines at the crossroads of obesity and mesenchymal stem cell therapy
Experimental & Molecular Medicine, Published online: 07 February 2023; doi:10.1038/s12276-023-00940-2Adjusting the activity of a group of molecules derived from body fat might improve treatment success for mesenchymal (adult) stem cell (MSC) therapy in metabolic disorders. MSC therapy shows promise for treating obesity and other metabolic conditions, however the obese microenvironment can impair MSC potency, function, and survival. To help clarify why this happens, Pil-Hoon Park and co-workers at Yeungnam University in Gyeongsan, Korea, reviewed current understanding of adipokines, a group of signaling molecules and ho...
Source: Experimental and Molecular Medicine - February 7, 2023 Category: Molecular Biology Authors: Duc-Vinh Pham Thi-Kem Nguyen Pil-Hoon Park Source Type: research

Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant
Experimental & Molecular Medicine, Published online: 03 February 2023; doi:10.1038/s12276-023-00930-4A protein regulating gene expression called Vax1 is essential for building the optic chiasm (OC), a brain structure where nerves from the left and right eyes cross to the other side of the brain. Signals from both eyes must be integrated for space and depth perception. Although some cues guiding optic nerve growth are known, those for the OC are not. Jin Woo Kim at the Korea Advanced Institute of Science and Technology, Daejeon, South Korea, and co-workers investigated visual development in mice expressing a mutant Vax1...
Source: Experimental and Molecular Medicine - February 3, 2023 Category: Molecular Biology Authors: Kwang Wook Min Namsuk Kim Jae Hoon Lee Younghoon Sung Museong Kim Eun Jung Lee Jong-Myeong Kim Jae-Hyun Kim Jaeyoung Lee Wonjin Cho Jee Myung Yang Nury Kim Jaehoon Kim C. Justin Lee Young-Gyun Park Seung-Hee Lee Han-Woong Lee Jin Woo Kim Source Type: research

The role of the farnesoid X receptor in kidney health and disease: a potential therapeutic target in kidney diseases
Experimental & Molecular Medicine, Published online: 03 February 2023; doi:10.1038/s12276-023-00932-2Targeting the expression and activation of a critical bile acid receptor could be a novel therapeutic approach for kidney diseases. The prevalence of all types of kidney disease is rising due to ageing populations, but there are few therapeutic options available. In a review of recent research, Dong-Hyun Kim, Soo Wan Kim and co-workers at Chonnam National University in Gwangju, South Korea, examined the functional role of a key bile acid receptor protein called farnesoid X (FXR) in health and disease. FXR is widely expr...
Source: Experimental and Molecular Medicine - February 3, 2023 Category: Molecular Biology Authors: Dong-Hyun Kim Jung Sun Park Hoon-In Choi Chang Seong Kim Eun Hui Bae Seong Kwon Ma Soo Wan Kim Source Type: research

Superenhancers as master gene regulators and novel therapeutic targets in brain tumors
Experimental & Molecular Medicine, Published online: 01 February 2023; doi:10.1038/s12276-023-00934-0“Superenhancer” regions within the genome help coordinate the malignant growth of brain tumors, and could offer a target for the development of therapies and prognostic biomarkers. These regions contain a dense accumulation of gene regulatory sequences, which operate in collaboration to establish cellular identity. A review by Jian Qu and colleagues at Central South University, Changsha, China, shows how these regulatory sequences get hijacked in various brain cancers and can facilitate tumor cell proliferation and ...
Source: Experimental and Molecular Medicine - February 1, 2023 Category: Molecular Biology Authors: Hai-Hui Zhuang Qiang Qu Xin-Qi Teng Ying-Huan Dai Jian Qu Source Type: research

BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression
Experimental & Molecular Medicine, Published online: 01 February 2023; doi:10.1038/s12276-023-00936-yDrugs that target proteins involved in issuing stop and start commands to cancer-related genes help to sensitize melanoma cells to a widely used anti-cancer therapy, leading to tumor shrinkage in mice. Furong Zeng from Central South University in Changsha, China, and colleagues screened 240 approved anti-cancer agents in search of molecules that work synergistically with a BET inhibitor, an inhibitor of these proteins, to induce the death of melanoma cells. They found that a protein targeted by BET inhibitors (JQ1 and N...
Source: Experimental and Molecular Medicine - February 1, 2023 Category: Molecular Biology Authors: Furong Zeng Yayun Li Yu Meng Huiyan Sun Yi He Mingzhu Yin Xiang Chen Guangtong Deng Source Type: research

Chemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling
Experimental & Molecular Medicine, Published online: 01 February 2023; doi:10.1038/s12276-023-00929-xSepsis is a life-threatening condition that occurs when the body’s response to infection damages its own organs. Autophagy protects the body by degrading harmful materials in the cell using the lysosome. It has been an outstanding question whether autophagy can fight systemic inflammation in sepsis. Researchers in South Korea led by Eun-Kyeong Jo at Chungnam National University and Yong Tae Kwon at Seoul National University developed small molecule chemicals that target the autophagic receptor p62/SQSTSM-1/Sequestosom...
Source: Experimental and Molecular Medicine - February 1, 2023 Category: Molecular Biology Authors: Prashanta Silwal Young Jae Kim Yoon Jee Lee In Soo Kim Sang Min Jeon Taylor Roh Jin Kyung Kim Min Joung Lee Jun Young Heo Doo Sin Jo Sang-Hee Lee Dong-Hyung Cho Jin Man Kim Yong Tae Kwon Eun-Kyeong Jo Source Type: research

TRPV1 regulates ApoE4-disrupted intracellular lipid homeostasis and decreases synaptic phagocytosis by microglia
Experimental & Molecular Medicine, Published online: 01 February 2023; doi:10.1038/s12276-023-00935-zA chili pepper extract that activates a sensory protein helps to improve lipid metabolism in immune cells in the brain, leading to better nerve cell health in a mouse model of Alzheimer’s disease. A team led by Zhihua Yu and Hongzhuan Chen from the Shanghai Jiao Tong University School of Medicine, China, showed that mice carrying the ApoE4 risk factor gene for Alzheimer’s exhibited defects in how well their brain’s immune cells, known as microglia, processed lipids. These problems were exacerbated when the microgl...
Source: Experimental and Molecular Medicine - February 1, 2023 Category: Molecular Biology Authors: Chenfei Wang Jia Lu Xudong Sha Yu Qiu Hongzhuan Chen Zhihua Yu Source Type: research

Targeted dual base editing with Campylobacter jejuni Cas9 by single AAV-mediated delivery
Experimental & Molecular Medicine, Published online: 01 February 2023; doi:10.1038/s12276-023-00938-wTiny genome editors that can fit inside a single delivery system could potentially improve the efficiency and specificity of the editing technology known as CRISPR-Cas9. This technology is used to edit parts of the genome and shows promise for disease therapeutics. Cas9 is a bacterial enzyme that acts as molecular scissors to edit DNA and is guided to the correct DNA region by specific RNA segments (gRNAs). Yongsub Kim at the University of Ulsan in Seoul, South Korea, and co-workers used one of the smallest known Cas9 e...
Source: Experimental and Molecular Medicine - February 1, 2023 Category: Molecular Biology Authors: Jiyeon Kweon An-Hee Jang Eunji Kwon Ungi Kim Ha Rim Shin Jieun See Gayoung Jang Chaeyeon Lee Taeyoung Koo Seokjoong Kim Yongsub Kim Source Type: research

Single-molecule visualization of mRNA circularization during translation
Experimental & Molecular Medicine, Published online: 31 January 2023; doi:10.1038/s12276-023-00933-1Single-molecule fluorescence imaging is revealing the formation of circular mRNA and the complex interplay of messenger RNA (mRNA) and ribosomal proteins during translation, the decoding of mRNA to form proteins. Various translation factors encourage the circularization of mRNA, which might help control mRNA expression, but detailed insights have been limited. Jong-Bong Lee at Pohang University of Science & Technology, South Korea, and co-workers reviewed recent progress in single-molecule imaging of mRNA circularization...
Source: Experimental and Molecular Medicine - January 31, 2023 Category: Molecular Biology Authors: Byungju Kim Jincheol Seol Yoon Ki Kim Jong-Bong Lee Source Type: research

Retraction Note: Guangxi cobra venom-derived NGF promotes the osteogenic and therapeutic effects of porous BCP ceramic
Experimental & Molecular Medicine, Published online: 20 January 2023; doi:10.1038/s12276-023-00931-3Retraction Note: Guangxi cobra venom-derived NGF promotes the osteogenic and therapeutic effects of porous BCP ceramic (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - January 20, 2023 Category: Molecular Biology Authors: Pan Jin Fuqiang Yin Li Huang Li Zheng Jinmin Zhao Xingdong Zhang Source Type: research

Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis
Experimental & Molecular Medicine, Published online: 19 January 2023; doi:10.1038/s12276-022-00923-9The molecular mechanisms causing liver fibrosis, the tissue scarring associated with long-term liver disease, involve an enzyme called Parkin, suggesting that drugs enhancing Parkin activity might delay, reduce or prevent fibrosis. Researchers in China led by Jun Ren and Yingmei Zhang at Fudan University, Shanghai, studied cells from human and mouse liver to investigate the release of DNA from cell organelles called mitochondria, a key feature in the development of liver fibrosis. This DNA release triggers the abnormal i...
Source: Experimental and Molecular Medicine - January 19, 2023 Category: Molecular Biology Authors: Ne N. Wu Lifeng Wang Lu Wang Xihui Xu Gary D. Lopaschuk Yingmei Zhang Jun Ren Source Type: research

Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis
Experimental & Molecular Medicine, Published online: 19 January 2023; doi:10.1038/s12276-023-00926-0Detailed studies of epigenetic regulation in gastric cancer could provide novel targets for combination therapies. Gastric cancer development is heavily influenced by environmental factors such as diet, which drive epigenetic changes to DNA and gene expression. Tae-Hee Kim and colleagues at the Hospital for Sick Children in Toronto, Canada, reviewed current understanding of epigenetic regulation in gastric cancer, focusing on non-coding RNA and modifications to histones, proteins that bind to DNA. Histone modifications a...
Source: Experimental and Molecular Medicine - January 19, 2023 Category: Molecular Biology Authors: Adrian Kwan Ho Loe Lexin Zhu Tae-Hee Kim Source Type: research

SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis
Experimental & Molecular Medicine, Published online: 18 January 2023; doi:10.1038/s12276-023-00928-yInvestigation of a mitochondrial protein linked with intervertebral disc degeneration (IDD) provides possible therapeutic targets for lower back pain. Intervertebral discs act as shock absorbers in the spine, and excessive load over time can cause disc degeneration and pain. Liu Yang and Zhuojing Luo at Fourth Military Medical University in Xi’an, China, and co-workers analyzed the effect of excessive mechanical load on protein expression in IDD samples from human patients and rodent models. The sirtuin 5 (SIRT5) prote...
Source: Experimental and Molecular Medicine - January 18, 2023 Category: Molecular Biology Authors: Jianxin Mao Di Wang Dong Wang Qi Wu Qiliang Shang Chu Gao Huanbo Wang Han Wang Mu Du Pandi Peng Haoruo Jia Xiaolong Xu Jie Wang Liu Yang Zhuojing Luo Source Type: research