Experimental and Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer
This study discovered that HIFs and NRF2 can occasionally collaborate to aid cancer cells’ growth and treatment resistance. The key discoveries suggest that targeting these pathways could be a novel approach to cancer treatment, especially in tumors that have adapted to low oxygen conditions.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Taegeun Bae Steffanus Pranoto Hallis Mi-Kyoung Kwak Source Type: research

IL-27-induced PD-L1highSca-1+ innate lymphoid cells suppress contact hypersensitivity in an IL-10-dependent manner
Experimental & Molecular Medicine, Published online: 01 March 2024; doi:10.1038/s12276-024-01187-1Innate lymphoid cells (ILCs - a type of immune cell) are important for tissue health and immunity. However, the function of a specific group of these cells, known as IL-10+ ILCs, in skin inflammation is unclear. Scientists have found that a particular type of IL-10+ ILCs, named PD-L1highSca-1+ ILCs, can reduce skin inflammation in a mouse model of contact hypersensitivity (CHS - a type of allergic reaction). The research showed that these cells increase during inflammation and can lessen the activity of other immune cells....
Source: Experimental and Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Keun Young Min Do-Kyun Kim Min Geun Jo min Yeong Choi Dajeong Lee Jeong Won Park Young-Jun Park Yeonseok Chung Young Mi Kim Yeong-Min Park Hyuk Soon Kim Wahn Soo Choi Source Type: research

Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity
In conclusion, the research advances our understanding of how genetics can influence the risk of liver injury from TB drugs. This knowledge could lead to more personalized treatment plans and safer TB management in the future. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Jihoon G. Yoon Dong Geon Jang Sung-Gyu Cho Chaeyoung Lee Shin Hye Noh Soo Kyung Seo Jung Woo Yu Hyeon Woo Chung KyeoRe Han Soon Sung Kwon Dai Hoon Han Jaeseong Oh In-Jin Jang Sang-Hoon Kim Young-Koo Jee Hyun Lee Dong Won Park Jang Won Sohn Ho Joo Yoon Chu Source Type: research

RNA m5C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer
Experimental & Molecular Medicine, Published online: 01 March 2024; doi:10.1038/s12276-024-01184-4Ovarian cancer is the most lethal women’s reproductive system cancer globally, largely due to the absence of early detection techniques. Scientists have discovered that a gene named NSUN2, often found in excess in ovarian cancer, is vital for the cancer’s growth. The research, led by P.Y. and T.L., revealed that NSUN2 encourages the expansion and spread of ovarian cancer cells. They also found that NSUN2 controls the activity of another gene, E2F1, through a method called m5C modification (a process that alters gene ex...
Source: Experimental and Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Xiaoyi Liu Qinglv Wei Chenyue Yang Hongyan Zhao Jie Xu Youchaou Mobet Qingya Luo Dan Yang Xinzhao Zuo Ningxuan Chen Yu Yang Li Li Wei Wang Jianhua Yu Jing Xu Tao Liu Ping Yi Source Type: research

Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges
This study, led by Jiahn Choi and Leonard H. Augenlicht, explores intestinal stem cells. The researchers carried out a review, studying how ISCs work and how factors like aging and diet influence them. They used various methods, including gene expression profiling and single-cell RNA sequencing, to comprehend how ISCs maintain the gut and how this alters with age or different diets. The researchers discovered that aging and diet greatly impact ISCs and the cells that assist them. For instance, aging can lessen the ability of ISCs to renew the gut lining, while certain diets can either damage or enhance ISC function. These ...
Source: Experimental and Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Jiahn Choi Leonard H. Augenlicht Source Type: research

Role of lung ornithine aminotransferase in idiopathic pulmonary fibrosis: regulation of mitochondrial ROS generation and TGF-β1 activity
This study found that OAT was more present in the lungs of IPF patients, especially in areas with severe fibrotic (excessive tissue) remodeling. Increased OAT led to more fibroblast (cells that produce collagen and other fibers) growth, while less OAT reduced it. The study concluded that high OAT levels in IPF lungs contribute to fibrosis progression by enhancing TGF-β1 (a protein that controls cell growth and division) activity and increasing mitochondrial ROS generation. The findings suggest that stopping OAT may reduce fibrosis, offering a potential new treatment for IPF. This summary was initially drafted using artifi...
Source: Experimental and Molecular Medicine - February 28, 2024 Category: Molecular Biology Authors: Jong-Uk Lee Ki Sung Song Jisu Hong Hyesun Shin Eunji Park Junyeong Baek Shinhee Park Ae-Rin Baek Junehyuk Lee An Soo Jang Do Jin Kim Su Sie Chin U-Jin Kim Sung Hwan Jeong Sung-Woo Park Source Type: research

NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells
In this study, researchers focused on a protein called TBC1D15 (oncofetal protein), which interacts with another protein, NOTCH1, to influence TIC behavior. Using mouse models and human cell lines, the team investigated how TBC1D15 affects TICs and explored potential therapeutic strategies. The study revealed that TBC1D15 promotes the self-renewal and growth of TICs by interacting with NOTCH1 and affecting mitochondrial function. The researchers also identified small molecules that can disrupt the TBC1D15-NOTCH1 interaction, offering a new approach to target TICs in cancer treatment. The results showed that interfering wit...
Source: Experimental and Molecular Medicine - February 27, 2024 Category: Molecular Biology Authors: Hye Yeon Choi Yicheng Zhu Xuyao Zhao Simran Mehta Juan Carlos Hernandez Jae-Jin Lee Yi Kou Risa Machida Mauro Giacca Giannino Del Sal Ratna Ray Hyungjin Eoh Stanley M. Tahara Lin Chen Hidekazu Tsukamoto Keigo Machida Source Type: research

Cost and time-efficient construction of a 3′-end mRNA library from unpurified bulk RNA in a single tube
This study, led by Dunhee Bang, presents a new technique named Bulk transcriptOme profiling of cell Lysate in a single pot. BOLT-seq simplifies the RNA-seq procedure by using fewer steps and homemade reagents, significantly reducing both cost and time. BOLT-seq is an experiment where up to 1000 cells are processed directly in one tube without purifying the RNA first. The researchers concluded that BOLT-seq is a significant advancement for large-scale genetic studies. In the future, this method could make understanding how different treatments affect gene activity in cells easier and more affordable, potentially speeding up...
Source: Experimental and Molecular Medicine - February 27, 2024 Category: Molecular Biology Authors: Jungwon Choi Jungheun Hyun Jieun Hyun Jae-Hee Kim Ji Hyun Lee Duhee Bang Source Type: research

Helicobacter pylori CagA-mediated ether lipid biosynthesis promotes ferroptosis susceptibility in gastric cancer
Experimental & Molecular Medicine, Published online: 21 February 2024; doi:10.1038/s12276-024-01167-5Gastric cancer, a major cause of cancer death globally, is often associated with chronic infection by a bacterium named Helicobacter pylori. A specific strain of H. pylori that produces a protein named CagA is particularly harmful, as it can cause severe stomach diseases, including cancer. However, the connection between CagA and a kind of cell death known as ferroptosis in gastric cancer cells was unclear. In this research, scientists discovered that CagA boosts the production of certain fats in cells, making them more...
Source: Experimental and Molecular Medicine - February 21, 2024 Category: Molecular Biology Authors: Yanmei Peng Xuetao Lei Qingbin Yang Guofan Zhang Sixiao He Minghao Wang Ruoyu Ling Boyang Zheng Jiayong He Xinhua Chen Fengping Li Qiming Zhou Liying Zhao Gengtai Ye Guoxin Li Source Type: research

Baf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages
Experimental & Molecular Medicine, Published online: 19 February 2024; doi:10.1038/s12276-024-01169-3The development of nervous system requires a tightly controlled process of cell differentiation that originates from neural progenitor cells. Here, Ko and colleagues investigated the cellular and molecular basis underlying heterochromatin anchoring-dependent regulation of neural progenitor cell lineages by combining single-cell RNA sequencing and genetic analyses using Drosophila. They demonstrated the neurodevelopmental role of Barrier-to-autointegration factor (Baf), a chromatin-binding proteins mediating subnuclear p...
Source: Experimental and Molecular Medicine - February 19, 2024 Category: Molecular Biology Authors: Byung Su Ko Myeong Hoon Han Min Jee Kwon Dong Gon Cha Yuri Ji Eun Seo Park Min Jae Jeon Somi Kim Kyeongho Lee Yoon Ha Choi Jusung Lee Monica Torras-Llort Ki-Jun Yoon Hyosang Lee Jong Kyoung Kim Sung Bae Lee Source Type: research

Distinct characteristics of the DNA damage response in mammalian oocytes
Experimental & Molecular Medicine, Published online: 14 February 2024; doi:10.1038/s12276-024-01178-2Understanding how our cells fix DNA damage is key to understanding why certain diseases, like cancer, happen. Researchers conducted a review, to create a clearer picture of DNA repair in oocytes. They discovered that oocytes have a unique method of handling DNA damage compared to other cell types. The study also noted that as women age, their oocytes become less skilled at repairing DNA, which can affect fertility. The researchers emphasized that oocytes have a strong system for fixing DNA damage, which is crucial for p...
Source: Experimental and Molecular Medicine - February 14, 2024 Category: Molecular Biology Authors: Jiyeon Leem Crystal Lee Da Yi Choi Jeong Su Oh Source Type: research

Emerging roles of MITF as a crucial regulator of immunity
This study investigates how MITF interacts with immune cells, and how it might influence treatments for diseases like melanoma. The key findings reveal that MITF has a complex relationship with the immune system. The researchers propose that understanding MITF’s role in the immune system could lead to improved treatments for cancer and other diseases. They believe that targeting MITF might enhance the efficacy of current therapies and assist in developing new ones. The potential future implications of this research could be significant for improving patient outcomes in various diseases.This summary was initially drafted ...
Source: Experimental and Molecular Medicine - February 13, 2024 Category: Molecular Biology Authors: Aram Lee Jihyun Lim Jong-Seok Lim Source Type: research

Author Correction: Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway
Experimental & Molecular Medicine, Published online: 13 February 2024; doi:10.1038/s12276-024-01171-9Author Correction: Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - February 13, 2024 Category: Molecular Biology Authors: Peng-yu Duan Yuan Ma Xi-na Li Feng-zhi Qu Liang Ji Xiao-yu Guo Wang-jun Zhang Fan Xiao Le Li Ji-sheng Hu Bei Sun Gang Wang Source Type: research

Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer’s disease
This study explores sphingolipid metabolism. However, when this process malfunctions, it can cause various diseases. The enzyme acid sphingomyelinase is key as it produces ceramide, a lipid that, in excess, can cause cell death and contribute to diseases like Alzheimer’s and major depression. The study compiles recent findings on how ASM contributes to neurological disorders, particularly Alzheimer’s disease. It investigates how ASM impacts brain cells and blood, leading to symptoms like memory loss and inflammation. The review also discusses potential drugs that target ASM, offering hope for treating these disorders. ...
Source: Experimental and Molecular Medicine - February 9, 2024 Category: Molecular Biology Authors: Byung Jo Choi Min Hee Park Hee Kyung Jin Jae-sung Bae Source Type: research

Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway
Experimental & Molecular Medicine, Published online: 05 February 2024; doi:10.1038/s12276-024-01168-4Low back pain, a main reason for disability, is often due to intervertebral disc degeneration (IDD - the wear and tear of the discs between the vertebrae of the spine). This degeneration, accounting for about 40% of chronic low back pain instances, results in the damage of spinal structure and function. In this research, scientists explored the role of inflammation in IDD, focusing on the role of macrophages. They found that macrophages with different polarized phenotypes (observable traits) existed in degenerative inte...
Source: Experimental and Molecular Medicine - February 5, 2024 Category: Molecular Biology Authors: Shuo Tian Xuanzuo Chen Wei Wu Hui Lin Xiangcheng Qing Sheng Liu BaiChuan Wang Yan Xiao Zengwu Shao Yizhong Peng Source Type: research