Experimental and Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Mouse models of Kras activation in gastric cancer
Experimental & Molecular Medicine, Published online: 11 November 2022; doi:10.1038/s12276-022-00882-1Improvements to genetically engineered mouse models for studying a specific oncogene, a gene with the potential to cause cancer, in gastrointestinal (GI) cancers could help identify the precise cellular origins of these diseases. Mutations affecting the Kirsten rat sarcoma viral oncogene (Kras) are among the most common drivers of cancer. Kras activation varies in terms of incidence rates and roles across GI cancers. Eunyoung Choi and Yoonkyung Won at Vanderbilt University Medical Center in Nashville, USA, reviewed the ...
Source: Experimental and Molecular Medicine - November 11, 2022 Category: Molecular Biology Authors: Yoonkyung Won Eunyoung Choi Source Type: research

Hypoxia-induced circRNF13 promotes the progression and glycolysis of pancreatic cancer
Experimental & Molecular Medicine, Published online: 11 November 2022; doi:10.1038/s12276-022-00877-yThe low-oxygen (hypoxic) conditions within pancreatic tumors promote production of a newly identified circular RNA molecule associated with aggressive tumor growth. Pancreatic cancers are generally difficult to treat, and the hypoxic conditions of the tumor interior are known to contribute to greater resistance to chemotherapy. Several studies have indicated that these conditions also lead to greater production of certain circular RNAs, and researchers led by Rong Wan at Shanghai Jiao Tong University School of Medicine,...
Source: Experimental and Molecular Medicine - November 11, 2022 Category: Molecular Biology Authors: Qiuyan Zhao Zhonglin Zhu Wenqin Xiao Guanzhao Zong Chuanyang Wang Weiliang Jiang Kai Li Jie Shen Xingya Guo Jianhua Cui Lihong Guo Rong Wan Source Type: research

The natural product salicin alleviates osteoarthritis progression by binding to IRE1α and inhibiting endoplasmic reticulum stress through the IRE1α-IκBα-p65 signaling pathway
Experimental & Molecular Medicine, Published online: 10 November 2022; doi:10.1038/s12276-022-00879-wSalicin, a small molecule extracted from willow bark, could provide a safe, effective injectable treatment for osteoarthritis, particularly in the early stages of the disease. Osteoarthritis is driven by stress in the intracellular endoplasmic reticulum (ER), which results in chronic inflammation and death of chondrocytes, the cells involved in cartilage formation. Salicin, which is metabolized into salicylic acid after oral ingestion, already forms the basis of aspirin and other anti-inflammatory pain relievers, but th...
Source: Experimental and Molecular Medicine - November 10, 2022 Category: Molecular Biology Authors: Zhenglin Zhu Shengqiang Gao Cheng Chen Wei Xu Pengcheng Xiao Zhiyu Chen Chengcheng Du Bowen Chen Yan Gao Chunli Wang Junyi Liao Wei Huang Source Type: research

WNK3 inhibition elicits antitumor immunity by suppressing PD-L1 expression on tumor cells and activating T-cell function
Experimental & Molecular Medicine, Published online: 10 November 2022; doi:10.1038/s12276-022-00876-zInhibiting the activity of the protein WNK lysine deficient protein kinase 3 (WNK3) boosts anti-tumor immunity by suppressing the production of another protein (PD-L1) whose activity promotes the programmed cell death of immune system T cells. Hyun Seok Kim, Ho-Keun Kwon and colleagues at Yonsei University in Seoul, South Korea, undertook a wide search for factors that could regulate PD-L1 levels in human lung cancer cells. While identifying WNK3 inhibition as a route towards restoring the anti-cancer activity of T cell...
Source: Experimental and Molecular Medicine - November 10, 2022 Category: Molecular Biology Authors: Hyun Ju Yoon Gi-Cheon Kim Sejin Oh Hakhyun Kim Yong Keon Kim Yunji Lee Min Seo Kim Gino Kwon Yeon-Su Ok Ho-Keun Kwon Hyun Seok Kim Source Type: research

Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages
Experimental & Molecular Medicine, Published online: 09 November 2022; doi:10.1038/s12276-022-00886-xThe inhalation of tiny particles known as particulate matter (PM) from polluted air induces an inflammatory response in the lungs that may contribute to tumor metastasis. PM contributes to a host of respiratory problems including lung cancer, and many of these toxic effects are thought to arise from chemical signals released by immune cells upon exposure to these pollutants. Seung-Ho Park at the Korea Research Institute of Bioscience and Biotechnology, Daejon, South Koread, and coworkers have determined that immune cell...
Source: Experimental and Molecular Medicine - November 9, 2022 Category: Molecular Biology Authors: Seung-Ho Park Sung-Jin Yoon Song Choi Jaeeun Jung Jun-Young Park Young-Ho Park Jinho Seo Jungwoon Lee Moo-Seung Lee Seon-Jin Lee Mi-Young Son Young-Lai Cho Jang-Seong Kim Hyo Jin Lee Jinyoung Jeong Dae-Soo Kim Young-Jun Park Source Type: research