Experimental and Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The polyol pathway and nuclear ketohexokinase A signaling drive hyperglycemia-induced metastasis of gastric cancer
This study offers a potential reason for the diabetes-cancer connection and implies that managing blood sugar levels in cancer patients with diabetes could be vital in preventing cancer progression. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - January 10, 2024 Category: Molecular Biology Authors: Ye-Lim Kang Jiyoung Kim Su-Bin Kwak Yi-Sook Kim June Huh Jong-Wan Park Source Type: research

Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration
In this study, researchers reviewed the internal and external processes involved in the regulation of HFSCs, melanocyte stem cells (MeSCs), and sebaceous gland (SG) stem cells during the hair growth cycle. The study also examined the effects of aging, metabolic changes, and stress on hair follicle regeneration. The researchers concluded that understanding the stem cell regulation-related signaling pathways in the hair follicles could be crucial for developing strategies for hair regeneration and the treatment of various hair and skin disorders.This summary was initially drafted using artificial intelligence, then revised a...
Source: Experimental and Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Jung Hyun Lee Sekyu Choi Source Type: research

Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies
Experimental & Molecular Medicine, Published online: 05 January 2024; doi:10.1038/s12276-023-01150-6Soluble receptors, a kind of cellular receptor that exist in a dissolvable form and can boost or interrupt cellular signaling pathways, are the focus of this study. Abnormal amounts of these receptors are associated with the severity of many diseases, including cancer. This research by Eun-Ji Park and Chang-Woo Lee delves into the role of soluble receptors in cancer, specifically soluble cytokine receptors and soluble immune checkpoints. Their study involved a thorough review of existing literature and data on these solu...
Source: Experimental and Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Eun-Ji Park Chang-Woo Lee Source Type: research

Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer
Experimental & Molecular Medicine, Published online: 04 January 2024; doi:10.1038/s12276-023-01131-9Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein with diverse roles in inflammation, macrophage polarization, apoptosis, and carcinogenesis. Pro-inflammatory effects of CHI3L1 are attributed to its response to various pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-1β, interleukin-6, and interferon-γ. Consequently, CHI3L1 is implicated in a wide range of inflammatory diseases. This review summarizes the significance of CHI3L1 as a potential target in multiple inflammatory disea...
Source: Experimental and Molecular Medicine - January 4, 2024 Category: Molecular Biology Authors: Ji Eun Yu In Jun Yeo Sang-Bae Han Jaesuk Yun Bongcheol Kim Yoon Ji Yong Young-soo Lim Tae Hun Kim Dong Ju Son Jin Tae Hong Source Type: research

Modification of immune cell-derived exosomes for enhanced cancer immunotherapy: current advances and therapeutic applications
Experimental & Molecular Medicine, Published online: 04 January 2024; doi:10.1038/s12276-023-01132-8The study investigates the use of tiny particles released from the immune system, known as immune cell-derived exosomes (IEXs), for cancer treatment. This research aspires to bridge the existing knowledge gap about engineering these IEXs to boost their inherent anti-cancer properties. The team of researchers, headed by PhD student, Inseong Jung and Sanghee Shin, and Professors Kyungmoo Yea and Moon-Chang Baek, investigated using gene alteration and physical and chemical changes to enhance the therapeutic potential of IEX...
Source: Experimental and Molecular Medicine - January 4, 2024 Category: Molecular Biology Authors: Inseong Jung Sanghee Shin Moon-Chang Baek Kyungmoo Yea Source Type: research

Vitamin D ameliorates age-induced nonalcoholic fatty liver disease by increasing the mitochondrial contact site and cristae organizing system (MICOS) 60 level
Experimental & Molecular Medicine, Published online: 04 January 2024; doi:10.1038/s12276-023-01125-7Nonalcoholic fatty liver disease (a condition in which fat builds up in the liver) (NAFLD) is increasingly affecting health, especially among the older population. The causes behind this disease are still unclear, but a fresh study by Lim and colleagues adds to our knowledge. They discovered that a reduction in a protein named Mic60 in the liver mitochondria of old mice leads to fat buildup, a major sign of NAFLD. However, when the mice consumed a diet enriched with vitamin D3, the Mic60 protein levels returned to normal...
Source: Experimental and Molecular Medicine - January 4, 2024 Category: Molecular Biology Authors: Gyu Hee Kim Hyeon-Ju Jeong Yoo Jeong Lee Hyeon Young Park Soo Kyung Koo Joo Hyun Lim Source Type: research

Relevance of the endoplasmic reticulum-mitochondria axis in cancer diagnosis and therapy
Experimental & Molecular Medicine, Published online: 04 January 2024; doi:10.1038/s12276-023-01137-3Understanding the cooperation between organelles, especially the endoplasmic reticulum and mitochondria (the energy factories of cells), is vital to uncover how cellular functions are controlled. However, the exact function of the membranes linking these organelles, termed mitochondria-associated ER membranes (MAMs), in diseases like cancer is still uncertain. In this research, scientists found MAMs to play a vital role in cancer cell function and metabolism by regulating calcium signaling, lipid metabolism, autophagy, a...
Source: Experimental and Molecular Medicine - January 4, 2024 Category: Molecular Biology Authors: Garam An Junho Park Jisoo Song Taeyeon Hong Gwonhwa Song Whasun Lim Source Type: research

Mitochondria as secretory organelles and therapeutic cargos
This study, by Joonho Suh and Yun-Sil Lee at Seoul National University in South Korea, explores the process of mitochondrial secretion and its potential therapeutic applications. The researchers reviewed the current understanding of mitochondrial secretion, focusing on the release of mitochondria as an entire organelle. They discovered that cells can secrete mitochondria via various methods, and these extracellular mitochondria can be absorbed by recipient cells to boost their functions. The study also emphasized the potential of using mitochondrial transplantation as a therapeutic strategy in various diseases. The authors...
Source: Experimental and Molecular Medicine - January 4, 2024 Category: Molecular Biology Authors: Joonho Suh Yun-Sil Lee Source Type: research

Current understanding of the Alzheimer’s disease-associated microbiome and therapeutic strategies
This study, led by Seo and Holtzman, investigates the role of the gut microbiome (the community of microorganisms in our digestive system) in Alzheimer’s disease. The scientists conducted a narrative review, summarizing recent discoveries and discussing new questions in the field. They discovered that the gut microbiome could impact the development of Alzheimer’s disease by controlling peripheral neurotransmitters, metabolites, and immune signaling molecules. The scientists concluded that targeting the gut bacteria could potentially be a treatment strategy for Alzheimer’s disease. However, they also emphasized the ne...
Source: Experimental and Molecular Medicine - January 4, 2024 Category: Molecular Biology Authors: Dong-oh Seo David M. Holtzman Source Type: research

Multifaceted roles of CCAR family proteins in the DNA damage response and cancer
Experimental & Molecular Medicine, Published online: 04 January 2024; doi:10.1038/s12276-023-01139-1Cell Division Cycle Apoptosis Regulator (CCAR, proteins that regulate cell division and death) proteins play various roles in stress response, DNA repair, and longevity regulation. Their absence or overexpression could lead to cancers, with unclear underlying mechanisms. Recent studies explored the roles of CCAR2 protein, using molecular and cellular techniques (methods for studying cells and molecules), which discovered that human CCAR2 directly aids in the repair of DNA double-strand breaks, highlighting its diverse ro...
Source: Experimental and Molecular Medicine - January 4, 2024 Category: Molecular Biology Authors: D. Lugano L. Barrett S. D. Westerheide Y. Kee Source Type: research

4-1BB immunotherapy: advances and hurdles
Experimental & Molecular Medicine, Published online: 04 January 2024; doi:10.1038/s12276-023-01136-44-1BB is a costimulatory T-cell receptor expressed on activated T cells and natural killer cells. Targeting 4-1BB with agonistic antibodies is a promising immuno-oncology approach and has shown potential in preclinical animal models. However, the clinical use of agonistic 4-1BB antibodies for cancer immunotherapy has been hampered by adverse effects and insufficient anti-cancer activity. In this review, the authors provide an overview of the 4-1BB costimulatory pathways in T-cell-mediated cancer immunity and summarize on...
Source: Experimental and Molecular Medicine - January 4, 2024 Category: Molecular Biology Authors: Rohit Singh Young-Ho Kim Sang-Jin Lee Hyeon-Seok Eom Beom K. Choi Source Type: research

Pathological phenotypes of astrocytes in Alzheimer’s disease
Experimental & Molecular Medicine, Published online: 04 January 2024; doi:10.1038/s12276-023-01148-0Alzheimer’s disease is a widespread type of dementia characterized by memory loss and cognitive dysfunction, with the death of neuronal cells being a key feature. However, the role of astrocytes in the disease’s progression is not fully understood. In a recent study by J.K., J.L., and J.-S.M., they reviewed the pathological phenotypes of astrocytes in Alzheimer’s disease. They explored Alzheimer’s-related astrocytes, discussing the pathological phenotypes in the context of human and mouse Alzheimer’s models. Th...
Source: Experimental and Molecular Medicine - January 4, 2024 Category: Molecular Biology Authors: Junhyung Kim Ik Dong Yoo Jaejoon Lim Jong-Seok Moon Source Type: research

Author Correction: SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs
Experimental & Molecular Medicine, Published online: 25 December 2023; doi:10.1038/s12276-023-01134-6Author Correction: SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - December 25, 2023 Category: Molecular Biology Authors: Junsoo Kim Daehwa Youn Seunghoon Choi Youn Woo Lee Dulguun Sumberzul Jeongeun Yoon Hanju Lee Jong Woo Bae Hyuna Noh Dain On Seung-Min Hong Se-Hee An Hui Jeong Jang Seo Yeon Kim Young Been Kim Ji-Yeon Hwang Hyo-Jung Lee Hong Bin Kim Jun Won Park Jun-Won Yu Source Type: research

Author Correction: Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells
Experimental & Molecular Medicine, Published online: 19 December 2023; doi:10.1038/s12276-023-01143-5Author Correction: Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - December 19, 2023 Category: Molecular Biology Authors: Joon Ho Moon Joonyub Lee Kyun Hoo Kim Hyun Jung Kim Hyeongseok Kim Hye-Na Cha Jungsun Park Hyeonkyu Lee So-young Park Hak Chul Jang Hail Kim Source Type: research

IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes
Experimental & Molecular Medicine, Published online: 01 December 2023; doi:10.1038/s12276-023-01126-6Osteoarthritis (OA, a common joint disease in adults due to imbalance in cartilage formation and decay), is a complex process impacting the entire joint with no current treatments. A research team led by G.M.K and S.Y.L looked into the function of Immunoglobulin superfamily-11 (IgSF11, a protein aiding cell sticking together and osteoclast differentiation - a process creating a type of bone cell). This protein is rapidly produced in osteoclasts undergoing differentiation and in the osteoarthritic subchondral bone (bone ...
Source: Experimental and Molecular Medicine - December 1, 2023 Category: Molecular Biology Authors: Gyeong Min Kim Jihee Kim June-Yong Lee Min-Chan Park Soo Young Lee Source Type: research