Multifaceted roles of CCAR family proteins in the DNA damage response and cancer

Experimental & Molecular Medicine, Published online: 04 January 2024; doi:10.1038/s12276-023-01139-1Cell Division Cycle Apoptosis Regulator (CCAR, proteins that regulate cell division and death) proteins play various roles in stress response, DNA repair, and longevity regulation. Their absence or overexpression could lead to cancers, with unclear underlying mechanisms. Recent studies explored the roles of CCAR2 protein, using molecular and cellular techniques (methods for studying cells and molecules), which discovered that human CCAR2 directly aids in the repair of DNA double-strand breaks, highlighting its diverse roles in stress responses. Studies also underscored the involvement of CCAR2 in the DNA damage response and repair, apoptosis, transcription, and aging. The findings could help in understanding and treating diseases that harbor alterations in CCAR2 gene.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research