Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies

Experimental & Molecular Medicine, Published online: 05 January 2024; doi:10.1038/s12276-023-01150-6Soluble receptors, a kind of cellular receptor that exist in a dissolvable form and can boost or interrupt cellular signaling pathways, are the focus of this study. Abnormal amounts of these receptors are associated with the severity of many diseases, including cancer. This research by Eun-Ji Park and Chang-Woo Lee delves into the role of soluble receptors in cancer, specifically soluble cytokine receptors and soluble immune checkpoints. Their study involved a thorough review of existing literature and data on these soluble receptors. They discovered that high levels of soluble receptors are found in the blood of cancer patients, suggesting their potential use as minimally invasive indicators for early cancer detection and prognosis. The authors also suggest that blocking these soluble receptors could enhance the effectiveness of current cancer treatments.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research