Experimental and Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Circulating MiRNA-21-enriched extracellular vesicles promote bone remodeling in traumatic brain injury patients
Experimental & Molecular Medicine, Published online: 03 March 2023; doi:10.1038/s12276-023-00956-8Extracellular vesicles enriched with a particular microRNA released following traumatic brain injury (TBI) help fractures heal faster and could inform treatments for skeletal disorders. Patients with TBI and associated fractures experience shorter fracture recovery times than patients with fractures only, but precisely why is unclear. Ze Lin at Huazhong University of Science and Technology, Wuhan, China, and co-workers examined molecules released during recovery in samples taken from patients with TBI and fractures, those ...
Source: Experimental and Molecular Medicine - March 3, 2023 Category: Molecular Biology Authors: Ze Lin Yuan Xiong Yun Sun Ruiyin Zeng Hang Xue Yiqiang Hu Lang Chen Guodong Liu Adriana C. Panayi Wu Zhou Faqi Cao Fei Gao Bobin Mi Guohui Liu Source Type: research

NLRP3-dependent lipid droplet formation contributes to posthemorrhagic hydrocephalus by increasing the permeability of the blood–cerebrospinal fluid barrier in the choroid plexus
Experimental & Molecular Medicine, Published online: 03 March 2023; doi:10.1038/s12276-023-00955-9Inhibiting a key inflammatory protein and thereby protecting the blood-brain barrier following brain hemorrhage may prevent the build-up of fluid on the brain (hydrocephalus). Using rat models and cell cultures, Yujie Chen and Hua Feng at the Third Military Medical University in Chongqing, China, and co-workers examined how posthemorrhagic hydrocephalus occurs. They found that the acute inflammatory response activated immediately after a brain hemorrhage, which is driven by a critical protein complex involved in innate imm...
Source: Experimental and Molecular Medicine - March 3, 2023 Category: Molecular Biology Authors: Zhaoqi Zhang Peiwen Guo Liang Liang Shiju Jila Xufang Ru Qiang Zhang Jingyu Chen Zhi Chen Hua Feng Yujie Chen Source Type: research

Whole-genome sequencing reveals an association between small genomic deletions and an increased risk of developing Parkinson’s disease
Experimental & Molecular Medicine, Published online: 03 March 2023; doi:10.1038/s12276-023-00952-yA whole-genome sequencing study of Korean individuals with Parkinson’s disease (PD) has identified several new genetic risk factors, ranging from single nucleotide variations (SNVs) to larger DNA deletions. PD is the second most prevalent neurodegenerative disease globally, but most studies have focused on SNVs in European populations. Using whole-genome sequencing, Ji-Hye Oh at the University of Ulsan, Seoul, South Korea, and co-workers were able to identify genetic differences between PD patients and healthy controls, ...
Source: Experimental and Molecular Medicine - March 3, 2023 Category: Molecular Biology Authors: Ji-Hye Oh Sungyang Jo Kye Won Park Eun-Jae Lee Seung Hyun Lee Yun Su Hwang Ha Ra Jeon Yeonjin Ryu Hee Jeong Yoon Sung-Min Chun Chong Jai Kim Tae Won Kim Chang Ohk Sung Sehyun Chae Sun Ju Chung Source Type: research

The role of the osmosensitive transcription factor NFAT5 in corneal edema resorption after injury
Experimental & Molecular Medicine, Published online: 03 March 2023; doi:10.1038/s12276-023-00954-wA protein called nuclear factor of activated T cells 5 (NFAT5) plays a significant role in maintaining fluid balance in the cornea, the anterior part of the eye. Disturbances in corneal fluid balance and pathological swelling known as edema potentially lead to loss of corneal transparency and blindness. Deniz Hos and colleagues at the University of Cologne, Germany, studied the functional role of NFAT5 in a mouse model of corneal injury. They found that corneal injury induced significantly increased NFAT5 activity. Further...
Source: Experimental and Molecular Medicine - March 3, 2023 Category: Molecular Biology Authors: Karina Hadrian Gwen Musial Alfrun Sch önberg Tihomir Georgiev Christoph K üper Felix Bock Jonathan Jantsch Claus Cursiefen Sabine A. Eming Deniz Hos Source Type: research

Senescent cancer cell-derived nanovesicle as a personalized therapeutic cancer vaccine
Experimental & Molecular Medicine, Published online: 01 March 2023; doi:10.1038/s12276-023-00951-zTherapeutic vaccines derived from tumor cells could provide a personalized strategy for training the immune system to find and destroy cancer. Past efforts to develop such vaccines have been hampered by the challenge of identifying tumor-specific proteins that elicit a strong immune response. To overcome this, Byung-Soo Kim and colleagues at Seoul National University pursued a strategy in which they subjected tumor cells to chemical treatments that halted proliferation and stimulated production of immunity-activating signa...
Source: Experimental and Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Jihye Hong Mungyo Jung Cheesue Kim Mikyung Kang Seokhyeong Go Heesu Sohn Sangjun Moon Sungpil Kwon Seuk Young Song Byung-Soo Kim Source Type: research

The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications
Experimental & Molecular Medicine, Published online: 01 March 2023; doi:10.1038/s12276-023-00944-yThe reversible addition of a chemical methyl group (CH3) to the base adenine in RNA molecules, creating N6-methyladenosine, regulates the activity of many non-coding RNAs that, unlike messenger RNAs, do not code for the formation of proteins. These RNAs can regulate gene activity. Researchers in China led by Gang Wang at Harbin Medical University, and Qiushi Tang at the Chinese Medical University, Liaoning, review the molecular mechanisms and significance of ‘m6A modification’ of non-coding RNAs. They focus on the prog...
Source: Experimental and Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Ziying Liu Lei Gao Long Cheng Gaoyuan Lv Bei Sun Gang Wang Qiushi Tang Source Type: research

Etiology of genetic muscle disorders induced by mutations in fast and slow skeletal MyBP-C paralogs
Experimental & Molecular Medicine, Published online: 01 March 2023; doi:10.1038/s12276-023-00953-xContraction and relaxation of both heart and skeletal muscles are regulated by different forms of a protein called MyBP-C, mutations in this protein being important causes of heart and skeletal muscle diseases. Although the cardiac form has been well studied, the two skeletal forms are not well understood. Taejeong Song and Sakthivel Sadayappan at the University of Cincinnati, USA, have reviewed current understanding of the structure and function of MyBP-C proteins, and links between mutations and disease. They report that...
Source: Experimental and Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Taejeong Song Maicon Landim-Vieira Mustafa Ozdemir Caroline Gott Onur Kanisicak Jose Renato Pinto Sakthivel Sadayappan Source Type: research

Inhibition of mitochondrial phosphate carrier prevents high phosphate-induced superoxide generation and vascular calcification
Experimental & Molecular Medicine, Published online: 01 March 2023; doi:10.1038/s12276-023-00950-0Drugs that block the transport of phosphate ions into mitochondria, the ‘powerhouses’ of the cell, could prevent life-threatening stiffening of blood vessel walls. Using smooth muscle cells taken from rat aortas, Kyu-Sang Park of Yonsei University Wonju College of Medicine, South Korea, and colleagues showed how mitochondrial uptake of phosphate via phosphate transport proteins triggered toxic metabolite generation, increased activity of bone formation genes and other reactions that collectively drive the deposition of...
Source: Experimental and Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Nhung Thi Nguyen Tuyet Thi Nguyen Ha Thu Nguyen Ji-Min Lee Min-Ji Kim Xu-Feng Qi Seung-Kuy Cha In-Kyu Lee Kyu-Sang Park Source Type: research

TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway
Experimental & Molecular Medicine, Published online: 01 March 2023; doi:10.1038/s12276-023-00947-9Studying a protein called TGFBI, which regulates adipose expansion, may help the development of new approaches to protect against obesity and related metabolic disorders such as type II diabetes. White adipose tissue (body fat) stores energy, and brown adipose tissue generates heat. Promoting “browning” of adipose tissue may help protect against obesity. Proteins that influence adipose microenvironment can be involved in metabolic diseases, so Seul Gi Lee and Ju-Ock Nam at Kyungpook National University, Taeg Kyu Kwon a...
Source: Experimental and Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Seul Gi Lee Jongbeom Chae Seon Min Woo Seung Un Seo Ha-Jeong Kim Sang-Yeob Kim David D. Schlaepfer In-San Kim Hee-Sae Park Taeg Kyu Kwon Ju-Ock Nam Source Type: research

An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone
Experimental & Molecular Medicine, Published online: 24 February 2023; doi:10.1038/s12276-023-00939-9An antibody targeting key signalling pathways could prevent brain tumor vessels from being abnormal, thereby improving drug delivery into tumor tissues. Glioblastoma multiforme is considered one of the most deadly cancers and it invades brain tissue coupled with the loss of vascular integrity. This pathological vascular changes are closely associated with the hyperactivation of a signalling pathway called VEGFR2 and inactivation of another pathway, Tie2. Now, Injune Kim at the Korea Advanced Institute of Science and Tec...
Source: Experimental and Molecular Medicine - February 24, 2023 Category: Molecular Biology Authors: Eunhyeong Lee Eun-Ah Lee Eunji Kong Haemin Chon Melissa Llaiqui-Condori Cheon Ho Park Beom Yong Park Nu Ri Kang Jin-San Yoo Hyun-Soo Lee Hyung-Seok Kim Sung-Hong Park Seung-Won Choi Dietmar Vestweber Jeong Ho Lee Pilhan Kim Weon Sup Lee Injune Kim Source Type: research

Fibulin2: a negative regulator of BMSC osteogenic differentiation in infected bone fracture healing
Experimental & Molecular Medicine, Published online: 17 February 2023; doi:10.1038/s12276-023-00942-0A protein that is overexpressed during bone fracture infection blocks a key signaling pathway and prevents bone repair. Infection following bone fracture remains a leading cause of delayed or unsuccessful healing. Stem cells from bone marrow are the main source of osteoblasts, bone-forming cells necessary for healthy bone regeneration and repair. Infection causes disruption to stem cell function and hinders bone healing, but the exact mechanisms involved remain unclear. In experiments on human tissue samples and a mouse...
Source: Experimental and Molecular Medicine - February 17, 2023 Category: Molecular Biology Authors: Shi-Dan Li Wei Xing Shao-Chuan Wang You-Bin Li Hao Jiang Han-Xuan Zheng Xiao-Ming Li Jing Yang De-Bin Guo Xiao-Yu Xie Ren-Qing Jiang Chao Fan Lei Li Xiang Xu Jun Fei Source Type: research

MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages
Experimental & Molecular Medicine, Published online: 17 February 2023; doi:10.1038/s12276-023-00946-wReduced activity of a key cell control gene mediates an interaction between gastric cancer cells and immune system cells called macrophages that allows the cancer to spread to the liver. Cancer cells migrating to the liver is a major cause of death for gastric cancer patients, but the mechanisms driving this process have been unclear. Researchers in China led by Tianhua Zhou and Wei Zhuo at Zhejiang University School of Medicine, Hangzhou, studied the activity of genes and their corresponding proteins in patients’ can...
Source: Experimental and Molecular Medicine - February 17, 2023 Category: Molecular Biology Authors: Shuang Li Dongyang Guo Qiang Sun Lu Zhang Yun Cui Min Liu Xixi Ma Yiman Liu Wenyu Cui Leimin Sun Lisong Teng Liangjing Wang Aifu Lin Wei Liu Wei Zhuo Tianhua Zhou Source Type: research

Author Correction: Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis
Experimental & Molecular Medicine, Published online: 15 February 2023; doi:10.1038/s12276-023-00948-8Author Correction: Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - February 15, 2023 Category: Molecular Biology Authors: Majid Ghareghani Vincent Pons Nataly Laflamme Kazem Zibara Serge Rivest Source Type: research

ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation
Experimental & Molecular Medicine, Published online: 13 February 2023; doi:10.1038/s12276-023-00937-xTreatment with a protein that stabilizes existing plaques within blood vessels could help reduce the risk of future cardiovascular events in patients with atherosclerosis. These plaques arise in part from a change in the behavior of the muscle cells within the walls of the blood vessels, which leads to the accumulation of lipids and other biomolecules and creates conditions that can ultimately result in a heart attack or stroke. Researchers led by Youngkeun Ahn and Yong Sook Kim at Chonnam National University Hospital, ...
Source: Experimental and Molecular Medicine - February 13, 2023 Category: Molecular Biology Authors: Dong Im Cho Min Joo Ahn Hyang Hee Cho Meeyoung Cho Ju Hee Jun Bo Gyeong Kang Soo Yeon Lim Soo Ji Yoo Mi Ra Kim Hyung-Seok Kim Su-Jin Lee Le Thanh Dat Changho Lee Yong Sook Kim Youngkeun Ahn Source Type: research

Activating transcription factor-2 supports the antioxidant capacity and ability of human mesenchymal stem cells to prevent asthmatic airway inflammation
Experimental & Molecular Medicine, Published online: 10 February 2023; doi:10.1038/s12276-023-00943-zA cellular protein that promotes a key antioxidant will be a crucial component in stem cell therapies for allergic asthma. Stem cells derived from umbilical cords have been proposed as treatments for incurable allergic asthma, due to their ability to combat inflammation and regenerate damaged cells. Now, Dong-Myung Shin at University of Ulsan College of Medicine in Seoul, South Korea, and co-workers have shown that the activating transcription factor 2 (ATF2) acts to maintain healthy levels of the antioxidant glutathion...
Source: Experimental and Molecular Medicine - February 10, 2023 Category: Molecular Biology Authors: Hyein Ju HongDuck Yun YongHwan Kim Yun Ji Nam Seungun Lee Jinwon Lee Seon Min Jeong Jinbeom Heo Hyungu Kwon You Sook Cho Gowun Jeong Chae-Min Ryu Dong-Myung Shin Source Type: research