Experimental and Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Pim1 promotes IFN-β production by interacting with IRF3
Experimental & Molecular Medicine, Published online: 29 November 2022; doi:10.1038/s12276-022-00893-yA signaling protein that promotes cell survival also helps manage the immune system’s ‘front-line’ response to viral infection. Immediately after infection, the cells of our innate or non-specific immune system rapidly mobilize to keep pathogens at bay until our T and B cells elicit a specific immune reaction. Soo Young Lee and colleagues at Ewha Womans University in Seoul, South Korea, have now linked the antiviral innate immune response to Pim1, a signaling protein known to prevent cell death in both healthy and...
Source: Experimental and Molecular Medicine - November 29, 2022 Category: Molecular Biology Authors: Ryeojin Ko Jeongin Seo Hana Park Nawon Lee Soo Young Lee Source Type: research

Biological roles of the RNA m6A modification and its implications in cancer
Experimental & Molecular Medicine, Published online: 29 November 2022; doi:10.1038/s12276-022-00897-8Further investigations are needed to understand the consequences of a common messenger RNA modification in human cancers. N6-methyladenosine (m6A) modification is vital to many biological processes, including maintaining DNA repair responses and genomic stability. However, m6A modification and proteins recognising this modification are significantly dysregulated in cancers, leading Ji Hoon Lee at the University of Texas Health Science Center at San Antonio, USA, and co-workers to review current knowledge of the function...
Source: Experimental and Molecular Medicine - November 29, 2022 Category: Molecular Biology Authors: Juyeong Hong Kexin Xu Ji Hoon Lee Source Type: research

Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury
Experimental & Molecular Medicine, Published online: 28 November 2022; doi:10.1038/s12276-022-00889-8The process of inflammation-induced cell death, necroptosis, in acute lung injury can be driven by the excessive accumulation of the small biomolecule citrate (a key intermediate of the tricarboxylic acid (TCA) cycle) inside the energy-processing parts of cells called mitochondria. Hui-Hui Yang in Central South University, Hunan, China, and colleagues uncovered this previously unknown mechanism for necroptosis in mouse lung cells exposed to lipopolysaccharide molecules in order to model acute lung injury. They described...
Source: Experimental and Molecular Medicine - November 28, 2022 Category: Molecular Biology Authors: Hui-Hui Yang Hui-Ling Jiang Jia-Hao Tao Chen-Yu Zhang Jian-Bing Xiong Jin-Tong Yang Yu-Biao Liu Wen-Jing Zhong Xin-Xin Guan Jia-Xi Duan Yan-Feng Zhang Shao-Kun Liu Jian-Xin Jiang Yong Zhou Cha-Xiang Guan Source Type: research

Correction: Prefrontal cortex miR-29b-3p plays a key role in the antidepressant-like effect of ketamine in rats
Experimental & Molecular Medicine, Published online: 28 November 2022; doi:10.1038/s12276-022-00900-2Correction: Prefrontal cortex miR-29b-3p plays a key role in the antidepressant-like effect of ketamine in rats (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - November 28, 2022 Category: Molecular Biology Authors: Yun-Qiang Wan Jian-Guo Feng Mao Li Mao-Zhou Wang Li Liu Xueru Liu Xiao-Xia Duan Chun-Xiang Zhang Xiao-Bin Wang Source Type: research

Delineating the dynamic evolution from preneoplasia to invasive lung adenocarcinoma by integrating single-cell RNA sequencing and spatial transcriptomics
Experimental & Molecular Medicine, Published online: 25 November 2022; doi:10.1038/s12276-022-00896-9A map showing how lung cancer progresses from static to invasive carcinomas could inform new therapeutic approaches. The World Health Organisation defines three stages of lung adenocarcinoma: first, in situ lesions, then minimally invasive, then fully invasive. Details about the cell populations involved and their locations during cancer development have been limited. Jianfei Zhu at Air Force Medical University in Xi’an, China, and co-workers have combined the strengths of single-cell RNA sequencing and spatial transc...
Source: Experimental and Molecular Medicine - November 25, 2022 Category: Molecular Biology Authors: Jianfei Zhu Yue Fan Yanlu Xiong Wenchen Wang Jiakuan Chen Yanmin Xia Jie Lei Li Gong Shiquan Sun Tao Jiang Source Type: research

SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice
Experimental & Molecular Medicine, Published online: 25 November 2022; doi:10.1038/s12276-022-00888-9An enzyme involved in vitamin C synthesis also mediates the ability of mice to generate heat in response to cold exposures. Hae Young Chung from Pusan National University in Busan, South Korea, and colleagues showed that mice without a working version of this enzyme, known as SMP30, do not lose weight under cold conditions. That’s because they cannot burn brown fat to create heat through a process called thermogenesis. The researchers detailed how vitamin C, whether produced naturally by SMP30-related signaling in mou...
Source: Experimental and Molecular Medicine - November 25, 2022 Category: Molecular Biology Authors: Bonggi Lee Hye Jin An Dae Hyun Kim Min-Kyeong Lee Hyeon Hak Jeong Ki Wung Chung Younghoon Go Arnold Y. Seo Il Yong Kim Je Kyung Seong Byung Pal Yu Jaewon Lee Eunok Im In-Kyu Lee Myung-Shik Lee Ken-ichi Yamada Hae Young Chung Source Type: research

The deubiquitinating enzyme STAMBP is a newly discovered driver of triple-negative breast cancer progression that maintains RAI14 protein stability
Experimental & Molecular Medicine, Published online: 25 November 2022; doi:10.1038/s12276-022-00890-1An enzyme that promotes tumor growth in triple-negative breast cancer (TNBC), one of the five main breast cancer subtypes, could provide a novel treatment target for this aggressive, life-limiting disease. There are limited treatment options for TNBC, and tumors often develop resistance to chemotherapy. Now, Xin Chen and Jinbao Liu at the Guangzhou Medical University, China, and co-workers have identified a key deubiquitinating enzyme involved in tumor growth in TNBC. High levels of this enzyme, the STAM binding protein...
Source: Experimental and Molecular Medicine - November 25, 2022 Category: Molecular Biology Authors: Qianqian Yang Ding Yan Chaoying Zou Qian Xue Shuhui Lin Qingtian Huang Xiaofen Li Daolin Tang Xin Chen Jinbao Liu Source Type: research

Protective effect of hepatocyte-enriched lncRNA-Mir122hg by promoting hepatocyte proliferation in acute liver injury
Experimental & Molecular Medicine, Published online: 24 November 2022; doi:10.1038/s12276-022-00881-2A long non-coding RNA promotes the growth of new healthy cells after liver injury, according to researchers in China. Some long non-coding RNAs incorporate micro-RNA sequences and are recent targets of interest to elucidate their biological roles. By analyzing liver injury datasets, Zhenjun Yu at Tianjin Medical University and co-workers found that a long non-coding RNA called Mir122hg is enriched in liver tissues found in both mice and humans. Using mouse models, the team observed that Mir122hg expression levels droppe...
Source: Experimental and Molecular Medicine - November 24, 2022 Category: Molecular Biology Authors: Zhenjun Yu Yuhan Li Shuai Shao Beichen Guo Mengxia Zhang Lina Zheng Kun Zhang Feng Zhou Li Zhang Chiyi Chen Wentao Jiang Wei Hong Tao Han Source Type: research

Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy
Experimental & Molecular Medicine, Published online: 16 November 2022; doi:10.1038/s12276-022-00878-xA new approach to treating the most common type of liver cancer, hepatocellular carcinoma, combines the chemotherapy drug sorafenib with procedures that restrict the supply of glucose to the diseased tissues. Jing Zhou at Guangxi Medical University, Nanning, China, and coworkers investigated the effects of this strategy in cultured cells and on mice with tumors that modeled liver cancers. They confirmed that glucose protects cells against the cancer cell-killing properties of sorafenib, but this could be effectively cou...
Source: Experimental and Molecular Medicine - November 16, 2022 Category: Molecular Biology Authors: Jing Zhou Ji Feng Yong Wu Hui-Qi Dai Guang-Zhi Zhu Pan-Hong Chen Li-Ming Wang Guang Lu Xi-Wen Liao Pei-Zhi Lu Wen-Jing Su Shing Chuan Hooi Xin-Pin Ye Han-Ming Shen Tao Peng Guo-Dong Lu Source Type: research

The equilibrium of tumor suppression: DUBs as active regulators of PTEN
Experimental & Molecular Medicine, Published online: 16 November 2022; doi:10.1038/s12276-022-00887-wStudying ways to reactivate a tumor-suppressing protein called PTEN may help in finding new cancer therapies. PTEN represses a signaling pathway that, when over-activated, strongly influences cells to become cancerous. Although some cancers are caused by mutations of PTEN itself, new research shows that proteins called deubiquitinases (DUBs), which regulate stability and activity of target proteins, can turn on and off PTEN activity and cancer. Su Jung Song at Soonchunhyang University, Cheonan-si, South Korea, and Min S...
Source: Experimental and Molecular Medicine - November 16, 2022 Category: Molecular Biology Authors: Audrey Christine Mi Kyung Park Su Jung Song Min Sup Song Source Type: research

Lnc Tmem235 promotes repair of early steroid-induced osteonecrosis of the femoral head by inhibiting hypoxia-induced apoptosis of BMSCs
Experimental & Molecular Medicine, Published online: 16 November 2022; doi:10.1038/s12276-022-00875-0Boosting the activity of a regulatory RNA molecule could improve the efficiency of stem cell therapies for a progressive bone disorder that results from prolonged steroid use for other medical conditions. Bone marrow-derived stem cells are commonly used to treat a steroid-induced disease that occurs when cells in the highest part of the thigh bone break down, leading to hip joint dysfunction and chronic pain. Wuxun Peng and colleagues from the Affiliated Hospital of Guizhou Medical University in Guiyang, China, showed t...
Source: Experimental and Molecular Medicine - November 16, 2022 Category: Molecular Biology Authors: Fei Zhang Wuxun Peng Tao Wang Jian Zhang Wentao Dong Chuan Wang Zhihong Xie Hong Luo Gang Liu Source Type: research

Single-cell analysis of multiple myelomas refines the molecular features of bortezomib treatment responsiveness
Experimental & Molecular Medicine, Published online: 15 November 2022; doi:10.1038/s12276-022-00884-zSingle-cell RNA sequencing reveals insights into treatment resistance in multiple myeloma, a form of blood cancer, and provides possible molecular targets for personalised therapies. Disease progression depends on the interactions between tumor cells and tumor microenvironments in the bone marrow. Bortezomib is used to treat myeloma, but success is hampered by poor responses and resistance in certain patients. To identify potential biomarkers for bortezomib resistance, Seung-Hyun Jung at The Catholic University of Korea...
Source: Experimental and Molecular Medicine - November 15, 2022 Category: Molecular Biology Authors: Seung-Hyun Jung Sung-Soo Park Ji-Young Lim Seon Yong Sohn Na Yung Kim Dokyeong Kim Sug Hyung Lee Yeun-Jun Chung Chang-Ki Min Source Type: research

Protein phosphatases regulate the liver microenvironment in the development of hepatocellular carcinoma
Experimental & Molecular Medicine, Published online: 15 November 2022; doi:10.1038/s12276-022-00883-0Enzymes called phosphatases, which deactivate proteins by removing a phosphate group, may be an excellent therapeutic target for treatment of hepatocellular carinoma (HCC), the most common liver cancer. Most liver cells perform essential liver functions, such as metabolism and detoxification. The remaining cells regulate the liver microenvironment, responding to injury and controlling inflammation. Overactivation of immune cells following liver injury or disease can lead to chronic inflammation, which promotes tumor gro...
Source: Experimental and Molecular Medicine - November 15, 2022 Category: Molecular Biology Authors: Joon-Sup Yoon Chang-Woo Lee Source Type: research

The mitochondrial unfolded protein response (UPRmt) protects against osteoarthritis
Experimental & Molecular Medicine, Published online: 15 November 2022; doi:10.1038/s12276-022-00885-yA cellular defense mechanism that helps preserve the function of mitochondria in the face of stressful stimuli also exerts a protective effect against cartilage degeneration, a key feature of OA. Using mouse cartilage cells, a team led by Jun Ma and Lei Zhu from the Naval Medical University in Shanghai, China, showed that the so-called mitochondrial unfolded protein response is induced by various molecular stimuli. Supplementing the diet with a form of vitamin B3 further enhanced this response, helping to promote mitoch...
Source: Experimental and Molecular Medicine - November 15, 2022 Category: Molecular Biology Authors: Zhibin Zhou Jiajia Lu Mei Yang Jiao Cai Qiang Fu Jun Ma Lei Zhu Source Type: research

Induction of Nanog in neural progenitor cells for adaptive regeneration of ischemic brain
Experimental & Molecular Medicine, Published online: 14 November 2022; doi:10.1038/s12276-022-00880-3The NANOG regulatory protein promotes neuronal regeneration by prompting the self-renewal of progenitor cells following a stroke due to blood vessel blockage (ischemic stroke). NANOG is involved in cellular plasticity and reprogramming, including the maintenance of pluripotent stem cells. Gyung-Ah Jung at the Catholic University of Korea in Seoul, South Korea, and co-workers have demonstrated that NANOG is also critical to the brain’s adaptive response to ischemic stroke. They found that NANOG is preferentially expres...
Source: Experimental and Molecular Medicine - November 14, 2022 Category: Molecular Biology Authors: Gyung-Ah Jung Jin-A Kim Hwan-Woo Park Hyemi Lee Mi-Sook Chang Kyung-Ok Cho Byeong-Wook Song Hyun-Ju Kim Yunhee Kim Kwon Il-Hoan Oh Source Type: research