Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity

Experimental & Molecular Medicine, Published online: 01 May 2023; doi:10.1038/s12276-023-00980-8Cell signaling processes are affected by the varying ways that sections of messenger RNA (mRNA), the molecule that carries genetic instructions copied from a gene, are spliced together to generate several different proteins from a single gene. Kee K. Kim et al. at Chungnam National University in Daejeon, South Korea, review the significance for cell signaling of the alternative splicing of mRNAs. Mutations or abnormal expression of splicing factors that lead to the splicing processes going awry are implicated in human diseases, including cancer. The authors examine the most recent research insights gained by applying emerging methods of genetic analysis to the role of mRNA splicing in several specific signaling pathways vital for normal development and health. They suggest that increasing understanding of faulty splicing in disease could open avenues toward new forms of treatment.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research