Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation

Experimental & Molecular Medicine, Published online: 01 June 2023; doi:10.1038/s12276-023-01009-wAn enzyme implicated in innate immunity offers a potential new target for treating liver injury due to acetaminophen, a common painkiller also known as paracetamol in many countries. A team from South Korea led by Seok Hee Park from Sungkyunkwan University in Suwon and Seong-Jin Kim from the GILO Foundation in Seoul showed that an enzyme called Pellino3 plays a critical role in triggering liver damage caused by acetaminophen. The researchers found that mice lacking Pellino3, an enzyme that marks proteins with chemical tags to mediate immune responses, showed reduced liver damage as measured by several indicators of liver stress. Pellino3 usually activates a specific pro-inflammatory protein and drugs directed at such activation could help protect the liver in regular users of this analgesic and anti-fever drug.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research