SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs
This study reveals that SARS-CoV-2 exhibits distinct profiles of viral gene expression in tissue microenvironments, with lower levels of subgenomic RNAs and subdued expansion compared to cell lines. Researchers discovered pseudoribosomal ribonucleoprotein (RNP) interactions developing in the lungs during SARS-CoV-2 pathogenesis, which may contribute to the accumulation of small Ribo-seq reads and affect translation elongation. Ribosome heterogeneity with compromised 5 S rRNP association was also observed, suggesting a potential strategy for coping with SARS-CoV-2 pathogenesis by resolving RBP complexes. The findings provide valuable insights into the molecular mechanisms underlying SARS-CoV-2 infection and potential therapeutic targets for COVID-19 treatment.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Junsoo Kim Daehwa Youn Seunghoon Choi Youn Woo Lee Dulguun Sumberzul Jeongeun Yoon Hanju Lee Jong Woo Bae Hyuna Noh Dain On Seung-Min Hong Se-Hee An Hui Jeong Jang Seo Yeon Kim Young Been Kim Ji-Yeon Hwang Hyo-Jung Lee Hong Bin Kim Jun Won Park Jun-Won Yu Source Type: research