HIRA vs. DAXX: the two axes shaping the histone H3.3 landscape

Experimental & Molecular Medicine, Published online: 01 February 2024; doi:10.1038/s12276-023-01145-3Histones are key components of chromain, influencing DNA compaction, gene expression, and genome integrity. Unlike other histones, H3.3 is added to chromatin throughout the cell cycle by specific histone chaperones, namely HIRA and DAXX. This review explores how these two chaperones position H3.3 onto DNA, impacting the cellular management of genetic information and gene activity. Investigating the two axes of H3.3 deposition pathways underscores the delicate balance between HIRA and DAXX in saptial and temporal regulation of the H3.3 landscape from the available histone pool. Summarizing the effects of mutations on H3.3 and its chaperones in cancer and developmental disorders, the authors offer valuable insights into chromatin dynamics, development, and disease. This knowledge deepens our understanding of the complex interplay between H3.3 chaperones, providing insights into potential therapeutic strategies for diseases linked to H3.3 dysregulation.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research